BRPI0107863B8 - método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina - Google Patents

método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina

Info

Publication number
BRPI0107863B8
BRPI0107863B8 BRPI0107863A BR0107863A BRPI0107863B8 BR PI0107863 B8 BRPI0107863 B8 BR PI0107863B8 BR PI0107863 A BRPI0107863 A BR PI0107863A BR 0107863 A BR0107863 A BR 0107863A BR PI0107863 B8 BRPI0107863 B8 BR PI0107863B8
Authority
BR
Brazil
Prior art keywords
preparing
pregabalin
cyano
methylhexanoic acid
preparation
Prior art date
Application number
BRPI0107863A
Other languages
English (en)
Other versions
BR0107863A (pt
BR0107863B1 (pt
Inventor
Andrew Ramsden James
Joseph Burk Mark
Simon Hoekstra Marvin
Prakash Goel Om
Arthur Mulhern Thomas
Frederick Mich Thomas
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0107863(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of BR0107863A publication Critical patent/BR0107863A/pt
Publication of BR0107863B1 publication Critical patent/BR0107863B1/pt
Publication of BRPI0107863B8 publication Critical patent/BRPI0107863B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton

Abstract

"síntese assimétrica da pregabalina". esta invenção proporciona um método de preparação do ácido (s)-(+)-3-(aminometil)-5-metilhexanôico (pregabalina) ou de um seu sal, através de uma síntese por hidrogenação assimétrica. a pregabalina é útil no tratamento e prevenção de distúrbios convulsivos, dores, e distúrbios psicóticos. a invenção também proporciona intermediários úteis na produção de pregabalina.
BRPI0107863A 2000-01-27 2001-01-11 método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina BRPI0107863B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17835900P 2000-01-27 2000-01-27
US19042700P 2000-03-17 2000-03-17
PCT/IB2001/000024 WO2001055090A1 (en) 2000-01-27 2001-01-11 Asymmetric synthesis of pregabalin

Publications (3)

Publication Number Publication Date
BR0107863A BR0107863A (pt) 2002-11-05
BR0107863B1 BR0107863B1 (pt) 2013-06-18
BRPI0107863B8 true BRPI0107863B8 (pt) 2017-04-25

Family

ID=26874236

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0107863A BRPI0107863B8 (pt) 2000-01-27 2001-01-11 método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina

Country Status (50)

Country Link
US (1) US6891059B2 (pt)
EP (1) EP1250311B1 (pt)
JP (2) JP4235384B2 (pt)
KR (1) KR100549748B1 (pt)
CN (1) CN1210253C (pt)
AP (1) AP1438A (pt)
AR (1) AR028499A1 (pt)
AT (1) ATE261930T1 (pt)
AU (1) AU777046B2 (pt)
BG (1) BG65560B1 (pt)
BR (1) BRPI0107863B8 (pt)
CA (1) CA2396090C (pt)
CO (1) CO5251411A1 (pt)
CR (1) CR6703A (pt)
CU (1) CU23221A3 (pt)
CY (1) CY2004011I1 (pt)
CZ (1) CZ302838B6 (pt)
DE (1) DE60102356T2 (pt)
DK (1) DK1250311T3 (pt)
DZ (1) DZ3268A1 (pt)
EA (1) EA004934B1 (pt)
EE (1) EE05216B1 (pt)
EG (1) EG24138A (pt)
ES (1) ES2219493T3 (pt)
GE (1) GEP20043236B (pt)
HN (1) HN2001000010A (pt)
HR (1) HRP20020627B1 (pt)
HU (1) HU228815B1 (pt)
IL (2) IL150633A0 (pt)
IS (1) IS2038B (pt)
MA (1) MA26869A1 (pt)
ME (1) ME00921B (pt)
MX (1) MXPA02007307A (pt)
MY (1) MY127152A (pt)
NO (1) NO327958B1 (pt)
NZ (1) NZ519551A (pt)
OA (1) OA12167A (pt)
PA (1) PA8510501A1 (pt)
PE (1) PE20011063A1 (pt)
PL (1) PL203985B1 (pt)
PT (1) PT1250311E (pt)
RS (1) RS50257B (pt)
SI (1) SI1250311T1 (pt)
SK (1) SK287303B6 (pt)
SV (1) SV2002000295A (pt)
TN (1) TNSN01016A1 (pt)
TR (1) TR200400953T4 (pt)
TW (1) TWI288128B (pt)
UA (1) UA75584C2 (pt)
WO (1) WO2001055090A1 (pt)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3693258B2 (ja) 1996-07-24 2005-09-07 ワーナー―ランバート・コンパニー イソブチルｇａｂａまたはその誘導体を含有する鎮静剤
CZ302838B6 (cs) * 2000-01-27 2011-12-07 Warner-Lambert Company Zpusob a meziprodukty pro prípravu derivátu (S)-kyano-5-methylhexanové kyseliny
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
AU2005221401A1 (en) * 2004-03-12 2005-09-22 Warner-Lambert Company Llc C1-symmetric bisphosphine ligands and their use in the asymmetric synthesis of pregabalin
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
KR100847928B1 (ko) * 2004-06-21 2008-07-22 워너-램버트 캄파니 엘엘씨 프레가발린 및 관련 화합물의 제조방법
WO2006108151A1 (en) * 2005-04-06 2006-10-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
MX2007012606A (es) * 2005-04-11 2008-01-11 Teva Pharma Proceso para elaborar (s)-pregabalina.
US7488846B2 (en) 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
EP1879851B1 (en) 2005-05-10 2010-11-03 Teva Pharmaceutical Industries Ltd Method for the preparation of pregabalin and salts thereof
WO2006122255A1 (en) 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of isobutylglutaric acid and a process for preparation thereof
EP1879854B1 (en) 2005-05-10 2011-09-07 Teva Pharmaceutical Industries Ltd Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
KR20080034205A (ko) * 2005-09-19 2008-04-18 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-프레가발린의 신규한 합성을 위한 주요 중간체인 키랄3-카르바모일메틸-5-메틸 헥산산
NL2000281C2 (nl) * 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
EP1904486A2 (en) * 2006-04-24 2008-04-02 Teva Pharmaceutical Industries Ltd Processes for the synthesis of 3-isobutylglutaric acid
KR20080027880A (ko) * 2006-05-24 2008-03-28 테바 파마슈티컬 인더스트리즈 리미티드 Ｒ-(+)-3-(카바모일메틸)-5-메틸헥산산 및 이의 염의 제조방법
BRPI0702897A2 (pt) * 2006-05-31 2011-03-15 Teva Pharmaceutical Ind Ltda processo para preparar um intermediário de pregabalina
US20080015385A1 (en) * 2006-05-31 2008-01-17 Lilach Hedvati Preparation of (S)-pregabalin-nitrile
EP1903027A1 (en) 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
KR101036536B1 (ko) * 2007-03-22 2011-05-24 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-(+)-3-(아미노메틸)-5-메틸 헥산산의 합성
EP2170813A4 (en) * 2007-06-25 2012-05-16 Reddy Manne Satyanarayana NEW METHOD OF PREPARING PREGABALIN
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
WO2009046309A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
EP2053040A1 (en) * 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Pregabalin intermediates and process for preparing them and Pregabalin
US20100312010A1 (en) * 2007-12-18 2010-12-09 Watson Pharma Private Limited Process for the Preparation of (S)-Pregabalin
CN101965328A (zh) * 2007-12-26 2011-02-02 基因里克斯(英国)有限公司 普瑞巴林的制备方法
WO2009087941A1 (ja) * 2008-01-10 2009-07-16 Sumitomo Chemical Company, Limited シクロプロパンカルボン酸化合物の製造方法およびその中間体
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
AU2009248750B2 (en) 2008-05-21 2015-05-21 Sandoz Ag Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) * 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
CN102464594B (zh) * 2010-11-17 2014-06-25 凯瑞斯德生化(苏州)有限公司 普瑞巴林的中间体化合物的制备方法
WO2014181359A1 (en) 2013-05-09 2014-11-13 Council Of Scientific & Industrial Research A process for the preparation of an anticonvulsant agent pregabalin hydrochloride
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS588390B2 (ja) * 1978-05-23 1983-02-15 住友化学工業株式会社 光学活性ω↓−シアノ↓−α↓−アシルアミノ酸誘導体の製造法
US4939288A (en) * 1989-01-23 1990-07-03 Monsanto Company Method of preparing (R)-succinic acid derivatives
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5171892A (en) * 1991-07-02 1992-12-15 E. I. Du Pont De Nemours And Company Chiral phospholanes via chiral 1,4-diol cyclic sulfates
US5616793A (en) * 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) * 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5840965A (en) * 1996-06-24 1998-11-24 E. I. Du Pont De Nemours And Company Process for the production of purified telephthalic acid
JP3693258B2 (ja) * 1996-07-24 2005-09-07 ワーナー―ランバート・コンパニー イソブチルｇａｂａまたはその誘導体を含有する鎮静剤
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
JP2002508345A (ja) 1997-12-17 2002-03-19 カイロテック・テクノロジー・リミテッド 不斉水素化
WO1999052852A1 (en) 1998-04-09 1999-10-21 Chirotech Technology Limited Asymmetric hydrogenation
CZ302838B6 (cs) * 2000-01-27 2011-12-07 Warner-Lambert Company Zpusob a meziprodukty pro prípravu derivátu (S)-kyano-5-methylhexanové kyseliny

Also Published As

Publication number Publication date
AU2213801A (en) 2001-08-07
CO5251411A1 (es) 2003-02-28
CZ20022520A3 (cs) 2002-10-16
JP4886753B2 (ja) 2012-02-29
BR0107863A (pt) 2002-11-05
SV2002000295A (es) 2002-06-07
DE60102356D1 (de) 2004-04-22
CA2396090A1 (en) 2001-08-02
US20030212290A1 (en) 2003-11-13
KR20020073187A (ko) 2002-09-19
MXPA02007307A (es) 2002-11-29
HRP20020627A2 (en) 2004-08-31
DZ3268A1 (fr) 2001-08-02
US6891059B2 (en) 2005-05-10
WO2001055090A1 (en) 2001-08-02
CZ302838B6 (cs) 2011-12-07
PL357077A1 (en) 2004-07-12
UA75584C2 (uk) 2006-05-15
TNSN01016A1 (fr) 2005-11-10
AP1438A (en) 2005-05-23
SK287303B6 (sk) 2010-06-07
NO20023582D0 (no) 2002-07-26
YU56202A (sh) 2006-01-16
NO327958B1 (no) 2009-10-26
ATE261930T1 (de) 2004-04-15
HU228815B1 (en) 2013-05-28
SK10782002A3 (sk) 2002-11-06
HRP20020627B1 (en) 2011-01-31
HUP0204307A3 (en) 2003-07-28
EE05216B1 (et) 2009-10-15
CN1210253C (zh) 2005-07-13
KR100549748B1 (ko) 2006-02-08
PA8510501A1 (es) 2002-02-21
ME00921B (me) 2012-06-20
AR028499A1 (es) 2003-05-14
HN2001000010A (es) 2001-06-13
BR0107863B1 (pt) 2013-06-18
RS50257B (sr) 2009-07-15
PE20011063A1 (es) 2001-10-18
DE60102356T2 (de) 2005-02-17
IS2038B (is) 2005-08-15
NO20023582L (no) 2002-09-02
CU23221A3 (es) 2007-07-20
BG65560B1 (bg) 2008-12-30
NZ519551A (en) 2004-02-27
PT1250311E (pt) 2004-07-30
EE200200403A (et) 2003-10-15
CY2004011I1 (el) 2010-07-28
SI1250311T1 (en) 2004-10-31
AU777046B2 (en) 2004-09-30
GEP20043236B (en) 2004-05-25
EP1250311B1 (en) 2004-03-17
EG24138A (en) 2008-08-06
ES2219493T3 (es) 2004-12-01
IL150633A0 (en) 2003-02-12
EA004934B1 (ru) 2004-10-28
EP1250311A1 (en) 2002-10-23
MA26869A1 (fr) 2004-12-20
AP2002002588A0 (en) 2002-09-30
HUP0204307A2 (hu) 2003-06-28
EA200200642A1 (ru) 2002-12-26
DK1250311T3 (da) 2004-08-16
CA2396090C (en) 2006-01-10
TR200400953T4 (tr) 2004-07-21
BG106849A (en) 2003-03-31
JP2009073841A (ja) 2009-04-09
TWI288128B (en) 2007-10-11
IS6430A (is) 2002-06-19
PL203985B1 (pl) 2009-11-30
CR6703A (es) 2003-06-24
JP2003520841A (ja) 2003-07-08
IL150633A (en) 2009-08-03
OA12167A (en) 2006-05-08
JP4235384B2 (ja) 2009-03-11
CN1396905A (zh) 2003-02-12
MY127152A (en) 2006-11-30

Similar Documents

Publication Publication Date Title
BRPI0107863B8 (pt) método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina
EP1400526A3 (en) ((cyclo)alkyl substituted)- gamma -aminobutyric acid derivatives (=Gaba analogues), their preparation and their use in the treatment of neurological disorders
BR0214705A (pt) Composição, seu uso, método para prevenção ou tratamento de doença neurodegenerativa, e kit
BR9910697A (pt) Compostos aminoácidos comprimidos estruturalmente tendo afinidade à subunidade alfa2delta de um canal de cálcio
HK1075259A1 (en) Prodrugs of excitatory amino acids
EA200200183A1 (ru) Композиция, содержащая трамадол и противосудорожное лекарственное средство
HK1087628A1 (en) Prodrugs of gaba analogs, compositions and uses thereof gaba
BRPI9917739B8 (pt) composto intermediário na preparação de inibidores de cox-2
WO2003027068A3 (en) Substituted amines for the treatment of neurological disorders
BR0308814A (pt) Aminoácidos com afinidade para a proteìna-alfa2gama
BRPI0408863A (pt) composto, composição farmacêutica, método para tratar doenças, e, uso de um composto.
BR0306855A (pt) Método para o tratamento de distúrbios cognitivos
BR9607443A (pt) Composto de 4-aminotetraidrobenzisoxazol ou-isatiazol composição farmacêutica e utilização do composto
BR0110549A (pt) Processo para a preparação de sais de metais alcalino-terrosos do ácido d-pantotênico
BR0116770A (pt) Composto, formulação farmacêutica, processo para preparar o composto, e, uso de um composto
BR0316392A (pt) Processo para preparar ácido indan-1,3-dicarboxìlico
NO990159L (no) FremgangsmÕte for fremstilling av enantiomerisk anrikede N-acylazetidin-2-karboksylsyrer
DE60220800D1 (de) Chirales dinapsolin
UY26560A1 (es) Síntesis asimétrica de pregabalin
WO2003006489A3 (en) Prodrugs of excitatory amino acids
BR0116724A (pt) Composto, método de tratamento de um distúrbio neurológico ou de uma doença neurodegenerativa, método de tratamento de dor, composição farmacêutica, uso de um composto, e, processos para a preparação e para a sìntese de um composto
BR0012866A (pt) Processo para a prepação de isotretinoìna
BR0314525A (pt) Composições e métodos para tratamento de disfunção sexual
PA8601101A1 (es) 2-hidroxi-3-diaminoalcanos de benzamida
BR9712844A (pt) Processo para a sìntese de benzotiofenos

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 227/04, C07C 253/30, C07C 255/23, A61K 31/197, A61P 25/08

Ipc: C07C 227/10 (2011.01), C07C 253/30 (2011.01), C07C

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07C Technical examination (opinion): republication [chapter 7.3 patent gazette]

Free format text: REPUBLICACAO DA COMUNICACAO DE ANUENCIA (7.5) PUBLICADA NA RPI NO 2187 DE 04-12-2012 PARA CORRECAO DA JUNTADA AO PEDIDO DOS DOCUMENTOS ENCAMINHADOS PELA ANVISA.

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 18/06/2013, OBSERVADAS AS CONDICOES LEGAIS.

B17A Notification of administrative nullity (patentee has 60 days time to reply to this notification)

Free format text: REQUERENTE DA NULIDADE: ZODIAC PRODUTOS FARMACEUTICOS S.A.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 18A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2497 DE 13-11-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.