DE3683186D1 - Rekombinantes humaninterleukin-1. - Google Patents

Rekombinantes humaninterleukin-1.

Info

Publication number
DE3683186D1
DE3683186D1 DE8686105538T DE3683186T DE3683186D1 DE 3683186 D1 DE3683186 D1 DE 3683186D1 DE 8686105538 T DE8686105538 T DE 8686105538T DE 3683186 T DE3683186 T DE 3683186T DE 3683186 D1 DE3683186 D1 DE 3683186D1
Authority
DE
Germany
Prior art keywords
humaninterleukin
recombinant
recombinant humaninterleukin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686105538T
Other languages
English (en)
Inventor
Ulrich A Gubler
Peter T Lomedico
Steven B Mizel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27110314&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3683186(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE3683186D1 publication Critical patent/DE3683186D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/73—Expression systems using phage (lambda) regulatory sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE8686105538T 1985-04-25 1986-04-22 Rekombinantes humaninterleukin-1. Expired - Fee Related DE3683186D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72077485A 1985-04-25 1985-04-25
US74863285A 1985-06-24 1985-06-24

Publications (1)

Publication Number Publication Date
DE3683186D1 true DE3683186D1 (de) 1992-02-13

Family

ID=27110314

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686105538T Expired - Fee Related DE3683186D1 (de) 1985-04-25 1986-04-22 Rekombinantes humaninterleukin-1.

Country Status (4)

Country Link
US (2) US5936066A (de)
EP (1) EP0200986B2 (de)
JP (2) JP2559705B2 (de)
DE (1) DE3683186D1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342614A (en) * 1984-12-21 1994-08-30 Otsuka Pharmaceutical Co., Ltd. Method of treating arthritus or inflammation with IL-1β or derivatives thereof
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
US6107465A (en) * 1984-12-21 2000-08-22 Otsuka Pharmaceutical Co., Ltd. IL-1β and derivatives thereof and drugs
EP0188920B1 (de) * 1984-12-25 1993-09-29 Dainippon Pharmaceutical Co., Ltd. Interleukin-1 und dessen Derivat
DE3683186D1 (de) 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
JPH07100663B2 (ja) * 1985-12-23 1995-11-01 大日本製薬株式会社 インタ−ロイキン１を有効成分とする感染症予防・治療剤
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US4894333A (en) * 1987-05-28 1990-01-16 Immunex Corporation Bovine interleukin-1α
US5266311A (en) * 1987-05-28 1993-11-30 Immunex Corporation Bovine interleukin-1α
JPH03502922A (ja) * 1987-12-18 1991-07-04 イミュネックス・コーポレーション インターロイキン‐１蛋白質を含む局所創傷治療用製剤
ZA89202B (en) * 1988-01-15 1989-09-27 Hoffmann La Roche Recombinant human interleukin-1 alpha polypeptides
US5290917A (en) * 1988-02-03 1994-03-01 Dainippon Pharmaceutical Co., Ltd. Modified polypeptides of IL-1α
JP2698976B2 (ja) * 1988-02-03 1998-01-19 大日本製薬株式会社 新規ポリペプチド及びそれをコードするｄｎａ
EP0352816A3 (de) * 1988-07-29 1991-03-20 Otsuka Pharmaceutical Co., Ltd. IL-1 alpha Derivate und Arzneimittel gegen Thrombozytopenie
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US6713605B1 (en) * 1996-04-10 2004-03-30 Kansas State University Research Foundation Synthetic peptides that inhibit leukocyte superoxide anion production and/or attract leukocytes
US7176179B1 (en) 1997-05-30 2007-02-13 The Regents Of The University Of California Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide
US6191269B1 (en) * 1997-05-30 2001-02-20 The Regents Of The University Of California Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide
US20030154504A1 (en) 1998-06-24 2003-08-14 Farese Robert V. Methods and compositions for modulating carbohydrate metabolism
US6265165B1 (en) * 1998-11-12 2001-07-24 The Regents Of The University Of California Methods for EST-specific full length cDNA cloning
US20030026806A1 (en) * 2000-10-27 2003-02-06 Amgen Inc. Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof
US8414714B2 (en) 2008-10-31 2013-04-09 Fort Wayne Metals Research Products Corporation Method for imparting improved fatigue strength to wire made of shape memory alloys, and medical devices made from such wire
JP5661777B2 (ja) * 2009-09-29 2015-01-28 ユナイテッド・テクノロジーズ・ユーティー・アクチェンゲゼルシャフト 組換え型ヒトインターロイキン−１を含む口腔ケア組成物
EA021042B1 (ru) 2009-10-08 2015-03-31 Юнайтед Технолоджиес Ют Аг Способ снижения выпадения волос при помощи косметических композиций, содержащих интерлейкин-1 альфа

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503035B1 (en) * 1978-11-24 1996-03-19 Hoffmann La Roche Protein purification process and product
US4298729A (en) * 1979-05-25 1981-11-03 Merck & Co., Inc. Xanthan gum-modified starches
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4411992A (en) * 1981-04-14 1983-10-25 Immunex Corporation Process for preparing murine interleukin 2
US4406830A (en) * 1981-04-17 1983-09-27 Shanksville Corporation, N.V. Regulatory glycoprotein for immune response and the use thereof in the production of T-cell growth factor
DE3149360A1 (de) * 1981-12-12 1983-06-16 Biotest-Serum-Institut Gmbh, 6000 Frankfurt "verfahren zur reinigung und/oder phytohaemagglutinin-abtrennung von human-interleukin-2"
DE3378128D1 (en) * 1982-04-20 1988-11-03 Sloan Kettering Inst Cancer Purification of interleukin 2
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
JPS59169492A (ja) * 1983-03-15 1984-09-25 Asahi Chem Ind Co Ltd ヒト融合細胞からの生理活性物質の産生方法
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
JPS6039762A (ja) * 1983-08-11 1985-03-01 Japan Storage Battery Co Ltd 電解液循環装置
JPS60112474A (ja) * 1983-11-25 1985-06-18 Ricoh Co Ltd 和文出力装置
JPS60171493A (ja) * 1984-02-17 1985-09-04 日立造船株式会社 燃料輸送容器への核燃料収納方法と燃料輸送容器用プラグ
JPS60200894A (ja) * 1984-03-27 1985-10-11 Nec Corp 液相成長装置
EP0161901B1 (de) * 1984-05-18 1993-12-01 New England Medical Center Hospitals, Inc. Menschliche IL-1-cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
US4762914A (en) * 1984-05-18 1988-08-09 Auron Philip E Truncated protein of interleukin-1
CA1341433C (en) * 1984-06-19 2003-06-24 Douglas P. Cerretti Purification of interleukin 1
EP0188920B1 (de) * 1984-12-25 1993-09-29 Dainippon Pharmaceutical Co., Ltd. Interleukin-1 und dessen Derivat
JP2579747B2 (ja) * 1984-12-25 1997-02-12 大日本製薬株式会社 ヒトインタ−ロイキン１をコ−ドする新規ｄｎａ
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene
DE3683186D1 (de) 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.

Also Published As

Publication number Publication date
JPS6229A (ja) 1987-01-06
JP2764028B2 (ja) 1998-06-11
US6268180B1 (en) 2001-07-31
US5936066A (en) 1999-08-10
JPH08252093A (ja) 1996-10-01
EP0200986B2 (de) 1998-03-11
JP2559705B2 (ja) 1996-12-04
EP0200986A1 (de) 1986-11-12
EP0200986B1 (de) 1992-01-02

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8339 Ceased/non-payment of the annual fee