CR6703A - Sintesis asimetrica de pregabalin - Google Patents

Sintesis asimetrica de pregabalin

Info

Publication number
CR6703A
CR6703A CR6703A CR6703A CR6703A CR 6703 A CR6703 A CR 6703A CR 6703 A CR6703 A CR 6703A CR 6703 A CR6703 A CR 6703A CR 6703 A CR6703 A CR 6703A
Authority
CR
Costa Rica
Prior art keywords
pregabalin
asymmetric synthesis
disorders
aminometil
uns
Prior art date
Application number
CR6703A
Other languages
English (en)
Inventor
Joseph Burk Mark
Prakash Goel Om
Simon Hoekstra Marvin
Federick Mich Thomas
Arthur Mulhern Thomas
Andrew Ramsden James
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR6703(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CR6703A publication Critical patent/CR6703A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)

Abstract

UN METODO PARA PREPARAR (S)-(+)-ACIDO 3-(AMINOMETIL)5-METIL-HEXANOICO (PREGABALIN) EN UNS SINTESIS ASIMETRICA. eL PREGABALIN ES UTIL PARA EL TRATAMIENTO Y LA PREVENCION DE TRASTORNOS CAUSADOS POR ATAQUES (ACCESOS), ASI COMO DEL DOLOR Y DE TRASTORNOS PSICOTICOS.
CR6703A 2000-01-27 2002-07-16 Sintesis asimetrica de pregabalin CR6703A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17835900P 2000-01-27 2000-01-27
US19042700P 2000-03-17 2000-03-17

Publications (1)

Publication Number Publication Date
CR6703A true CR6703A (es) 2003-06-24

Family

ID=26874236

Family Applications (1)

Application Number Title Priority Date Filing Date
CR6703A CR6703A (es) 2000-01-27 2002-07-16 Sintesis asimetrica de pregabalin

Country Status (50)

Country Link
US (1) US6891059B2 (es)
EP (1) EP1250311B1 (es)
JP (2) JP4235384B2 (es)
KR (1) KR100549748B1 (es)
CN (1) CN1210253C (es)
AP (1) AP1438A (es)
AR (1) AR028499A1 (es)
AT (1) ATE261930T1 (es)
AU (1) AU777046B2 (es)
BG (1) BG65560B1 (es)
BR (1) BRPI0107863B8 (es)
CA (1) CA2396090C (es)
CO (1) CO5251411A1 (es)
CR (1) CR6703A (es)
CU (1) CU23221A3 (es)
CY (1) CY2004011I1 (es)
CZ (1) CZ302838B6 (es)
DE (1) DE60102356T2 (es)
DK (1) DK1250311T3 (es)
DZ (1) DZ3268A1 (es)
EA (1) EA004934B1 (es)
EE (1) EE05216B1 (es)
EG (1) EG24138A (es)
ES (1) ES2219493T3 (es)
GE (1) GEP20043236B (es)
HN (1) HN2001000010A (es)
HR (1) HRP20020627B1 (es)
HU (1) HU228815B1 (es)
IL (2) IL150633A0 (es)
IS (1) IS2038B (es)
MA (1) MA26869A1 (es)
ME (1) ME00921B (es)
MX (1) MXPA02007307A (es)
MY (1) MY127152A (es)
NO (1) NO327958B1 (es)
NZ (1) NZ519551A (es)
OA (1) OA12167A (es)
PA (1) PA8510501A1 (es)
PE (1) PE20011063A1 (es)
PL (1) PL203985B1 (es)
PT (1) PT1250311E (es)
RS (1) RS50257B (es)
SI (1) SI1250311T1 (es)
SK (1) SK287303B6 (es)
SV (1) SV2002000295A (es)
TN (1) TNSN01016A1 (es)
TR (1) TR200400953T4 (es)
TW (1) TWI288128B (es)
UA (1) UA75584C2 (es)
WO (1) WO2001055090A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL189872B1 (pl) 1996-07-24 2005-10-31 Warner Lambert Co Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu
EP1250311B1 (en) * 2000-01-27 2004-03-17 Warner-Lambert Company Asymmetric synthesis of pregabalin
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
AU2005221401A1 (en) * 2004-03-12 2005-09-22 Warner-Lambert Company Llc C1-symmetric bisphosphine ligands and their use in the asymmetric synthesis of pregabalin
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
DK1831154T3 (da) 2004-06-21 2010-04-12 Warner Lambert Co Fremstilling af pregabalin og relaterede forbindelser
MX2007012396A (es) * 2005-04-06 2007-11-20 Teva Pharma Formas cristalinas de pregabalina.
CA2603215A1 (en) * 2005-04-11 2006-10-19 Teva Pharmaceutical Industries Ltd. Process for making (s)-pregabalin
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
ATE523484T1 (de) 2005-05-10 2011-09-15 Teva Pharma Optische lösung a us 3-carbamoylmethyl-5-methyl- hexansäure
KR20070067077A (ko) * 2005-05-10 2007-06-27 테바 파마슈티컬 인더스트리즈 리미티드 이소부틸글루타르산을 함유하지 않는 프레가발린 및 이의제조 방법
CA2604602A1 (en) 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Method for the preparation of pregabalin and salts thereof
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
WO2007035890A1 (en) 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. An asymmetric synthesis of ( s ) - ( + ) -3- (aminomethyl) -5-methylhexanoic acid
NL2000281C2 (nl) * 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
CA2646474A1 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 3-isobutylglutaric acid
WO2007139933A2 (en) * 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
BRPI0702897A2 (pt) * 2006-05-31 2011-03-15 Teva Pharmaceutical Ind Ltda processo para preparar um intermediário de pregabalina
WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
EP1903027A1 (en) * 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
EP2021318A2 (en) * 2007-03-22 2009-02-11 Teva Pharmaceutical Industries Ltd. Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
WO2009001372A2 (en) 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
WO2009046309A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
EP2053040A1 (en) * 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Pregabalin intermediates and process for preparing them and Pregabalin
EP2225199A2 (en) * 2007-12-18 2010-09-08 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
EP2222630A1 (en) * 2007-12-26 2010-09-01 Generics (UK) Limited Processes to pregabalin
WO2009087941A1 (ja) * 2008-01-10 2009-07-16 Sumitomo Chemical Company, Limited シクロプロパンカルボン酸化合物の製造方法およびその中間体
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
EP2116618A1 (en) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnosis and treatment of Kawasaki disease
WO2009141362A2 (en) 2008-05-21 2009-11-26 Sandoz Ag Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
KR20100107500A (ko) * 2008-06-23 2010-10-05 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ) 또는 (ｒ)-이소-부틸-글루타릭 에스테르의 입체선택적 효소 합성방법
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) * 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
CN102464594B (zh) * 2010-11-17 2014-06-25 凯瑞斯德生化(苏州)有限公司 普瑞巴林的中间体化合物的制备方法
US9422230B2 (en) 2013-05-09 2016-08-23 Council Of Scientific And Industrial Research Process for the preparation of an anticonvulsant agent pregabalin hydrochloride
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS588390B2 (ja) * 1978-05-23 1983-02-15 住友化学工業株式会社 光学活性ω↓−シアノ↓−α↓−アシルアミノ酸誘導体の製造法
US4939288A (en) * 1989-01-23 1990-07-03 Monsanto Company Method of preparing (R)-succinic acid derivatives
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5171892A (en) * 1991-07-02 1992-12-15 E. I. Du Pont De Nemours And Company Chiral phospholanes via chiral 1,4-diol cyclic sulfates
US5616793A (en) 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) * 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5840965A (en) * 1996-06-24 1998-11-24 E. I. Du Pont De Nemours And Company Process for the production of purified telephthalic acid
PL189872B1 (pl) * 1996-07-24 2005-10-31 Warner Lambert Co Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
AU1572399A (en) 1997-12-17 1999-07-05 Chirotech Technology Limited Asymmetric hydrogenation
WO1999052852A1 (en) 1998-04-09 1999-10-21 Chirotech Technology Limited Asymmetric hydrogenation
EP1250311B1 (en) * 2000-01-27 2004-03-17 Warner-Lambert Company Asymmetric synthesis of pregabalin

Also Published As

Publication number Publication date
SI1250311T1 (en) 2004-10-31
EE200200403A (et) 2003-10-15
BG106849A (en) 2003-03-31
JP4886753B2 (ja) 2012-02-29
ES2219493T3 (es) 2004-12-01
HU228815B1 (en) 2013-05-28
HN2001000010A (es) 2001-06-13
PT1250311E (pt) 2004-07-30
BG65560B1 (bg) 2008-12-30
TR200400953T4 (tr) 2004-07-21
MY127152A (en) 2006-11-30
NO327958B1 (no) 2009-10-26
OA12167A (en) 2006-05-08
BRPI0107863B8 (pt) 2017-04-25
PE20011063A1 (es) 2001-10-18
MA26869A1 (fr) 2004-12-20
DE60102356T2 (de) 2005-02-17
AP1438A (en) 2005-05-23
YU56202A (sh) 2006-01-16
HUP0204307A2 (hu) 2003-06-28
IL150633A (en) 2009-08-03
IS6430A (is) 2002-06-19
SV2002000295A (es) 2002-06-07
DZ3268A1 (fr) 2001-08-02
IL150633A0 (en) 2003-02-12
WO2001055090A1 (en) 2001-08-02
EP1250311B1 (en) 2004-03-17
DE60102356D1 (de) 2004-04-22
UA75584C2 (uk) 2006-05-15
CO5251411A1 (es) 2003-02-28
JP2003520841A (ja) 2003-07-08
EG24138A (en) 2008-08-06
US6891059B2 (en) 2005-05-10
KR100549748B1 (ko) 2006-02-08
HUP0204307A3 (en) 2003-07-28
EE05216B1 (et) 2009-10-15
EP1250311A1 (en) 2002-10-23
CZ302838B6 (cs) 2011-12-07
CN1396905A (zh) 2003-02-12
RS50257B (sr) 2009-07-15
MXPA02007307A (es) 2002-11-29
CA2396090A1 (en) 2001-08-02
AR028499A1 (es) 2003-05-14
CN1210253C (zh) 2005-07-13
TWI288128B (en) 2007-10-11
BR0107863A (pt) 2002-11-05
KR20020073187A (ko) 2002-09-19
ME00921B (me) 2012-06-20
NZ519551A (en) 2004-02-27
EA004934B1 (ru) 2004-10-28
SK10782002A3 (sk) 2002-11-06
PA8510501A1 (es) 2002-02-21
EA200200642A1 (ru) 2002-12-26
IS2038B (is) 2005-08-15
US20030212290A1 (en) 2003-11-13
CZ20022520A3 (cs) 2002-10-16
BR0107863B1 (pt) 2013-06-18
PL357077A1 (en) 2004-07-12
TNSN01016A1 (fr) 2005-11-10
JP4235384B2 (ja) 2009-03-11
SK287303B6 (sk) 2010-06-07
JP2009073841A (ja) 2009-04-09
ATE261930T1 (de) 2004-04-15
HRP20020627B1 (en) 2011-01-31
PL203985B1 (pl) 2009-11-30
GEP20043236B (en) 2004-05-25
AU777046B2 (en) 2004-09-30
CA2396090C (en) 2006-01-10
DK1250311T3 (da) 2004-08-16
HRP20020627A2 (en) 2004-08-31
NO20023582D0 (no) 2002-07-26
AP2002002588A0 (en) 2002-09-30
NO20023582L (no) 2002-09-02
CU23221A3 (es) 2007-07-20
CY2004011I1 (el) 2010-07-28
AU2213801A (en) 2001-08-07

Similar Documents

Publication Publication Date Title
CR6703A (es) Sintesis asimetrica de pregabalin
DE60044152D1 (de) Bupropion Metaboliten zur Behandlung von Angstzuständen
DE60144064D1 (de) Sulfone, die die aktivität von gamma-secretase modulieren
BR0200320A (pt) Bactéria corineforme, método para produzir l-glutamina, e, dna
BRPI0408476A (pt) métodos para melhorar a qualidade da pele
DOP2005000055A (es) Bioconversion estereoselectiva de dinitrilos alifaticos en acidos cianocarboxilicos.
ES2282685T3 (es) Derivados de hidroxietilamina para el tratamiento de la enfermedad de alzheimer.
ATE238783T1 (de) Mikrobenbeständige und stabilisierte lösungen, die gamma-hydroxybuttersäuresalze zur behandlung von narkolepsie enthalten
HK1085140A1 (en) Pharmaceutical compositions and method of using levodopa and carbidopa
AU3831301A (en) Method for treating ocular pain
DE602004031893D1 (de) Verwendung des Enantiomers (1S, 2R) von Milnacipran zur Herstellung eines Arzneimittels
ATE446285T1 (de) Für die behandlung von alzheimer-krankheit und ähnlichen leiden geeignete 1-alkyl-3- thiosubstituierte indol-2-alkinsäuren
FR2848851B1 (fr) Procede d'obtention d'un principe actif presentant des capacites apaisantes, principe actif et compositions obtenues
EA200400793A1 (ru) Применение ингибиторов обратного захвата норэпинефрина для лечения нарушения познавательной функции
BR0306855A (pt) Método para o tratamento de distúrbios cognitivos
ES2163220T3 (es) Dioxacicloalcan-8-ona.
BRPI0411174A (pt) combinação do modafinil analéptico e um antidepressivo para o tratamento da depressão
CY1110156T1 (el) Υποκατεστημενες ενωσεις 4,5,6,7-τετραϋδρο-βενζοθειαζολ-2-υλαμινης
EP1546377A4 (en) METHODS AND COMPOSITIONS FOR TREATING PAIN AND PAIN DISORDERS USING MOLECULES 9949, 14230, 760, 62553, 41897, 47174, 33408, 10002, 16209, 314, 636, 27410, 33260, 619, 15985, 69112, 2158, 224, 615, 44373, 95431, 22245, 2387, 16658, 55054, 9569 OR 13424
DE60137534D1 (de) Calciumkanalantagonisten vom n-typ zur behandlung von schmerzen
DK1455770T3 (da) Anvendelse af norepinephringenoptagelsesinhibitorer til behandling af tic lidelser
FR2854800B1 (fr) Procede d'obtention d'un principe actif pour des traitements de la peau seche, actions generees et actif obtenu
TW200505435A (en) Treatment of ocular disorders
FR2845285B1 (fr) Procede d'obtention d'un principe actif de stimulation du bronzage et principe actif obtenu
ATE286390T1 (de) Felabamat-derivate zur behandlung von neuropathischem schmerz