ATE449753T1 - Verfahren zur herstellung von (r)-3-hydroxy-3-(2- phenylethyl) hexansäure und dessen zwischenprodukt - Google Patents
Verfahren zur herstellung von (r)-3-hydroxy-3-(2- phenylethyl) hexansäure und dessen zwischenproduktInfo
- Publication number
- ATE449753T1 ATE449753T1 AT02779967T AT02779967T ATE449753T1 AT E449753 T1 ATE449753 T1 AT E449753T1 AT 02779967 T AT02779967 T AT 02779967T AT 02779967 T AT02779967 T AT 02779967T AT E449753 T1 ATE449753 T1 AT E449753T1
- Authority
- AT
- Austria
- Prior art keywords
- phenylethyl
- hydroxy
- producing
- hexanic acid
- hexanic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/73—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002030724 | 2002-02-07 | ||
JP2002041480 | 2002-02-19 | ||
JP2002105772 | 2002-04-08 | ||
JP2002242741 | 2002-08-22 | ||
PCT/JP2002/011348 WO2003066564A1 (en) | 2002-02-07 | 2002-10-31 | Process for producing (r)-3-hydroxy-3-(2-phenylethyl)hexanoic acid and its intermediate |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE449753T1 true ATE449753T1 (de) | 2009-12-15 |
Family
ID=27739275
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07023540T ATE438611T1 (de) | 2002-02-07 | 2002-10-31 | Verfahren zum herstellen von racemischem 3- hydroxy-3-(2-phenylethyl)-hexansäureester |
AT02779967T ATE449753T1 (de) | 2002-02-07 | 2002-10-31 | Verfahren zur herstellung von (r)-3-hydroxy-3-(2- phenylethyl) hexansäure und dessen zwischenprodukt |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07023540T ATE438611T1 (de) | 2002-02-07 | 2002-10-31 | Verfahren zum herstellen von racemischem 3- hydroxy-3-(2-phenylethyl)-hexansäureester |
Country Status (12)
Country | Link |
---|---|
US (2) | US6683207B2 (de) |
EP (2) | EP1894912B1 (de) |
JP (2) | JP4108611B2 (de) |
KR (1) | KR20040098637A (de) |
CN (1) | CN1301244C (de) |
AT (2) | ATE438611T1 (de) |
AU (1) | AU2002344438B2 (de) |
BR (1) | BR0215593A (de) |
CA (1) | CA2475332A1 (de) |
DE (2) | DE60233279D1 (de) |
IL (1) | IL163330A (de) |
WO (1) | WO2003066564A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
JP2006225272A (ja) * | 2005-02-15 | 2006-08-31 | Sumitomo Chemical Co Ltd | (r)−n−(3,4−ジメトキシベンジル)−1−フェニルエチルアミンl−酒石酸塩およびそれを用いる(r)−n−(3,4−ジメトキシベンジル)−1−フェニルエチルアミンの精製方法 |
CN100448836C (zh) * | 2005-06-03 | 2009-01-07 | 浙江中贝化工有限公司 | 一种抗艾滋病药物关键中间体的制备方法 |
CN102010327B (zh) * | 2009-09-07 | 2013-04-10 | 浙江九洲药业股份有限公司 | (±)-2-(3-苯甲酰基)-苯基丙酸的拆分方法 |
FR2961209B1 (fr) * | 2010-06-11 | 2013-03-01 | Sanofi Aventis | Procede de synthese de la ferroquine par amination reductrice convergente. |
CN102320929A (zh) * | 2011-10-31 | 2012-01-18 | 天津市佰斯康科技有限公司 | 2-甲基异莰醇的合成方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1085879B (it) * | 1976-04-08 | 1985-05-28 | Basf Ag | Processo per la preparazione di chetoni superiori |
EP1015441B1 (de) * | 1997-09-11 | 2004-05-12 | PHARMACIA & UPJOHN COMPANY | Verfahren zur herstellung von als protease inhibitoren wervollen 4-hydroxy-2-oxo-pyran-derivaten |
AU3699100A (en) * | 1999-03-18 | 2000-10-04 | Pharmacia & Upjohn Company | Improved process for asymmetric hydrogenation |
JP2001072644A (ja) * | 1999-09-06 | 2001-03-21 | Yamakawa Yakuhin Kogyo Kk | 光学活性な2−クロロマンデル酸の製造方法および製造の中間体 |
DE10031604A1 (de) | 2000-06-29 | 2002-01-17 | Consortium Elektrochem Ind | Verfahren zur Herstellung von beta-Hydroxy- und beta-Aminocarbonylverbindungen |
US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
US7141681B2 (en) | 2001-02-22 | 2006-11-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Continuous process for preparing dihydropyrones |
JP2003112045A (ja) * | 2001-10-03 | 2003-04-15 | Sumika Fine Chemicals Co Ltd | 活性化亜鉛およびその用途、製造方法、ならびにこれを用いた3−ヒドロキシ−3−(2−フェニルエチル)ヘキサン酸エチルの製造方法 |
JP2003137835A (ja) * | 2001-10-30 | 2003-05-14 | Sumika Fine Chemicals Co Ltd | (r)−3−ヒドロキシ−3−(2−フェニルエチル)ヘキサン酸の製造方法 |
-
2002
- 2002-10-31 EP EP07023540A patent/EP1894912B1/de not_active Expired - Lifetime
- 2002-10-31 EP EP02779967A patent/EP1481961B1/de not_active Expired - Lifetime
- 2002-10-31 DE DE60233279T patent/DE60233279D1/de not_active Expired - Lifetime
- 2002-10-31 DE DE60234537T patent/DE60234537D1/de not_active Expired - Lifetime
- 2002-10-31 AU AU2002344438A patent/AU2002344438B2/en not_active Ceased
- 2002-10-31 BR BR0215593-1A patent/BR0215593A/pt not_active IP Right Cessation
- 2002-10-31 CN CNB028279395A patent/CN1301244C/zh not_active Expired - Fee Related
- 2002-10-31 AT AT07023540T patent/ATE438611T1/de active
- 2002-10-31 KR KR10-2004-7012171A patent/KR20040098637A/ko active IP Right Grant
- 2002-10-31 WO PCT/JP2002/011348 patent/WO2003066564A1/ja active Application Filing
- 2002-10-31 JP JP2003565940A patent/JP4108611B2/ja not_active Expired - Fee Related
- 2002-10-31 AT AT02779967T patent/ATE449753T1/de active
- 2002-10-31 CA CA002475332A patent/CA2475332A1/en not_active Abandoned
- 2002-12-16 US US10/320,325 patent/US6683207B2/en not_active Expired - Fee Related
-
2003
- 2003-12-04 US US10/727,398 patent/US7038075B2/en not_active Expired - Fee Related
-
2004
- 2004-08-03 IL IL163330A patent/IL163330A/en not_active IP Right Cessation
-
2008
- 2008-02-26 JP JP2008045245A patent/JP4801685B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4108611B2 (ja) | 2008-06-25 |
ATE438611T1 (de) | 2009-08-15 |
US7038075B2 (en) | 2006-05-02 |
WO2003066564A1 (en) | 2003-08-14 |
DE60234537D1 (de) | 2010-01-07 |
BR0215593A (pt) | 2004-12-21 |
AU2002344438B2 (en) | 2008-09-11 |
JP2008163041A (ja) | 2008-07-17 |
DE60233279D1 (de) | 2009-09-17 |
EP1894912B1 (de) | 2009-08-05 |
EP1481961B1 (de) | 2009-11-25 |
CN1617846A (zh) | 2005-05-18 |
US20040138496A1 (en) | 2004-07-15 |
US6683207B2 (en) | 2004-01-27 |
EP1481961A4 (de) | 2006-05-10 |
CA2475332A1 (en) | 2003-08-14 |
KR20040098637A (ko) | 2004-11-20 |
CN1301244C (zh) | 2007-02-21 |
IL163330A (en) | 2008-08-07 |
AU2002344438A1 (en) | 2003-09-02 |
EP1894912A1 (de) | 2008-03-05 |
EP1481961A1 (de) | 2004-12-01 |
JPWO2003066564A1 (ja) | 2005-05-26 |
JP4801685B2 (ja) | 2011-10-26 |
US20030176507A1 (en) | 2003-09-18 |
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