ES485697A1 - Procedimiento para la obtencion de derivados de 2-hidroxime-til-3,4,5-trihidroxi-piperidina. - Google Patents

Procedimiento para la obtencion de derivados de 2-hidroxime-til-3,4,5-trihidroxi-piperidina.

Info

Publication number
ES485697A1
ES485697A1 ES485697A ES485697A ES485697A1 ES 485697 A1 ES485697 A1 ES 485697A1 ES 485697 A ES485697 A ES 485697A ES 485697 A ES485697 A ES 485697A ES 485697 A1 ES485697 A1 ES 485697A1
Authority
ES
Spain
Prior art keywords
trihydroxy
hydroxymethyl
preparation
piperidine derivatives
medicaments containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES485697A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES485697A1 publication Critical patent/ES485697A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Husbandry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Fodder In General (AREA)

Abstract

Procedimiento para la obtención de derivados de 2- hidroximetil-3,4,5-trihidroxi-6-ciano-piperidina de fórmula (I) **(Fórmula)** donde R significa un resto hidrocarburo alifático, en caso dado sustituido, de cadena recta, ramificada ó cíclica, saturado ó insaturado, en caso dado interrumpido por heteroátomos, tales como O ó S, un resto aromático, en caso dado sustituido, ó un resto heterocíclico, en caso dado sustituido, caracterizado porque 2-hidroximetil-3,4,5-trihidroxi-6-ciano-piperidina se sililizan en los grupos OH por calentamiento con hexaalquildisilazanos, ó haluros de trialquilsilicio bajo adición de un catalizador, se hace reaccionar con un reactante organometálico adecuado de fórmula R - Y donde R tiene el significado arriba indicado e Y significa un metal ó un metal halógeno, y los grupos protectores sililo se disocian.
ES485697A 1978-11-06 1979-11-05 Procedimiento para la obtencion de derivados de 2-hidroxime-til-3,4,5-trihidroxi-piperidina. Expired ES485697A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782848117 DE2848117A1 (de) 1978-11-06 1978-11-06 Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels

Publications (1)

Publication Number Publication Date
ES485697A1 true ES485697A1 (es) 1980-05-16

Family

ID=6054001

Family Applications (1)

Application Number Title Priority Date Filing Date
ES485697A Expired ES485697A1 (es) 1978-11-06 1979-11-05 Procedimiento para la obtencion de derivados de 2-hidroxime-til-3,4,5-trihidroxi-piperidina.

Country Status (7)

Country Link
US (1) US4328233A (es)
EP (1) EP0010745B1 (es)
JP (2) JPS5566559A (es)
AT (1) ATE3033T1 (es)
CA (1) CA1142942A (es)
DE (2) DE2848117A1 (es)
ES (1) ES485697A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634765A (en) * 1984-12-18 1987-01-06 Merrell Dow Pharmaceuticals Inc. Homodisaccharide hypoglycemic agents
DE3620645A1 (de) * 1985-12-20 1987-07-02 Bayer Ag 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung
DE3737523A1 (de) * 1987-11-05 1989-05-18 Bayer Ag Verwendung von substituierten hydroxypiperidinen als antivirale mittel
US5100797A (en) * 1989-06-27 1992-03-31 Monsanto Company Fucosidase inhibitors
JPH0472793U (es) * 1990-11-07 1992-06-26
US5258518A (en) * 1992-04-01 1993-11-02 G. D. Searle & Co. 2-substituted tertiary carbinol derivatives of deoxynojirimycin
EP1682504B1 (en) * 2003-11-12 2012-12-26 Amicus Therapeutics Inc. Hydroxy piperidine derivatives to treat gaucher disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555654A (en) * 1977-06-25 1979-11-14 Exxon Research Engineering Co Agricultural burner apparatus
DE2656602C3 (de) * 1975-12-29 1981-11-26 Nippon Shinyaku Co., Ltd., Kyoto Verfahren zum Extrahieren von 2-Hydroxymethyl-3,4,5-trihydroxypiperidin aus Maulbeerpflanzen
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.

Also Published As

Publication number Publication date
CA1142942A (en) 1983-03-15
US4328233A (en) 1982-05-04
EP0010745B1 (de) 1983-04-13
DE2965218D1 (en) 1983-05-19
EP0010745A1 (de) 1980-05-14
DE2848117A1 (de) 1980-05-14
JPS60166615A (ja) 1985-08-29
ATE3033T1 (de) 1983-04-15
JPS5566559A (en) 1980-05-20
JPS617191B2 (es) 1986-03-04

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