HRP20020627B1 - Asymmetric synthesis of pregabalin - Google Patents

Asymmetric synthesis of pregabalin

Info

Publication number
HRP20020627B1
HRP20020627B1 HR20020627A HRP20020627A HRP20020627B1 HR P20020627 B1 HRP20020627 B1 HR P20020627B1 HR 20020627 A HR20020627 A HR 20020627A HR P20020627 A HRP20020627 A HR P20020627A HR P20020627 B1 HRP20020627 B1 HR P20020627B1
Authority
HR
Croatia
Prior art keywords
pregabalin
asymmetric synthesis
formula
co2y
co2h
Prior art date
Application number
HR20020627A
Other languages
English (en)
Croatian (hr)
Inventor
Joseph Burk Mark
Prakash Goel Om
Simon Hoekstra Marvin
Frederick Mich Thomas
Arthur Mulhern Thomas
Andrew Ramsden James
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20020627(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of HRP20020627A2 publication Critical patent/HRP20020627A2/hr
Publication of HRP20020627B1 publication Critical patent/HRP20020627B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
HR20020627A 2000-01-27 2002-07-24 Asymmetric synthesis of pregabalin HRP20020627B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17835900P 2000-01-27 2000-01-27
US19042700P 2000-03-17 2000-03-17
PCT/IB2001/000024 WO2001055090A1 (en) 2000-01-27 2001-01-11 Asymmetric synthesis of pregabalin

Publications (2)

Publication Number Publication Date
HRP20020627A2 HRP20020627A2 (en) 2004-08-31
HRP20020627B1 true HRP20020627B1 (en) 2011-01-31

Family

ID=26874236

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020627A HRP20020627B1 (en) 2000-01-27 2002-07-24 Asymmetric synthesis of pregabalin

Country Status (50)

Country Link
US (1) US6891059B2 (xx)
EP (1) EP1250311B1 (xx)
JP (2) JP4235384B2 (xx)
KR (1) KR100549748B1 (xx)
CN (1) CN1210253C (xx)
AP (1) AP1438A (xx)
AR (1) AR028499A1 (xx)
AT (1) ATE261930T1 (xx)
AU (1) AU777046B2 (xx)
BG (1) BG65560B1 (xx)
BR (1) BRPI0107863B8 (xx)
CA (1) CA2396090C (xx)
CO (1) CO5251411A1 (xx)
CR (1) CR6703A (xx)
CU (1) CU23221A3 (xx)
CY (1) CY2004011I1 (xx)
CZ (1) CZ302838B6 (xx)
DE (1) DE60102356T2 (xx)
DK (1) DK1250311T3 (xx)
DZ (1) DZ3268A1 (xx)
EA (1) EA004934B1 (xx)
EE (1) EE05216B1 (xx)
EG (1) EG24138A (xx)
ES (1) ES2219493T3 (xx)
GE (1) GEP20043236B (xx)
HN (1) HN2001000010A (xx)
HR (1) HRP20020627B1 (xx)
HU (1) HU228815B1 (xx)
IL (2) IL150633A0 (xx)
IS (1) IS2038B (xx)
MA (1) MA26869A1 (xx)
ME (1) ME00921B (xx)
MX (1) MXPA02007307A (xx)
MY (1) MY127152A (xx)
NO (1) NO327958B1 (xx)
NZ (1) NZ519551A (xx)
OA (1) OA12167A (xx)
PA (1) PA8510501A1 (xx)
PE (1) PE20011063A1 (xx)
PL (1) PL203985B1 (xx)
PT (1) PT1250311E (xx)
RS (1) RS50257B (xx)
SI (1) SI1250311T1 (xx)
SK (1) SK287303B6 (xx)
SV (1) SV2002000295A (xx)
TN (1) TNSN01016A1 (xx)
TR (1) TR200400953T4 (xx)
TW (1) TWI288128B (xx)
UA (1) UA75584C2 (xx)
WO (1) WO2001055090A1 (xx)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1094757C (zh) 1996-07-24 2002-11-27 沃尼尔·朗伯公司 用于治疗疼痛的异丁基γ－氨基丁酸及其衍生物
AU777046B2 (en) * 2000-01-27 2004-09-30 Warner-Lambert Company Llc Asymmetric synthesis of pregabalin
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
RU2335342C2 (ru) * 2004-03-12 2008-10-10 Уорнер-Ламберт Компани Ллс C1-симметричные бисфосфиновые лиганды и их применение в асимметрическом синтезе прегабалина
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
ME01067B (me) * 2004-06-21 2012-10-20 Warner Lambert Co Dobijanje pregabalina i srodnih jedinjenja
EP1866275A1 (en) * 2005-04-06 2007-12-19 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
CN101300224A (zh) * 2005-04-11 2008-11-05 特瓦制药工业有限公司 制备(s)-普瑞巴林的方法
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
WO2006122258A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Method for the preparation of pregabalin and salts thereof
BRPI0605833A (pt) * 2005-05-10 2007-12-18 Teva Pharma pregabalina livre de ácido isobutilglutárico e um processo para sua preparação
ATE523484T1 (de) 2005-05-10 2011-09-15 Teva Pharma Optische lösung a us 3-carbamoylmethyl-5-methyl- hexansäure
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
WO2007035789A1 (en) 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin
NL2000281C2 (nl) 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
CA2646474A1 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 3-isobutylglutaric acid
US7462738B2 (en) 2006-05-24 2008-12-09 Teva Pharmaceutical Industries Ltd. Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
WO2007143113A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. The use of enzymatic resolution for the preparation of intermediates of pregabalin
US20080015385A1 (en) * 2006-05-31 2008-01-17 Lilach Hedvati Preparation of (S)-pregabalin-nitrile
EP1903027A1 (en) * 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
US8097754B2 (en) * 2007-03-22 2012-01-17 Teva Pharmaceutical Industries Ltd. Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
WO2009001372A2 (en) * 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
WO2009046309A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
EP2053040A1 (en) * 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Pregabalin intermediates and process for preparing them and Pregabalin
WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
AU2008339583A1 (en) * 2007-12-26 2009-07-02 Generics [Uk] Limited Processes to pregabalin
EP2241551A4 (en) * 2008-01-10 2014-01-01 Sumitomo Chemical Co METHOD FOR PRODUCING A CYCLOPROPAN CARBOXYLIC COMPOUND AND INTERMEDIATE PRODUCT THEREOF
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
UA103997C2 (ru) 2008-05-21 2013-12-25 Сандоз Аг Способ стереоселективного ферментативного гидролиза эстера 5-метил-3-нитрометилгексановой кислоты
WO2009158343A1 (en) * 2008-06-23 2009-12-30 Teva Pharmaceutical Industries, Ltd. Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
CN102464594B (zh) * 2010-11-17 2014-06-25 凯瑞斯德生化(苏州)有限公司 普瑞巴林的中间体化合物的制备方法
WO2014181359A1 (en) 2013-05-09 2014-11-13 Council Of Scientific & Industrial Research A process for the preparation of an anticonvulsant agent pregabalin hydrochloride
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0380463A2 (en) * 1989-01-23 1990-08-01 Monsanto Company Method for preparing (R)-succinic acid derivatives
WO1996038405A1 (en) * 1995-06-02 1996-12-05 Warner-Lambert Company Methods of making (s)-3-(aminomethyl)-5-methylhexanoic acid
WO1996040617A1 (en) * 1995-06-07 1996-12-19 Warner-Lambert Company Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid

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JPS588390B2 (ja) * 1978-05-23 1983-02-15 住友化学工業株式会社 光学活性ω↓−シアノ↓−α↓−アシルアミノ酸誘導体の製造法
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5171892A (en) 1991-07-02 1992-12-15 E. I. Du Pont De Nemours And Company Chiral phospholanes via chiral 1,4-diol cyclic sulfates
US5840965A (en) * 1996-06-24 1998-11-24 E. I. Du Pont De Nemours And Company Process for the production of purified telephthalic acid
CN1094757C (zh) 1996-07-24 2002-11-27 沃尼尔·朗伯公司 用于治疗疼痛的异丁基γ－氨基丁酸及其衍生物
US6127418A (en) 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
DE69813297T2 (de) 1997-12-17 2003-12-11 Chirotech Technology Ltd., Cambridge Asymmetrische hydrierung
AU3433199A (en) 1998-04-09 1999-11-01 Chirotech Technology Limited Asymmetric hydrogenation
AU777046B2 (en) * 2000-01-27 2004-09-30 Warner-Lambert Company Llc Asymmetric synthesis of pregabalin

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0380463A2 (en) * 1989-01-23 1990-08-01 Monsanto Company Method for preparing (R)-succinic acid derivatives
WO1996038405A1 (en) * 1995-06-02 1996-12-05 Warner-Lambert Company Methods of making (s)-3-(aminomethyl)-5-methylhexanoic acid
WO1996040617A1 (en) * 1995-06-07 1996-12-19 Warner-Lambert Company Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid

Also Published As

Publication number Publication date
BG106849A (en) 2003-03-31
CA2396090C (en) 2006-01-10
HUP0204307A2 (hu) 2003-06-28
UA75584C2 (uk) 2006-05-15
DE60102356T2 (de) 2005-02-17
SV2002000295A (es) 2002-06-07
DE60102356D1 (de) 2004-04-22
CA2396090A1 (en) 2001-08-02
US20030212290A1 (en) 2003-11-13
JP2009073841A (ja) 2009-04-09
NO327958B1 (no) 2009-10-26
MA26869A1 (fr) 2004-12-20
EA200200642A1 (ru) 2002-12-26
YU56202A (sh) 2006-01-16
SI1250311T1 (en) 2004-10-31
CO5251411A1 (es) 2003-02-28
IS2038B (is) 2005-08-15
PE20011063A1 (es) 2001-10-18
BG65560B1 (bg) 2008-12-30
AU2213801A (en) 2001-08-07
JP2003520841A (ja) 2003-07-08
US6891059B2 (en) 2005-05-10
IS6430A (is) 2002-06-19
DK1250311T3 (da) 2004-08-16
MXPA02007307A (es) 2002-11-29
EG24138A (en) 2008-08-06
SK287303B6 (sk) 2010-06-07
EP1250311B1 (en) 2004-03-17
EE05216B1 (et) 2009-10-15
BR0107863B1 (pt) 2013-06-18
CZ302838B6 (cs) 2011-12-07
AP1438A (en) 2005-05-23
AP2002002588A0 (en) 2002-09-30
EA004934B1 (ru) 2004-10-28
DZ3268A1 (fr) 2001-08-02
BRPI0107863B8 (pt) 2017-04-25
CN1210253C (zh) 2005-07-13
HRP20020627A2 (en) 2004-08-31
PL203985B1 (pl) 2009-11-30
HN2001000010A (es) 2001-06-13
ES2219493T3 (es) 2004-12-01
HU228815B1 (en) 2013-05-28
IL150633A0 (en) 2003-02-12
JP4886753B2 (ja) 2012-02-29
AR028499A1 (es) 2003-05-14
GEP20043236B (en) 2004-05-25
HUP0204307A3 (en) 2003-07-28
NO20023582L (no) 2002-09-02
CU23221A3 (es) 2007-07-20
EP1250311A1 (en) 2002-10-23
EE200200403A (et) 2003-10-15
NZ519551A (en) 2004-02-27
PL357077A1 (en) 2004-07-12
PT1250311E (pt) 2004-07-30
ATE261930T1 (de) 2004-04-15
ME00921B (me) 2012-06-20
MY127152A (en) 2006-11-30
IL150633A (en) 2009-08-03
JP4235384B2 (ja) 2009-03-11
KR100549748B1 (ko) 2006-02-08
RS50257B (sr) 2009-07-15
TNSN01016A1 (fr) 2005-11-10
TWI288128B (en) 2007-10-11
CZ20022520A3 (cs) 2002-10-16
CN1396905A (zh) 2003-02-12
PA8510501A1 (es) 2002-02-21
KR20020073187A (ko) 2002-09-19
SK10782002A3 (sk) 2002-11-06
WO2001055090A1 (en) 2001-08-02
CY2004011I1 (el) 2010-07-28
TR200400953T4 (tr) 2004-07-21
BR0107863A (pt) 2002-11-05
AU777046B2 (en) 2004-09-30
OA12167A (en) 2006-05-08
CR6703A (es) 2003-06-24
NO20023582D0 (no) 2002-07-26

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