ES8202798A1 - Procedimiento para la preparacion de sulfonilureas - Google Patents

Procedimiento para la preparacion de sulfonilureas

Info

Publication number
ES8202798A1
ES8202798A1 ES498225A ES498225A ES8202798A1 ES 8202798 A1 ES8202798 A1 ES 8202798A1 ES 498225 A ES498225 A ES 498225A ES 498225 A ES498225 A ES 498225A ES 8202798 A1 ES8202798 A1 ES 8202798A1
Authority
ES
Spain
Prior art keywords
compounds
processes
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498225A
Other languages
English (en)
Other versions
ES498225A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8202798A1 publication Critical patent/ES8202798A1/es
Publication of ES498225A0 publication Critical patent/ES498225A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE SULFONILUREAS, DE FORMULA (I), DONDE X SIGNIFICA ALCOHILENO O ALQUENILENO CON 3 A 6 ATOMOS DE CARBONO, O CICLOALCOHILEN-ALCOHILO; Y SIGNIFICA ALCOHILENO CON 2 A 3 ATOMOS DE CARBONO; R1 SIGNIFICA ALCOHILO CON 4 A 6 ATOMOS DE CARBONO, CICLOALCOHILO, CLOROCICLOHEXILO, ADAMANTINO O BENCILO; Y SUS SALES FISOLOGICAMENTE COMPATIBLES. CONSISTE EN REEMPLAZAR EL ATOMO DE AZUFRE POR UN ATOMO DE OXIGENO EN LAS BENZOSULFONILTIOREAS SUSTITUIDAS CON UN RADICAL DE FORMULA (II), MEDIANTE LA UTILIZACION DE AGENTES OXIDANTES TALES COMO PEROXIDO DE HIDROGENO, PEROXIDO SODICO, ACIDO NITROSO O PERMANGANATOS. LOS COMPUESTOS DE FORMULA (I) SE TRATAN CON AGENTES ALCALINOS PARA LA FORMACION DE SALES. DE USO EN LA PREPARACION DE MEDICAMENTOS POR SUS PROPIEDADES HIPOGLUCEMICAS.
ES498225A 1979-12-19 1980-12-30 Procedimiento para la preparacion de sulfonilureas Granted ES498225A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792951135 DE2951135A1 (de) 1979-12-19 1979-12-19 Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung

Publications (2)

Publication Number Publication Date
ES8202798A1 true ES8202798A1 (es) 1982-03-01
ES498225A0 ES498225A0 (es) 1982-03-01

Family

ID=6088937

Family Applications (6)

Application Number Title Priority Date Filing Date
ES497661A Granted ES497661A0 (es) 1979-12-19 1980-12-12 Procedimiento para la preparacion de sulfonilureas
ES498227A Granted ES498227A0 (es) 1979-12-19 1980-12-30 Procedimiento para la preparacion de sulfonilureas
ES498225A Granted ES498225A0 (es) 1979-12-19 1980-12-30 Procedimiento para la preparacion de sulfonilureas
ES498228A Granted ES498228A0 (es) 1979-12-19 1980-12-30 Procedimiento para la preparacion de sulfonilureas
ES498224A Expired ES8202541A1 (es) 1979-12-19 1980-12-30 Procedimiento para la preparacion de sulfonilureas
ES498226A Granted ES498226A0 (es) 1979-12-19 1980-12-30 Procedimiento para la preparacion de sulfonilureas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES497661A Granted ES497661A0 (es) 1979-12-19 1980-12-12 Procedimiento para la preparacion de sulfonilureas
ES498227A Granted ES498227A0 (es) 1979-12-19 1980-12-30 Procedimiento para la preparacion de sulfonilureas

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES498228A Granted ES498228A0 (es) 1979-12-19 1980-12-30 Procedimiento para la preparacion de sulfonilureas
ES498224A Expired ES8202541A1 (es) 1979-12-19 1980-12-30 Procedimiento para la preparacion de sulfonilureas
ES498226A Granted ES498226A0 (es) 1979-12-19 1980-12-30 Procedimiento para la preparacion de sulfonilureas

Country Status (21)

Country Link
US (1) US4379785A (es)
EP (1) EP0031058B1 (es)
JP (1) JPS56108762A (es)
AR (3) AR240922A1 (es)
AT (1) ATE6934T1 (es)
AU (1) AU538129B2 (es)
CA (1) CA1167033A (es)
DE (2) DE2951135A1 (es)
DK (1) DK156434C (es)
ES (6) ES497661A0 (es)
FI (1) FI75338C (es)
GR (1) GR72534B (es)
HU (1) HU184943B (es)
IE (1) IE50635B1 (es)
IL (1) IL61733A (es)
LU (1) LU90244I2 (es)
MX (4) MX6926E (es)
NL (1) NL950026I2 (es)
NO (2) NO155290C (es)
PT (1) PT72226B (es)
ZA (1) ZA807911B (es)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
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PT72226A (de) 1981-01-01
JPS56108762A (en) 1981-08-28
MX6926E (es) 1986-12-01
JPH0139424B2 (es) 1989-08-21
AU6552380A (en) 1981-06-25
FI75338C (fi) 1988-06-09
LU90244I2 (fr) 1998-07-20
CA1167033A (en) 1984-05-08
NO155290B (no) 1986-12-01
DK540280A (da) 1981-06-20
MX8254A (es) 1993-04-01
ATE6934T1 (de) 1984-04-15
NO1996009I1 (no) 1996-07-30
ES498224A0 (es) 1982-02-01
NL950026I2 (nl) 1997-01-06
ES8200665A1 (es) 1981-11-01
AU538129B2 (en) 1984-08-02
NL950026I1 (es) 1996-01-02
IL61733A (en) 1985-05-31
DK156434B (da) 1989-08-21
ES8202542A1 (es) 1982-02-01
MX174496B (es) 1994-05-19
IE802676L (en) 1981-06-19
IL61733A0 (en) 1981-01-30
ES8202543A1 (es) 1982-02-01
ES497661A0 (es) 1981-11-01
ES498228A0 (es) 1982-02-01
NO803855L (no) 1981-06-22
GR72534B (es) 1983-11-17
HU184943B (en) 1984-11-28
EP0031058B1 (de) 1984-04-04
AR240922A2 (es) 1991-03-27
US4379785A (en) 1983-04-12
FI75338B (fi) 1988-02-29
ES8202541A1 (es) 1982-02-01
AR240922A1 (es) 1991-03-27
NO155290C (no) 1987-03-11
ES498225A0 (es) 1982-03-01
DE2951135A1 (de) 1981-06-25
AR230989A1 (es) 1984-08-31
FI803937L (fi) 1981-06-20
EP0031058A1 (de) 1981-07-01
PT72226B (de) 1982-03-26
ES498227A0 (es) 1982-02-01
IE50635B1 (en) 1986-05-28
ES8202799A1 (es) 1982-03-01
MX8352A (es) 1993-11-01
AR231131A1 (es) 1984-09-28
DE3067390D1 (en) 1984-05-10
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DK156434C (da) 1990-01-22

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