HRP20190749T1 - Ljudska antitijela na pd-l1 - Google Patents
Ljudska antitijela na pd-l1 Download PDFInfo
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- HRP20190749T1 HRP20190749T1 HRP20190749TT HRP20190749T HRP20190749T1 HR P20190749 T1 HRP20190749 T1 HR P20190749T1 HR P20190749T T HRP20190749T T HR P20190749TT HR P20190749 T HRP20190749 T HR P20190749T HR P20190749 T1 HRP20190749 T1 HR P20190749T1
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- antibody
- antigen
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- binding fragment
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- 239000012634 fragment Substances 0.000 claims 24
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 239000000825 pharmaceutical preparation Substances 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 102100034608 Angiopoietin-2 Human genes 0.000 claims 1
- 101710145634 Antigen 1 Proteins 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 241000712899 Lymphocytic choriomeningitis mammarenavirus Species 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 238000003782 apoptosis assay Methods 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940121647 egfr inhibitor Drugs 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000007917 intracranial administration Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- 230000005522 programmed cell death Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000004565 tumor cell growth Effects 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (18)
1. Izolirano antitijelo ili njegov fragment koji se vezuje za antigen koji se vezuje za protein ljudskog liganda programirane stanične smrti 1 (PD-L1), naznačen time, što izolirano antitijelo ili njegov fragment koji se vezuje za antitijelo sadrži tri regije koje određuju komplementarnost (CDR) varijabilne regije teškog lanca (HCVR) koja ima aminokiselinsku sekvencu SEQ ID NO: 82 te tri CDR-a varijabilne regije lakog lanca (LCVR) koja ima aminokiselinsku sekvencu SEQ ID NO: 90.
2. Izolirano antitijelo ili njegov fragment koji se vezuje za antigen prema patentnom zahtjevu 1, naznačen time, što antitijelo ili njegov fragment koji se vezuje za antigen sadrži HCDR1 koja ima aminokiselinsku sekvencu SEQ ID NO: 84, HCDR2 koja ima aminokiselinsku sekvencu SEQ ID NO: 86, HCDR3 koja ima aminokiselinsku sekvencu SEQ ID NO: 88, LCDR1 koja ima aminokiselinsku sekvencu SEQ ID NO: 92, LCDR2 koja ima aminokiselinsku sekvencu SEQ ID NO: 94 i LCDR3 koja ima aminokiselinsku sekvencu SEQ ID NO: 96.
3. Izolirano antitijelo ili fragment koji se vezuje za antigen prema patentnom zahtjevu 1 ili 2, koji sadrži par aminokiselinske sekvence HCVR-a/LCVR-a sa SEQ ID NO: 82/90.
4. Izolirano antitijelo ili njegov fragment koji se vezuje za antigen prema bilo kojem patentnom zahtjevu od 1 do 3, koji je IgG1 ili IgG4.
5. Izolirano antitijelo ili njegov fragment koji se vezuje za antigen prema bilo kojem patentnom zahtjevu od 1 do 4, naznačen time, što je antitijelo ili njegov fragment koji se vezuje za antigen multispecifična molekula koja se vezuje za antigen.
6. Farmaceutski pripravak koji sadrži izolirano antitijelo ili njegov fragment koji se vezuje za antigen koji se vezuje za PD-L1 prema bilo kojem patentnom zahtjevu od 1 do 5 te farmaceutski prihvatljivi nosač ili otapalo.
7. Izolirana polinukleotidna molekula koja šifrira antitijelo ili fragment koji se vezuje za antigen kako je navedeno u patentnom zahtjevu 3.
8. Vektor koji sadrži polinukleotid prema patentnom zahtjevu 7.
9. Stanica koja eksprimira vektor prema patentnom zahtjevu 8.
10. Metoda proizvodnje anti-PD-L1 antitijela ili njegovog fragmenta koji se vezuje za antigen, pri čemu se spomenuta metoda sastoji od uzgajanja stanice prema patentnom zahtjevu 9 u uvjetima koji omogućavaju proizvodnju antitijela ili fragmenta i prikupljanja antitijela ili fragmenta koji je proizveden na taj način.
11. Antitijelo ili njegov fragment koji se vezuje za antigen prema bilo kojem patentnom zahtjevu od 1 do 5 ili farmaceutski pripravak prema patentnom zahtjevu 6 za primjenu u pojačavanju imunološkog odgovora kod subjekta ili za pojačavanje aktivacije T stanica kod subjekta.
12. Antitijelo, njegov fragment koji se vezuje za antigen ili farmaceutski pripravak za primjenu prema patentnom zahtjevu 11, naznačen time, što subjekt ima tumor.
13. Antitijelo, njegov fragment koji se vezuje za antigen ili farmaceutski pripravak za primjenu prema patentnom zahtjevu 11, naznačen time, što subjekt ima virusnu infekciju, opcionalno naznačen time, što virusna infekcija jest HIV, HBV, HCV, HPV, LCMV ili SIV infekcija.
14. Antitijelo prema bilo kojem patentnom zahtjevu od 1 do 5 ili farmaceutski pripravak prema patentnom zahtjevu 6 za primjenu u metodi inhibicije rasta tumora ili tumorske stanice.
15. Antitijelo, njegov fragment koji se vezuje za antigen ili farmaceutski pripravak za primjenu prema patentnom zahtjevu 12 ili 14, naznačen time, što se tumor sastoji od karcinoma bubrežnih stanica, raka mozga, karcinoma pločastih stanica glave i vrata, raka želuca, raka bubrega, raka dojke, raka jajnika, raka prostate, nemikrocelularnog karcinoma pluća, kolorektalnog raka, multiplog mijeloma ili melanoma.
16. Antitijelo, njegov fragment koji se vezuje za antigen ili farmaceutski pripravak za primjenu prema patentnom zahtjevu 14 ili 15, naznačen time, što antitijelo ili njegov fragment koji se vezuje za antigen, ili farmaceutski pripravak koji sadrži antitijelo ili njegov fragment koji se vezuje za antigen, služi za primjenu kod subjekta u kombinaciji s drugim terapijskim sredstvom, opcionalno naznačen time, što se drugo terapijsko sredstvo sastoji od nesteroidnog protiupalnog lijeka (NSAID), kortikosteroida, antitijela na koinhibitor T-stanica, antitijela na antigen specifičan za tumor, antitijela na PD-1, inhibitora indoleamin-2,3-dioksigelnaze, inhibitora Ang2, cjepiva protiv raka, inhibitora EGFR-a, inhibitora TGFβ, dodatka prehrani kao što je antioksidans, antagonista VEGF-a kao što je anti-VEGF antitijelo, inhibitora mikrocelularne kinaze receptora VEGF-a ili fuzijskog proteina koji inhibira VEGF, kirurškog zahvata, zračenja, kemoterapijskog sredstva, citotoksičnog sredstva ili njihove kombinacije.
17. Antitijelo, njegov fragment koji se vezuje za antigen ili farmaceutski pripravak za primjenu prema bilo kojim patentnim zahtjevima od 11 do 16, naznačen time, što je antitijelo ili njegov fragment koji se vezuje za antigen namijenjen za supkutanu, intravensku, intradermalnu, intraperitonealnu, oralnu, intramuskularnu ili intrakranijalnu primjenu.
18. Antitijelo, njegov fragment koji se vezuje za antigen ili farmaceutski pripravak za primjenu prema bilo kojim patentnim zahtjevima od 11 do 17, naznačen time, što je antitijelo ili njegov fragment koji se vezuje za antigen namijenjen za primjenu u dozi od oko 0,1 mg/kg tjelesne težine do oko 60 mg/kg tjelesne težine subjekta.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461930582P | 2014-01-23 | 2014-01-23 | |
US201462089549P | 2014-12-09 | 2014-12-09 | |
PCT/US2015/012595 WO2015112805A1 (en) | 2014-01-23 | 2015-01-23 | Human antibodies to pd-l1 |
EP15703380.4A EP3097120B1 (en) | 2014-01-23 | 2015-01-23 | Human antibodies to pd-l1 |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20190749T1 true HRP20190749T1 (hr) | 2019-08-23 |
Family
ID=52463178
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190749TT HRP20190749T1 (hr) | 2014-01-23 | 2019-04-23 | Ljudska antitijela na pd-l1 |
Country Status (29)
Country | Link |
---|---|
US (3) | US9938345B2 (hr) |
EP (2) | EP3097120B1 (hr) |
JP (2) | JP2017507650A (hr) |
KR (1) | KR102182925B1 (hr) |
CN (1) | CN106103482B (hr) |
AU (1) | AU2015209238B2 (hr) |
BR (1) | BR112016016207B1 (hr) |
CA (1) | CA2937343C (hr) |
CL (1) | CL2016001879A1 (hr) |
CY (2) | CY1122005T1 (hr) |
DK (2) | DK3097120T3 (hr) |
EA (1) | EA034695B1 (hr) |
ES (2) | ES2878091T3 (hr) |
HR (1) | HRP20190749T1 (hr) |
HU (2) | HUE043672T2 (hr) |
IL (1) | IL246661B (hr) |
LT (1) | LT3097120T (hr) |
ME (1) | ME03642B (hr) |
MX (1) | MX2016009444A (hr) |
MY (1) | MY188355A (hr) |
PH (1) | PH12016501384B1 (hr) |
PL (2) | PL3097120T3 (hr) |
PT (2) | PT3097120T (hr) |
RS (1) | RS58638B1 (hr) |
SG (1) | SG11201605908WA (hr) |
SI (1) | SI3097120T1 (hr) |
TW (1) | TWI680138B (hr) |
UY (1) | UY35965A (hr) |
WO (1) | WO2015112805A1 (hr) |
Families Citing this family (274)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20120341A1 (es) | 2008-12-09 | 2012-04-24 | Genentech Inc | Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t |
ES2671748T3 (es) | 2011-07-21 | 2018-06-08 | Tolero Pharmaceuticals, Inc. | Inhibidores heterocíclicos de proteína quinasas |
CA2893597C (en) | 2012-12-07 | 2021-06-29 | Chemocentryx, Inc. | Diazole lactams |
AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
WO2015048520A1 (en) | 2013-09-27 | 2015-04-02 | Genentech, Inc. | Anti-pdl1 antibody formulations |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
TWI680138B (zh) * | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
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