BR0107863B1 - mÉtodo para preparar um derivado do Ácido (s)-3- ciano-5-metilhexanoico, composto intermediÁrio, seu mÉtodo de preparaÇço e mÉtodo para preparar a pregabalina - Google Patents

mÉtodo para preparar um derivado do Ácido (s)-3- ciano-5-metilhexanoico, composto intermediÁrio, seu mÉtodo de preparaÇço e mÉtodo para preparar a pregabalina

Info

Publication number
BR0107863B1
BR0107863B1 BRPI0107863-1B1A BR0107863A BR0107863B1 BR 0107863 B1 BR0107863 B1 BR 0107863B1 BR 0107863 A BR0107863 A BR 0107863A BR 0107863 B1 BR0107863 B1 BR 0107863B1
Authority
BR
Brazil
Prior art keywords
preparing
cyano
derivative
preparation
intermediate compound
Prior art date
Application number
BRPI0107863-1B1A
Other languages
English (en)
Other versions
BR0107863A (pt
BRPI0107863B8 (pt
Inventor
Mark Joseph Burk
Om Prakash Goel
Marvin Simon Hoekstra
Thomas Frederick Mich
Thomas Arthur Mulhern
James Andrew Ramsden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0107863(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of BR0107863A publication Critical patent/BR0107863A/pt
Publication of BR0107863B1 publication Critical patent/BR0107863B1/pt
Publication of BRPI0107863B8 publication Critical patent/BRPI0107863B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0107863A 2000-01-27 2001-01-11 método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina BRPI0107863B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17835900P 2000-01-27 2000-01-27
US19042700P 2000-03-17 2000-03-17
PCT/IB2001/000024 WO2001055090A1 (en) 2000-01-27 2001-01-11 Asymmetric synthesis of pregabalin

Publications (3)

Publication Number Publication Date
BR0107863A BR0107863A (pt) 2002-11-05
BR0107863B1 true BR0107863B1 (pt) 2013-06-18
BRPI0107863B8 BRPI0107863B8 (pt) 2017-04-25

Family

ID=26874236

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0107863A BRPI0107863B8 (pt) 2000-01-27 2001-01-11 método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina

Country Status (50)

Country Link
US (1) US6891059B2 (pt)
EP (1) EP1250311B1 (pt)
JP (2) JP4235384B2 (pt)
KR (1) KR100549748B1 (pt)
CN (1) CN1210253C (pt)
AP (1) AP1438A (pt)
AR (1) AR028499A1 (pt)
AT (1) ATE261930T1 (pt)
AU (1) AU777046B2 (pt)
BG (1) BG65560B1 (pt)
BR (1) BRPI0107863B8 (pt)
CA (1) CA2396090C (pt)
CO (1) CO5251411A1 (pt)
CR (1) CR6703A (pt)
CU (1) CU23221A3 (pt)
CY (1) CY2004011I1 (pt)
CZ (1) CZ302838B6 (pt)
DE (1) DE60102356T2 (pt)
DK (1) DK1250311T3 (pt)
DZ (1) DZ3268A1 (pt)
EA (1) EA004934B1 (pt)
EE (1) EE05216B1 (pt)
EG (1) EG24138A (pt)
ES (1) ES2219493T3 (pt)
GE (1) GEP20043236B (pt)
HN (1) HN2001000010A (pt)
HR (1) HRP20020627B1 (pt)
HU (1) HU228815B1 (pt)
IL (2) IL150633A0 (pt)
IS (1) IS2038B (pt)
MA (1) MA26869A1 (pt)
ME (1) ME00921B (pt)
MX (1) MXPA02007307A (pt)
MY (1) MY127152A (pt)
NO (1) NO327958B1 (pt)
NZ (1) NZ519551A (pt)
OA (1) OA12167A (pt)
PA (1) PA8510501A1 (pt)
PE (1) PE20011063A1 (pt)
PL (1) PL203985B1 (pt)
PT (1) PT1250311E (pt)
RS (1) RS50257B (pt)
SI (1) SI1250311T1 (pt)
SK (1) SK287303B6 (pt)
SV (1) SV2002000295A (pt)
TN (1) TNSN01016A1 (pt)
TR (1) TR200400953T4 (pt)
TW (1) TWI288128B (pt)
UA (1) UA75584C2 (pt)
WO (1) WO2001055090A1 (pt)

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IL126999A (en) 1996-07-24 2002-03-10 Warner Lambert Co Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain
AU777046B2 (en) * 2000-01-27 2004-09-30 Warner-Lambert Company Llc Asymmetric synthesis of pregabalin
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
PT1727620E (pt) * 2004-03-12 2007-11-05 Warner Lambert Co Ligandos de biofosfina c1-simétricos e a sua utilização na síntese assimétrica da pregabalina
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
ATE455093T1 (de) * 2004-06-21 2010-01-15 Warner Lambert Co Herstellung von pregabalin und verwandten verbindungen
WO2006108151A1 (en) * 2005-04-06 2006-10-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
US7488846B2 (en) 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
EP1768950A2 (en) * 2005-04-11 2007-04-04 Teva Pharmaceutical Industries Ltd. Process for making (s)-pregabalin
KR20070118305A (ko) * 2005-05-10 2007-12-14 테바 파마슈티컬 인더스트리즈 리미티드 3-카르바모일메틸-5-메틸 헥산산의 광학 분할
MX2007000525A (es) 2005-05-10 2007-03-28 Teva Pharma Pregabalina libre de acido isobutilglutarico y un proceso para la preparacion de ella.
ATE486841T1 (de) 2005-05-10 2010-11-15 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
KR20080034205A (ko) 2005-09-19 2008-04-18 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-프레가발린의 신규한 합성을 위한 주요 중간체인 키랄3-카르바모일메틸-5-메틸 헥산산
NL2000281C2 (nl) 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
CA2646474A1 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 3-isobutylglutaric acid
WO2007139933A2 (en) * 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
KR20080036060A (ko) * 2006-05-31 2008-04-24 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린의 중간체의 제조에 효소 분할을 이용하는 방법
EP1912931A2 (en) * 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
EP1903027A1 (en) * 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
TW200846308A (en) * 2007-03-22 2008-12-01 Teva Pharma Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
WO2009001372A2 (en) * 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
EP2053040A1 (en) * 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Pregabalin intermediates and process for preparing them and Pregabalin
WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
JP2011507941A (ja) * 2007-12-26 2011-03-10 ジェネリクス・（ユーケー）・リミテッド プレガバリンの製造方法
US8263797B2 (en) * 2008-01-10 2012-09-11 Sumitomo Chemical Company, Limited Method for producing cyclopropane carboxylic acid compound and intermediate therefor
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
KR20110025917A (ko) 2008-05-21 2011-03-14 산도즈 아게 ５－메틸－３－니트로메틸－헥산산 에스테르의 입체선택적 효소 가수분해 방법
WO2009158343A1 (en) * 2008-06-23 2009-12-30 Teva Pharmaceutical Industries, Ltd. Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) * 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
CN102464594B (zh) * 2010-11-17 2014-06-25 凯瑞斯德生化(苏州)有限公司 普瑞巴林的中间体化合物的制备方法
WO2014181359A1 (en) 2013-05-09 2014-11-13 Council Of Scientific & Industrial Research A process for the preparation of an anticonvulsant agent pregabalin hydrochloride
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin

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Also Published As

Publication number Publication date
IS2038B (is) 2005-08-15
EP1250311B1 (en) 2004-03-17
NZ519551A (en) 2004-02-27
CN1210253C (zh) 2005-07-13
DZ3268A1 (fr) 2001-08-02
HRP20020627B1 (en) 2011-01-31
RS50257B (sr) 2009-07-15
US6891059B2 (en) 2005-05-10
PL203985B1 (pl) 2009-11-30
ES2219493T3 (es) 2004-12-01
EP1250311A1 (en) 2002-10-23
IS6430A (is) 2002-06-19
BG65560B1 (bg) 2008-12-30
SV2002000295A (es) 2002-06-07
HN2001000010A (es) 2001-06-13
MXPA02007307A (es) 2002-11-29
AU777046B2 (en) 2004-09-30
GEP20043236B (en) 2004-05-25
HUP0204307A3 (en) 2003-07-28
BR0107863A (pt) 2002-11-05
JP4886753B2 (ja) 2012-02-29
EA004934B1 (ru) 2004-10-28
BG106849A (en) 2003-03-31
IL150633A0 (en) 2003-02-12
OA12167A (en) 2006-05-08
CN1396905A (zh) 2003-02-12
CR6703A (es) 2003-06-24
EA200200642A1 (ru) 2002-12-26
PA8510501A1 (es) 2002-02-21
MA26869A1 (fr) 2004-12-20
HRP20020627A2 (en) 2004-08-31
WO2001055090A1 (en) 2001-08-02
CA2396090A1 (en) 2001-08-02
CZ20022520A3 (cs) 2002-10-16
NO20023582D0 (no) 2002-07-26
EE05216B1 (et) 2009-10-15
JP2009073841A (ja) 2009-04-09
PL357077A1 (en) 2004-07-12
DK1250311T3 (da) 2004-08-16
CA2396090C (en) 2006-01-10
NO327958B1 (no) 2009-10-26
ATE261930T1 (de) 2004-04-15
AP2002002588A0 (en) 2002-09-30
CY2004011I1 (el) 2010-07-28
PT1250311E (pt) 2004-07-30
AR028499A1 (es) 2003-05-14
NO20023582L (no) 2002-09-02
CO5251411A1 (es) 2003-02-28
CZ302838B6 (cs) 2011-12-07
TR200400953T4 (tr) 2004-07-21
US20030212290A1 (en) 2003-11-13
KR100549748B1 (ko) 2006-02-08
DE60102356T2 (de) 2005-02-17
SK10782002A3 (sk) 2002-11-06
EG24138A (en) 2008-08-06
IL150633A (en) 2009-08-03
EE200200403A (et) 2003-10-15
HUP0204307A2 (hu) 2003-06-28
AP1438A (en) 2005-05-23
KR20020073187A (ko) 2002-09-19
CU23221A3 (es) 2007-07-20
ME00921B (me) 2012-06-20
JP4235384B2 (ja) 2009-03-11
UA75584C2 (uk) 2006-05-15
SI1250311T1 (en) 2004-10-31
BRPI0107863B8 (pt) 2017-04-25
MY127152A (en) 2006-11-30
HU228815B1 (en) 2013-05-28
JP2003520841A (ja) 2003-07-08
SK287303B6 (sk) 2010-06-07
DE60102356D1 (de) 2004-04-22
TNSN01016A1 (fr) 2005-11-10
TWI288128B (en) 2007-10-11
YU56202A (sh) 2006-01-16
PE20011063A1 (es) 2001-10-18
AU2213801A (en) 2001-08-07

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

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