SI1250311T1 - Asymmetric synthesis of pregabalin - Google Patents

Asymmetric synthesis of pregabalin

Info

Publication number
SI1250311T1
SI1250311T1 SI200130109T SI200130109T SI1250311T1 SI 1250311 T1 SI1250311 T1 SI 1250311T1 SI 200130109 T SI200130109 T SI 200130109T SI 200130109 T SI200130109 T SI 200130109T SI 1250311 T1 SI1250311 T1 SI 1250311T1
Authority
SI
Slovenia
Prior art keywords
pregabalin
asymmetric synthesis
asymmetric
synthesis
Prior art date
Application number
SI200130109T
Other languages
English (en)
Slovenian (sl)
Inventor
Mark Joseph Burk
Om Prakash Goel
Marvin Simon Hoekstra
Thomas Frederick Mich
Thomas Arthur Mulhern
James Andrew Ramsden
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1250311(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of SI1250311T1 publication Critical patent/SI1250311T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
SI200130109T 2000-01-27 2001-01-11 Asymmetric synthesis of pregabalin SI1250311T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17835900P 2000-01-27 2000-01-27
US19042700P 2000-03-17 2000-03-17
EP01900035A EP1250311B1 (en) 2000-01-27 2001-01-11 Asymmetric synthesis of pregabalin
PCT/IB2001/000024 WO2001055090A1 (en) 2000-01-27 2001-01-11 Asymmetric synthesis of pregabalin

Publications (1)

Publication Number Publication Date
SI1250311T1 true SI1250311T1 (en) 2004-10-31

Family

ID=26874236

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130109T SI1250311T1 (en) 2000-01-27 2001-01-11 Asymmetric synthesis of pregabalin

Country Status (50)

Country Link
US (1) US6891059B2 (pt)
EP (1) EP1250311B1 (pt)
JP (2) JP4235384B2 (pt)
KR (1) KR100549748B1 (pt)
CN (1) CN1210253C (pt)
AP (1) AP1438A (pt)
AR (1) AR028499A1 (pt)
AT (1) ATE261930T1 (pt)
AU (1) AU777046B2 (pt)
BG (1) BG65560B1 (pt)
BR (1) BRPI0107863B8 (pt)
CA (1) CA2396090C (pt)
CO (1) CO5251411A1 (pt)
CR (1) CR6703A (pt)
CU (1) CU23221A3 (pt)
CY (1) CY2004011I1 (pt)
CZ (1) CZ302838B6 (pt)
DE (1) DE60102356T2 (pt)
DK (1) DK1250311T3 (pt)
DZ (1) DZ3268A1 (pt)
EA (1) EA004934B1 (pt)
EE (1) EE05216B1 (pt)
EG (1) EG24138A (pt)
ES (1) ES2219493T3 (pt)
GE (1) GEP20043236B (pt)
HN (1) HN2001000010A (pt)
HR (1) HRP20020627B1 (pt)
HU (1) HU228815B1 (pt)
IL (2) IL150633A0 (pt)
IS (1) IS2038B (pt)
MA (1) MA26869A1 (pt)
ME (1) ME00921B (pt)
MX (1) MXPA02007307A (pt)
MY (1) MY127152A (pt)
NO (1) NO327958B1 (pt)
NZ (1) NZ519551A (pt)
OA (1) OA12167A (pt)
PA (1) PA8510501A1 (pt)
PE (1) PE20011063A1 (pt)
PL (1) PL203985B1 (pt)
PT (1) PT1250311E (pt)
RS (1) RS50257B (pt)
SI (1) SI1250311T1 (pt)
SK (1) SK287303B6 (pt)
SV (1) SV2002000295A (pt)
TN (1) TNSN01016A1 (pt)
TR (1) TR200400953T4 (pt)
TW (1) TWI288128B (pt)
UA (1) UA75584C2 (pt)
WO (1) WO2001055090A1 (pt)

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US6001876A (en) 1996-07-24 1999-12-14 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
ES2219493T3 (es) * 2000-01-27 2004-12-01 Warner-Lambert Company Sintesis asimetrica de la pregabalina.
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
KR100847922B1 (ko) * 2004-03-12 2008-07-22 워너-램버트 캄파니 엘엘씨 Ｃ1-대칭 비스포스핀 리간드 및 프레가발린의 비대칭합성에서의 이들의 용도
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
WO2006000904A2 (en) 2004-06-21 2006-01-05 Warner-Lambert Company Llc Preparation of pregabalin and related compounds
EP1866275A1 (en) 2005-04-06 2007-12-19 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
CN101300224A (zh) * 2005-04-11 2008-11-05 特瓦制药工业有限公司 制备(s)-普瑞巴林的方法
MX2007014129A (es) * 2005-05-10 2008-01-11 Teva Pharma Resolucion optica del acido 3-carbamoilmetil-5-metil hexanoico.
DE602006017995D1 (de) * 2005-05-10 2010-12-16 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
KR20070067077A (ko) * 2005-05-10 2007-06-27 테바 파마슈티컬 인더스트리즈 리미티드 이소부틸글루타르산을 함유하지 않는 프레가발린 및 이의제조 방법
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
US7563923B2 (en) 2005-09-19 2009-07-21 Teva Pharmaceutical Industries Ltd. Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the synthesis of (S)-Pregabalin
NL2000281C2 (nl) 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
KR20080016658A (ko) * 2006-04-24 2008-02-21 테바 파마슈티컬 인더스트리즈 리미티드 3-이소부틸글루타르산의 합성 방법
WO2007139933A2 (en) 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
EP1912931A2 (en) * 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
WO2007143113A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. The use of enzymatic resolution for the preparation of intermediates of pregabalin
EP1903027A1 (en) 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
BRPI0803092A2 (pt) 2007-03-22 2011-08-30 Teva Pharma sìntese de (s)-(+)-3-(aminometil)-5-metil ácido hexanóico, (s)-pregabalina
US8168828B2 (en) 2007-06-25 2012-05-01 Msn Laboratories, Limited Process for the preparation of pregabalin
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
WO2009046309A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
EP2053040A1 (en) * 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Pregabalin intermediates and process for preparing them and Pregabalin
EP2225199A2 (en) * 2007-12-18 2010-09-08 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
JP2011507941A (ja) * 2007-12-26 2011-03-10 ジェネリクス・（ユーケー）・リミテッド プレガバリンの製造方法
US8263797B2 (en) * 2008-01-10 2012-09-11 Sumitomo Chemical Company, Limited Method for producing cyclopropane carboxylic acid compound and intermediate therefor
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
SG176464A1 (en) 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
KR20110025917A (ko) 2008-05-21 2011-03-14 산도즈 아게 ５－메틸－３－니트로메틸－헥산산 에스테르의 입체선택적 효소 가수분해 방법
EP2297090A1 (en) * 2008-06-23 2011-03-23 Teva Pharmaceutical Industries Ltd. Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) * 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
CN102464594B (zh) * 2010-11-17 2014-06-25 凯瑞斯德生化(苏州)有限公司 普瑞巴林的中间体化合物的制备方法
WO2014181359A1 (en) 2013-05-09 2014-11-13 Council Of Scientific & Industrial Research A process for the preparation of an anticonvulsant agent pregabalin hydrochloride
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin

Family Cites Families (12)

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JPS588390B2 (ja) * 1978-05-23 1983-02-15 住友化学工業株式会社 光学活性ω↓−シアノ↓−α↓−アシルアミノ酸誘導体の製造法
US4939288A (en) * 1989-01-23 1990-07-03 Monsanto Company Method of preparing (R)-succinic acid derivatives
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5171892A (en) * 1991-07-02 1992-12-15 E. I. Du Pont De Nemours And Company Chiral phospholanes via chiral 1,4-diol cyclic sulfates
US5616793A (en) 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) * 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5840965A (en) * 1996-06-24 1998-11-24 E. I. Du Pont De Nemours And Company Process for the production of purified telephthalic acid
US6001876A (en) * 1996-07-24 1999-12-14 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
CA2309668A1 (en) 1997-12-17 1999-06-24 Chirotech Technology Limited Asymmetric hydrogenation
AU3433199A (en) 1998-04-09 1999-11-01 Chirotech Technology Limited Asymmetric hydrogenation
ES2219493T3 (es) * 2000-01-27 2004-12-01 Warner-Lambert Company Sintesis asimetrica de la pregabalina.

Also Published As

Publication number Publication date
CO5251411A1 (es) 2003-02-28
IS6430A (is) 2002-06-19
SK10782002A3 (sk) 2002-11-06
AU2213801A (en) 2001-08-07
GEP20043236B (en) 2004-05-25
AP2002002588A0 (en) 2002-09-30
EE05216B1 (et) 2009-10-15
HUP0204307A2 (hu) 2003-06-28
AR028499A1 (es) 2003-05-14
DZ3268A1 (fr) 2001-08-02
EG24138A (en) 2008-08-06
MA26869A1 (fr) 2004-12-20
BG65560B1 (bg) 2008-12-30
PL203985B1 (pl) 2009-11-30
KR20020073187A (ko) 2002-09-19
NO20023582D0 (no) 2002-07-26
EA200200642A1 (ru) 2002-12-26
NO327958B1 (no) 2009-10-26
US6891059B2 (en) 2005-05-10
HU228815B1 (en) 2013-05-28
PL357077A1 (en) 2004-07-12
JP2009073841A (ja) 2009-04-09
SK287303B6 (sk) 2010-06-07
IS2038B (is) 2005-08-15
NZ519551A (en) 2004-02-27
BRPI0107863B8 (pt) 2017-04-25
IL150633A (en) 2009-08-03
HUP0204307A3 (en) 2003-07-28
US20030212290A1 (en) 2003-11-13
TR200400953T4 (tr) 2004-07-21
IL150633A0 (en) 2003-02-12
EA004934B1 (ru) 2004-10-28
JP2003520841A (ja) 2003-07-08
CA2396090A1 (en) 2001-08-02
CY2004011I1 (el) 2010-07-28
MY127152A (en) 2006-11-30
JP4235384B2 (ja) 2009-03-11
BR0107863B1 (pt) 2013-06-18
KR100549748B1 (ko) 2006-02-08
ATE261930T1 (de) 2004-04-15
JP4886753B2 (ja) 2012-02-29
HRP20020627A2 (en) 2004-08-31
SV2002000295A (es) 2002-06-07
PE20011063A1 (es) 2001-10-18
CR6703A (es) 2003-06-24
RS50257B (sr) 2009-07-15
PT1250311E (pt) 2004-07-30
CZ20022520A3 (cs) 2002-10-16
UA75584C2 (uk) 2006-05-15
TNSN01016A1 (fr) 2005-11-10
AU777046B2 (en) 2004-09-30
WO2001055090A1 (en) 2001-08-02
BR0107863A (pt) 2002-11-05
OA12167A (en) 2006-05-08
TWI288128B (en) 2007-10-11
CZ302838B6 (cs) 2011-12-07
ES2219493T3 (es) 2004-12-01
HN2001000010A (es) 2001-06-13
BG106849A (en) 2003-03-31
DK1250311T3 (da) 2004-08-16
DE60102356D1 (de) 2004-04-22
DE60102356T2 (de) 2005-02-17
CU23221A3 (es) 2007-07-20
CN1396905A (zh) 2003-02-12
HRP20020627B1 (en) 2011-01-31
AP1438A (en) 2005-05-23
EP1250311A1 (en) 2002-10-23
EE200200403A (et) 2003-10-15
NO20023582L (no) 2002-09-02
MXPA02007307A (es) 2002-11-29
ME00921B (me) 2012-06-20
CA2396090C (en) 2006-01-10
CN1210253C (zh) 2005-07-13
EP1250311B1 (en) 2004-03-17
YU56202A (sh) 2006-01-16
PA8510501A1 (es) 2002-02-21

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