EA200200642A1 - Асимметрический синтез прегабалина - Google Patents

Асимметрический синтез прегабалина

Info

Publication number
EA200200642A1
EA200200642A1 EA200200642A EA200200642A EA200200642A1 EA 200200642 A1 EA200200642 A1 EA 200200642A1 EA 200200642 A EA200200642 A EA 200200642A EA 200200642 A EA200200642 A EA 200200642A EA 200200642 A1 EA200200642 A1 EA 200200642A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pregabalin
asymmetric synthesis
proposed
useful
synthesis
Prior art date
Application number
EA200200642A
Other languages
English (en)
Other versions
EA004934B1 (ru
Inventor
Марк Джозеф Берк
Ом Прэйкэш Гоуэл
Марвин Саймон Хокстрэй
Томас Фредерик Мич
Томас Артур Малхерн
Джеймс Эндрю Рэмзден
Original Assignee
Уорнер-Ламберт Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200200642(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Уорнер-Ламберт Компани filed Critical Уорнер-Ламберт Компани
Publication of EA200200642A1 publication Critical patent/EA200200642A1/ru
Publication of EA004934B1 publication Critical patent/EA004934B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Согласно данному изобретению предложен способ получения (S)-(+)-3-(аминометил)-5-метилгексановой кислоты (прегабалина) или его соли посредством синтеза с ассиметрическим гидрированием. Прегабалин полезен для лечения и предупреждения эпилептических припадков, боли и психотических расстройств. Согласно изобретению также предложены промежуточные вещества, полезные в производстве прегабалина.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200642A 2000-01-27 2001-01-11 Асимметрический синтез прегабалина EA004934B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17835900P 2000-01-27 2000-01-27
US19042700P 2000-03-17 2000-03-17
PCT/IB2001/000024 WO2001055090A1 (en) 2000-01-27 2001-01-11 Asymmetric synthesis of pregabalin

Publications (2)

Publication Number Publication Date
EA200200642A1 true EA200200642A1 (ru) 2002-12-26
EA004934B1 EA004934B1 (ru) 2004-10-28

Family

ID=26874236

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200642A EA004934B1 (ru) 2000-01-27 2001-01-11 Асимметрический синтез прегабалина

Country Status (50)

Country Link
US (1) US6891059B2 (ru)
EP (1) EP1250311B1 (ru)
JP (2) JP4235384B2 (ru)
KR (1) KR100549748B1 (ru)
CN (1) CN1210253C (ru)
AP (1) AP1438A (ru)
AR (1) AR028499A1 (ru)
AT (1) ATE261930T1 (ru)
AU (1) AU777046B2 (ru)
BG (1) BG65560B1 (ru)
BR (1) BRPI0107863B8 (ru)
CA (1) CA2396090C (ru)
CO (1) CO5251411A1 (ru)
CR (1) CR6703A (ru)
CU (1) CU23221A3 (ru)
CY (1) CY2004011I1 (ru)
CZ (1) CZ302838B6 (ru)
DE (1) DE60102356T2 (ru)
DK (1) DK1250311T3 (ru)
DZ (1) DZ3268A1 (ru)
EA (1) EA004934B1 (ru)
EE (1) EE05216B1 (ru)
EG (1) EG24138A (ru)
ES (1) ES2219493T3 (ru)
GE (1) GEP20043236B (ru)
HN (1) HN2001000010A (ru)
HR (1) HRP20020627B1 (ru)
HU (1) HU228815B1 (ru)
IL (2) IL150633A0 (ru)
IS (1) IS2038B (ru)
MA (1) MA26869A1 (ru)
ME (1) ME00921B (ru)
MX (1) MXPA02007307A (ru)
MY (1) MY127152A (ru)
NO (1) NO327958B1 (ru)
NZ (1) NZ519551A (ru)
OA (1) OA12167A (ru)
PA (1) PA8510501A1 (ru)
PE (1) PE20011063A1 (ru)
PL (1) PL203985B1 (ru)
PT (1) PT1250311E (ru)
RS (1) RS50257B (ru)
SI (1) SI1250311T1 (ru)
SK (1) SK287303B6 (ru)
SV (1) SV2002000295A (ru)
TN (1) TNSN01016A1 (ru)
TR (1) TR200400953T4 (ru)
TW (1) TWI288128B (ru)
UA (1) UA75584C2 (ru)
WO (1) WO2001055090A1 (ru)

Families Citing this family (43)

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WO1998003167A1 (en) 1996-07-24 1998-01-29 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
EE05216B1 (et) * 2000-01-27 2009-10-15 Warner-Lambert Company Pregabaliini asmmeetriline sntees
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
ATE371496T1 (de) * 2004-03-12 2007-09-15 Warner Lambert Co C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin
UA82292C2 (ru) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Способ стереоселективного превращения алифатических динитрилов в цианокарбоновые кислоты (варианты)
DE602005018965D1 (de) * 2004-06-21 2010-03-04 Warner Lambert Co Herstellung von pregabalin und verwandten verbindungen
CN101160281A (zh) * 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
MX2007012606A (es) * 2005-04-11 2008-01-11 Teva Pharma Proceso para elaborar (s)-pregabalina.
CA2604624A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
EP1879851B1 (en) * 2005-05-10 2010-11-03 Teva Pharmaceutical Industries Ltd Method for the preparation of pregabalin and salts thereof
JP2008505980A (ja) * 2005-05-10 2008-02-28 テバ ファーマシューティカル インダストリーズ リミティド イソブチルグルタル酸を有さないプレガバリン及びその調製方法
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
CA2619472A1 (en) * 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin
NL2000281C2 (nl) * 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
BRPI0702865A2 (pt) * 2006-04-24 2012-08-07 Teva Pharma processos para preparaÇço do Ácido 3-isobutilglutÁrico e de (s)- pregabalin, a partir de combinaÇÕes de composiÇÕes com fàrmulas especÍficas para uso na dita preparaÇço
TW200815323A (en) * 2006-05-24 2008-04-01 Teva Pharma Processes for the preparation of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof
EP2071032A3 (en) * 2006-05-31 2009-07-08 Teva Pharmaceutical Industries Ltd The use of enzymatic resolution for the preparation of intermediates of pregabalin
US20080015385A1 (en) * 2006-05-31 2008-01-17 Lilach Hedvati Preparation of (S)-pregabalin-nitrile
EP1903027A1 (en) 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
BRPI0803092A2 (pt) * 2007-03-22 2011-08-30 Teva Pharma sìntese de (s)-(+)-3-(aminometil)-5-metil ácido hexanóico, (s)-pregabalina
US8168828B2 (en) 2007-06-25 2012-05-01 Msn Laboratories, Limited Process for the preparation of pregabalin
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
US20090137842A1 (en) * 2007-10-03 2009-05-28 Vollerner Yuri Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
EP2053040A1 (en) * 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Pregabalin intermediates and process for preparing them and Pregabalin
WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
US20100324139A1 (en) * 2007-12-26 2010-12-23 Generics [Uk] Limited Process to pregabalin
EP2241551A4 (en) * 2008-01-10 2014-01-01 Sumitomo Chemical Co METHOD FOR PRODUCING A CYCLOPROPAN CARBOXYLIC COMPOUND AND INTERMEDIATE PRODUCT THEREOF
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
UA103997C2 (ru) 2008-05-21 2013-12-25 Сандоз Аг Способ стереоселективного ферментативного гидролиза эстера 5-метил-3-нитрометилгексановой кислоты
KR20100107500A (ko) * 2008-06-23 2010-10-05 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ) 또는 (ｒ)-이소-부틸-글루타릭 에스테르의 입체선택적 효소 합성방법
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) * 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
CN102464594B (zh) * 2010-11-17 2014-06-25 凯瑞斯德生化(苏州)有限公司 普瑞巴林的中间体化合物的制备方法
WO2014181359A1 (en) 2013-05-09 2014-11-13 Council Of Scientific & Industrial Research A process for the preparation of an anticonvulsant agent pregabalin hydrochloride
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin

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EE05216B1 (et) * 2000-01-27 2009-10-15 Warner-Lambert Company Pregabaliini asmmeetriline sntees

Also Published As

Publication number Publication date
MXPA02007307A (es) 2002-11-29
HRP20020627B1 (en) 2011-01-31
AP1438A (en) 2005-05-23
MA26869A1 (fr) 2004-12-20
WO2001055090A1 (en) 2001-08-02
AP2002002588A0 (en) 2002-09-30
US20030212290A1 (en) 2003-11-13
PL203985B1 (pl) 2009-11-30
CN1396905A (zh) 2003-02-12
JP2003520841A (ja) 2003-07-08
PL357077A1 (en) 2004-07-12
ATE261930T1 (de) 2004-04-15
BG65560B1 (bg) 2008-12-30
IS2038B (is) 2005-08-15
MY127152A (en) 2006-11-30
CZ20022520A3 (cs) 2002-10-16
JP4886753B2 (ja) 2012-02-29
HN2001000010A (es) 2001-06-13
PT1250311E (pt) 2004-07-30
CU23221A3 (es) 2007-07-20
DZ3268A1 (fr) 2001-08-02
SV2002000295A (es) 2002-06-07
IL150633A (en) 2009-08-03
JP4235384B2 (ja) 2009-03-11
DK1250311T3 (da) 2004-08-16
CA2396090C (en) 2006-01-10
TR200400953T4 (tr) 2004-07-21
RS50257B (sr) 2009-07-15
EA004934B1 (ru) 2004-10-28
ME00921B (me) 2012-06-20
UA75584C2 (ru) 2006-05-15
NO327958B1 (no) 2009-10-26
KR20020073187A (ko) 2002-09-19
EP1250311B1 (en) 2004-03-17
SI1250311T1 (en) 2004-10-31
KR100549748B1 (ko) 2006-02-08
HRP20020627A2 (en) 2004-08-31
DE60102356T2 (de) 2005-02-17
IS6430A (is) 2002-06-19
HUP0204307A2 (hu) 2003-06-28
AU777046B2 (en) 2004-09-30
BR0107863A (pt) 2002-11-05
IL150633A0 (en) 2003-02-12
EE200200403A (et) 2003-10-15
US6891059B2 (en) 2005-05-10
CR6703A (es) 2003-06-24
NZ519551A (en) 2004-02-27
TWI288128B (en) 2007-10-11
CN1210253C (zh) 2005-07-13
HUP0204307A3 (en) 2003-07-28
CY2004011I1 (el) 2010-07-28
BR0107863B1 (pt) 2013-06-18
EE05216B1 (et) 2009-10-15
DE60102356D1 (de) 2004-04-22
CO5251411A1 (es) 2003-02-28
PA8510501A1 (es) 2002-02-21
EP1250311A1 (en) 2002-10-23
GEP20043236B (en) 2004-05-25
YU56202A (sh) 2006-01-16
CA2396090A1 (en) 2001-08-02
SK287303B6 (sk) 2010-06-07
AU2213801A (en) 2001-08-07
EG24138A (en) 2008-08-06
BG106849A (en) 2003-03-31
NO20023582L (no) 2002-09-02
SK10782002A3 (sk) 2002-11-06
PE20011063A1 (es) 2001-10-18
TNSN01016A1 (fr) 2005-11-10
BRPI0107863B8 (pt) 2017-04-25
HU228815B1 (en) 2013-05-28
ES2219493T3 (es) 2004-12-01
OA12167A (en) 2006-05-08
JP2009073841A (ja) 2009-04-09
NO20023582D0 (no) 2002-07-26
AR028499A1 (es) 2003-05-14
CZ302838B6 (cs) 2011-12-07

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