ES8200684A1 - Procedimiento para la preparacion de sulfonilureas - Google Patents
Procedimiento para la preparacion de sulfonilureasInfo
- Publication number
- ES8200684A1 ES8200684A1 ES497659A ES497659A ES8200684A1 ES 8200684 A1 ES8200684 A1 ES 8200684A1 ES 497659 A ES497659 A ES 497659A ES 497659 A ES497659 A ES 497659A ES 8200684 A1 ES8200684 A1 ES 8200684A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- benzene
- processes
- preparation
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE SULFONILUREAS Y DE SUS SALES FISILOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R! PUEDE SE UNO DE VARIOS TIPOS DE RADICALES, Y ES ACOHILENO C2-3 Y X ES UNO DE LOS RADICALES DE FORMULA NII), (III) O (IV), DONDE R ES HIDROGENO O HALOGENO. CONSISTE EN LA REACCION DE UNA AMINA DE GORMULA R1NH2 O SUS SALES, EN LA QUE R1 TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON BENZOSULFONILISOCIANATOS, ESTERES O TIOLESTERES DE ACIDOS BENZOSULFONILCARBAMICOS, BENZOSULFONILUREAS, BENZOSULFONILSEMICARBAZIDAS O BENZOSULFONILSEMICARBAZONAS, SUSTITUIDOS EN POSICION 4 CON EL RADICAL DE FORMULA X-CO-NH-Y-, EN LA QUE X E Y SON LOS MISMOS QUE EN LA FORMULA (I), SEGUIDA DE DESDOBLAMIENTO POR HIDROLISIS ALCALINA. EN LAS BENZOSULFONILTIOUREAS SUSTITUIDAS CON EL RADICAL XCONHY-, FORMADAS, SE REEMPLAZA EL ATOMO DE AZUFRE POR OXIGENO, Y A CONTINUACION SE EFECTUA LA ACILACION CON DERIVADOS REACTIVOS DEL ACIDO X-COOH. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUSPROPIEDADES HIPOGLUCEMICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2951060 | 1979-12-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES497659A0 ES497659A0 (es) | 1981-11-01 |
ES8200684A1 true ES8200684A1 (es) | 1981-11-01 |
Family
ID=6088881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES497659A Expired ES8200684A1 (es) | 1979-12-19 | 1980-12-12 | Procedimiento para la preparacion de sulfonilureas |
Country Status (6)
Country | Link |
---|---|
US (1) | US4325963A (es) |
EP (1) | EP0031088A1 (es) |
JP (1) | JPS5697290A (es) |
AU (1) | AU6552280A (es) |
ES (1) | ES8200684A1 (es) |
ZA (1) | ZA807912B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4490527A (en) * | 1982-09-30 | 1984-12-25 | American Home Products Corporation | Benzo-fused heterocyclic anti-ulcer agents |
DE3242477A1 (de) * | 1982-11-18 | 1984-05-24 | Basf Ag, 6700 Ludwigshafen | Heterocyclisch substituierte nitrile, ihre herstellung und verwendung als arzneimittel |
GB9612331D0 (en) * | 1996-06-13 | 1996-08-14 | Leo Pharm Prod Ltd | Chemical compounds |
EP1391460A1 (en) * | 1999-09-30 | 2004-02-25 | Pfizer Products Inc. | Tricyclic pyrrolyl amides as glycogen phosphorylase inhibitors |
ES2211454T3 (es) | 1999-09-30 | 2004-07-16 | Pfizer Products Inc. | Pirrolilamidas como inhibidores de la colageno fosforilasa. |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU47776A1 (es) * | 1964-07-30 | 1966-07-13 | ||
DE1493672C3 (de) * | 1964-08-01 | 1974-05-02 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
DE1445783A1 (de) * | 1964-10-30 | 1969-01-23 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
US3646009A (en) * | 1967-03-15 | 1972-02-29 | Boehringer & Soehne Gmbh | Anti-diabetically active sulfonyl-semicarbazides |
US3819633A (en) * | 1970-04-01 | 1974-06-25 | Erba Carlo Spa | (iso)quinolyl sulfonylureas having antidiabetic activity |
DE2238870C3 (de) * | 1972-08-07 | 1978-09-28 | Hoechst Ag, 6000 Frankfurt | Benzolsulfonylharnstoffe |
DE2256979C3 (de) * | 1972-11-21 | 1981-05-21 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
DE2621958A1 (de) * | 1976-05-18 | 1977-12-08 | Hoechst Ag | Benzolsulfonylharnstoffe und verfahren zu ihrer herstellung |
-
1980
- 1980-12-11 EP EP80107818A patent/EP0031088A1/de not_active Withdrawn
- 1980-12-12 ES ES497659A patent/ES8200684A1/es not_active Expired
- 1980-12-17 US US06/217,526 patent/US4325963A/en not_active Expired - Fee Related
- 1980-12-18 AU AU65522/80A patent/AU6552280A/en not_active Abandoned
- 1980-12-18 ZA ZA00807912A patent/ZA807912B/xx unknown
- 1980-12-19 JP JP18117880A patent/JPS5697290A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES497659A0 (es) | 1981-11-01 |
ZA807912B (en) | 1981-12-30 |
JPS5697290A (en) | 1981-08-05 |
AU6552280A (en) | 1981-06-25 |
US4325963A (en) | 1982-04-20 |
EP0031088A1 (de) | 1981-07-01 |
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