ES2180335T3 - Ligandos y complejos para la hidrogenacion enantioselectiva. - Google Patents
Ligandos y complejos para la hidrogenacion enantioselectiva.Info
- Publication number
- ES2180335T3 ES2180335T3 ES99958031T ES99958031T ES2180335T3 ES 2180335 T3 ES2180335 T3 ES 2180335T3 ES 99958031 T ES99958031 T ES 99958031T ES 99958031 T ES99958031 T ES 99958031T ES 2180335 T3 ES2180335 T3 ES 2180335T3
- Authority
- ES
- Spain
- Prior art keywords
- complexes
- ligandos
- enantioselective hydrogenation
- ligand
- ferroceneylphosphine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000005984 hydrogenation reaction Methods 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 abstract 3
- 230000003197 catalytic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Ligandos enriquecidos en enantiómeros de fórmula general (I) y sus sales, en la que ** (Fórmula)** R1, R2 significan, independientemente uno de otro, R8, NR6R7, SR6, alquilo (C1-C18), alcoxi (C1C18), alcoxialquilo (C2-C18), aciloxi (C1-C18), arilo (C6-C18), aralquilo (C7-C19), heteroarilo (C3-C18), heteroaralquilo (C4-C19), alquil (C1-C8)-arilo (C6-C18), alquil (C1-C8)-heteroalquilo (C3-C19), cicloalquilo (C3-C8), alquil (C1-C8)-cicloalquilo (C3-C8), cicloalquil (C3-C8)-alquilo (C1-C8), o R1 y R2 están unidos mediante un carbociclo (C3-C7), que puede estar sustituido una o varias veces por alquilo (C1-C8), acilo (C1-C8), alcoxi (C1-C8), alcoxialquilo (C2-C8), lineales o ramificados y/o puede contener en el anillo heteroátomos tales como N, O, P, S, R3, R4 significan, independientemente uno de otro, H, alquilo (C1-C18), alcoxi (C1-C18), alcoxialquilo (C2-C18), aciloxi (C1-C18), arilo (C6-C18), aralquilo (C7-C19), heteroarilo (C3-C18), heteroaralquilo (C4C19), alquil (C1-C8)-arilo (C6-C18), alquil (C1-C8)-heteroalquilo (C3-C19), cicloalquilo (C3-C8), alquil (C1C8)-cicloalquilo (C3-C8), cicloalquil (C3-C8)-alquilo (C1-C8), o R3 y R4 están unidos mediante un puente (C3-C5), que puede contener uno o varios dobles enlaces y/o puede estar sustituido una o varias veces por alquilo (C1-C8), acilo (C1-C8), alcoxi (C1-C8), alcoxialquilo (C2-C8), lineales o ramificados, y/o puede contener en el anillo heteroátomos tales como N, O, P, S, R5 significa alquilo (C1-C18), arilo (C6-C18), heteroarilo (C3-C18), alquil (C1-C8)-arilo (C6-C18), alquil (C1-C8)-heteroalquilo (C3-C19), cicloalquilo (C3-C8), alquil (C1-C8)-cicloalquilo (C3-C8), en donde los restos R5 pueden ser diferentes en el mismo átomo de fósforo y/o en los dos átomos de fósforo, R6, R7 significan, independientemente uno de otro, H, alquilo (C1-C18), alcoxi (C1-C18), alcoxialquilo (C2-C18), acilo (C1-C18), arilo (C6-C18), aralquilo (C7-C19), heteroarilo (C3-C18), heteroaralquilo (C4-C19), alquil (C1-C8)arilo (C6-C18), alquil(C1-C8)-heteroalquilo (C3-C19), cicloalquilo (C3-C8), alquil (C1C8)-cicloalquilo (C3-C8), cicloalquil (C3-C6)-alquilo (C1-C8), o R6 y R7 están unidos mediante un carbociclo (C3-C7), que puede estar sustituido una o varias veces por alquilo (C1-C8), acilo (C1-C8), alcoxi (C1-C8), alcoxialquilo (C2-C8), lineales o ramificados y/o puede contener en el anillo heteroátomos tales como N, O, P, S, R8 significa H o un resto B-X-Z, siendo B un resto del grupo CR92, NR9, O, S, SiR92, X es un espaciador como, por ejemplo, 1, 4¿-bifenilo, 1-etileno, 2-etileno, 1-propileno, 3-propileno, PEG- (2-10) y Z representa un resto unido a un polímero mediante un grupo funcional, como por ejemplo, O-, NH-, COO-, CONH, etenil-, NHCONH-, OCONH- o NHCOO-, o los restos R8 de ambos anillos de ciclopentadienilo están unidos entre sí mediante un puente a, walquileno (C2-C4), R9 significa H, alquilo (C1-C18).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19858865 | 1998-12-19 | ||
DE19952348A DE19952348A1 (de) | 1998-12-19 | 1999-10-30 | Liganden und Komplexe zur enantioselektiven Hydrierung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2180335T3 true ES2180335T3 (es) | 2003-02-01 |
Family
ID=26050881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99958031T Expired - Lifetime ES2180335T3 (es) | 1998-12-19 | 1999-11-12 | Ligandos y complejos para la hidrogenacion enantioselectiva. |
Country Status (10)
Country | Link |
---|---|
US (1) | US6191284B1 (es) |
EP (1) | EP1140956B1 (es) |
JP (1) | JP4567201B2 (es) |
AT (1) | ATE222918T1 (es) |
CA (1) | CA2356154C (es) |
DE (2) | DE19952348A1 (es) |
DK (1) | DK1140956T3 (es) |
ES (1) | ES2180335T3 (es) |
PT (1) | PT1140956E (es) |
WO (1) | WO2000037478A1 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6284698B1 (en) * | 1997-09-15 | 2001-09-04 | The Dow Chemical Company | Highly activated bimetallic complexes and polymerization process |
DE10017430A1 (de) * | 2000-04-07 | 2001-10-11 | Basf Ag | Polymerisationskatalysator |
WO2002002578A1 (en) * | 2000-07-03 | 2002-01-10 | Solvias Ag | Ferrocenyl diphosphines and their use |
US6562989B2 (en) | 2000-08-07 | 2003-05-13 | Yale University | Catalyst for aromatic C—O, C—N, and C—C bond formation |
US6919292B2 (en) * | 2000-12-20 | 2005-07-19 | Tosoh Corporation | Transition metal compound, coordinative compound, catalyst for polymerization of olefin, and process for polymerization of olefin using the catalyst |
AUPS044502A0 (en) * | 2002-02-11 | 2002-03-07 | Commonwealth Scientific And Industrial Research Organisation | Novel catalysts and processes for their preparation |
DE10211250A1 (de) * | 2002-03-13 | 2003-10-23 | Degussa | Ferrocenylliganden und ihre Verwendung in der Katalyse |
DE10219490A1 (de) * | 2002-04-30 | 2003-11-13 | Degussa | Ferrocenylliganden und ein Verfahren zur Herstellung solcher Liganden |
GB0228018D0 (en) * | 2002-11-30 | 2003-01-08 | Lucite Int Uk Ltd | Carbonylation of ester |
ES2429871T3 (es) | 2002-09-12 | 2013-11-18 | Lucite International Uk Limited | Un sistema catalizador que comprende un ligando de 1,2-bis-(fosfin)metaloceno |
US7560136B2 (en) * | 2003-01-13 | 2009-07-14 | Nantero, Inc. | Methods of using thin metal layers to make carbon nanotube films, layers, fabrics, ribbons, elements and articles |
JP2007516197A (ja) | 2003-07-03 | 2007-06-21 | ルーサイト インターナショナル ユーケー リミテッド | エチレン性不飽和化合物のヒドロホルミル化方法 |
CN1890253A (zh) * | 2003-12-12 | 2007-01-03 | 索尔维亚斯股份公司 | 制备邻位金属化和邻位取代芳族化合物的方法 |
WO2005056568A1 (de) * | 2003-12-12 | 2005-06-23 | Solvias Ag | Ferrocenyl-1, 2-diphosphine, deren herstellung und deren verwendung |
GB0400720D0 (en) | 2004-01-14 | 2004-02-18 | Stylacats Ltd | Novel ferrocene-based phosphorus chiral phosphines |
GB0403592D0 (en) | 2004-02-18 | 2004-03-24 | Lucite Int Uk Ltd | A catalyst system |
DE102004012438A1 (de) * | 2004-03-12 | 2005-09-29 | Degussa Ag | Verfahren zur Herstellung von enantiomerenangereicherten Ferrocenylliganden |
WO2005108409A2 (en) * | 2004-05-07 | 2005-11-17 | Umicore Ag & Co. Kg | Ferrocenyl ligands for homogeneous, enantioselective hydrogenation catalysts |
GB0411951D0 (en) * | 2004-05-28 | 2004-06-30 | Lucite Int Uk Ltd | Carbonylation of ester |
RU2408600C2 (ru) * | 2005-04-20 | 2011-01-10 | Умикоре Аг Унд Ко. Кг | Дифосфины и металлокомплексы |
GB0516556D0 (en) * | 2005-08-12 | 2005-09-21 | Lucite Int Uk Ltd | Improved catalyst system |
KR101633325B1 (ko) | 2005-11-17 | 2016-06-24 | 루사이트 인터내셔널 유케이 리미티드 | 에틸렌성 불포화 화합물의 카르보닐화 |
GB0607494D0 (en) | 2006-04-13 | 2006-05-24 | Lucite Int Uk Ltd | Metal complexes |
CN100465182C (zh) * | 2006-08-11 | 2009-03-04 | 郑州大学 | 环钯化二茂铁亚胺-氨基膦配合物及其应用 |
WO2008065448A1 (en) * | 2006-12-02 | 2008-06-05 | Lucite International Uk Limited | Novel carbonylation ligands and their use in the carbonylation of ethylenically unsaturated compounds |
GB0625518D0 (en) * | 2006-12-21 | 2007-01-31 | Lucite Int Uk Ltd | Carbonylation of conjugated dienes |
DE102007022389A1 (de) * | 2007-05-10 | 2008-11-13 | Umicore Ag & Co. Kg | Ruthenium-Komplexe mit (P-P)-koordinierten Ferrocenyl-diphosphinliganden, Verfahren zu ihrer Herstellung sowie ihre Anwendung in der homogenen Katalyse |
EP1995248A1 (en) | 2007-05-23 | 2008-11-26 | Evonik Degussa GmbH | Process for the production of amino alcohols by asymmetric hydrogenation |
WO2009086283A1 (en) * | 2007-12-21 | 2009-07-09 | Cambrex Charles City, Inc. | Synthesis of enantiomerically pure 2-hydroxy-2-aryl-ethylamines |
KR101579992B1 (ko) | 2007-12-28 | 2015-12-23 | 액테리온 파마슈티칼 리미티드 | 삼치환된 3,4-디하이드로-1h-이소퀴놀린 화합물, 상기 화합물의 제조 공정 및 상기 화합물의 용도 |
JP5398737B2 (ja) | 2007-12-28 | 2014-01-29 | アクテリオン ファーマシューティカルズ リミテッド | 鏡像異性3置換3,4−ジヒドロ−イソキノリン誘導体の製造のための方法 |
EP2107065A1 (de) | 2008-04-01 | 2009-10-07 | Umicore AG & Co. KG | Ruthenium-Komplexe mit (P-P)-koordinierten Di-Phosphor-Donorliganden sowie Verfahren zu ihrer Herstellung |
GB0812297D0 (en) * | 2008-07-04 | 2008-08-13 | Lucite Int Uk Ltd | Novel carbonylation ligand sand thier use of in the carbonylation of ethylenically unsaturated compounds |
GB201000078D0 (en) | 2010-01-05 | 2010-02-17 | Lucite Int Uk Ltd | Process for the carbonylation of ethylenically unsaturated compounds, novel carbonylation ligands and catalyst systems incorporatng such ligands |
CN101885743B (zh) * | 2010-06-25 | 2013-07-17 | 洛阳师范学院 | 含嘧啶基环钯金属配体及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0564406B1 (de) * | 1992-04-02 | 1999-05-06 | Novartis AG | Ferrocenyldiphosphine als Liganden für homogene Katalysatoren |
SG42938A1 (en) * | 1993-02-26 | 1997-10-17 | Ciba Geigy Ag | Ferrocenc diphosphines as ligands for homogeneous catalysts |
SG42925A1 (en) * | 1993-10-01 | 1997-10-17 | Ciba Geigy Ag | Fluoroalkyl-substituted ferrocenyl diphosphines as ligands for homogeneous catalysts |
JPH09508400A (ja) * | 1994-02-02 | 1997-08-26 | チバ−ガイギー アクチエンゲゼルシャフト | 水素化触媒、その調製方法および水素化方法 |
PL320698A1 (en) * | 1994-11-29 | 1997-10-27 | Lonza Ag | Method of obtaining optically active metalocenylophosphines |
CA2216153C (en) * | 1995-04-11 | 2008-02-05 | Novartis Ag | Dihalogenated ferrocenes and processes for the preparation thereof |
JP4218088B2 (ja) * | 1997-10-14 | 2009-02-04 | ロンザ リミテッド | 二核型イリジウム(i)フォスフィン錯化合物およびオレフィンの不整ハイドロアミネーションの触媒としての使用 |
-
1999
- 1999-10-30 DE DE19952348A patent/DE19952348A1/de not_active Withdrawn
- 1999-11-12 CA CA002356154A patent/CA2356154C/en not_active Expired - Lifetime
- 1999-11-12 WO PCT/EP1999/008736 patent/WO2000037478A1/de active IP Right Grant
- 1999-11-12 EP EP99958031A patent/EP1140956B1/de not_active Expired - Lifetime
- 1999-11-12 ES ES99958031T patent/ES2180335T3/es not_active Expired - Lifetime
- 1999-11-12 PT PT99958031T patent/PT1140956E/pt unknown
- 1999-11-12 JP JP2000589548A patent/JP4567201B2/ja not_active Expired - Lifetime
- 1999-11-12 DE DE59902501T patent/DE59902501D1/de not_active Expired - Lifetime
- 1999-11-12 AT AT99958031T patent/ATE222918T1/de active
- 1999-11-12 DK DK99958031T patent/DK1140956T3/da active
- 1999-12-20 US US09/466,936 patent/US6191284B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1140956B1 (de) | 2002-08-28 |
DE59902501D1 (de) | 2002-10-02 |
EP1140956A1 (de) | 2001-10-10 |
JP2002533351A (ja) | 2002-10-08 |
WO2000037478A1 (de) | 2000-06-29 |
CA2356154C (en) | 2009-06-30 |
JP4567201B2 (ja) | 2010-10-20 |
DK1140956T3 (da) | 2002-11-11 |
US6191284B1 (en) | 2001-02-20 |
CA2356154A1 (en) | 2000-06-29 |
DE19952348A1 (de) | 2000-06-21 |
PT1140956E (pt) | 2003-01-31 |
ATE222918T1 (de) | 2002-09-15 |
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