JP2019099502A - 口腔用組成物製造方法 - Google Patents
口腔用組成物製造方法 Download PDFInfo
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- JP2019099502A JP2019099502A JP2017232021A JP2017232021A JP2019099502A JP 2019099502 A JP2019099502 A JP 2019099502A JP 2017232021 A JP2017232021 A JP 2017232021A JP 2017232021 A JP2017232021 A JP 2017232021A JP 2019099502 A JP2019099502 A JP 2019099502A
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- JP
- Japan
- Prior art keywords
- hydroxyethyl cellulose
- hydrogenated castor
- castor oil
- blending
- polyoxyethylene hydrogenated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Landscapes
- Cosmetics (AREA)
Abstract
Description
項1.
以下の工程(A)〜(D):
(A)水と有機酸又はその塩とを混合する工程、
(B)β−グリチルレチン酸、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を配合する工程、
(C)塩化セチルピリジニウムを配合する工程、
(D)ヒドロキシエチルセルロースを配合する工程、
を、この順に含む、
口腔用組成物を製造する方法。
項2.
工程(D)のヒドロキシエチルセルロースとして、ヒドロキシエチルセルロース分散グリセリン液を用いる、
項1に記載の方法。
項3.
工程(B)が、β−グリチルレチン酸、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を含む混合物を配合する工程である、
項1又は2に記載の方法。
項4.
工程(B)が、β−グリチルレチン酸、トコフェロール、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を配合する工程である、
項1〜3に記載の方法。
項5.
工程(B)が、β−グリチルレチン酸、トコフェロール、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を含む混合物を配合する工程である、
項4に記載の方法。
項6.
以下の工程(A)〜(D):
(A)水と有機酸又はその塩とを混合する工程、
(B)β−グリチルレチン酸、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を配合する工程、
(C)塩化セチルピリジニウムを配合する工程、
(D)ヒドロキシエチルセルロースを配合する工程、
を含み、且つ以下の条件を満たす、口腔用組成物を製造する方法。
(条件1):工程(A)を最初に行う。
(条件2):工程(B)及び(C)は、この順に行う。
(条件3):工程(D)のヒドロキシエチルセルロースとして、ヒドロキシエチルセルロース分散グリセリン液を用いる。
(A)水と有機酸又はその塩とを混合する工程
(B)β−グリチルレチン酸、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を配合する工程
(C)塩化セチルピリジニウムを配合する工程
(D)ヒドロキシエチルセルロースを配合する工程
工程(A)で用いる成分について説明する。水としては、特に制限されず、蒸留水、脱イオン水、水道水等、適宜選択して用いることができる。また、有機酸又はその塩としては、口腔用組成物に配合される公知の有機酸又はその塩を適宜選択して用いることができる。有機酸としては、例えばヒドロキシカルボン酸が挙げられ、より具体的にはクエン酸、硫酸、リンゴ酸等が好ましく例示される。有機酸の塩としては、例えばカリウム塩、ナトリウム塩等が好ましく挙げられる。特に好ましい例として、クエン酸ナトリウム及び無水クエン酸が挙げられる。有機酸又はその塩は、1種単独で又は2種以上を組み合わせて用いることができる。
(条件1):工程(A)を最初に行う。
(条件2):工程(B)及び(C)を、この順に行う。
(条件3):工程(D)のヒドロキシエチルセルロースとして、ヒドロキシエチルセルロース分散グリセリン液を用いる。
ステンレス缶に水を入れ、クエン酸ナトリウム(0.07%)と無水クエン酸(0.01%)を溶解して仕掛りAを調製した。その後、別容器で温めたプロピレングリコール(3%)にパラオキシ安息香酸メチル(0.2%)及びポリオキシエチレン硬化ヒマシ油(0.4%)を溶解し、酢酸トコフェロール(0.05%)を溶解した香料(0.1%)と混合し、β−グリチルレチン酸(0.04%又は0.05%)を加えて仕掛りBを調製し、これを仕掛りA(ステンレス缶)に投入して混合し、溶解させた。その後、塩化セチルピリジニウム(0.05%)を前記混合液(ステンレス缶)に投入して溶解させた。最後にヒドロキシエチルセルロース(0.2%)を濃グリセリン(10%)に分散して調製した仕掛りDを、前記混合液(ステンレス缶)に投入して溶解させた。なお、用いたポリオキシエチレン硬化ヒマシ油のエチレンオキサイド(EO)の平均付加モル数は60であった。
ステンレス缶に水を入れ、クエン酸ナトリウム(0.07%)と無水クエン酸(0.01%)、濃グリセリン(10%)を溶解して仕掛りAを調製した。その後、別容器で温めたプロピレングリコール(3%)にパラオキシ安息香酸メチル(0.2%)及びポリオキシエチレン硬化ヒマシ油(0.4%)を溶解し、これを酢酸トコフェロール(0.05%)を溶解させた香料と混合し、さらにβ−グリチルレチン酸(0.04%又は0.05%)を加えて仕掛りBを調製した。さらにヒドロキシエチルセルロース(0.2%)を仕掛りBに分散した後で、仕掛りA(ステンレス缶)に投入、溶解させた。最後に塩化セチルピリジニウム(0.05%)をステンレス缶に投入、溶解させた。
当該結果から、(A)水と有機酸又はその塩とを混合する工程、(B)β−グリチルレチン酸、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を配合する工程、(C)塩化セチルピリジニウムを配合する工程、(D)ヒドロキシエチルセルロースを配合する工程、を、この順に行うことにより、β−グリチルレチン酸は析出することなく、安定に口腔用組成物に配合され得ることがわかった。
ステンレス缶に水を入れ、クエン酸ナトリウム(0.07%)と無水クエン酸(0.01%)を溶解して仕掛りAを調製した。その後、ヒドロキシエチルセルロース(0.2%)を濃グリセリン(10%)に分散して調製した仕掛りDを仕掛りA(ステンレス缶)に投入し、溶解させた。その後、別容器で温めたプロピレングリコール(3%)にパラオキシ安息香酸メチル(0.2%)及びポリオキシエチレン硬化ヒマシ油(0.4%)を溶解し、これを酢酸トコフェロール(0.05%)を溶解した香料(0.1%)と混合し、さらにβ−グリチルレチン酸(0.04%又は0.05%)を加えて仕掛りBを調製した。当該仕掛りBをステンレス缶に投入し、溶解させた。最後に塩化セチルピリジニウム(0.05%)をステンレス缶に投入し、溶解させた。
Claims (6)
- 以下の工程(A)〜(D):
(A)水と有機酸又はその塩とを混合する工程、
(B)β−グリチルレチン酸、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を配合する工程、
(C)塩化セチルピリジニウムを配合する工程、
(D)ヒドロキシエチルセルロースを配合する工程、
を、この順に含む、
口腔用組成物を製造する方法。 - 工程(D)のヒドロキシエチルセルロースとして、ヒドロキシエチルセルロース分散グリセリン液を用いる、
請求項1に記載の方法。 - 工程(B)が、β−グリチルレチン酸、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を含む混合物を配合する工程である、
請求項1又は2に記載の方法。 - 工程(B)が、β−グリチルレチン酸、トコフェロール、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を配合する工程である、
請求項1〜3に記載の方法。 - 工程(B)が、β−グリチルレチン酸、トコフェロール、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を含む混合物を配合する工程である、
請求項4に記載の方法。 - 以下の工程(A)〜(D):
(A)水と有機酸又はその塩とを混合する工程、
(B)β−グリチルレチン酸、プロピレングリコール、及びポリオキシエチレン硬化ヒマシ油を配合する工程、
(C)塩化セチルピリジニウムを配合する工程、
(D)ヒドロキシエチルセルロースを配合する工程、
を含み、且つ以下の条件を満たす、口腔用組成物を製造する方法。
(条件1):工程(A)を最初に行う。
(条件2):工程(B)及び(C)は、この順に行う。
(条件3):工程(D)のヒドロキシエチルセルロースとして、ヒドロキシエチルセルロース分散グリセリン液を用いる。
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JP2019099503A (ja) * | 2017-12-01 | 2019-06-24 | サンスター株式会社 | 口腔用組成物 |
JP2022021546A (ja) * | 2020-07-22 | 2022-02-03 | 花王株式会社 | 液体口腔用組成物 |
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JP2010024227A (ja) * | 2008-06-17 | 2010-02-04 | Sunstar Inc | 液体口腔用組成物 |
JP2011051927A (ja) * | 2009-09-01 | 2011-03-17 | Sunstar Inc | 口腔用組成物 |
WO2016104536A1 (ja) * | 2014-12-26 | 2016-06-30 | 花王株式会社 | 液体口腔用組成物の製造方法及び液体口腔用組成物 |
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JPS58208208A (ja) * | 1982-05-27 | 1983-12-03 | Lion Corp | 練歯磨の製造方法 |
JP2010024227A (ja) * | 2008-06-17 | 2010-02-04 | Sunstar Inc | 液体口腔用組成物 |
JP2011051927A (ja) * | 2009-09-01 | 2011-03-17 | Sunstar Inc | 口腔用組成物 |
WO2016104536A1 (ja) * | 2014-12-26 | 2016-06-30 | 花王株式会社 | 液体口腔用組成物の製造方法及び液体口腔用組成物 |
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JP2019099503A (ja) * | 2017-12-01 | 2019-06-24 | サンスター株式会社 | 口腔用組成物 |
JP7146389B2 (ja) | 2017-12-01 | 2022-10-04 | サンスター株式会社 | 口腔用組成物 |
JP2022021546A (ja) * | 2020-07-22 | 2022-02-03 | 花王株式会社 | 液体口腔用組成物 |
JP7402765B2 (ja) | 2020-07-22 | 2023-12-21 | 花王株式会社 | 液体口腔用組成物 |
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