HRP20161307T1 - Postupak za pripravu praškaste formulacije međuproizvoda i konačni kruti oblik doziranja uz korištenje koraka zgrušavanja raspršivanjem - Google Patents
Postupak za pripravu praškaste formulacije međuproizvoda i konačni kruti oblik doziranja uz korištenje koraka zgrušavanja raspršivanjem Download PDFInfo
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- HRP20161307T1 HRP20161307T1 HRP20161307TT HRP20161307T HRP20161307T1 HR P20161307 T1 HRP20161307 T1 HR P20161307T1 HR P20161307T T HRP20161307T T HR P20161307TT HR P20161307 T HRP20161307 T HR P20161307T HR P20161307 T1 HRP20161307 T1 HR P20161307T1
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- dosage form
- solid dosage
- powder
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- 238000000034 method Methods 0.000 title claims 13
- 239000000203 mixture Substances 0.000 title claims 12
- 239000000843 powder Substances 0.000 title claims 9
- 239000007909 solid dosage form Substances 0.000 title claims 6
- 238000002360 preparation method Methods 0.000 title claims 3
- 239000007921 spray Substances 0.000 title claims 2
- 238000009472 formulation Methods 0.000 title 1
- 238000002844 melting Methods 0.000 claims 6
- 230000008018 melting Effects 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 229940060184 oil ingredients Drugs 0.000 claims 3
- 229920001515 polyalkylene glycol Polymers 0.000 claims 3
- 229930003231 vitamin Natural products 0.000 claims 3
- 239000011782 vitamin Substances 0.000 claims 3
- 229940088594 vitamin Drugs 0.000 claims 3
- 235000013343 vitamin Nutrition 0.000 claims 3
- 150000003722 vitamin derivatives Chemical class 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 235000012438 extruded product Nutrition 0.000 claims 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 238000005507 spraying Methods 0.000 claims 2
- 230000008719 thickening Effects 0.000 claims 2
- 229930003799 tocopherol Natural products 0.000 claims 2
- 239000011732 tocopherol Substances 0.000 claims 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 239000008118 PEG 6000 Substances 0.000 claims 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229940105329 carboxymethylcellulose Drugs 0.000 claims 1
- 229920003086 cellulose ether Polymers 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- 238000000280 densification Methods 0.000 claims 1
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 229940067606 lecithin Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- -1 poly(vinyl alcohol) Polymers 0.000 claims 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229940083037 simethicone Drugs 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 150000003611 tocopherol derivatives Chemical class 0.000 claims 1
- 235000019149 tocopherols Nutrition 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (15)
1. Postupak za pripravu praška naznačen time da obuhvaća korake
i) osiguravanje barem jedne prve komponente, pri čemu barem jedna prva komponenta sadrži ili predstavlja vitaminsko ulje, lecitin ili simetikon,
ii) osiguravanje barem jedne druge komponente koja ima točku taljenja ili raspon taljenja iznad sobne temperature, naznačen time da barem jedna druga komponenta sadrži ili se sastoji od polialkilen glikola,
iii) formiranje homogene tekuće smjese koja sadrži navedenu barem jednu prvu komponentu i navedenu barem jednu drugu komponentu miješanjem i zagrijavanjem smjese na ili održavanjem smjese na temperaturi u rasponu od iznad točke taljenja ili rasponu taljenja navedene druge komponente do 120 °C, pri čemu homogena tekuća smjesa sadrži od 92 tež. % do 99.9 tež. % barem jedne druge komponente i od 0.1 tež. % do 8 tež. % barem jedne prve komponente,
iv) prenošenje tekuće smjese u barem jednu jedinicu za zgušnjavanje raspršivanjem pomoću barem jedne jedinice za prenošenje, koja je prilagođena da održava smjesu u tekućem obliku tijekom njezinog prijenosa,
v) zgušnjavanje raspršivanjem navedene smjese, te
vi) izoliranje praška koji se dobije nakon zgušnjavanja raspršivanjem.
2. Postupak u skladu s patentnim zahtjevom 1, naznačen time da barem jedna prva komponenta sadrži ili se sastoji od tokoferola i/ili derivata tokoferola.
3. Postupak u skladu s bilo kojim od prethodnih zahtjeva, naznačen time da barem jedna druga komponenta sadrži ili se sastoji od polietilen glikola.
4. Postupak u skladu s patentnim zahtjevom 3, naznačen time da polietilen glikol je polietilen glikol 6000 (PEG 6000).
5. Postupak u skladu s bilo kojim od prethodnih zahtjeva, naznačen time da navedena jedinica za prenošenje sadrži barem jedan vod za dobavu i barem jednu crpku, pri čemu je barem navedeni vod za dobavu prilagođen da se može zagrijavati.
6. Postupak u skladu s bilo kojim od prethodnih zahtjeva, naznačen time da točka taljenja ili raspon taljenja druge komponente je u rasponu od >40 °C do 120°C.
7. Prašak naznačen time da se može dobiti postupkom prema bilo kojem od prethodnih zahtjeva.
8. Prašak prema zahtjevu 7 naznačen time da sadrži ili se sastoji od 92 tež. % do 99.9 tež. polialkilen glikola kao navedene barem jedne druge komponente, te od 0.1 tež. % do 8 tež. % tokoferola kao navedene barem jedne prve komponente.
9. Prašak prema zahtjevu 7 ili 8 naznačen time da ima distribuciju veličine čestica d50 u rasponu od 40 µm do 300 µm.
10. Uporaba praška prema bilo kojem od zahtjeva 7 do 9 naznačena time da je za pripremanje krutog oblika doziranja koji sadrži barem jedan farmaceutski aktivni sastojak.
11. Uporaba prema zahtjevu 10, naznačena time da navedeni kruti oblik doziranja sadrži barem jedan farmaceutski aktivni sastojak, barem jedan poli(alkilen oksid), barem jedan derivat celuloza etera, barem jedan polialkilen glikol, te barem jedno vitaminsko ulje.
12. Uporaba prema zahtjevu 11, naznačena time da je navedeno vitaminsko ulje prisutno u količini od manje od 1 tež.-%, u odnosu na ukupnu težinu krutog oblika doziranja.
13. Postupak za pripremanje krutog oblika doziranja naznačen time da sadrži korake:
a) osiguravanje praška prema postupku iz bilo kojeg od patentnih zahtjeva 1 do 6 (komponenta a),
b) osiguravanje barem jednog farmaceutski aktivnog sastojka (komponenta b),
c) osiguravanje barem jedne treće komponente (komponenta c),
d) formiranje smjese koja sadrži komponente a, b i c,
e) transformiranje navedene smjese u kruti oblik doziranja.
14. Postupak u skladu s patentnim zahtjevom 13, naznačen time da je navedena barem jedna treća komponenta (komponenta c) odabrana iz skupine koju čine poli(alkilen oksid), poli(vinil alkohol), hidroksimetil celuloza, hidroksietil celuloza, hidroksipropil celuloza, hidroksipropil metilceluloza i karboksi metilceluloza.
15. Postupak za pripremu tablete prema zahtjevu 13 ili 14 naznačen time da sadrži korake:
a) osiguravanje praška prema postupku iz bilo kojeg od patentnih zahtjeva 1 do 6 (komponenta a),
b) osiguravanje barem jednog farmaceutski aktivnog sastojka (komponenta b),
c) osiguravanje barem jedne treće komponente (komponenta c),
d) formiranje smjese koja sadrži komponente a, b i c,
e) ekstrudiranje navedene rastaljene smjese,
f) prikupljanje ekstrudiranog produkta, te
g) komprimiranje ekstrudiranog proizvoda u tabletu.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08008749 | 2008-05-09 | ||
EP09741898.2A EP2273983B1 (en) | 2008-05-09 | 2009-05-08 | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
PCT/EP2009/003290 WO2009135680A1 (en) | 2008-05-09 | 2009-05-08 | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20161307T1 true HRP20161307T1 (hr) | 2016-12-02 |
Family
ID=40050124
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20161307TT HRP20161307T1 (hr) | 2008-05-09 | 2016-10-10 | Postupak za pripravu praškaste formulacije međuproizvoda i konačni kruti oblik doziranja uz korištenje koraka zgrušavanja raspršivanjem |
Country Status (26)
Country | Link |
---|---|
US (1) | US9161917B2 (hr) |
EP (1) | EP2273983B1 (hr) |
JP (1) | JP5674641B2 (hr) |
KR (1) | KR101690094B1 (hr) |
CN (1) | CN102123701B (hr) |
AU (1) | AU2009243681B2 (hr) |
BR (1) | BRPI0912014A2 (hr) |
CA (1) | CA2723438C (hr) |
CO (1) | CO6341546A2 (hr) |
CY (1) | CY1118085T1 (hr) |
DK (1) | DK2273983T3 (hr) |
EC (1) | ECSP10010613A (hr) |
ES (1) | ES2599031T3 (hr) |
HR (1) | HRP20161307T1 (hr) |
HU (1) | HUE030803T2 (hr) |
IL (1) | IL209044A (hr) |
LT (1) | LT2273983T (hr) |
MX (1) | MX2010012039A (hr) |
NZ (1) | NZ588863A (hr) |
PL (1) | PL2273983T3 (hr) |
PT (1) | PT2273983T (hr) |
RU (1) | RU2508092C2 (hr) |
SI (1) | SI2273983T1 (hr) |
TW (1) | TWI524904B (hr) |
WO (1) | WO2009135680A1 (hr) |
ZA (1) | ZA201007818B (hr) |
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US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
US20070048228A1 (en) * | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10336400A1 (de) * | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102005005446A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10361596A1 (de) * | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102004032103A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
US20090052818A1 (en) * | 2007-07-10 | 2009-02-26 | Jason Matthew Mitmesser | Hybrid bearing |
EP2249811A1 (en) | 2008-01-25 | 2010-11-17 | Grünenthal GmbH | Pharmaceutical dosage form |
EP2273983B1 (en) | 2008-05-09 | 2016-07-20 | Grünenthal GmbH | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
PL2456424T3 (pl) | 2009-07-22 | 2013-12-31 | Gruenenthal Gmbh | Stabilizowana przed utlenianiem odporna na naruszenie postać dawkowania |
PL2456427T3 (pl) | 2009-07-22 | 2015-07-31 | Gruenenthal Gmbh | Wytłaczana na gorąco postać dawki o kontrolowanym uwalnianiu |
US9579285B2 (en) | 2010-02-03 | 2017-02-28 | Gruenenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of an extruder |
MX2013002293A (es) | 2010-09-02 | 2013-05-09 | Gruenenthal Gmbh | Forma de dosificacion resistente a alteracion que comprende un polimero anionico. |
AU2011297901B2 (en) | 2010-09-02 | 2014-07-31 | Grunenthal Gmbh | Tamper resistant dosage form comprising inorganic salt |
PE20141638A1 (es) | 2011-07-29 | 2014-11-22 | Gruenenthal Chemie | Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato |
US20130028972A1 (en) | 2011-07-29 | 2013-01-31 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
US20130225697A1 (en) | 2012-02-28 | 2013-08-29 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
EA201401139A1 (ru) | 2012-04-18 | 2015-03-31 | Грюненталь Гмбх | Устойчивая к разрушению и к сбросу дозы фармацевтическая лекарственная форма |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
JP6445537B2 (ja) | 2013-05-29 | 2018-12-26 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 1個または複数の粒子を含有する改変防止(tamper−resistant)剤形 |
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