HU208147B - Process for producing etoposide-aminophosphate derivatives - Google Patents

Process for producing etoposide-aminophosphate derivatives

Info

Publication number
HU208147B
HU208147B HU905862A HU586288A HU208147B HU 208147 B HU208147 B HU 208147B HU 905862 A HU905862 A HU 905862A HU 586288 A HU586288 A HU 586288A HU 208147 B HU208147 B HU 208147B
Authority
HU
Hungary
Prior art keywords
aminophosphate
derivatives
etoposide
producing
producing etoposide
Prior art date
Application number
HU905862A
Other languages
English (en)
Hungarian (hu)
Other versions
HU905862D0 (en
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HU905862D0 publication Critical patent/HU905862D0/hu
Publication of HU208147B publication Critical patent/HU208147B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cable Accessories (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
HU905862A 1987-08-04 1988-08-03 Process for producing etoposide-aminophosphate derivatives HU208147B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (2)

Publication Number Publication Date
HU905862D0 HU905862D0 (en) 1991-03-28
HU208147B true HU208147B (en) 1993-08-30

Family

ID=26765636

Family Applications (3)

Application Number Title Priority Date Filing Date
HU905862A HU208147B (en) 1987-08-04 1988-08-03 Process for producing etoposide-aminophosphate derivatives
HU884081A HU202547B (en) 1987-08-04 1988-08-03 Process for producing epipodophyllotoxin-glycoside-4'-phosphate derivatives and pharmaceutical compositions comprising such active ingredient
HU95P/P00387P HU211960A9 (en) 1987-08-04 1995-06-22 Epipodophyllotoxinglucosid-4'-phosphat-derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
HU884081A HU202547B (en) 1987-08-04 1988-08-03 Process for producing epipodophyllotoxin-glycoside-4'-phosphate derivatives and pharmaceutical compositions comprising such active ingredient
HU95P/P00387P HU211960A9 (en) 1987-08-04 1995-06-22 Epipodophyllotoxinglucosid-4'-phosphat-derivatives

Country Status (34)

Country Link
US (3) US4904768A (Direct)
JP (1) JPH0699465B2 (Direct)
KR (1) KR900006230B1 (Direct)
CN (1) CN1027169C (Direct)
AT (1) AT398974B (Direct)
BE (1) BE1002982A4 (Direct)
CA (1) CA1310637C (Direct)
CH (1) CH676716A5 (Direct)
CY (1) CY1625A (Direct)
CZ (1) CZ286893B6 (Direct)
DD (2) DD274423A5 (Direct)
DE (1) DE3826562A1 (Direct)
DK (2) DK169344B1 (Direct)
ES (1) ES2010775A6 (Direct)
FI (1) FI87790C (Direct)
FR (1) FR2622193B1 (Direct)
GB (1) GB2207674B (Direct)
GR (1) GR1000490B (Direct)
HK (1) HK6392A (Direct)
HU (3) HU208147B (Direct)
IE (1) IE61040B1 (Direct)
IL (1) IL87290A (Direct)
IT (1) IT1226825B (Direct)
LU (2) LU87290A1 (Direct)
MX (1) MX173843B (Direct)
MY (1) MY104321A (Direct)
NL (2) NL192683C (Direct)
NO (4) NO170284C (Direct)
NZ (1) NZ225615A (Direct)
PT (1) PT88186B (Direct)
SE (1) SE502214C2 (Direct)
SG (1) SG101291G (Direct)
SK (1) SK279325B6 (Direct)
YU (3) YU143688A (Direct)

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US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (Direct) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
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US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
JP2005511550A (ja) * 2001-10-26 2005-04-28 サントル・ナショナル・ドゥ・ラ・ルシェルシュ・シャンティフィク エトポシドおよび類似体の誘導体、ならびにそれを含有する医薬組成物
DE60335383D1 (de) 2002-07-15 2011-01-27 Univ Texas Antikörper mit bindung an anionische phospholipide und aminophospholipide und ihre verwendung bei der behandlung von virusinfektionen
MXPA05007322A (es) * 2003-01-06 2006-02-17 Angiochem Inc Aprotinina y analogos como portadores a traves de la barrera sangre-cerebro.
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
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WO2009036106A1 (en) * 2007-09-13 2009-03-19 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
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CN102596993A (zh) 2009-07-02 2012-07-18 安吉奥开米公司 多聚体肽结合物以及其应用
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CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
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FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
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JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
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Also Published As

Publication number Publication date
DD299067A5 (de) 1992-03-26
SG101291G (en) 1992-01-17
FR2622193B1 (fr) 1993-12-17
PT88186A (pt) 1989-06-30
HK6392A (en) 1992-01-17
SK541288A3 (en) 1998-10-07
LU90138I2 (fr) 1997-11-26
NO920277D0 (no) 1992-01-22
MX9202851A (es) 1992-06-30
FI883596A7 (fi) 1989-02-05
DK434088A (da) 1989-02-05
CA1310637C (en) 1992-11-24
GB2207674A (en) 1989-02-08
NL970042I1 (nl) 1998-03-02
DK11992A (da) 1992-01-31
PT88186B (pt) 1995-07-03
NO172440B (no) 1993-04-13
SK279325B6 (sk) 1998-10-07
ES2010775A6 (es) 1989-12-01
KR900006230B1 (ko) 1990-08-27
CH676716A5 (Direct) 1991-02-28
NO920665L (no) 1989-02-24
NO920665D0 (no) 1992-02-20
AU2030688A (en) 1989-06-08
NL970042I2 (Direct) 2005-06-01
US4904768A (en) 1990-02-27
CN1027169C (zh) 1994-12-28
YU10490A (en) 1990-06-30
US5041424A (en) 1991-08-20
NL192683B (Direct) 1997-08-01
IT8821535A0 (it) 1988-07-28
SE8802815L (sv) 1989-02-05
ATA195588A (de) 1994-07-15
BE1002982A4 (fr) 1991-10-15
IE61040B1 (en) 1994-09-07
NO172440C (no) 1993-07-21
DK434088D0 (da) 1988-08-03
HU202547B (en) 1991-03-28
HU211960A9 (en) 1996-01-29
NO883299D0 (no) 1988-07-26
KR890003790A (ko) 1989-04-18
DE3826562A1 (de) 1989-02-16
FI87790C (fi) 1993-02-25
GR880100512A (en) 1989-05-25
CY1625A (en) 1992-07-10
HU905862D0 (en) 1991-03-28
MX173843B (es) 1994-03-30
FI883596A0 (fi) 1988-08-01
GR1000490B (el) 1992-07-30
CZ286893B6 (cs) 2000-07-12
YU10390A (en) 1990-06-30
MY104321A (en) 1994-03-31
CN1061225A (zh) 1992-05-20
NO170284C (no) 1992-09-30
DD274423A5 (de) 1989-12-20
IT1226825B (it) 1991-02-19
NO170284B (no) 1992-06-22
NO1998002I1 (no) 1998-01-14
DK169344B1 (da) 1994-10-10
DE3826562C2 (Direct) 1993-04-08
SE8802815D0 (sv) 1988-08-03
NL192683C (nl) 1997-12-02
IE882378L (en) 1989-02-04
GB2207674B (en) 1991-09-11
USRE35524E (en) 1997-06-03
AT398974B (de) 1995-02-27
NO883299L (no) 1989-02-24
YU143688A (en) 1990-04-30
NZ225615A (en) 1991-06-25
HUT47303A (en) 1989-02-28
FR2622193A1 (fr) 1989-04-28
NL8801934A (nl) 1989-03-01
GB8818462D0 (en) 1988-09-07
DK11992D0 (da) 1992-01-31
JPH0699465B2 (ja) 1994-12-07
CZ541288A3 (cs) 1999-12-15
AU610619B2 (en) 1991-05-23
SE502214C2 (sv) 1995-09-18
IL87290A0 (en) 1989-01-31
LU87290A1 (fr) 1990-02-07
NO920277L (no) 1989-02-24
JPH01100188A (ja) 1989-04-18
IL87290A (en) 1993-01-31
FI87790B (fi) 1992-11-13

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