HK87384A - Microbial expression of quasi-synthetic genes - Google Patents

Microbial expression of quasi-synthetic genes

Info

Publication number
HK87384A
HK87384A HK873/84A HK87384A HK87384A HK 87384 A HK87384 A HK 87384A HK 873/84 A HK873/84 A HK 873/84A HK 87384 A HK87384 A HK 87384A HK 87384 A HK87384 A HK 87384A
Authority
HK
Hong Kong
Prior art keywords
quasi
synthetic genes
microbial expression
microbial
expression
Prior art date
Application number
HK873/84A
Other languages
English (en)
Inventor
David V Goeddel
Herbert L Heyneker
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26733870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK87384(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of HK87384A publication Critical patent/HK87384A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormones [GH] (Somatotropin)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185Escherichia
    • C12R2001/19Escherichia coli
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/12Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
HK873/84A 1979-07-05 1984-11-08 Microbial expression of quasi-synthetic genes HK87384A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/055,126 US4342832A (en) 1979-07-05 1979-07-05 Method of constructing a replicable cloning vehicle having quasi-synthetic genes

Publications (1)

Publication Number Publication Date
HK87384A true HK87384A (en) 1984-11-16

Family

ID=26733870

Family Applications (3)

Application Number Title Priority Date Filing Date
HK873/84A HK87384A (en) 1979-07-05 1984-11-08 Microbial expression of quasi-synthetic genes
HK875/84A HK87584A (en) 1979-07-05 1984-11-08 Bacterial plasmid encoding human growth hormone
HK874/84A HK87484A (en) 1979-07-05 1984-11-08 Plasmid with tandem promoter system

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK875/84A HK87584A (en) 1979-07-05 1984-11-08 Bacterial plasmid encoding human growth hormone
HK874/84A HK87484A (en) 1979-07-05 1984-11-08 Plasmid with tandem promoter system

Country Status (42)

Country Link
US (7) US4342832A (de)
EP (1) EP0022242B1 (de)
JP (4) JPH0612996B2 (de)
KR (2) KR830003574A (de)
AR (1) AR244341A1 (de)
AT (1) ATE82324T1 (de)
AU (2) AU533697B2 (de)
BE (1) BE884012A (de)
BG (1) BG41135A3 (de)
BR (1) BR8008736A (de)
CA (2) CA1164375A (de)
CH (1) CH661939A5 (de)
CS (3) CS250652B2 (de)
DD (3) DD157343A5 (de)
DE (3) DE3050725C2 (de)
DK (2) DK173503B1 (de)
EG (1) EG14819A (de)
ES (2) ES493149A0 (de)
FI (2) FI802030A (de)
FR (2) FR2460330B1 (de)
GB (2) GB2121047B (de)
GR (1) GR69320B (de)
HK (3) HK87384A (de)
IE (3) IE50460B1 (de)
IL (3) IL69492A (de)
IT (1) IT1131393B (de)
KE (3) KE3451A (de)
MX (1) MX172674B (de)
MY (3) MY8500764A (de)
NL (1) NL930114I2 (de)
NO (2) NO167673C (de)
NZ (2) NZ201312A (de)
OA (1) OA06562A (de)
PH (1) PH19814A (de)
PL (1) PL149278B1 (de)
PT (1) PT71487A (de)
RO (1) RO93374B (de)
SG (1) SG56984G (de)
WO (1) WO1981000114A1 (de)
YU (3) YU163580A (de)
ZA (1) ZA803600B (de)
ZW (1) ZW14180A1 (de)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4898830A (en) * 1979-07-05 1990-02-06 Genentech, Inc. Human growth hormone DNA
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US6455275B1 (en) 1980-02-25 2002-09-24 The Trustees Of Columbia University In The City Of New York DNA construct for producing proteinaceous materials in eucaryotic cells
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
US4711843A (en) * 1980-12-31 1987-12-08 Cetus Corporation Method and vector organism for controlled accumulation of cloned heterologous gene products in Bacillus subtilis
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
IL59690A (en) * 1980-03-24 1983-11-30 Yeda Res & Dev Production of bovine growth hormone by microorganisms and modified microorganisms adapted to produce it
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US6610830B1 (en) 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
DK339781A (da) * 1980-08-05 1982-02-06 Searle & Co Syntetisk gen
US7101981B1 (en) 1980-08-26 2006-09-05 Regents Of The University Of California Bovine growth hormone recombinantly produced in E. coli
US4725549A (en) * 1980-09-22 1988-02-16 The Regents Of The University Of California Human and rat prolactin and preprolactin cloned genes
NZ198445A (en) * 1980-09-25 1984-05-31 Genentech Inc Production of human fibroblast interferon by recombinant dna technology
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS57181098A (en) * 1981-04-30 1982-11-08 Japan Found Cancer Novel recombinant dna
US4810645A (en) * 1981-08-14 1989-03-07 Hoffmann-La Roche Inc. Microbial production of mature human leukocyte interferon K and L
US4801685A (en) * 1981-08-14 1989-01-31 Hoffmann-La Roche Inc. Microbial production of mature human leukocyte interferon K and L
US4880910A (en) * 1981-09-18 1989-11-14 Genentech, Inc. Terminal methionyl bovine growth hormone and its use
NZ201918A (en) * 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
US5254463A (en) * 1981-09-18 1993-10-19 Genentech, Inc. Method for expression of bovine growth hormone
US5236831A (en) * 1981-12-29 1993-08-17 Kiowa Hakko Kogyo Co., Ltd. Amino acid synthesis in corynebacteria using E. coli genes
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US4446235A (en) * 1982-03-22 1984-05-01 Genentech, Inc. Method for cloning human growth hormone varient genes
US4665160A (en) * 1982-03-22 1987-05-12 Genentech, Inc. Novel human growth hormone like protein HGH-V encoded in the human genome
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
DE3380262D1 (en) * 1982-05-25 1989-08-31 Lilly Co Eli Cloning vectors for expression of exogenous protein
US4778759A (en) * 1982-07-09 1988-10-18 Boyce, Thompson Institute For Plant Research, Inc. Genetic engineering in cyanobacteria
US4891315A (en) * 1982-10-25 1990-01-02 American Cyanamid Company Production of herpes simplex viral porteins
AU2038283A (en) * 1982-08-10 1984-03-07 Trustees Of Columbia University In The City Of New York, The The use of eucaryotic promoter sequences in the production ofproteinaceous materials
US4530904A (en) * 1982-09-03 1985-07-23 Eli Lilly And Company Method for conferring bacteriophage resistance to bacteria
CA1209501A (en) * 1982-09-16 1986-08-12 Nikos Panayotatos Expression vector
WO1984001150A1 (en) * 1982-09-16 1984-03-29 Amgen Avian growth hormones
US4666839A (en) * 1982-12-01 1987-05-19 Amgen Methods and materials for obtaining microbial expression of polypeptides including bovine prolactin
JPS59106297A (ja) * 1982-12-07 1984-06-19 Rikagaku Kenkyusho ヒト生長ホルモンのカルボキシ末端遺伝子の合成法
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
US5618697A (en) * 1982-12-10 1997-04-08 Novo Nordisk A/S Process for preparing a desired protein
US4634678A (en) * 1982-12-13 1987-01-06 Molecular Genetics Research And Development Limited Partnership Plasmid cloning and expression vectors for use in microorganisms
GB8303383D0 (en) * 1983-02-08 1983-03-16 Biogen Nv Sequences recombinant dna molecules
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
US4859600A (en) * 1983-04-25 1989-08-22 Genentech, Inc. Recombinant procaryotic cell containing correctly processed human growth hormone
IL71991A (en) * 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
US5242798A (en) * 1983-07-21 1993-09-07 Scripps Clinic And Research Foundation Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same
US4900811A (en) * 1983-07-21 1990-02-13 Scripps Clinic And Research Foundation Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same
JPS60137291A (ja) * 1983-12-26 1985-07-20 Takeda Chem Ind Ltd 発現ベクター
CA1213537A (en) * 1984-05-01 1986-11-04 Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee Polypeptide expression method
CA1272144A (en) * 1984-06-29 1990-07-31 Tamio Mizukami Fish growth hormone polypeptide
US5489529A (en) * 1984-07-19 1996-02-06 De Boer; Herman A. DNA for expression of bovine growth hormone
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
ATE78515T1 (de) * 1984-10-05 1992-08-15 Genentech Inc Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung.
US4680262A (en) * 1984-10-05 1987-07-14 Genentech, Inc. Periplasmic protein recovery
NZ213759A (en) * 1984-10-19 1989-01-27 Genentech Inc Lhrh-ctp protein conjugates influencing prolactin fsh and lh release
US4645829A (en) * 1984-10-29 1987-02-24 Monsanto Company Method for separating polypeptides
US4861868A (en) * 1985-02-22 1989-08-29 Monsanto Company Production of proteins in procaryotes
US4652630A (en) * 1985-02-22 1987-03-24 Monsanto Company Method of somatotropin naturation
DK151585D0 (da) * 1985-04-03 1985-04-03 Nordisk Gentofte Dna-sekvens
DE3683186D1 (de) * 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
DE3681787D1 (de) * 1985-07-05 1991-11-07 Whitehead Biomedical Inst Expression von fremdem genetischem material in epithelzellen.
US5041381A (en) 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
US4892764A (en) * 1985-11-26 1990-01-09 Loctite Corporation Fiber/resin composites, and method of making the same
US5552528A (en) * 1986-03-03 1996-09-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bovine b-endothelial cell growth factor
US5827826A (en) 1986-03-03 1998-10-27 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compositions of human endothelial cell growth factor
EP0245218B1 (de) * 1986-05-07 1993-12-29 ENIRICERCHE S.p.A. Plasmidvektor zur Expression im Bazillus, dessen Umwendung für die Klonierung des menschlichen Wachstumshormongens und Verfahren zur Produktion des Hormons
EP0252588A3 (de) * 1986-05-12 1989-07-12 Smithkline Beecham Corporation Verfahren zur Isolierung und Reinigung von P. falciparum CS-Protein in rekombinantem E. coli sowie seine Verwendung als Impfstoff
US4806239A (en) * 1986-11-28 1989-02-21 Envirotech Corporation Apparatus for shifting filter plates in a filter press
JPS63159244A (ja) * 1986-12-23 1988-07-02 三菱マテリアル株式会社 二層の押出成形珪酸質―石灰質系成形品の製造方法
EP0295286B1 (de) * 1986-12-31 1995-03-08 Lucky, Ltd. Verfahren zur herstellung eines lachswachstumshormons mittels eines kunstgens
JPH02502604A (ja) * 1987-01-07 1990-08-23 アライド・コーポレーション ペプチドオリゴマーの微生物生産法
US4977089A (en) * 1987-01-30 1990-12-11 Eli Lilly And Company Vector comprising signal peptide-encoding DNA for use in Bacillus and other microorganisms
KR960015610B1 (ko) * 1987-06-22 1996-11-18 제네틱스 인스티튜트, 인코포레이티드 신규의 혈전붕괴 단백질의 제조방법
FR2624835B2 (fr) * 1987-08-05 1990-09-07 Hassevelde Roger Support ergonomique a creme glacee, a cuillere integree, transformable en tout autre objet apres son utilisation premiere
US5268267A (en) * 1987-08-21 1993-12-07 The General Hospital Corporation Method for diagnosing small cell carcinoma
IT1223577B (it) * 1987-12-22 1990-09-19 Eniricerche Spa Procedimento migliorato per la preparazione dell'ormone della crescita umano naturale in forma pura
JPH0231042U (de) * 1988-08-19 1990-02-27
US5130422A (en) * 1988-08-29 1992-07-14 Monsanto Company Variant somatotropin-encoding DNA
EP0763543A2 (de) 1988-09-02 1997-03-19 The Rockefeller University Eine Methode für die Präparation eines inflammatorisches Cytokins (MIP-2) und diagnostische und therapeutische Applikationen für das Cytokin oder dessen Antikörper
US5079230A (en) * 1988-09-12 1992-01-07 Pitman-Moore, Inc. Stable bioactive somatotropins
US5082767A (en) * 1989-02-27 1992-01-21 Hatfield G Wesley Codon pair utilization
US5075227A (en) * 1989-03-07 1991-12-24 Zymogenetics, Inc. Directional cloning
US4960301A (en) * 1989-03-27 1990-10-02 Fry Steven A Disposable liner for pickup truck beds
US5164180A (en) 1989-05-18 1992-11-17 Mycogen Corporation Bacillus thuringiensis isolates active against lepidopteran pests
US5266477A (en) * 1990-02-02 1993-11-30 Pitman-Moore, Inc. Monoclonal antibodies which differentiate between native and modified porcine somatotropins
CA2041446A1 (en) 1990-05-15 1991-11-16 August J. Sick Bacillus thuringiensis genes encoding novel dipteran-active toxins
US5849694A (en) * 1990-07-16 1998-12-15 Synenki; Richard M. Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
US5744139A (en) * 1991-06-28 1998-04-28 University Of Tennessee Research Corporation Insulin-like growth factor I (IGF-1) induced improvement of depressed T4/T8 ratios
US5202119A (en) * 1991-06-28 1993-04-13 Genentech, Inc. Method of stimulating immune response
US5591709A (en) * 1991-08-30 1997-01-07 Life Medical Sciences, Inc. Compositions and methods for treating wounds
HUT67319A (en) * 1991-08-30 1995-03-28 Life Medical Sciences Inc Compositions for treating wounds
US5317012A (en) * 1991-10-04 1994-05-31 The University Of Tennessee Research Corporation Human growth hormone induced improvement in depressed T4/T8 ratio
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
WO1994008611A1 (en) * 1992-10-22 1994-04-28 Sloan-Kettering Institute For Cancer Research GROWTH HORMONE FRAGMENT hGH 108-129
JPH08508640A (ja) 1993-03-10 1996-09-17 スミスクライン・ビーチャム・コーポレイション ヒト脳ホスホジエステラーゼ
FR2738842B1 (fr) * 1995-09-15 1997-10-31 Rhone Poulenc Rorer Sa Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique
GB9526733D0 (en) * 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US5760187A (en) * 1996-02-22 1998-06-02 Mitsui Toatsu Chemicals, Inc. Purification process of a human growth hormone
JP3794748B2 (ja) * 1996-03-04 2006-07-12 第一アスビオファーマ株式会社 メタノール代謝系を有する微生物の培養法
US6503729B1 (en) 1996-08-22 2003-01-07 The Board Of Trustees Of The University Of Illinois Selected polynucleotide and polypeptide sequences of the methanogenic archaeon, methanococcus jannashii
MX9605082A (es) 1996-10-24 1998-04-30 Univ Autonoma De Nuevo Leon Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano.
WO1998019689A1 (en) * 1996-11-01 1998-05-14 Smithkline Beecham Corporation Novel coding sequences
US6068991A (en) * 1997-12-16 2000-05-30 Bristol-Myers Squibb Company High expression Escherichia coli expression vector
DE69835538T2 (de) 1997-12-18 2008-01-03 Monsanto Technology Llc Insekten-resistante transgene pflanzen und verfahren zur verbesserung von der aktivität von delta-endotoxine gegen insekte
US6087128A (en) * 1998-02-12 2000-07-11 Ndsu Research Foundation DNA encoding an avian E. coli iss
IL138658A0 (en) 1998-03-31 2001-10-31 Tonghua Gantech Biotechnology Chimeric protein
US6271444B1 (en) 1998-07-10 2001-08-07 Calgene Llc Enhancer elements for increased translation in plant plastids
US6512162B2 (en) 1998-07-10 2003-01-28 Calgene Llc Expression of eukaryotic peptides in plant plastids
US7097974B1 (en) 1998-08-28 2006-08-29 Febit Biotech Gmbh Support for a method for determining an analyte and a method for producing the support
EP1728860B1 (de) 1999-02-19 2010-01-27 febit holding GmbH Verfahren zur Herstellung von Polymeren
US6946265B1 (en) 1999-05-12 2005-09-20 Xencor, Inc. Nucleic acids and proteins with growth hormone activity
US6187750B1 (en) 1999-08-25 2001-02-13 Everyoung Technologies, Inc. Method of hormone treatment for patients with symptoms consistent with multiple sclerosis
AT408721B (de) 1999-10-01 2002-02-25 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung enthaltend ein antigen
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
US6562790B2 (en) 2000-02-05 2003-05-13 Chein Edmund Y M Hormone therapy methods and hormone products for abating coronary artery blockage
EP1276849A4 (de) 2000-04-12 2004-06-09 Human Genome Sciences Inc Albumin fusionsproteine
US6995246B1 (en) * 2000-10-19 2006-02-07 Akzo Nobel N.V. Methods for removing suspended particles from soluble protein solutions
EP2062593A3 (de) 2000-12-01 2011-08-17 Takeda Pharmaceutical Company Limited Verfahren zur Herstellung einer Zubereitung mit bioaktiven Peptiden
WO2002046435A2 (en) * 2000-12-05 2002-06-13 Alexion Pharmaceuticals, Inc. Engineered plasmids and their use for in situ production of genes
US20020164712A1 (en) * 2000-12-11 2002-11-07 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence
WO2002097038A2 (en) * 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Chemokine beta-1 fusion proteins
US6720538B2 (en) * 2001-06-18 2004-04-13 Homedics, Inc. Thermostat variation compensating knob
NZ532027A (en) 2001-10-10 2008-09-26 Neose Technologies Inc Remodeling and glycoconjugation of peptides
US20030171285A1 (en) * 2001-11-20 2003-09-11 Finn Rory F. Chemically-modified human growth hormone conjugates
EP1463752A4 (de) 2001-12-21 2005-07-13 Human Genome Sciences Inc Albuminfusionsproteine
EP2277889B1 (de) 2001-12-21 2014-07-09 Human Genome Sciences, Inc. Fusionsproteine von Albumin und Interferon beta
CA2498319A1 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
TWI281864B (en) * 2002-11-20 2007-06-01 Pharmacia Corp N-terminally monopegylated human growth hormone conjugates and process for their preparation
CA2512052C (en) 2002-12-31 2016-06-21 Altus Pharmaceuticals Inc. Human growth hormone crystals and methods for preparing them
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
WO2004074345A2 (en) * 2003-02-19 2004-09-02 Pharmacia Corporation Carbonate esters of polyethylene glycol activated by means of oxalate esters
EA008254B1 (ru) * 2003-05-09 2007-04-27 Фармекса А/С Детоксифицированный tnf и способ получения
AU2005319099B2 (en) 2004-02-02 2010-09-16 Ambrx, Inc. Modified human growth hormone
AU2005211362B2 (en) 2004-02-02 2008-03-13 Ambrx, Inc. Modified human interferon polypeptides and their uses
DE602004031982D1 (de) * 2004-06-23 2011-05-05 Usv Ltd Chimeres, von den placenta- und hypophysenisoformen abgeleitetes humanes wachstumshormon und verfahren zur gewinnung der chimere
US20060024288A1 (en) * 2004-08-02 2006-02-02 Pfizer Inc. tRNA synthetase fragments
US8282921B2 (en) * 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
NZ555386A (en) * 2004-12-22 2011-01-28 Ambrx Inc Formulations of human growth hormone comprising a non-naturally encoded amino acid
EP1836316A4 (de) 2004-12-22 2009-07-22 Ambrx Inc Verfahren zur expression und reinigung von rekombinantem menschlichem wachstumshormon
EP2386571B1 (de) 2005-04-08 2016-06-01 ratiopharm GmbH Zusammensetzungen und Verfahren zur Herstellung von Glycosylierungsmutanten eines Proteaseresistenten menschlichen Wachstumshormons
CA2607901C (en) 2005-06-13 2016-08-16 Rigel Pharmaceuticals, Inc. Methods and compositions for treating degenerative bone disorders using a syk inhibitory 2,4-pyrimidinediamine
US8030271B2 (en) * 2005-07-05 2011-10-04 Emisphere Technologies, Inc. Compositions and methods for buccal delivery of human growth hormone
US20100010068A1 (en) * 2005-08-19 2010-01-14 Binhai Ren Liver-directed gene therapy
EP1951890A4 (de) 2005-11-16 2009-06-24 Ambrx Inc Verfahren und zusammensetzungen mit nichtnatürlichen aminosäuren
AU2006330833A1 (en) * 2005-12-23 2007-07-05 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
DE102006039479A1 (de) 2006-08-23 2008-03-06 Febit Biotech Gmbh Programmierbare Oligonukleotidsynthese
AU2007333959A1 (en) 2006-12-18 2008-06-26 Altus Pharmaceuticals Inc. Human growth hormone formulations
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
AU2008279584A1 (en) * 2007-04-27 2009-01-29 Dow Global Technologies Inc. Improved production and in vivo assembly of soluble recombinant icosahedral virus-like particles
UA100692C2 (ru) 2007-05-02 2013-01-25 Мериал Лимитед Днк-плазмиды, имеющие повышенную экспрессию и стабильность
AU2008275911A1 (en) * 2007-07-19 2009-01-22 Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University Self- anchoring MEMS intrafascicular neural electrode
US7939447B2 (en) * 2007-10-26 2011-05-10 Asm America, Inc. Inhibitors for selective deposition of silicon containing films
SG188143A1 (en) 2008-02-08 2013-03-28 Ambrx Inc Modified leptin polypeptides and their uses
ES2875426T3 (es) 2008-04-29 2021-11-10 Ascendis Pharma Endocrinology Div A/S Compuestos de hormona de crecimiento humana recombinante pegilada
CN102171341A (zh) 2008-04-30 2011-08-31 格兰达利斯有限公司 高纯度质粒dna制备物及其制备方法
DK2303314T3 (da) * 2008-06-25 2014-01-13 Braasch Biotech Llc Chloramphenicol-acetyltransferase (cat)-defekt somatostatin-fusionsprotein og anvendelser deraf til kvæg
JP5627581B2 (ja) * 2008-06-25 2014-11-19 ブラーシュ・バイオテック・エルエルシー ソマトスタチン免疫原性増進のための組成物および方法
US8703717B2 (en) * 2009-02-03 2014-04-22 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
CN116925238A (zh) 2009-02-03 2023-10-24 阿穆尼克斯制药公司 延伸重组多肽和包含该延伸重组多肽的组合物
US9238878B2 (en) 2009-02-17 2016-01-19 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
WO2010094772A1 (en) 2009-02-20 2010-08-26 Febit Holding Gmbh Synthesis of sequence-verified nucleic acids
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
CN102741422B (zh) 2009-08-24 2016-06-08 阿穆尼克斯运营公司 凝血因子ⅶ组合物及其制备和使用方法
MX349301B (es) 2009-12-21 2017-07-21 Ambrx Inc Polipéptidos de somatotropina bovina modificados y sus usos.
BR112012015597A2 (pt) 2009-12-21 2017-01-31 Ambrx Inc peptídeos de somatotropina suínos modificados e seus usos
WO2011103325A1 (en) 2010-02-17 2011-08-25 Elona Biotechnologies Methods for preparing human growth hormone
EP2446898A1 (de) 2010-09-30 2012-05-02 Laboratorios Del. Dr. Esteve, S.A. Verwendung von Wachstumshormonen zur Verbesserung der Immunantwort bei immunsupprimierten Patienten
RU2606016C2 (ru) 2011-01-14 2017-01-10 Редвуд Байосайнс, Инк. Меченые альдегидом полипептиды иммуноглобулина и способы их применения
RU2473556C1 (ru) * 2011-07-14 2013-01-27 Закрытое акционерное общество "ГЕНЕРИУМ" Промышленный способ получения и очистки рекомбинантного гормона роста человека из телец включения
US9821114B2 (en) 2012-02-07 2017-11-21 Global Bio Therapeutics, Inc. Compartmentalized method of nucleic acid delivery and compositions and uses thereof
JP6256882B2 (ja) 2012-02-15 2018-01-10 アムニクス オペレーティング インコーポレイテッド 第viii因子組成物、ならびに組成物の作製方法および用途
JP6383666B2 (ja) 2012-02-15 2018-08-29 バイオベラティブ セラピューティクス インコーポレイテッド 組換え第viii因子タンパク質
CA2868473A1 (en) 2012-03-26 2013-10-03 Pronutria, Inc. Nutritive fragments, proteins and methods
JP2015518470A (ja) 2012-03-26 2015-07-02 プロニュートリア・インコーポレイテッドPronutria, Inc. 栄養タンパク質および方法
US9700071B2 (en) 2012-03-26 2017-07-11 Axcella Health Inc. Nutritive fragments, proteins and methods
EP2831098A4 (de) 2012-03-26 2016-12-07 Axcella Health Inc Geladene nährstoffproteine und verfahren
US9457096B2 (en) 2012-07-06 2016-10-04 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Concet) Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery
CN105813579B (zh) 2013-08-08 2019-05-07 全球生物疗法有限公司 用于微创手术过程的夹具装置和其应用
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
EP3048904A2 (de) 2013-09-25 2016-08-03 Pronutria Biosciences, Inc. Zusammensetzungen und formulierungen zur behandlung von absorptionsstörungen und entzündungen des magen-darm-trakts sowie verfahren zur herstellung und verwendung davon
BR112018002150A2 (pt) 2015-08-03 2018-09-18 Bioverativ Therapeutics Inc proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas
CA3019398A1 (en) 2016-04-26 2017-11-02 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
KR20210024082A (ko) 2018-06-25 2021-03-04 제이씨알 파마 가부시키가이샤 단백질 함유 수성 액제
CN109486847B (zh) * 2018-12-17 2021-03-02 江南大学 基于人工串联启动子的枯草芽孢杆菌高效诱导表达系统

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853833A (en) * 1971-04-27 1974-12-10 Hormone Res Foundation Synthetic human growth-promoting and lactogenic hormones and method of producing same
US3853832A (en) * 1971-04-27 1974-12-10 Harmone Res Foundation Synthetic human pituitary growth hormone and method of producing it
GB1521032A (en) * 1974-08-08 1978-08-09 Ici Ltd Biological treatment
US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
NL7607683A (nl) * 1976-07-12 1978-01-16 Akzo Nv Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan.
US4190495A (en) * 1976-09-27 1980-02-26 Research Corporation Modified microorganisms and method of preparing and using same
NZ187300A (en) * 1977-05-27 1982-08-17 Univ California Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
US4363877B1 (en) * 1977-09-23 1998-05-26 Univ California Recombinant dna transfer vectors
CH630089A5 (de) * 1977-09-09 1982-05-28 Ciba Geigy Ag Verfahren zur herstellung von siliciummodifizierten imidyl-phthalsaeurederivaten.
JPS5449837A (en) * 1977-09-19 1979-04-19 Kobashi Kogyo Kk Safety apparatus of soil block making machine
US4407948A (en) * 1977-09-23 1983-10-04 The Regents Of The University Of California Purification of nucleotide sequences suitable for expression in bacteria
ZA782933B (en) * 1977-09-23 1979-05-30 Univ California Purification of nucleotide sequences suitable for expression in bacteria
US4321365A (en) * 1977-10-19 1982-03-23 Research Corporation Oligonucleotides useful as adaptors in DNA cloning, adapted DNA molecules, and methods of preparing adaptors and adapted molecules
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
NO158880C (no) * 1977-11-08 1988-11-09 Genentech Inc Fremgangsmaate for fremstilling av et spesifikt pattedyrhormon.
IE47889B1 (en) * 1977-11-08 1984-07-11 Genentech Inc Synthetic dna and process tehrefor
BR7807288A (pt) * 1977-11-08 1979-06-12 Genentech Inc Processo para sintese de polinucleotidos
IE47891B1 (en) * 1977-11-08 1984-07-11 Genentech Inc Plasmid suitable for transformation of a bacterial host to render it capable of polypeptide expression
US4356270A (en) * 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4652525A (en) * 1978-04-19 1987-03-24 The Regents Of The University Of California Recombinant bacterial plasmids containing the coding sequences of insulin genes
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
US4565785A (en) * 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
FI792481A (fi) * 1978-08-11 1980-02-12 Univ California Syntes av enkaroytiskt protein genom anvaendning av mikro-organismer
DE2963374D1 (en) * 1978-10-10 1982-09-09 Univ Leland Stanford Junior Recombinant dna, method for preparing it and production of foreign proteins by unicellular hosts containing it
US4332892A (en) * 1979-01-15 1982-06-01 President And Fellows Of Harvard College Protein synthesis
IE52036B1 (en) * 1979-05-24 1987-05-27 Univ California Non-passageable viruses
ZA802992B (en) * 1979-06-01 1981-10-28 Univ California Human pre-growth hormone
US4898830A (en) * 1979-07-05 1990-02-06 Genentech, Inc. Human growth hormone DNA
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
GR70279B (de) * 1979-09-12 1982-09-03 Univ California
IL59690A (en) * 1980-03-24 1983-11-30 Yeda Res & Dev Production of bovine growth hormone by microorganisms and modified microorganisms adapted to produce it
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
US4859600A (en) * 1983-04-25 1989-08-22 Genentech, Inc. Recombinant procaryotic cell containing correctly processed human growth hormone
CA1267615A (en) * 1984-08-27 1990-04-10 Dan Hadary Method for recovering purified growth hormones from genetically engineered microorganisms

Also Published As

Publication number Publication date
DK97381A (da) 1981-03-04
JPH05268970A (ja) 1993-10-19
ATE82324T1 (de) 1992-11-15
MY8500764A (en) 1985-12-31
ES499043A0 (es) 1982-06-01
IE801214L (en) 1981-01-05
GB2055382A (en) 1981-03-04
RO93374B (ro) 1988-01-31
CA1202256A (en) 1986-03-25
DE3050722C2 (de) 1987-09-24
NO860680L (no) 1981-02-20
PL225376A1 (en) 1983-07-18
IL69492A (en) 1985-04-30
AU5949880A (en) 1981-01-15
AU574351B2 (en) 1988-07-07
US4342832A (en) 1982-08-03
HK87584A (en) 1984-11-16
ES8205265A1 (es) 1982-06-01
IE50461B1 (en) 1986-04-30
NZ194043A (en) 1983-09-30
EP0022242B1 (de) 1992-11-11
FR2460330A1 (fr) 1981-01-23
US5424199A (en) 1995-06-13
KR830003574A (ko) 1983-06-21
AR244341A1 (es) 1993-10-29
ZA803600B (en) 1981-07-29
IE50460B1 (en) 1986-04-30
NO167673C (no) 1991-11-27
DK251490A (da) 1990-10-18
GB2121047A (en) 1983-12-14
US4604359A (en) 1986-08-05
US4658021A (en) 1987-04-14
ZW14180A1 (en) 1980-09-10
JPH0612996B2 (ja) 1994-02-23
HK87484A (en) 1984-11-16
IL60312A (en) 1985-04-30
OA06562A (fr) 1981-07-31
IE50462B1 (en) 1986-04-30
NO810608L (no) 1981-02-20
KE3451A (en) 1984-10-05
MX172674B (es) 1994-01-06
EP0022242A2 (de) 1981-01-14
PL149278B1 (en) 1990-01-31
GB2055382B (en) 1983-10-19
JPH0648987B2 (ja) 1994-06-29
JP2622479B2 (ja) 1997-06-18
KE3446A (en) 1984-10-05
ES8105386A1 (es) 1981-05-16
NL930114I2 (nl) 1994-10-17
BG41135A3 (en) 1987-04-15
IT8023070A0 (it) 1980-06-26
US4601980A (en) 1986-07-22
FR2518572B1 (fr) 1985-08-23
NO167674B (no) 1991-08-19
NO167673B (no) 1991-08-19
CH661939A5 (de) 1987-08-31
NZ201312A (en) 1983-09-30
DK251490D0 (da) 1990-10-18
JPH08242881A (ja) 1996-09-24
ES493149A0 (es) 1981-05-16
DD210071A5 (de) 1984-05-30
CA1164375A (en) 1984-03-27
IT1131393B (it) 1986-06-18
JPS5621596A (en) 1981-02-28
FI802030A (fi) 1981-01-06
IL69492A0 (en) 1983-11-30
KR870000701B1 (ko) 1987-04-07
DK173503B1 (da) 2001-01-15
AU2583484A (en) 1984-07-12
CS250652B2 (en) 1987-05-14
WO1981000114A1 (en) 1981-01-22
FI850198L (fi) 1985-01-16
IE842193L (en) 1981-01-05
KE3450A (en) 1984-10-05
IL60312A0 (en) 1980-09-16
PH19814A (en) 1986-07-08
CS270884A2 (en) 1987-07-16
MY8500765A (en) 1985-12-31
DE3023627A1 (de) 1981-01-22
RO93374A (ro) 1988-01-30
FR2460330B1 (fr) 1985-07-19
NO167674C (no) 1991-11-27
BE884012A (fr) 1980-12-29
GR69320B (de) 1982-05-14
DK172132B1 (da) 1997-11-24
GB2121047B (en) 1984-06-06
US5795745A (en) 1998-08-18
CS254973B2 (en) 1988-02-15
FI850198A0 (fi) 1985-01-16
SG56984G (en) 1985-03-08
MY8500763A (en) 1985-12-31
AU533697B2 (en) 1983-12-08
YU121183A (en) 1984-02-29
BR8008736A (pt) 1981-04-28
AU1838883A (en) 1984-01-05
JPH02478A (ja) 1990-01-05
NL930114I1 (nl) 1993-10-18
US4634677A (en) 1987-01-06
EG14819A (en) 1985-03-31
DE3050725C2 (de) 1988-03-10
YU121283A (en) 1984-02-29
EP0022242A3 (en) 1982-04-07
PT71487A (en) 1980-08-01
DD210070A5 (de) 1984-05-30
FR2518572A1 (fr) 1983-06-24
CS250655B2 (en) 1987-05-14
YU163580A (en) 1984-02-29
DD157343A5 (de) 1982-11-03

Similar Documents

Publication Publication Date Title
GB2055382B (en) Microbial expression of quasi-synthetic genes
GB2010327B (en) Preparations of micro-organisms
AU538684B2 (en) Microbial dentrification of tobacco
AU538740B2 (en) Amides of acyl-carnitines
ZA807631B (en) Oligomrtization of oleffins
GB2049457B (en) Fermentation reactors
GB2061081B (en) Shell fish culture
JPS5666255A (en) Incubator
JPS5655391A (en) Imidazolylethoxymethyl derivative of dioxoloquinoline
JPS5497232A (en) Cultivation of horseeradish
GB2121048B (en) Microbial expression of quasi-synthetic genes
JPS5424743A (en) Culture of shiitakeemushroom
JPS5415848A (en) Culture of maitakeemushroom
JPS55128000A (en) Treating of broth
AU574351C (en) Microbial expression of quasi-synthetic genes
GB2058023B (en) Defining sets of sheets
GB2047860B (en) Tuyeres
GB2023144B (en) Microbial preparation of 12s-hydroxy-cardenolide derivatives
JPS5697283A (en) Imidazolylethoxymethyl derivative of pyrazole
JPS5692791A (en) Sterilization of fixed enzyme
JPS5429732A (en) Culture of shiitakeemushroom
ZA80408B (en) Anaerobic thermaphilic culture
GB2060691B (en) Preparation of microbial cells
GR63394B (en) New type of jacket
JPS5697414A (en) Improved shape of general purpose desk

Legal Events

Date Code Title Description
PE Patent expired