ES470226A1 - Procedimiento para la preparacion de 4-fenil-8-amino-tetra- hidroisoquinoleinas - Google Patents

Procedimiento para la preparacion de 4-fenil-8-amino-tetra- hidroisoquinoleinas

Info

Publication number
ES470226A1
ES470226A1 ES470226A ES470226A ES470226A1 ES 470226 A1 ES470226 A1 ES 470226A1 ES 470226 A ES470226 A ES 470226A ES 470226 A ES470226 A ES 470226A ES 470226 A1 ES470226 A1 ES 470226A1
Authority
ES
Spain
Prior art keywords
tetrahydroisoquinolines
phenyl
amino
preparation
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470226A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES470226A1 publication Critical patent/ES470226A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la preparación de 4-fenil-8-amino-tetrahidroisoquinoleínas de la fórmula I **(Fórmula-01)** en la que R1 representa bromo y R2 hidrógeno, o tanto R1 como R2 significan cloro, y sus sales con ácidos fisiológicamente inocuos, caracterizado porque se cicliza un compuesto de la fórmula II **(Fórmula-02)** en que X significa halógeno, hidroxi, un correspondiente grupo éster de ácido carboxílico, un grupo éster de ácido sulfúrico, un grupo éster de ácido alcohilsulfónico o arilsulfónico, con un agente ciclizador ácido y a partir de ello se prepara eventualmente una sal con un ácido fisiológicamente inocuo.
ES470226A 1977-06-01 1978-05-26 Procedimiento para la preparacion de 4-fenil-8-amino-tetra- hidroisoquinoleinas Expired ES470226A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772724610 DE2724610A1 (de) 1977-06-01 1977-06-01 4-phenyl-8-amino-tetrahydroisochinoline

Publications (1)

Publication Number Publication Date
ES470226A1 true ES470226A1 (es) 1979-01-01

Family

ID=6010350

Family Applications (1)

Application Number Title Priority Date Filing Date
ES470226A Expired ES470226A1 (es) 1977-06-01 1978-05-26 Procedimiento para la preparacion de 4-fenil-8-amino-tetra- hidroisoquinoleinas

Country Status (17)

Country Link
US (1) US4185105A (es)
EP (1) EP0000013B1 (es)
JP (1) JPS543078A (es)
AT (1) AT361482B (es)
AU (1) AU517664B2 (es)
CA (1) CA1093079A (es)
DE (2) DE2724610A1 (es)
DK (1) DK242278A (es)
EG (1) EG13777A (es)
ES (1) ES470226A1 (es)
FI (1) FI781717A (es)
HU (1) HU176978B (es)
IL (1) IL54810A0 (es)
IT (1) IT1094899B (es)
NO (1) NO781896L (es)
PT (1) PT68123A (es)
ZA (1) ZA783122B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4340600A (en) * 1980-05-22 1982-07-20 Smithkline Corporation Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines
PH19604A (en) * 1982-06-04 1986-05-27 Egyt Gyogyszervegyeszeti Gyar Isoquinoline derivatives and pharmaceutical compositions containing the same
DE3310878A1 (de) * 1983-03-25 1984-09-27 Hoechst Ag, 6230 Frankfurt Optische antipoden von 8-amino-4-phenyl-1,2,3,4-tetrahydroisochinolin, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit antidepressiver wirkung
BG45572A1 (en) * 1986-10-23 1989-07-14 Druzhestven N Izsledovatelski Antiulcer means
AU2004244672B2 (en) * 2003-06-10 2011-02-10 Resmed Limited Multiple stage blower and enclosure therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3384640A (en) * 1966-03-15 1968-05-21 Bristol Myers Co Amino isoquinolinium salts
DE1670694B2 (de) * 1966-05-05 1976-07-22 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von tetrahydroisochinolinen

Also Published As

Publication number Publication date
ZA783122B (en) 1979-06-27
AU3670578A (en) 1979-12-06
EP0000013A1 (de) 1978-12-20
AU517664B2 (en) 1981-08-20
FI781717A (fi) 1978-12-02
PT68123A (en) 1978-06-01
DE2860212D1 (en) 1981-01-22
JPS543078A (en) 1979-01-11
DE2724610A1 (de) 1978-12-14
EP0000013B1 (de) 1980-10-15
ATA395078A (de) 1980-08-15
IT7823996A0 (it) 1978-05-30
HU176978B (hu) 1981-06-28
DK242278A (da) 1978-12-02
NO781896L (no) 1978-12-04
AT361482B (de) 1981-03-10
EG13777A (en) 1982-03-31
CA1093079A (en) 1981-01-06
IL54810A0 (en) 1978-07-31
IT1094899B (it) 1985-08-10
US4185105A (en) 1980-01-22

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