MA26869A1 - Synthese asymetrique de pregabaline - Google Patents

Synthese asymetrique de pregabaline

Info

Publication number
MA26869A1
MA26869A1 MA26738A MA26738A MA26869A1 MA 26869 A1 MA26869 A1 MA 26869A1 MA 26738 A MA26738 A MA 26738A MA 26738 A MA26738 A MA 26738A MA 26869 A1 MA26869 A1 MA 26869A1
Authority
MA
Morocco
Prior art keywords
pregabalin
pregabaline
asymmetric synthesis
synthesis
asymmetric
Prior art date
Application number
MA26738A
Other languages
English (en)
Inventor
Joseph Burk Mark
Simon Hoekstra Marvin
Arthur Mulhern Thomas
Andrew Ramsden James
Prakash Goel Om
Frederick Mich Thomas
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA26869(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of MA26869A1 publication Critical patent/MA26869A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

DEPOSANT Société dite : WARNER-LAMBERT COMPANY REVENDICATION DE PRIORITES US 25 Janvier 2000 60/178,261 ?Synthèse asymétrique de prégabaline" L'invention propose un procédé pour la préparation d'acide (S)-(+)-3-(aminomethyl)-5-méthylhexanoïque (prégabaline) ou d'un de ses sels par une synthèse par hydrogénation asymétrique. La prégabaline est utile pour le traitement et la prévention d'attaques cérébrales, de la douleur et de troubles psychotiques. La présente invention propose également des intermédiaires utiles dans la production de la prégabaline.
MA26738A 2000-01-27 2002-07-23 Synthese asymetrique de pregabaline MA26869A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17835900P 2000-01-27 2000-01-27
US19042700P 2000-03-17 2000-03-17

Publications (1)

Publication Number Publication Date
MA26869A1 true MA26869A1 (fr) 2004-12-20

Family

ID=26874236

Family Applications (1)

Application Number Title Priority Date Filing Date
MA26738A MA26869A1 (fr) 2000-01-27 2002-07-23 Synthese asymetrique de pregabaline

Country Status (50)

Country Link
US (1) US6891059B2 (fr)
EP (1) EP1250311B1 (fr)
JP (2) JP4235384B2 (fr)
KR (1) KR100549748B1 (fr)
CN (1) CN1210253C (fr)
AP (1) AP1438A (fr)
AR (1) AR028499A1 (fr)
AT (1) ATE261930T1 (fr)
AU (1) AU777046B2 (fr)
BG (1) BG65560B1 (fr)
BR (1) BRPI0107863B8 (fr)
CA (1) CA2396090C (fr)
CO (1) CO5251411A1 (fr)
CR (1) CR6703A (fr)
CU (1) CU23221A3 (fr)
CY (1) CY2004011I1 (fr)
CZ (1) CZ302838B6 (fr)
DE (1) DE60102356T2 (fr)
DK (1) DK1250311T3 (fr)
DZ (1) DZ3268A1 (fr)
EA (1) EA004934B1 (fr)
EE (1) EE05216B1 (fr)
EG (1) EG24138A (fr)
ES (1) ES2219493T3 (fr)
GE (1) GEP20043236B (fr)
HN (1) HN2001000010A (fr)
HR (1) HRP20020627B1 (fr)
HU (1) HU228815B1 (fr)
IL (2) IL150633A0 (fr)
IS (1) IS2038B (fr)
MA (1) MA26869A1 (fr)
ME (1) ME00921B (fr)
MX (1) MXPA02007307A (fr)
MY (1) MY127152A (fr)
NO (1) NO327958B1 (fr)
NZ (1) NZ519551A (fr)
OA (1) OA12167A (fr)
PA (1) PA8510501A1 (fr)
PE (1) PE20011063A1 (fr)
PL (1) PL203985B1 (fr)
PT (1) PT1250311E (fr)
RS (1) RS50257B (fr)
SI (1) SI1250311T1 (fr)
SK (1) SK287303B6 (fr)
SV (1) SV2002000295A (fr)
TN (1) TNSN01016A1 (fr)
TR (1) TR200400953T4 (fr)
TW (1) TWI288128B (fr)
UA (1) UA75584C2 (fr)
WO (1) WO2001055090A1 (fr)

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BR9710536A (pt) 1996-07-24 1999-08-17 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
HU228815B1 (en) * 2000-01-27 2013-05-28 Warner Lambert Co Asymmetric synthesis of pregabalin
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
EP1543831A1 (fr) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Composition de pregabaline
ES2292107T3 (es) * 2004-03-12 2008-03-01 Warner-Lambert Company Llc Ligandos de bifosfina simetricos en c1 y su uso en la sintesis asimetrica de pregabalina.
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
DK1831154T3 (da) * 2004-06-21 2010-04-12 Warner Lambert Co Fremstilling af pregabalin og relaterede forbindelser
CN101160281A (zh) * 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
CN101300224A (zh) * 2005-04-11 2008-11-05 特瓦制药工业有限公司 制备(s)-普瑞巴林的方法
US7488846B2 (en) 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
DE602006017995D1 (de) 2005-05-10 2010-12-16 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
MX2007000525A (es) 2005-05-10 2007-03-28 Teva Pharma Pregabalina libre de acido isobutilglutarico y un proceso para la preparacion de ella.
EP1879854B1 (fr) 2005-05-10 2011-09-07 Teva Pharmaceutical Industries Ltd Resolution optique de l'acide 3-carbamoylmethyl-5-methyl hexanoique
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
WO2007035890A1 (fr) 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. Synthese asymetrique de l'acide (s)-(+)-3-(aminomethyl)-5-methylhexanoique
NL2000281C2 (nl) 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
US20070259917A1 (en) * 2006-04-24 2007-11-08 Kansal Vinod K Processes for the synthesis of 3-isobutylglutaric acid
US7462738B2 (en) 2006-05-24 2008-12-09 Teva Pharmaceutical Industries Ltd. Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
EP2071032A3 (fr) * 2006-05-31 2009-07-08 Teva Pharmaceutical Industries Ltd Utilisation d'une résolution enzymatique pour la préparation d'intermédiaires de la prégabaline
WO2007143152A2 (fr) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Préparation de (s)-prégabaline nitrile
EP1903027A1 (fr) * 2006-09-13 2008-03-26 Novartis AG Procédé de préparation de l' acide amino-4 butyrique ou de ses derivés et leur utilisation pour la préparation des inhibiteurs NEP
MX2008014759A (es) 2007-03-22 2009-03-09 Teva Pharma Sintesis del acido (s)-(+)-3-(aminometil)-5-metil hexanoico.
EP2170813A4 (fr) * 2007-06-25 2012-05-16 Reddy Manne Satyanarayana Nouveau procédé pour la préparation de la prégabaline
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
EP2053040A1 (fr) * 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Intermédiaires de la Prégabaline et leurs procédés de préparation et Prégabaline
WO2009087674A2 (fr) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Procédé perfectionné pour la préparation de (s)-prégabaline
CA2710152A1 (fr) * 2007-12-26 2009-07-02 Generics (Uk) Limited Procedes de preparation de la pregabaline
CN101910120B (zh) * 2008-01-10 2014-04-23 住友化学株式会社 用于制备环丙烷羧酸化合物的方法及用于此的中间体
EP2110372A1 (fr) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermédiaires pour la préparation de prégabaline et leur procédé de préparation
SG176464A1 (en) 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
CA2724828C (fr) 2008-05-21 2016-01-12 Sandoz Ag Procede pour l'hydrolyse enzymatique stereoselective d'un ester d'acide 5-methyl-3-nitromethyl-hexanoique
KR20100107500A (ko) * 2008-06-23 2010-10-05 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ) 또는 (ｒ)-이소-부틸-글루타릭 에스테르의 입체선택적 효소 합성방법
WO2010070593A2 (fr) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Esters de malonate
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (fr) 2010-05-14 2011-11-17 Lupin Limited Synthèse améliorée d'un ester alkylique optiquement pur de l'acide (s) - 3-cyano-5-méthyl-hexanoïque, intermédiaire de la (s)-prégabaline
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (fr) * 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Procédé de préparation de dérivés d'acide (s)-3-cyano-5-méthylhexanoïque et de prégabaline
CN102464594B (zh) * 2010-11-17 2014-06-25 凯瑞斯德生化(苏州)有限公司 普瑞巴林的中间体化合物的制备方法
US9422230B2 (en) 2013-05-09 2016-08-23 Council Of Scientific And Industrial Research Process for the preparation of an anticonvulsant agent pregabalin hydrochloride
WO2016075082A1 (fr) 2014-11-10 2016-05-19 Sandoz Ag Amination réductrice stéréosélective d'aldéhydes alpha-chiraux au moyen d'ω-transaminases pour la synthèse de précurseurs de la prégabaline et du brivaracétam
WO2017019791A1 (fr) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthèse de (s)-prégabaline

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Also Published As

Publication number Publication date
GEP20043236B (en) 2004-05-25
AU777046B2 (en) 2004-09-30
BRPI0107863B8 (pt) 2017-04-25
CY2004011I1 (el) 2010-07-28
DK1250311T3 (da) 2004-08-16
JP2009073841A (ja) 2009-04-09
TNSN01016A1 (fr) 2005-11-10
AR028499A1 (es) 2003-05-14
IL150633A0 (en) 2003-02-12
MY127152A (en) 2006-11-30
HU228815B1 (en) 2013-05-28
SI1250311T1 (en) 2004-10-31
IL150633A (en) 2009-08-03
US6891059B2 (en) 2005-05-10
CA2396090C (fr) 2006-01-10
NO20023582D0 (no) 2002-07-26
RS50257B (sr) 2009-07-15
JP4235384B2 (ja) 2009-03-11
EA200200642A1 (ru) 2002-12-26
EE200200403A (et) 2003-10-15
IS2038B (is) 2005-08-15
CN1396905A (zh) 2003-02-12
CR6703A (es) 2003-06-24
SV2002000295A (es) 2002-06-07
EP1250311B1 (fr) 2004-03-17
WO2001055090A1 (fr) 2001-08-02
UA75584C2 (uk) 2006-05-15
CZ302838B6 (cs) 2011-12-07
EE05216B1 (et) 2009-10-15
PL203985B1 (pl) 2009-11-30
HRP20020627A2 (en) 2004-08-31
BG65560B1 (bg) 2008-12-30
BR0107863B1 (pt) 2013-06-18
KR20020073187A (ko) 2002-09-19
AP1438A (en) 2005-05-23
YU56202A (sh) 2006-01-16
HN2001000010A (es) 2001-06-13
BG106849A (en) 2003-03-31
MXPA02007307A (es) 2002-11-29
CZ20022520A3 (cs) 2002-10-16
ATE261930T1 (de) 2004-04-15
SK10782002A3 (sk) 2002-11-06
ME00921B (me) 2012-06-20
OA12167A (en) 2006-05-08
HUP0204307A3 (en) 2003-07-28
JP4886753B2 (ja) 2012-02-29
AP2002002588A0 (en) 2002-09-30
DE60102356T2 (de) 2005-02-17
CN1210253C (zh) 2005-07-13
EG24138A (en) 2008-08-06
EA004934B1 (ru) 2004-10-28
NO20023582L (no) 2002-09-02
JP2003520841A (ja) 2003-07-08
TWI288128B (en) 2007-10-11
NO327958B1 (no) 2009-10-26
DZ3268A1 (fr) 2001-08-02
HRP20020627B1 (en) 2011-01-31
PL357077A1 (en) 2004-07-12
HUP0204307A2 (hu) 2003-06-28
TR200400953T4 (tr) 2004-07-21
SK287303B6 (sk) 2010-06-07
KR100549748B1 (ko) 2006-02-08
PA8510501A1 (es) 2002-02-21
DE60102356D1 (de) 2004-04-22
CU23221A3 (es) 2007-07-20
PT1250311E (pt) 2004-07-30
PE20011063A1 (es) 2001-10-18
EP1250311A1 (fr) 2002-10-23
IS6430A (is) 2002-06-19
NZ519551A (en) 2004-02-27
AU2213801A (en) 2001-08-07
CA2396090A1 (fr) 2001-08-02
US20030212290A1 (en) 2003-11-13
ES2219493T3 (es) 2004-12-01
BR0107863A (pt) 2002-11-05
CO5251411A1 (es) 2003-02-28

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