HU228045B1 - Graft rejection suppressing agents - Google Patents

Graft rejection suppressing agents Download PDF

Info

Publication number
HU228045B1
HU228045B1 HU0303332A HUP0303332A HU228045B1 HU 228045 B1 HU228045 B1 HU 228045B1 HU 0303332 A HU0303332 A HU 0303332A HU P0303332 A HUP0303332 A HU P0303332A HU 228045 B1 HU228045 B1 HU 228045B1
Authority
HU
Hungary
Prior art keywords
antibody
ailim
region
polypeptide
transplantation
Prior art date
Application number
HU0303332A
Other languages
English (en)
Hungarian (hu)
Inventor
Seiichi Suzuki
Mitsuaki Isobe
Original Assignee
Japan Tobacco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco filed Critical Japan Tobacco
Publication of HUP0303332A2 publication Critical patent/HUP0303332A2/hu
Publication of HU228045B1 publication Critical patent/HU228045B1/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Graft Or Block Polymers (AREA)
  • External Artificial Organs (AREA)
  • Cylinder Crankcases Of Internal Combustion Engines (AREA)
  • Transplanting Machines (AREA)
  • Soil Working Implements (AREA)
HU0303332A 2001-03-01 2002-02-05 Graft rejection suppressing agents HU228045B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001056216 2001-03-01
JP2001056209 2001-03-01
JP2002008028 2002-01-16
PCT/JP2002/000930 WO2002070010A1 (fr) 2001-03-01 2002-02-05 Inhibiteurs de rejet du greffon

Publications (2)

Publication Number Publication Date
HUP0303332A2 HUP0303332A2 (hu) 2003-12-29
HU228045B1 true HU228045B1 (en) 2012-09-28

Family

ID=27346134

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0303332A HU228045B1 (en) 2001-03-01 2002-02-05 Graft rejection suppressing agents
HU1100018A HU228108B1 (en) 2001-03-01 2002-02-05 Graft rejection suppressing agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU1100018A HU228108B1 (en) 2001-03-01 2002-02-05 Graft rejection suppressing agents

Country Status (24)

Country Link
US (2) US7438905B2 (enExample)
EP (2) EP1769807B1 (enExample)
JP (1) JP4212278B2 (enExample)
KR (1) KR100609444B1 (enExample)
CN (1) CN1518458B (enExample)
AT (2) ATE352318T1 (enExample)
AU (1) AU2002228435B2 (enExample)
BR (1) BR0207787A (enExample)
CA (1) CA2439858C (enExample)
CY (1) CY1110143T1 (enExample)
CZ (1) CZ20032406A3 (enExample)
DE (2) DE60217839T2 (enExample)
DK (1) DK1769807T3 (enExample)
ES (1) ES2344219T3 (enExample)
HU (2) HU228045B1 (enExample)
IL (2) IL156845A0 (enExample)
MX (1) MXPA03006736A (enExample)
NO (2) NO331690B1 (enExample)
NZ (1) NZ527076A (enExample)
PT (1) PT1769807E (enExample)
RU (1) RU2263512C2 (enExample)
SI (1) SI1769807T1 (enExample)
SK (1) SK288048B6 (enExample)
WO (1) WO2002070010A1 (enExample)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112655B1 (en) 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
DE19821060A1 (de) * 1997-09-23 1999-04-15 Bundesrepublik Deutschland Let Ko-stimulierendes Polypeptid von T-Zellen, monoklonale Antikörper sowie die Herstellung und deren Verwendung
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
HRP20050176A2 (en) * 1999-12-16 2005-08-31 Teva Pharmaceutical Industries Ltd. Novel processes for making - and a new crystalline form of-leflunomide
JP3597140B2 (ja) 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤
RU2291675C2 (ru) * 2004-07-09 2007-01-20 Институт теоретической и экспериментальной биофизики РАН Способ обработки трансплантатов для сердечно-сосудистой хирургии
GB0504544D0 (en) * 2005-03-04 2005-04-13 Novartis Ag Organic compounds
JP2006321765A (ja) * 2005-05-20 2006-11-30 Mikiko Ueda 肝移植における拒絶反応の予防又は治療薬、或いは拒絶反応とは断定できない肝機能異常の治療薬
EP2703011A3 (en) * 2007-05-07 2014-03-26 MedImmune, LLC Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease
US9931386B2 (en) * 2008-06-16 2018-04-03 Atsuo Ochi Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of antigen-specific immunity
JPWO2011007747A1 (ja) 2009-07-16 2012-12-27 株式会社糖鎖工学研究所 糖鎖付加ailim細胞外ドメイン及びその製造方法
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
EP2558024B1 (en) * 2010-04-12 2017-03-08 The University Of Miami Macroporous bioengineered scaffolds for cell transplantation
CN106749662B (zh) * 2011-03-31 2021-06-18 国家医疗保健研究所 抗icos的抗体及其用途
US20150139994A1 (en) * 2013-11-12 2015-05-21 The Regents Of The University Of California Compositions and methods for preventing allogeneic immune rejection
HRP20190184T1 (hr) * 2013-11-22 2019-03-22 Shire Viropharma Incorporated Postupci liječenja odbacivanja uzrokovanog protutijelima kod pacijenata s presađenim organom inhibitorom esteraze c1
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US10941446B2 (en) 2014-03-12 2021-03-09 Icahn School Of Medicine At Mount Sinai Method for identifying kidney allograft recipients at risk for chronic injury
WO2015200873A1 (en) 2014-06-26 2015-12-30 Icahn School Of Medicine At Mount Sinai Methods for diagnosing risk of renal allograft fibrosis and rejection
CN113444783B (zh) 2014-06-26 2024-04-09 西奈山伊坎医学院 通过分析预示性基因集诊断亚临床和临床的急性排异的方法
MA41414A (fr) 2015-01-28 2017-12-05 Centre Nat Rech Scient Protéines de liaison agonistes d' icos
CR20180286A (es) 2015-12-03 2018-07-16 Glaxosmithkline Ip Dev Ltd Dinucleotidos de purina cíclicos como moduladores de sting
WO2017098421A1 (en) 2015-12-08 2017-06-15 Glaxosmithkline Intellectual Property Development Limited Benzothiadiazine compounds
WO2017153952A1 (en) 2016-03-10 2017-09-14 Glaxosmithkline Intellectual Property Development Limited 5-sulfamoyl-2-hydroxybenzamide derivatives
JP6746712B2 (ja) 2016-04-07 2020-08-26 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited タンパク質調節因子として有用な複素環式アミド
EP3440072B1 (en) 2016-04-07 2020-01-29 GlaxoSmithKline Intellectual Property Development Ltd Heterocyclic amides useful as protein modulators
MX2018013519A (es) 2016-05-05 2019-03-14 Glaxosmithkline Ip No 2 Ltd Inhibidores del potenciador del homologo zeste 2.
CN116903741A (zh) 2016-06-20 2023-10-20 科马布有限公司 特异性结合于pd-l1的抗体或其抗原结合片段及其用途
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
WO2018029474A2 (en) 2016-08-09 2018-02-15 Kymab Limited Anti-icos antibodies
AU2017300123A1 (en) 2016-07-20 2019-01-31 Glaxosmithkline Intellectual Property Development Limited Isoquinoline derivatives as PERK inhibitors
CN117736325A (zh) 2016-08-09 2024-03-22 科马布有限公司 分离抗体及其应用
WO2018083248A1 (en) 2016-11-03 2018-05-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
CA3052767A1 (en) 2017-02-27 2018-08-30 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
EP3634483A1 (en) 2017-06-09 2020-04-15 GlaxoSmithKline Intellectual Property Development Limited Combination therapy
EP3635010A1 (en) 2017-06-09 2020-04-15 GlaxoSmithKline Intellectual Property Development Limited Combination therapy with icos agonist and ox40 agonist to treat cancer
CA3066007A1 (en) 2017-06-09 2018-12-13 Glaxosmithkline Intellectual Property Development Limited Combination therapy with icos agonist and ox40 agonist to treat cancer
GB201709808D0 (en) 2017-06-20 2017-08-02 Kymab Ltd Antibodies
WO2019021208A1 (en) 2017-07-27 2019-01-31 Glaxosmithkline Intellectual Property Development Limited USEFUL INDAZOLE DERIVATIVES AS PERK INHIBITORS
WO2019053617A1 (en) 2017-09-12 2019-03-21 Glaxosmithkline Intellectual Property Development Limited CHEMICAL COMPOUNDS
US20200255526A1 (en) 2017-09-14 2020-08-13 Glaxosmithkline Intellectual Property Development Limited Combination treatment for cancer
US11377440B2 (en) 2017-10-05 2022-07-05 Glaxosmithkline Intellectual Property Development Limited Modulators of stimulator of interferon genes (STING)
EP3692033A1 (en) 2017-10-05 2020-08-12 GlaxoSmithKline Intellectual Property Development Limited Modulators of stimulator of interferon genes (sting) useful in treating hiv
WO2019122882A1 (en) 2017-12-19 2019-06-27 Kymab Limited Bispecific antibody for icos and pd-l1
GB201721338D0 (en) 2017-12-19 2018-01-31 Kymab Ltd Anti-icos Antibodies
RU2688172C1 (ru) * 2018-04-05 2019-05-20 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ профилактики отторжения трансплантата трупной почки
WO2019204267A1 (en) 2018-04-16 2019-10-24 Icahn School Of Medicine At Mount Sinai Method and kits for prediction of acute rejection and renal allograft loss using pre-transplant transcriptomic signatures in recipient blood
GB201807924D0 (en) 2018-05-16 2018-06-27 Ctxt Pty Ltd Compounds
CA3101561A1 (en) 2018-05-31 2019-12-05 Glaxosmithkline Intellectual Property Development Limited Combined therapy with icos binding proteins and argininemethyltransferase inhibitors
WO2019229614A1 (en) 2018-05-31 2019-12-05 Glaxosmithkline Intellectual Property Development Limited Combination of a type ii protein arginine methyltransferase inhibitor and an icos binding protein to treat cancer
WO2020031087A1 (en) 2018-08-06 2020-02-13 Glaxosmithkline Intellectual Property Development Limited Combination therapy
US20210324081A1 (en) 2018-10-22 2021-10-21 Glaxosmithkline Intellectual Property Development Limited Dosing
US20200368369A1 (en) * 2019-05-22 2020-11-26 Wyvern Pharmaceuticals Inc. Composition for endogenous production of checkpoint protein precursors
GB201910304D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
GB201910305D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
WO2021018941A1 (en) 2019-07-31 2021-02-04 Glaxosmithkline Intellectual Property Development Limited Methods of treating cancer
WO2021046293A1 (en) 2019-09-06 2021-03-11 Glaxosmithkline Intellectual Property Development Limited Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and tremelimumab
WO2021043961A1 (en) 2019-09-06 2021-03-11 Glaxosmithkline Intellectual Property Development Limited Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and chemotherapy
WO2021058711A2 (en) 2019-09-27 2021-04-01 Glaxosmithkline Intellectual Property Development Limited Antigen binding proteins
WO2021119753A1 (en) 2019-12-18 2021-06-24 Ctxt Pty Limited Compounds
CN113294813B (zh) * 2020-02-24 2022-09-02 宁波方太厨具有限公司 一种电磁灶
CN115698075A (zh) 2020-04-14 2023-02-03 葛兰素史密斯克莱知识产权发展有限公司 涉及抗icos和抗pd1抗体,任选地进一步涉及抗tim3抗体的癌症的组合治疗
WO2021209356A1 (en) 2020-04-14 2021-10-21 Glaxosmithkline Intellectual Property Development Limited Combination treatment for cancer
CA3175490A1 (en) 2020-04-14 2021-10-21 Glaxosmithkline Intellectual Property Limited Combination treatment for cancer based upon an icos antibody and a pd-l1 antibody tgf-beta-receptor fusion protein
GB202007099D0 (en) 2020-05-14 2020-07-01 Kymab Ltd Tumour biomarkers for immunotherapy
AU2022230795B2 (en) 2021-03-02 2025-02-13 Glaxosmithkline Intellectual Property Development Limited Substituted pyridines as dnmt1 inhibitors
EP4314060A1 (en) 2021-03-31 2024-02-07 GlaxoSmithKline Intellectual Property Development Limited Antigen binding proteins and combinations thereof
WO2022243378A1 (en) 2021-05-18 2022-11-24 Kymab Limited Uses of anti-icos antibodies
GB202107994D0 (en) 2021-06-04 2021-07-21 Kymab Ltd Treatment of cancer
US20250340641A1 (en) 2022-05-18 2025-11-06 Kymab Limited Uses of anti-icos antibodies

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506126A (en) * 1988-02-25 1996-04-09 The General Hospital Corporation Rapid immunoselection cloning method
US6075181A (en) * 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5521288A (en) * 1990-03-26 1996-05-28 Bristol-Myers Squibb Company CD28IG fusion protein
KR100333120B1 (ko) * 1991-06-11 2002-04-18 리차드 엘. 콘 세포간 부착 분자-3 및 그것의 결합 리간드
US5770197A (en) * 1991-06-27 1998-06-23 Bristol-Myers Squibb Company Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules
JP3162438B2 (ja) 1991-09-12 2001-04-25 住友製薬株式会社 高感度特異的抗体測定法
US5484892A (en) * 1993-05-21 1996-01-16 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells
US6719972B1 (en) * 1994-06-03 2004-04-13 Repligen Corporation Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies
US5747461A (en) * 1994-07-26 1998-05-05 Markov; Angel K. Synergistic administration of cyclosporine and fructose diphosphate
WO1997026912A2 (en) 1996-01-23 1997-07-31 Genentech, Inc. Anti-cd18 antibodies for use against stroke
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
AU723669B2 (en) 1996-09-18 2000-08-31 Zetesis S.P.A Use of proteins as agents against autoimmune diseases
EP1878748A2 (en) * 1996-11-08 2008-01-16 Biogen Idec Inc. Identification of unique binding interactions between certain antibodies and the human B7.1 and B7.2 costimulatory antigens
AU4145597A (en) 1997-02-20 1998-09-09 Cedars-Sinai Medical Center Ulcerative colitis panca secretory vesicle antigen and methods of using sa me
FI107538B (fi) * 1997-02-26 2001-08-31 Raisio Benecol Oy Menetelmä stanoliesterien valmistamiseksi
US7112655B1 (en) * 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
JP3521382B2 (ja) * 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
WO2001018022A1 (en) 1999-09-03 2001-03-15 Human Genome Sciences, Inc. 52 human secreted proteins
SI1325932T1 (enExample) 1997-04-07 2005-08-31 Genentech Inc
DE19821060A1 (de) * 1997-09-23 1999-04-15 Bundesrepublik Deutschland Let Ko-stimulierendes Polypeptid von T-Zellen, monoklonale Antikörper sowie die Herstellung und deren Verwendung
WO1999015553A2 (de) * 1997-09-23 1999-04-01 Bundesrepublik Deutschland Letztvertreten Durch Den Direktor Des Robert-Koch-Instituts Ko-stimulierendes polypeptid von t-zellen, monoklonale antikörper sowie die herstellung und deren verwendung
JPH11228442A (ja) * 1998-02-09 1999-08-24 Cypros Pharmaceut Corp 臓器移植後のシクロスポリン投与量を低減するためのフルクトース二リン酸の使用
JP2000154151A (ja) * 1998-09-14 2000-06-06 Kyo Jo 免疫抑制剤
AU767241B2 (en) * 1998-09-14 2003-11-06 Qiang Xu Immunosuppressive agents
WO2000019988A1 (en) 1998-10-07 2000-04-13 Millennium Pharmaceuticals, Inc. NOVEL Th2-SPECIFIC MOLECULES AND USES THEREOF
NZ583002A (en) * 1999-02-03 2011-12-22 Amgen Inc Novel polypeptide B7RP-1 T cell ligand-receptor pair involved in immune response modulation
CZ20013964A3 (cs) 1999-05-06 2002-06-12 Genetics Institute, Inc. Pouľití rozpustných kostimulačních molekul pro výrobu léčiva ke zvyąování imunitních odpovědí
AU6615500A (en) 1999-07-28 2001-02-19 Genetics Institute Inc. Preventing immune-mediated abortion by inhibiting costimulation
AU6458400A (en) 1999-08-11 2001-03-13 Isis Innovation Limited Nucleic acid, polypeptides, assays, therapeutic methods and means
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
JP3871503B2 (ja) * 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP4737905B2 (ja) 1999-09-21 2011-08-03 ジェネティクス インスティテュート,エルエルシー Gl50分子およびその使用
AU1342501A (en) 1999-10-29 2001-05-14 Human Genome Sciences, Inc. 32 human secreted proteins
WO2001064704A1 (en) 2000-03-02 2001-09-07 Mayo Foundation For Medical Education And Research hB7-H2, A NOVEL CO-STIMULATORY MOLECULE
JP3597140B2 (ja) * 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途
AU2002217969B2 (en) 2000-11-28 2007-12-20 Amgen Canada Inc. Polypeptides involved in immune response
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤

Also Published As

Publication number Publication date
EP1374901B9 (en) 2007-11-07
RU2003129166A (ru) 2005-03-10
HU228108B1 (en) 2012-11-28
NO331690B1 (no) 2012-02-27
JP4212278B2 (ja) 2009-01-21
HK1102293A1 (en) 2007-11-16
US20090047292A1 (en) 2009-02-19
US20040253229A1 (en) 2004-12-16
CN1518458B (zh) 2010-05-26
RU2263512C2 (ru) 2005-11-10
PT1769807E (pt) 2010-06-02
EP1374901A1 (en) 2004-01-02
NO20033839L (no) 2003-11-03
ES2344219T3 (es) 2010-08-20
KR20030078946A (ko) 2003-10-08
ATE352318T1 (de) 2007-02-15
IL156845A0 (en) 2004-02-08
AU2002228435B2 (en) 2005-03-10
HK1061531A1 (en) 2004-09-24
SI1769807T1 (sl) 2010-08-31
ATE463256T1 (de) 2010-04-15
EP1769807B1 (en) 2010-04-07
IL156845A (en) 2011-10-31
JP2003277293A (ja) 2003-10-02
DE60217839D1 (de) 2007-03-15
KR100609444B1 (ko) 2006-08-03
DE60235928D1 (de) 2010-05-20
DE60217839T2 (de) 2007-11-15
EP1374901A4 (en) 2004-09-15
NO20110218L (no) 2003-11-03
CA2439858A1 (en) 2002-09-12
NO20033839D0 (no) 2003-08-29
CY1110143T1 (el) 2015-01-14
SK12142003A3 (sk) 2004-05-04
SK288048B6 (sk) 2013-03-01
MXPA03006736A (es) 2004-05-31
DK1769807T3 (da) 2010-07-19
HUP0303332A2 (hu) 2003-12-29
NZ527076A (en) 2006-03-31
CA2439858C (en) 2009-07-14
BR0207787A (pt) 2004-03-23
CN1518458A (zh) 2004-08-04
EP1374901B1 (en) 2007-01-24
WO2002070010A1 (fr) 2002-09-12
US7438905B2 (en) 2008-10-21
EP1769807A1 (en) 2007-04-04
CZ20032406A3 (cs) 2004-10-13

Similar Documents

Publication Publication Date Title
HU228045B1 (en) Graft rejection suppressing agents
JP3611573B2 (ja) モノクローナル抗体の免疫抑制活性および毒性のモジュレーションのための方法ならびに物質
US11207329B2 (en) Methods for treating GI syndrome and graft versus host disease
BR112019026907A2 (pt) Anticorpos apenas de cadeia pesadaanti-bcma, polinucleotídeo, vetor, célula,composição farmacêutica, seus usos e método paraproduzir os mesmos
HU230768B1 (hu) Aß peptidet kiválasztó humanizált ellenanyagok
JP2002356443A (ja) 炎症性腸疾患治療剤
BR112019026803A2 (pt) anticorpos apenas de cadeia pesada anti-bcma
US20220251191A1 (en) Therapeutic compositions and methods for treating cancer in combination with analogs of interleukin proteins
US20240270845A1 (en) Anti-cd2 antibodies
Quesenberry et al. Allogeneic chimerism with low-dose irradiation, antigen presensitization, and costimulator blockade in H-2 mismatched mice
JP2004514423A (ja) トランスジェニックxenomouse(登録商標)から獲得されるpeudomonasaeruginosalpsに対するヒト抗体
ES2936075T3 (es) Activador de células T reguladoras, y uso del mismo
HK1061531B (en) Graft rejection suppressors
HK1102293B (en) Graft rejection suppressors

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees