EE05216B1 - Pregabaliini asmmeetriline sntees - Google Patents

Pregabaliini asmmeetriline sntees

Info

Publication number
EE05216B1
EE05216B1 EEP200200403A EEP200200403A EE05216B1 EE 05216 B1 EE05216 B1 EE 05216B1 EE P200200403 A EEP200200403 A EE P200200403A EE P200200403 A EEP200200403 A EE P200200403A EE 05216 B1 EE05216 B1 EE 05216B1
Authority
EE
Estonia
Prior art keywords
pregabalin
asymmetric synthesis
asymmetric
synthesis
Prior art date
Application number
EEP200200403A
Other languages
English (en)
Estonian (et)
Inventor
Joseph Burk Mark
Prakash Goel Om
Simon Hoekstra Marvin
Frederick Mich Thomas
Arthur Mulhern Thomas
Andrew Ramsden James
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE05216(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of EE200200403A publication Critical patent/EE200200403A/xx
Publication of EE05216B1 publication Critical patent/EE05216B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EEP200200403A 2000-01-27 2001-01-11 Pregabaliini asmmeetriline sntees EE05216B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17835900P 2000-01-27 2000-01-27
US19042700P 2000-03-17 2000-03-17
PCT/IB2001/000024 WO2001055090A1 (en) 2000-01-27 2001-01-11 Asymmetric synthesis of pregabalin

Publications (2)

Publication Number Publication Date
EE200200403A EE200200403A (et) 2003-10-15
EE05216B1 true EE05216B1 (et) 2009-10-15

Family

ID=26874236

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200403A EE05216B1 (et) 2000-01-27 2001-01-11 Pregabaliini asmmeetriline sntees

Country Status (50)

Country Link
US (1) US6891059B2 (xx)
EP (1) EP1250311B1 (xx)
JP (2) JP4235384B2 (xx)
KR (1) KR100549748B1 (xx)
CN (1) CN1210253C (xx)
AP (1) AP1438A (xx)
AR (1) AR028499A1 (xx)
AT (1) ATE261930T1 (xx)
AU (1) AU777046B2 (xx)
BG (1) BG65560B1 (xx)
BR (1) BRPI0107863B8 (xx)
CA (1) CA2396090C (xx)
CO (1) CO5251411A1 (xx)
CR (1) CR6703A (xx)
CU (1) CU23221A3 (xx)
CY (1) CY2004011I1 (xx)
CZ (1) CZ302838B6 (xx)
DE (1) DE60102356T2 (xx)
DK (1) DK1250311T3 (xx)
DZ (1) DZ3268A1 (xx)
EA (1) EA004934B1 (xx)
EE (1) EE05216B1 (xx)
EG (1) EG24138A (xx)
ES (1) ES2219493T3 (xx)
GE (1) GEP20043236B (xx)
HN (1) HN2001000010A (xx)
HR (1) HRP20020627B1 (xx)
HU (1) HU228815B1 (xx)
IL (2) IL150633A0 (xx)
IS (1) IS2038B (xx)
MA (1) MA26869A1 (xx)
ME (1) ME00921B (xx)
MX (1) MXPA02007307A (xx)
MY (1) MY127152A (xx)
NO (1) NO327958B1 (xx)
NZ (1) NZ519551A (xx)
OA (1) OA12167A (xx)
PA (1) PA8510501A1 (xx)
PE (1) PE20011063A1 (xx)
PL (1) PL203985B1 (xx)
PT (1) PT1250311E (xx)
RS (1) RS50257B (xx)
SI (1) SI1250311T1 (xx)
SK (1) SK287303B6 (xx)
SV (1) SV2002000295A (xx)
TN (1) TNSN01016A1 (xx)
TR (1) TR200400953T4 (xx)
TW (1) TWI288128B (xx)
UA (1) UA75584C2 (xx)
WO (1) WO2001055090A1 (xx)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
BRPI0107863B8 (pt) * 2000-01-27 2017-04-25 Warner-Lambert Company método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
PT1727620E (pt) * 2004-03-12 2007-11-05 Warner Lambert Co Ligandos de biofosfina c1-simétricos e a sua utilização na síntese assimétrica da pregabalina
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
AU2005256945B2 (en) * 2004-06-21 2008-11-13 Upjohn Us 1 Llc Preparation of pregabalin and related compounds
CN101160281A (zh) * 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
US7488846B2 (en) 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
WO2006110783A2 (en) * 2005-04-11 2006-10-19 Teva Pharmaceutical Industries Ltd. Process for making (s)-pregabalin
ATE486841T1 (de) * 2005-05-10 2010-11-15 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
CA2604624A1 (en) 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
JP2008505980A (ja) 2005-05-10 2008-02-28 テバ ファーマシューティカル インダストリーズ リミティド イソブチルグルタル酸を有さないプレガバリン及びその調製方法
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
EP1841726B1 (en) 2005-09-19 2012-10-31 Teva Pharmaceutical Industries Ltd An asymmetric synthesis of (s)-(+)-3-(aminomethyl)-5-methylhexanoic acid
NL2000281C2 (nl) 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
WO2007127309A2 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 3-isobutylglutaric acid
TW200815323A (en) * 2006-05-24 2008-04-01 Teva Pharma Processes for the preparation of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof
BRPI0702897A2 (pt) * 2006-05-31 2011-03-15 Teva Pharmaceutical Ind Ltda processo para preparar um intermediário de pregabalina
WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
EP1903027A1 (en) * 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
BRPI0803092A2 (pt) 2007-03-22 2011-08-30 Teva Pharma sìntese de (s)-(+)-3-(aminometil)-5-metil ácido hexanóico, (s)-pregabalina
WO2009001372A2 (en) * 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
US20090137842A1 (en) * 2007-10-03 2009-05-28 Vollerner Yuri Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
EP2053040A1 (en) * 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Pregabalin intermediates and process for preparing them and Pregabalin
WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
JP2011507941A (ja) * 2007-12-26 2011-03-10 ジェネリクス・（ユーケー）・リミテッド プレガバリンの製造方法
CN101910120B (zh) * 2008-01-10 2014-04-23 住友化学株式会社 用于制备环丙烷羧酸化合物的方法及用于此的中间体
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
WO2009141362A2 (en) 2008-05-21 2009-11-26 Sandoz Ag Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) * 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
CN102464594B (zh) * 2010-11-17 2014-06-25 凯瑞斯德生化(苏州)有限公司 普瑞巴林的中间体化合物的制备方法
US9422230B2 (en) 2013-05-09 2016-08-23 Council Of Scientific And Industrial Research Process for the preparation of an anticonvulsant agent pregabalin hydrochloride
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
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JPS588390B2 (ja) * 1978-05-23 1983-02-15 住友化学工業株式会社 光学活性ω↓−シアノ↓−α↓−アシルアミノ酸誘導体の製造法
US4939288A (en) * 1989-01-23 1990-07-03 Monsanto Company Method of preparing (R)-succinic acid derivatives
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5171892A (en) * 1991-07-02 1992-12-15 E. I. Du Pont De Nemours And Company Chiral phospholanes via chiral 1,4-diol cyclic sulfates
US5616793A (en) * 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) * 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5840965A (en) * 1996-06-24 1998-11-24 E. I. Du Pont De Nemours And Company Process for the production of purified telephthalic acid
KR100491282B1 (ko) * 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
WO1999031041A1 (en) 1997-12-17 1999-06-24 Chirotech Technology Limited Asymmetric hydrogenation
WO1999052852A1 (en) 1998-04-09 1999-10-21 Chirotech Technology Limited Asymmetric hydrogenation
BRPI0107863B8 (pt) * 2000-01-27 2017-04-25 Warner-Lambert Company método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina

Also Published As

Publication number Publication date
PL357077A1 (en) 2004-07-12
BRPI0107863B8 (pt) 2017-04-25
EP1250311B1 (en) 2004-03-17
RS50257B (sr) 2009-07-15
AP2002002588A0 (en) 2002-09-30
PL203985B1 (pl) 2009-11-30
TWI288128B (en) 2007-10-11
UA75584C2 (uk) 2006-05-15
HRP20020627A2 (en) 2004-08-31
KR20020073187A (ko) 2002-09-19
EA200200642A1 (ru) 2002-12-26
CA2396090C (en) 2006-01-10
CY2004011I1 (el) 2010-07-28
CZ302838B6 (cs) 2011-12-07
AP1438A (en) 2005-05-23
DZ3268A1 (fr) 2001-08-02
CZ20022520A3 (cs) 2002-10-16
MXPA02007307A (es) 2002-11-29
TR200400953T4 (tr) 2004-07-21
BR0107863A (pt) 2002-11-05
NO327958B1 (no) 2009-10-26
ES2219493T3 (es) 2004-12-01
OA12167A (en) 2006-05-08
HUP0204307A3 (en) 2003-07-28
PA8510501A1 (es) 2002-02-21
AU2213801A (en) 2001-08-07
JP2003520841A (ja) 2003-07-08
CA2396090A1 (en) 2001-08-02
EE200200403A (et) 2003-10-15
IS2038B (is) 2005-08-15
WO2001055090A1 (en) 2001-08-02
SI1250311T1 (en) 2004-10-31
IS6430A (is) 2002-06-19
EG24138A (en) 2008-08-06
BG65560B1 (bg) 2008-12-30
US20030212290A1 (en) 2003-11-13
DK1250311T3 (da) 2004-08-16
CN1210253C (zh) 2005-07-13
ATE261930T1 (de) 2004-04-15
SV2002000295A (es) 2002-06-07
AR028499A1 (es) 2003-05-14
KR100549748B1 (ko) 2006-02-08
BR0107863B1 (pt) 2013-06-18
IL150633A (en) 2009-08-03
EA004934B1 (ru) 2004-10-28
DE60102356T2 (de) 2005-02-17
DE60102356D1 (de) 2004-04-22
JP4886753B2 (ja) 2012-02-29
CN1396905A (zh) 2003-02-12
CR6703A (es) 2003-06-24
JP2009073841A (ja) 2009-04-09
IL150633A0 (en) 2003-02-12
SK287303B6 (sk) 2010-06-07
JP4235384B2 (ja) 2009-03-11
US6891059B2 (en) 2005-05-10
GEP20043236B (en) 2004-05-25
MA26869A1 (fr) 2004-12-20
YU56202A (sh) 2006-01-16
CU23221A3 (es) 2007-07-20
TNSN01016A1 (fr) 2005-11-10
SK10782002A3 (sk) 2002-11-06
NO20023582L (no) 2002-09-02
CO5251411A1 (es) 2003-02-28
NO20023582D0 (no) 2002-07-26
BG106849A (en) 2003-03-31
PE20011063A1 (es) 2001-10-18
HRP20020627B1 (en) 2011-01-31
EP1250311A1 (en) 2002-10-23
NZ519551A (en) 2004-02-27
PT1250311E (pt) 2004-07-30
HU228815B1 (en) 2013-05-28
AU777046B2 (en) 2004-09-30
MY127152A (en) 2006-11-30
HUP0204307A2 (hu) 2003-06-28
ME00921B (me) 2012-06-20
HN2001000010A (es) 2001-06-13

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Legal Events

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Effective date: 20101231

HC1A Change of owner name
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Effective date: 20180111