AR028499A1 - Sintesis asimetrica de pregabalin - Google Patents

Sintesis asimetrica de pregabalin

Info

Publication number
AR028499A1
AR028499A1 ARP010100316A ARP010100316A AR028499A1 AR 028499 A1 AR028499 A1 AR 028499A1 AR P010100316 A ARP010100316 A AR P010100316A AR P010100316 A ARP010100316 A AR P010100316A AR 028499 A1 AR028499 A1 AR 028499A1
Authority
AR
Argentina
Prior art keywords
pregabalin
asymmetric synthesis
provides
useful
aminomethyl
Prior art date
Application number
ARP010100316A
Other languages
English (en)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR028499(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of AR028499A1 publication Critical patent/AR028499A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Este invento proporciona un método para preparar (S)-(+)ácido 3-(aminometil)-5-metil-hexanoico (pregabalin) o una de sus sales por medio de una síntesis de hidrogenacion asimétrica, El pregabalin es util para el tratamiento y la prevencion de trastornos causados por ataques (accesos) del dolor y trastornos psicoticos. El invento proporciona también compuestos intermedios utiles en la produccion de pregabalin.
ARP010100316A 2000-01-27 2001-01-25 Sintesis asimetrica de pregabalin AR028499A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17835900P 2000-01-27 2000-01-27
US19042700P 2000-03-17 2000-03-17

Publications (1)

Publication Number Publication Date
AR028499A1 true AR028499A1 (es) 2003-05-14

Family

ID=26874236

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010100316A AR028499A1 (es) 2000-01-27 2001-01-25 Sintesis asimetrica de pregabalin

Country Status (50)

Country Link
US (1) US6891059B2 (es)
EP (1) EP1250311B1 (es)
JP (2) JP4235384B2 (es)
KR (1) KR100549748B1 (es)
CN (1) CN1210253C (es)
AP (1) AP1438A (es)
AR (1) AR028499A1 (es)
AT (1) ATE261930T1 (es)
AU (1) AU777046B2 (es)
BG (1) BG65560B1 (es)
BR (1) BRPI0107863B8 (es)
CA (1) CA2396090C (es)
CO (1) CO5251411A1 (es)
CR (1) CR6703A (es)
CU (1) CU23221A3 (es)
CY (1) CY2004011I1 (es)
CZ (1) CZ302838B6 (es)
DE (1) DE60102356T2 (es)
DK (1) DK1250311T3 (es)
DZ (1) DZ3268A1 (es)
EA (1) EA004934B1 (es)
EE (1) EE05216B1 (es)
EG (1) EG24138A (es)
ES (1) ES2219493T3 (es)
GE (1) GEP20043236B (es)
HN (1) HN2001000010A (es)
HR (1) HRP20020627B1 (es)
HU (1) HU228815B1 (es)
IL (2) IL150633A0 (es)
IS (1) IS2038B (es)
MA (1) MA26869A1 (es)
ME (1) ME00921B (es)
MX (1) MXPA02007307A (es)
MY (1) MY127152A (es)
NO (1) NO327958B1 (es)
NZ (1) NZ519551A (es)
OA (1) OA12167A (es)
PA (1) PA8510501A1 (es)
PE (1) PE20011063A1 (es)
PL (1) PL203985B1 (es)
PT (1) PT1250311E (es)
RS (1) RS50257B (es)
SI (1) SI1250311T1 (es)
SK (1) SK287303B6 (es)
SV (1) SV2002000295A (es)
TN (1) TNSN01016A1 (es)
TR (1) TR200400953T4 (es)
TW (1) TWI288128B (es)
UA (1) UA75584C2 (es)
WO (1) WO2001055090A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9710536A (pt) 1996-07-24 1999-08-17 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
HU228815B1 (en) * 2000-01-27 2013-05-28 Warner Lambert Co Asymmetric synthesis of pregabalin
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
ES2292107T3 (es) * 2004-03-12 2008-03-01 Warner-Lambert Company Llc Ligandos de bifosfina simetricos en c1 y su uso en la sintesis asimetrica de pregabalina.
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
DK1831154T3 (da) * 2004-06-21 2010-04-12 Warner Lambert Co Fremstilling af pregabalin og relaterede forbindelser
CN101160281A (zh) * 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
CN101300224A (zh) * 2005-04-11 2008-11-05 特瓦制药工业有限公司 制备(s)-普瑞巴林的方法
US7488846B2 (en) 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
DE602006017995D1 (de) 2005-05-10 2010-12-16 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
MX2007000525A (es) 2005-05-10 2007-03-28 Teva Pharma Pregabalina libre de acido isobutilglutarico y un proceso para la preparacion de ella.
EP1879854B1 (en) 2005-05-10 2011-09-07 Teva Pharmaceutical Industries Ltd Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
WO2007035890A1 (en) 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. An asymmetric synthesis of ( s ) - ( + ) -3- (aminomethyl) -5-methylhexanoic acid
NL2000281C2 (nl) 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
US20070259917A1 (en) * 2006-04-24 2007-11-08 Kansal Vinod K Processes for the synthesis of 3-isobutylglutaric acid
US7462738B2 (en) 2006-05-24 2008-12-09 Teva Pharmaceutical Industries Ltd. Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
EP2071032A3 (en) * 2006-05-31 2009-07-08 Teva Pharmaceutical Industries Ltd The use of enzymatic resolution for the preparation of intermediates of pregabalin
WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
EP1903027A1 (en) * 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
MX2008014759A (es) 2007-03-22 2009-03-09 Teva Pharma Sintesis del acido (s)-(+)-3-(aminometil)-5-metil hexanoico.
EP2170813A4 (en) * 2007-06-25 2012-05-16 Reddy Manne Satyanarayana NEW METHOD OF PREPARING PREGABALIN
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
EP2053040A1 (en) * 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Pregabalin intermediates and process for preparing them and Pregabalin
WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
CA2710152A1 (en) * 2007-12-26 2009-07-02 Generics (Uk) Limited Processes to pregabalin
CN101910120B (zh) * 2008-01-10 2014-04-23 住友化学株式会社 用于制备环丙烷羧酸化合物的方法及用于此的中间体
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
SG176464A1 (en) 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
CA2724828C (en) 2008-05-21 2016-01-12 Sandoz Ag Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
KR20100107500A (ko) * 2008-06-23 2010-10-05 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ) 또는 (ｒ)-이소-부틸-글루타릭 에스테르의 입체선택적 효소 합성방법
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) * 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
CN102464594B (zh) * 2010-11-17 2014-06-25 凯瑞斯德生化(苏州)有限公司 普瑞巴林的中间体化合物的制备方法
US9422230B2 (en) 2013-05-09 2016-08-23 Council Of Scientific And Industrial Research Process for the preparation of an anticonvulsant agent pregabalin hydrochloride
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS588390B2 (ja) * 1978-05-23 1983-02-15 住友化学工業株式会社 光学活性ω↓−シアノ↓−α↓−アシルアミノ酸誘導体の製造法
US4939288A (en) * 1989-01-23 1990-07-03 Monsanto Company Method of preparing (R)-succinic acid derivatives
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5171892A (en) * 1991-07-02 1992-12-15 E. I. Du Pont De Nemours And Company Chiral phospholanes via chiral 1,4-diol cyclic sulfates
US5616793A (en) * 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5840965A (en) * 1996-06-24 1998-11-24 E. I. Du Pont De Nemours And Company Process for the production of purified telephthalic acid
BR9710536A (pt) * 1996-07-24 1999-08-17 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
ATE236869T1 (de) 1997-12-17 2003-04-15 Chirotech Technology Ltd Asymmetrische hydrierung
EP1070043B1 (en) 1998-04-09 2004-02-18 Chirotech Technology Limited Asymmetric hydrogenation
HU228815B1 (en) * 2000-01-27 2013-05-28 Warner Lambert Co Asymmetric synthesis of pregabalin

Also Published As

Publication number Publication date
GEP20043236B (en) 2004-05-25
AU777046B2 (en) 2004-09-30
BRPI0107863B8 (pt) 2017-04-25
CY2004011I1 (el) 2010-07-28
DK1250311T3 (da) 2004-08-16
JP2009073841A (ja) 2009-04-09
TNSN01016A1 (fr) 2005-11-10
IL150633A0 (en) 2003-02-12
MY127152A (en) 2006-11-30
HU228815B1 (en) 2013-05-28
SI1250311T1 (en) 2004-10-31
IL150633A (en) 2009-08-03
US6891059B2 (en) 2005-05-10
CA2396090C (en) 2006-01-10
NO20023582D0 (no) 2002-07-26
RS50257B (sr) 2009-07-15
JP4235384B2 (ja) 2009-03-11
EA200200642A1 (ru) 2002-12-26
EE200200403A (et) 2003-10-15
IS2038B (is) 2005-08-15
CN1396905A (zh) 2003-02-12
CR6703A (es) 2003-06-24
SV2002000295A (es) 2002-06-07
EP1250311B1 (en) 2004-03-17
WO2001055090A1 (en) 2001-08-02
UA75584C2 (uk) 2006-05-15
CZ302838B6 (cs) 2011-12-07
EE05216B1 (et) 2009-10-15
PL203985B1 (pl) 2009-11-30
HRP20020627A2 (en) 2004-08-31
BG65560B1 (bg) 2008-12-30
BR0107863B1 (pt) 2013-06-18
KR20020073187A (ko) 2002-09-19
AP1438A (en) 2005-05-23
MA26869A1 (fr) 2004-12-20
YU56202A (sh) 2006-01-16
HN2001000010A (es) 2001-06-13
BG106849A (en) 2003-03-31
MXPA02007307A (es) 2002-11-29
CZ20022520A3 (cs) 2002-10-16
ATE261930T1 (de) 2004-04-15
SK10782002A3 (sk) 2002-11-06
ME00921B (me) 2012-06-20
OA12167A (en) 2006-05-08
HUP0204307A3 (en) 2003-07-28
JP4886753B2 (ja) 2012-02-29
AP2002002588A0 (en) 2002-09-30
DE60102356T2 (de) 2005-02-17
CN1210253C (zh) 2005-07-13
EG24138A (en) 2008-08-06
EA004934B1 (ru) 2004-10-28
NO20023582L (no) 2002-09-02
JP2003520841A (ja) 2003-07-08
TWI288128B (en) 2007-10-11
NO327958B1 (no) 2009-10-26
DZ3268A1 (fr) 2001-08-02
HRP20020627B1 (en) 2011-01-31
PL357077A1 (en) 2004-07-12
HUP0204307A2 (hu) 2003-06-28
TR200400953T4 (tr) 2004-07-21
SK287303B6 (sk) 2010-06-07
KR100549748B1 (ko) 2006-02-08
PA8510501A1 (es) 2002-02-21
DE60102356D1 (de) 2004-04-22
CU23221A3 (es) 2007-07-20
PT1250311E (pt) 2004-07-30
PE20011063A1 (es) 2001-10-18
EP1250311A1 (en) 2002-10-23
IS6430A (is) 2002-06-19
NZ519551A (en) 2004-02-27
AU2213801A (en) 2001-08-07
CA2396090A1 (en) 2001-08-02
US20030212290A1 (en) 2003-11-13
ES2219493T3 (es) 2004-12-01
BR0107863A (pt) 2002-11-05
CO5251411A1 (es) 2003-02-28

Similar Documents

Publication Publication Date Title
AR028499A1 (es) Sintesis asimetrica de pregabalin
DK1696931T3 (da) Amino-substituerede diaryl[A,D]cyclohepten-analoger som muskarinske agonister og fremgangsmåder til behandling af neuropsykiatriske sygdomme
DK1694318T3 (da) (S)-2-N-propylamino-5-hydroxytetralin som D3-agonistisk terapeutikum
CY1105880T1 (el) Χρηση μιας φαρμακευτικης συνθεσεως πepιεχουσης γαλακτικο οξυ ή γαλακτικη ριζα και καλιο για την αγωγη του εγκεφαλικου οιδηματος ή του τραυματισμου του εγκεφαλου
HK1087628A1 (en) Prodrugs of gaba analogs, compositions and uses thereof gaba
BRPI0508051A (pt) derivados de heteroarilaminopirazol utilizáveis para o tratamento de diabetes
NO20062663L (no) Nukleinsyre som spesifikt binder bioaktivt ghrelin
NO20050122L (no) Prodrug av eksitasjonsaminosyrer
AR048690A1 (es) Bioconversion estereoselectiva de dinitrilos alifaticos en acidos cianocarboxilicos
DK1341749T3 (da) Fremgangsmåde til fremstilling af gabapentin
UY28375A1 (es) Agente terapéuticos
UY26560A1 (es) Síntesis asimétrica de pregabalin
NO20045089L (no) Substituerte aminoalkanfosfonsyrer for behandling av neuropatisk smerte, affektive og oppmerksomhetsforstyrrelser, schizofreni, tinnitus, myopi og andre okulaere lidelser
ATE413867T1 (de) Methode zur behandlung von bewegungsstörungen mit barbitursäure derivaten.
DE602006003204D1 (de) Reinigungsverfahren von Moxonidine
DK1455770T3 (da) Anvendelse af norepinephringenoptagelsesinhibitorer til behandling af tic lidelser
GT200100017A (es) Sintesis asimetrica de pregabalina.
EA200801894A1 (ru) НОВЫЕ ЭНАНТИОМЕРНОЧИСТЫЕ β-АГОНИСТЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ
MXPA04002492A (es) Uso novedoso de aminometil cromanos sustituidos.
AR039306A1 (es) Procedimiento para la obtencion de poliamidas
HUP0204460A2 (en) Method for increasing the gene expression of transfected genes
ATE338759T1 (de) 2-(aminomethyl)tetrahydro-9-oxa-1,3- diazacyclopentaca)naphthalinylderivate mit antipsychotischer wirkung
PT1406832E (pt) Processo para a preparacao de uma solucao aquosa de hidroxilamina isenta de sais
HN2002000132A (es) Resolución de sal quiral
CU23562A3 (es) Bioconversión estereoselectiva de dinitrilos alifáticos en ácidos cianocarboxílicos

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed, e.g., due to non-payment of fee