HK16897A - Fluid handling in microfabricated analytical devices - Google Patents

Fluid handling in microfabricated analytical devices

Info

Publication number
HK16897A
HK16897A HK16897A HK16897A HK16897A HK 16897 A HK16897 A HK 16897A HK 16897 A HK16897 A HK 16897A HK 16897 A HK16897 A HK 16897A HK 16897 A HK16897 A HK 16897A
Authority
HK
Hong Kong
Prior art keywords
sperm
inlet port
sample
flow channel
microfabricated
Prior art date
Application number
HK16897A
Other languages
English (en)
Inventor
Peter Wilding
Larry J Kricka
Jay N Zemel
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27542279&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK16897(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/877,661 external-priority patent/US5296375A/en
Priority claimed from US07/877,536 external-priority patent/US5304487A/en
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of HK16897A publication Critical patent/HK16897A/xx

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/18Apparatus therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D71/00Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02Inorganic material
    • B01D71/0213Silicon
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/717Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7182Feed mechanisms characterised by the means for feeding the components to the mixer with means for feeding the material with a fractal or tree-type distribution in a surface
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2325/00Details relating to properties of membranes
    • B01D2325/02Details relating to pores or porosity of the membranes
    • B01D2325/028Microfluidic pore structures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/41Mixers of the fractal type
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/0059Sequential processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00722Nucleotides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00824Ceramic
    • B01J2219/00828Silicon wafers or plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00833Plastic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00889Mixing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14Process control and prevention of errors
    • B01L2200/143Quality control, feedback systems
    • B01L2200/146Employing pressure sensors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0645Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physiology (AREA)
  • Water Supply & Treatment (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Measuring Cells (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Flow Control (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
HK16897A 1992-05-01 1997-02-13 Fluid handling in microfabricated analytical devices HK16897A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US87770192A 1992-05-01 1992-05-01
US87770292A 1992-05-01 1992-05-01
US87766292A 1992-05-01 1992-05-01
US07/877,661 US5296375A (en) 1992-05-01 1992-05-01 Mesoscale sperm handling devices
US07/877,536 US5304487A (en) 1992-05-01 1992-05-01 Fluid handling in mesoscale analytical devices
PCT/US1993/004018 WO1993022055A2 (fr) 1992-05-01 1993-04-29 Manipulation de fluides dans des dispositifs d'analyse micro-usines

Publications (1)

Publication Number Publication Date
HK16897A true HK16897A (en) 1997-02-13

Family

ID=27542279

Family Applications (2)

Application Number Title Priority Date Filing Date
HK16897A HK16897A (en) 1992-05-01 1997-02-13 Fluid handling in microfabricated analytical devices
HK98100122A HK1001305A1 (en) 1992-05-01 1998-01-07 Polynucleotide amplification analysis using a microfabricated device

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK98100122A HK1001305A1 (en) 1992-05-01 1998-01-07 Polynucleotide amplification analysis using a microfabricated device

Country Status (10)

Country Link
EP (5) EP0637998B2 (fr)
JP (5) JP3207424B2 (fr)
AT (5) ATE140025T1 (fr)
AU (5) AU677197B2 (fr)
CA (5) CA2134478C (fr)
DE (5) DE69322774T2 (fr)
ES (2) ES2127276T3 (fr)
GR (2) GR3025037T3 (fr)
HK (2) HK16897A (fr)
WO (5) WO1993022058A1 (fr)

Families Citing this family (387)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5935401A (en) * 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
US7297313B1 (en) 1991-08-31 2007-11-20 The Regents Of The University Of California Microfabricated reactor, process for manufacturing the reactor, and method of amplification
WO1993022058A1 (fr) * 1992-05-01 1993-11-11 Trustees Of The University Of Pennsylvania Analyse par amplification de polynucleotide a l'aide d'un dispositif micro-fabrique
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US6156270A (en) * 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6767510B1 (en) 1992-05-21 2004-07-27 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6905882B2 (en) 1992-05-21 2005-06-14 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
FR2709250B1 (fr) * 1993-08-23 1995-10-13 Ccd Laboratoire Dispositif pour sélectionner des spermatozoïdes.
DE4405004A1 (de) * 1994-02-17 1995-08-24 Rossendorf Forschzent Chemischer Mikro-Analysator
US5725831A (en) * 1994-03-14 1998-03-10 Becton Dickinson And Company Nucleic acid amplification apparatus
CA2143365A1 (fr) * 1994-03-14 1995-09-15 Hugh V. Cottingham Methode et appareil pour l'amplification de l'acide nucleique
US6287850B1 (en) 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
DE4420732A1 (de) * 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
DE4435107C1 (de) * 1994-09-30 1996-04-04 Biometra Biomedizinische Analy Miniaturisierter Fluß-Thermocycler
US5707799A (en) * 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5641400A (en) * 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
KR100367064B1 (ko) * 1994-10-22 2003-02-19 브리티쉬 뉴클리어 퓨얼 피엘씨 비혼화성유체들간에물질을확산에의해전달하는방법및장치
JP4015187B2 (ja) * 1994-10-22 2007-11-28 ブリティッシュ ニュークリア フュエルズ パブリック リミティド カンパニー 不混和性流体間の拡散移動のための方法及び装置
DE4438785C2 (de) * 1994-10-24 1996-11-07 Wita Gmbh Wittmann Inst Of Tec Mikrochemische Reaktions- und Analyseeinheit
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
ATE277450T1 (de) * 1994-11-10 2004-10-15 Orchid Biosciences Inc Flüssigkeitsverteilungssystem
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
CA2181189C (fr) * 1994-11-14 1999-09-21 Peter Wilding Dispositifs d'amplification de polynucleotides a meso-echelle
CN1110369C (zh) * 1994-11-14 2003-06-04 宾夕法尼亚州大学信托人 用于测定和加工分析物的中尺度样品制备设备和系统
DE19507638C2 (de) * 1995-03-04 1997-09-25 Danfoss As Analysenvorrichtung
DE19519015C1 (de) * 1995-05-24 1996-09-05 Inst Physikalische Hochtech Ev Miniaturisierter Mehrkammer-Thermocycler
US5776674A (en) * 1995-06-05 1998-07-07 Seq, Ltd Chemical biochemical and biological processing in thin films
US5922210A (en) * 1995-06-16 1999-07-13 University Of Washington Tangential flow planar microfabricated fluid filter and method of using thereof
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
TW293783B (fr) * 1995-06-16 1996-12-21 Ciba Geigy Ag
US6454945B1 (en) 1995-06-16 2002-09-24 University Of Washington Microfabricated devices and methods
DE69628016T2 (de) * 1995-06-16 2004-04-01 University Of Washington, Seattle Miniaturisierte differentielle extraktionsvorrichtung und verfahren
US6524532B1 (en) * 1995-06-20 2003-02-25 The Regents Of The University Of California Microfabricated sleeve devices for chemical reactions
US5589136A (en) * 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6132580A (en) * 1995-09-28 2000-10-17 The Regents Of The University Of California Miniature reaction chamber and devices incorporating same
EP1577010A3 (fr) * 1995-12-05 2005-11-16 Tecan Trading AG Plate-forme à microsystème et son utilisage
ATE291225T1 (de) * 1995-12-05 2005-04-15 Gamera Bioscience Corp Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung
US6709869B2 (en) 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
CA2243197A1 (fr) * 1996-01-17 1997-07-24 Flinders Technology Pty. Ltd. Enrichissement en phase solide de cellules intactes a l'aide de constituants intracellulaires
DE59700294D1 (de) * 1996-01-23 1999-09-02 Novartis Ag Vorrichtung und verfahren zum synthetisieren von makromolekülen
US6541213B1 (en) 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
DE69700499T2 (de) * 1996-04-03 2000-03-23 Perkin Elmer Corp Vorrichtung und verfahren zum nachweis mehrerer analyten
US7235406B1 (en) 1996-04-03 2007-06-26 Applera Corporation Nucleic acid analysis device
US7244622B2 (en) 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US6825047B1 (en) 1996-04-03 2004-11-30 Applera Corporation Device and method for multiple analyte detection
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
EP0808906B1 (fr) * 1996-05-23 2000-09-20 QIAGEN GmbH Utilisation d'un osmolyte pour réduire ou abolir des liaisons non-covalentes des molécules biologiques à des surfaces inertes
US5964239A (en) * 1996-05-23 1999-10-12 Hewlett-Packard Company Housing assembly for micromachined fluid handling structure
US6150094A (en) * 1996-05-23 2000-11-21 Qiagen Gmbh Use of an osmolyte for reducing or abolishing no-covalent interactions of biological molecules to inert surfaces
JP2000512541A (ja) 1996-06-14 2000-09-26 ユニバーシティ オブ ワシントン 吸収力が向上した差違抽出装置
EP0927265A4 (fr) * 1996-06-17 2000-07-12 Trustees Of Board Of Appareil et procede de thermocyclage
CA2258489C (fr) 1996-06-28 2004-01-27 Caliper Technologies Corporation Systeme de dosage de criblage a fort rendement dans des dispositifs microscopiques de transfert de fluides
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
AU4236597A (en) * 1996-08-27 1998-03-19 Visible Genetics Inc. Apparatus and method for performing sequencing of nucleic acid polymers
EP0925494B1 (fr) * 1996-09-04 2001-12-19 Scandinavian Micro Biodevices A/S Systeme a microdebit pour separation et analyse de particules
GB9618595D0 (en) * 1996-09-06 1996-10-16 Central Research Lab Ltd Reaction cell
WO1998022803A1 (fr) * 1996-11-18 1998-05-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Cellule micromecanique de mesure de transmission
DE19648441A1 (de) * 1996-11-22 1998-05-28 Abb Patent Gmbh Analysegerät
DE19648695C2 (de) 1996-11-25 1999-07-22 Abb Patent Gmbh Vorrichtung zur automatischen und kontinuierlichen Analyse von Flüssigkeitsproben
WO1998028623A1 (fr) 1996-12-20 1998-07-02 Gamera Bioscience Corporation Systeme a base de liaisons par affinite permettant de detecter des particules dans un fluide
SE9700205D0 (sv) 1997-01-24 1997-01-24 Peter Lindberg Integrated microfluidic element
FR2758884B1 (fr) * 1997-01-30 1999-04-02 Bio Merieux Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu
AP9901660A0 (en) * 1997-02-28 1999-09-30 Burstein Lab Inc Laboratory in a disk.
CA2284612A1 (fr) * 1997-04-04 1998-10-15 Michael Knapp Analyseurs biochimiques fonctionnant en boucle fermee
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US5998224A (en) * 1997-05-16 1999-12-07 Abbott Laboratories Magnetically assisted binding assays utilizing a magnetically responsive reagent
EP0981408B1 (fr) 1997-05-16 2004-04-21 Alberta Research Council Systeme microfluidique et ses utilisations
US6632619B1 (en) 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
CA2291180A1 (fr) 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. Systeme et appareil destines au traitement sequentiel des analytes
US6632399B1 (en) 1998-05-22 2003-10-14 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays
US6063589A (en) 1997-05-23 2000-05-16 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system
US6156273A (en) * 1997-05-27 2000-12-05 Purdue Research Corporation Separation columns and methods for manufacturing the improved separation columns
AU9020698A (en) 1997-08-15 1999-03-08 Alexion Pharmaceuticals, Inc. Apparatus for performing assays at reaction sites
US6102068A (en) * 1997-09-23 2000-08-15 Hewlett-Packard Company Selector valve assembly
JP2001518624A (ja) 1997-09-26 2001-10-16 ユニバーシティ・オブ・ワシントン 同時の粒子分離および化学反応
US7115884B1 (en) * 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
WO1999024828A1 (fr) * 1997-11-12 1999-05-20 The Perkin-Elmer Corporation Canal d'electrophorese en serpentin a courbes auto-correctrices
DE59803938D1 (de) * 1997-11-19 2002-05-29 Biognosis Gmbh Vorrichtung zur sequentiellen ausgabe von fliessfähigen reagenzien
US6251343B1 (en) * 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
CA2230653A1 (fr) 1998-02-27 1999-08-27 The Governors Of The University Of Alberta Analyse enzymatique a l'aide d'une puce informatique
AU2848099A (en) * 1998-03-25 1999-10-18 Gert Blankenstein Micro system and method for field manipulation of particules
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
DE19846958C2 (de) * 1998-08-19 2001-06-13 Fraunhofer Ges Forschung Verfahren zur Herstellung einer Einrichtung zum Transport von kleinsten Flüssigkeitsmengen
WO2000015321A1 (fr) 1998-09-17 2000-03-23 Advanced Bioanalytical Services, Inc. Systeme monolithique integre microfabrique d'electronebulisation et de chromatographie en phase liquide et procede associe
US6245227B1 (en) 1998-09-17 2001-06-12 Kionix, Inc. Integrated monolithic microfabricated electrospray and liquid chromatography system and method
JP2002526103A (ja) 1998-10-08 2002-08-20 アストラゼネカ・アクチエボラーグ 微細組み立てセル注入器
DE19846466A1 (de) * 1998-10-08 2000-04-27 Ghs Gesundheits Service Ag Analyseverfahren zur simultanen Bestimmung von Parametern aus unterschiedlichen Medien
US6633031B1 (en) 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
DE19910392B4 (de) 1999-03-05 2005-03-17 Clondiag Chip Technologies Gmbh Mikrosäulenreaktor
US6193647B1 (en) 1999-04-08 2001-02-27 The Board Of Trustees Of The University Of Illinois Microfluidic embryo and/or oocyte handling device and method
US6375817B1 (en) 1999-04-16 2002-04-23 Perseptive Biosystems, Inc. Apparatus and methods for sample analysis
US6605475B1 (en) 1999-04-16 2003-08-12 Perspective Biosystems, Inc. Apparatus and method for sample delivery
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7332326B1 (en) 1999-05-14 2008-02-19 Tecan Trading Ag Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
JP4495866B2 (ja) * 1999-05-28 2010-07-07 セフィード 化学反応を制御するためのカートリッジ
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
ATE272213T1 (de) 1999-06-18 2004-08-15 Gamera Bioscience Corp Vorrichtungen und verfahren zur durchführung miniaturisierter homogener tests
JP2001004628A (ja) * 1999-06-18 2001-01-12 Kanagawa Acad Of Sci & Technol 免疫分析装置と免疫分析方法
DE19928410C2 (de) * 1999-06-22 2002-11-28 Agilent Technologies Inc Gerätegehäuse mit einer Einrichtung zum Betrieb eines Labor-Mikrochips
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
DE19933458B4 (de) * 1999-07-15 2015-08-20 Eppendorf Ag Einrichtungen und Systeme zum Handhaben von Flüssigkeitsproben
AU782726B2 (en) 1999-07-28 2005-08-25 Commissariat A L'energie Atomique Integration of biochemical protocols in a continuous flow microfluidic device
DE19935433A1 (de) 1999-08-01 2001-03-01 Febit Ferrarius Biotech Gmbh Mikrofluidischer Reaktionsträger
US6319719B1 (en) * 1999-10-28 2001-11-20 Roche Diagnostics Corporation Capillary hematocrit separation structure and method
US6875619B2 (en) * 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
JP2001145486A (ja) * 1999-11-19 2001-05-29 Natl Inst Of Advanced Industrial Science & Technology Meti 多試料用の微小容量化学反応装置
US6613561B1 (en) 1999-11-26 2003-09-02 Olympus Optical Co., Ltd. High-density capillary array for reaction and detection of fluid
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CA2290731A1 (fr) 1999-11-26 2001-05-26 D. Jed Harrison Appareil et methode de piegeage de reactifs en forme de perles, dans le cadre d'un systeme d'analyse de microfluides
CN1237572C (zh) 1999-12-30 2006-01-18 阿德维昂生物科学公司 多电雾化装置、系统和方法
DE10001116C2 (de) * 2000-01-13 2002-11-28 Meinhard Knoll Vorrichtung und Verfahren zur optischen oder elektrochemischen quantitativen Bestimmung chemischer oder biochemischer Substanzen in flüssigen Proben
JP2003520962A (ja) 2000-01-18 2003-07-08 アドビオン バイオサイエンシーズ インコーポレーティッド 分離媒体、複式電気噴霧ノズルシステム、および方法
US7241423B2 (en) * 2000-02-03 2007-07-10 Cellular Process Chemistry, Inc. Enhancing fluid flow in a stacked plate microreactor
DE10006214A1 (de) 2000-02-11 2001-08-16 Roche Diagnostics Gmbh System zur einfachen Nukleinsäureanalytik
DE10010587A1 (de) * 2000-03-03 2001-09-06 Roche Diagnostics Gmbh System zur Bestimmung von Analytkonzentrationen in Körperflüssigkeiten
AU5963501A (en) * 2000-05-12 2001-11-26 Univ Illinois Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation
DE10035911A1 (de) * 2000-07-21 2002-02-07 Abb Research Ltd Verfahren und Sensor zum Überwachen von Flüssigkeiten
GB2366793B (en) * 2000-09-13 2005-03-09 Imperial College Chemical processing system and method
WO2002029411A2 (fr) * 2000-10-03 2002-04-11 Minerva Biotechnologies Corporation Dilution in situ par voie magnetique
ATE336298T1 (de) * 2000-10-25 2006-09-15 Boehringer Ingelheim Micropart Mikrostrukturierte plattform für die untersuchung einer flüssigkeit
WO2002044695A1 (fr) * 2000-11-16 2002-06-06 Burstein Technologies, Inc. Methodes et appareils destines a la detection et au denombrement de lymphocytes utilisant des biodisques optiques
AU2002239289A1 (en) * 2000-11-22 2002-06-03 Burstein Technologies, Inc. Apparatus and methods for separating agglutinants and disperse particles
JP4002720B2 (ja) * 2000-11-22 2007-11-07 独立行政法人科学技術振興機構 一細胞長期培養顕微観察装置
US7054258B2 (en) 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
WO2002046721A2 (fr) 2000-12-08 2002-06-13 Burstein Technologies, Inc. Disques optiques permettant de mesurer des analytes
US7091034B2 (en) 2000-12-15 2006-08-15 Burstein Technologies, Inc. Detection system for disk-based laboratory and improved optical bio-disc including same
JP4733838B2 (ja) * 2001-02-07 2011-07-27 株式会社ティー・ワイ・エー 体液成分の検査方法及びこれに用いる検査器具
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
JP4797196B2 (ja) * 2001-02-14 2011-10-19 株式会社 フューエンス マイクロチップ
DE10111458B4 (de) * 2001-03-09 2008-09-11 Siemens Ag Analyseeinrichtung
JP4323806B2 (ja) 2001-03-19 2009-09-02 ユィロス・パテント・アクチボラグ 反応可変要素の特徴付け
ES2287351T3 (es) 2001-04-25 2007-12-16 Cornell Research Foundation, Inc. Dispositivos y metodos para sistemas de cultivos de celulas basados en farmacocinetica.
JP4714366B2 (ja) * 2001-05-10 2011-06-29 パナソニックエコシステムズ株式会社 特定微生物計量装置
DE10125018A1 (de) * 2001-05-22 2002-12-05 Infineon Technologies Ag Verfahren und Sensor-Anordnung zum Erfassen von Molekülen in einer zu untersuchenden Flüssigkeit
US7141416B2 (en) 2001-07-12 2006-11-28 Burstein Technologies, Inc. Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
US7338760B2 (en) 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US20030138819A1 (en) * 2001-10-26 2003-07-24 Haiqing Gong Method for detecting disease
CA2467740A1 (fr) * 2001-11-19 2003-05-30 Burstein Technologies, Inc. Methode et appareil de typage sanguin a l'aide de bio-disques
WO2003044481A2 (fr) * 2001-11-20 2003-05-30 Burstein Technologies, Inc. Biodisques optiques et circuits fluidiques utilises pour l'analyse de cellules et methodes correspondantes
IE20020619A1 (en) * 2001-12-31 2003-07-23 Provost Fellows And Scholors O An assay assembly
DE10203211A1 (de) * 2002-01-28 2003-08-14 Siemens Ag Mikrofluidikprobenmodul mit Mitteln zur Temperaturbeeinflussung
DE10204414A1 (de) * 2002-02-04 2003-09-04 Siemens Ag Mikrofluidik-System
JP2003225083A (ja) * 2002-02-05 2003-08-12 Sony Corp 円盤状培養媒体
JP2002357607A (ja) * 2002-03-20 2002-12-13 Olympus Optical Co Ltd 集積化反応装置
JP2003294743A (ja) * 2002-04-03 2003-10-15 Mitsubishi Heavy Ind Ltd 可撓性アレイ、該可撓性アレイの製造方法、該可撓性アレイのハイブリダイゼーション方法、及び該可撓性アレイの測定方法
FR2839660B1 (fr) 2002-05-17 2005-01-21 Commissariat Energie Atomique Microreacteur,son procede de preparation,et procede pour realiser une reaction biochimique ou biologique
JPWO2003100086A1 (ja) * 2002-05-23 2005-09-22 富士電機ホールディングス株式会社 生細胞の計数方法および装置
EP1371419A1 (fr) * 2002-06-12 2003-12-17 F. Hoffmann-La Roche AG Procédé et dispositif pour détecter la présence d'un analyte dans un échantillon
JP4199609B2 (ja) * 2002-07-12 2008-12-17 三菱化学株式会社 分析用チップ、分析用チップユニット及び分析装置ならびに分析用チップの作製方法
AU2003248273A1 (en) * 2002-07-12 2004-02-02 Mitsubishi Chemical Corporation Analytical chip, analytical chip unit, analyzing apparatus, method of analysis using the apparatus, and method of producing the analytical chip
CA2494540C (fr) * 2002-08-06 2014-06-03 The Regents Of The University Of California Osmometrie de film lacrymal
US7905134B2 (en) 2002-08-06 2011-03-15 The Regents Of The University Of California Biomarker normalization
US7810380B2 (en) 2003-03-25 2010-10-12 Tearlab Research, Inc. Systems and methods for collecting tear film and measuring tear film osmolarity
US8020433B2 (en) 2003-03-25 2011-09-20 Tearlab Research, Inc. Systems and methods for a sample fluid collection device
WO2004029221A2 (fr) 2002-09-27 2004-04-08 The General Hospital Corporation Dispositif microfluidique pour la separation de cellules et utilisations de ce dispositif
DE10245845B4 (de) * 2002-09-30 2006-06-29 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Meßchip für die Verwendung ein einer Vorrichtung zur quantitativen Bestimmung eines Analyten in einer Probe und Vorrichtung mit diesem Meßchip
GB2395006A (en) * 2002-10-29 2004-05-12 Micro Chemical Systems Ltd Apparatus and method for performing an assay
US6929945B2 (en) * 2002-12-09 2005-08-16 Advanced Fluidix Laboratories Llc Male fertility assay method and device
CA2512071A1 (fr) 2002-12-30 2004-07-22 The Regents Of The University Of California Procedes et appareil pour la detection et l'analyse d'agents pathogenes
GB0306098D0 (en) 2003-03-18 2003-04-23 Platform Diagnostics Group Ltd Sample testing device
JP2004301515A (ja) * 2003-03-28 2004-10-28 Dkk Toa Corp 活性物質の固定化方法
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
JP2004317128A (ja) * 2003-04-10 2004-11-11 Kanagawa Acad Of Sci & Technol マイクロチャンネル構造体とマイクロチップデバイス
DE10320869A1 (de) * 2003-05-09 2004-12-16 Evotec Technologies Gmbh Verfahren und Vorrichtungen zur Flüssigkeitsbehandlung suspendierter Partikel
EP1655363A1 (fr) * 2003-06-20 2006-05-10 Nitto Denko Corporation Micropuce a cellule
WO2005058477A1 (fr) * 2003-12-16 2005-06-30 Unilever Plc Dispositif microfluidique
FR2864625B1 (fr) * 2003-12-24 2006-08-25 Rhodia Chimie Sa Procede et installation de determination des caracteristiques representatives d'une transformation physique et/ou chimique intervenant dans un micro-reacteur
KR100580639B1 (ko) * 2003-12-30 2006-05-16 삼성전자주식회사 미세유체 검출을 위한 형광검출기
JP2007524849A (ja) * 2004-01-06 2007-08-30 ユィロス・パテント・アクチボラグ 接触加熱アレンジメント
KR100552706B1 (ko) 2004-03-12 2006-02-20 삼성전자주식회사 핵산 증폭 방법 및 장치
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
JP2007236202A (ja) * 2004-04-06 2007-09-20 Bussan Nanotech Research Institute Inc 細菌検出装置及び細菌検出方法
WO2005098022A1 (fr) * 2004-04-06 2005-10-20 Bussan Nanotech Research Institute, Inc. Méthode de comptage des bactéries et compteur de bactéries
US7473551B2 (en) 2004-05-21 2009-01-06 Atonomics A/S Nano-mechanic microsensors and methods for detecting target analytes
EP1758981A4 (fr) 2004-05-28 2013-01-16 Wafergen Inc Appareil et procedes pour effectuer des analyses multiplex
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
JP4756835B2 (ja) * 2004-07-14 2011-08-24 キヤノン株式会社 生化学反応カートリッジ
CN102759466A (zh) 2004-09-15 2012-10-31 英特基因有限公司 微流体装置
JP2006087336A (ja) * 2004-09-22 2006-04-06 Shimadzu Corp 細胞分析装置
US7550267B2 (en) 2004-09-23 2009-06-23 University Of Washington Microscale diffusion immunoassay utilizing multivalent reactants
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
JP4185904B2 (ja) * 2004-10-27 2008-11-26 株式会社日立ハイテクノロジーズ 液体搬送基板、分析システム、分析方法
GB0423885D0 (en) 2004-10-28 2004-12-01 Platform Diagnostics Ltd Blood analysis
DE102004055662A1 (de) * 2004-11-18 2006-06-01 Evotec Technologies Gmbh Mikrofluidisches System mit einer Kanalaufweitung
JP4850072B2 (ja) * 2004-11-22 2012-01-11 日水製薬株式会社 マイクロチップ
TWI295730B (en) * 2004-11-25 2008-04-11 Ind Tech Res Inst Microfluidic chip for sample assay and method thereof
KR100601982B1 (ko) 2005-01-20 2006-07-18 삼성전자주식회사 흡열반응을 통한 가열-냉각 과정에 의한 세포 용해 방법
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
EP1874469A4 (fr) * 2005-04-14 2014-02-26 Gyros Patent Ab Dispositif microfluidique comprenant des valves digitiformes
GB0508983D0 (en) 2005-05-03 2005-06-08 Oxford Gene Tech Ip Ltd Cell analyser
JP2008544214A (ja) 2005-05-09 2008-12-04 セラノス, インコーポレイテッド ポイントオブケア流体システムおよびその使用
JP3805352B1 (ja) * 2005-05-25 2006-08-02 株式会社エンプラス 流体取扱装置およびそれに用いる流体取扱ユニット
US20070175768A1 (en) 2005-06-30 2007-08-02 Applera Corporation Microfluidic systems including porous polymer electrodes
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
JP4721414B2 (ja) 2005-08-15 2011-07-13 キヤノン株式会社 反応カートリッジ、反応装置および反応カートリッジの溶液の移動方法
EP1764418B1 (fr) 2005-09-14 2012-08-22 STMicroelectronics Srl Procédé et dispositif pour le traitement d'échantillons biologiques par la diélectrophorèse
US8075851B2 (en) 2005-09-29 2011-12-13 Siemens Medical Solutions Usa, Inc. Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography
WO2007043619A1 (fr) * 2005-10-13 2007-04-19 Nissui Pharmaceutical Co., Ltd. Dispositif d'essais
JP4753367B2 (ja) * 2005-11-25 2011-08-24 日本電子株式会社 有機合成反応装置
EP1984738A2 (fr) 2006-01-11 2008-10-29 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procédés d'utilisation dans la formation et le contrôle de nanoréacteurs
EP1979079A4 (fr) 2006-02-03 2012-11-28 Integenx Inc Dispositifs microfluidiques
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8900828B2 (en) * 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
EP2481815B1 (fr) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Dispositifs microfluidiques
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
DE102006023223B3 (de) * 2006-05-18 2007-11-15 Bruker Biospin Gmbh Apparatur zur Analyse einer flüssigen Probe mit einer Multi-Lumen-Kapillare
WO2007147074A2 (fr) 2006-06-14 2007-12-21 Living Microsystems, Inc. Utilisation de génotypage snp fortement parallèle pour diagnostic fœtal
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
EP1886727A1 (fr) 2006-07-14 2008-02-13 Roche Diagnostics GmbH Dispositif pour analyse
EP3536396B1 (fr) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Tensioactifs fluorocarbonés stabilisateurs d'émulsions
GB0617035D0 (en) 2006-08-30 2006-10-11 Inverness Medical Switzerland Fluidic indicator device
FR2907226B1 (fr) * 2006-10-13 2008-12-12 Rhodia Recherches & Tech Dispositif d'analyse fluidique,dispositif de determination de caracteristiques d'un fluide comprenant ce dispositif d'analyse,procedes de mise en oeuvre et procede de criblage correspondants
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
CN103173346B (zh) 2006-11-06 2017-04-19 科隆迪亚戈有限公司 使用结合元件用于分析的装置和方法
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
US20080152543A1 (en) * 2006-11-22 2008-06-26 Hideyuki Karaki Temperature regulation method of microfluidic chip, sample analysis system and microfluidic chip
JP2008136415A (ja) * 2006-12-01 2008-06-19 Nikon Corp 観察装置
CN101711257A (zh) 2007-01-22 2010-05-19 瓦弗根公司 用于高通量化学反应的装置
WO2008091694A2 (fr) 2007-01-23 2008-07-31 Siemens Medical Solutions Usa, Inc. Système microfluidique entièrement automatisé pour réaliser la synthèse de biomarqueurs radiomarqués pour tomographie par émission de positons
WO2008115626A2 (fr) 2007-02-05 2008-09-25 Microchip Biotechnologies, Inc. Dispositifs, systèmes et applications microfluidiques et nanofluidiques
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8071035B2 (en) 2007-04-12 2011-12-06 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis system for positron emission tomography biomarkers
JP2010531295A (ja) 2007-04-12 2010-09-24 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド 陽電子放出断層撮影法バイオマーカーのためのマイクロ流体放射合成システム(関連出願)本出願は、2007年4月12日に出願された米国特許仮出願第60/923,086号明細書、2007年4月13日に出願された米国特許仮出願第60/923,407号明細書、2007年8月23日に出願された米国特許非仮出願第11/895,636号明細書、及び2008年1月11日に出願された米国特許仮出願第61/010,822号明細書に基づく優先権を主張し、それらの各々の内容が参照により全体として本明細書に組み込まれる。
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
CN103495439B (zh) * 2007-05-04 2015-09-16 欧普科诊断有限责任公司 流体连接器和微流体系统
DE102007022915A1 (de) * 2007-05-14 2008-11-20 Stiftung Caesar Center Of Advanced European Studies And Research Polymerisationssensor
BRPI0814582B1 (pt) 2007-07-23 2021-05-11 Clondiag Gmbh método, e, uso da carga viral total em uma amostra de sangue integral não tratada
WO2009015296A1 (fr) 2007-07-24 2009-01-29 The Regents Of The University Of California Générateur de gouttelettes microfabriqué
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
CA3138078C (fr) 2007-10-02 2024-02-13 Labrador Diagnostics Llc Dispositifs modulaires a utiliser sur place et leurs utilisations
DE102007054043B4 (de) * 2007-11-13 2010-02-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Modulare mikrofluidische Funktionsplattform und deren Verwendung
CN101896273B (zh) 2007-11-29 2014-10-01 国际商业机器公司 用于检测样本中的被分析物的设备和方法
US20090253181A1 (en) 2008-01-22 2009-10-08 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
EP2108451A1 (fr) * 2008-04-11 2009-10-14 Eppendorf AG Dispositif d'exécution de réactions dans des échantillons
US9533879B2 (en) 2008-06-02 2017-01-03 Bionano Genomics, Inc. Integrated analysis devices and related fabrication methods and analysis techniques
JP2010004770A (ja) * 2008-06-25 2010-01-14 Yuji Tsuji 精子検査器
JP5415538B2 (ja) 2008-07-16 2014-02-12 チルドレンズ メディカル センター コーポレーション マイクロチャネルを有する臓器模倣装置ならびにその使用および製造方法
EP4047367A1 (fr) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Procedé de détection d'analytes cibles au moyens des bibliothèques de gouttelettes
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
CA2638458A1 (fr) 2008-07-31 2010-01-31 Spartan Bioscience Inc. Recyclage thermique au moyen du positionnement d'une source de temperature allant de relative a fixe
LT2562268T (lt) 2008-09-20 2017-04-25 The Board Of Trustees Of The Leland Stanford Junior University Neinvazinis fetalinės aneuploidijos diagnozavimas sekvenavimu
WO2010040103A1 (fr) 2008-10-03 2010-04-08 Micronics, Inc. Appareil microfluidique et procédés d’exécution de détermination de groupe sanguin et épreuve de compatibilité croisée
US20110212440A1 (en) * 2008-10-10 2011-09-01 Cnrs-Dae Cell sorting device
WO2010077322A1 (fr) 2008-12-31 2010-07-08 Microchip Biotechnologies, Inc. Instrument doté d'une puce microfluidique
US9157550B2 (en) 2009-01-05 2015-10-13 The Board Of Trustees Of The University Of Illinois Microfluidic systems and methods
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
DE102009016712A1 (de) * 2009-04-09 2010-10-14 Bayer Technology Services Gmbh Einweg-Mikrofluidik-Testkassette zur Bioassay von Analyten
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
WO2010141921A1 (fr) 2009-06-05 2010-12-09 Integenx Inc. Système universel de préparation d'échantillons, et son utilisation dans un système d'analyse intégré
WO2011042564A1 (fr) 2009-10-09 2011-04-14 Universite De Strasbourg Nanomatériau marqué à base de silice à propriétés améliorées et ses utilisations
NZ599873A (en) 2009-10-19 2014-09-26 Theranos Inc Integrated health data capture and analysis system
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
WO2011079176A2 (fr) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Systèmes microfluidiques et procédés pour réduire l'échange de molécules entre des gouttelettes
WO2011100604A2 (fr) 2010-02-12 2011-08-18 Raindance Technologies, Inc. Analyse numérique d'analytes
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
JP2011220768A (ja) * 2010-04-07 2011-11-04 Sharp Corp 分析装置および分析方法
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
DE102011015184B4 (de) 2010-06-02 2013-11-21 Thinxxs Microtechnology Ag Vorrichtung für den Transport kleiner Volumina eines Fluids, insbesondere Mikropumpe oder Mikroventil
WO2012011074A2 (fr) 2010-07-22 2012-01-26 Hach Company Laboratoire-sur-puce pour une analyse d'alcalinité
WO2012024658A2 (fr) 2010-08-20 2012-02-23 IntegenX, Inc. Système d'analyse intégrée
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
WO2012045012A2 (fr) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Dosages sandwich dans des gouttelettes
ES2381721B1 (es) 2010-11-04 2013-05-06 Universitat Autónoma De Barcelona Método para determinar la producción de especies reactivas de oxígeno en una población celular.
CN103282121B (zh) * 2010-11-30 2015-11-25 康特姆斯集团有限公司 用于核酸提取和分级分离的微流体装置
CN106290160A (zh) 2011-01-21 2017-01-04 提拉诺斯公司 样品使用最大化的系统和方法
WO2012109600A2 (fr) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Procédés de formation de gouttelettes mélangées
WO2012112804A1 (fr) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions et méthodes de marquage moléculaire
EP3709018A1 (fr) 2011-06-02 2020-09-16 Bio-Rad Laboratories, Inc. Appareil microfluidique pour l'identification de composants d'une reaction chimique
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
JP5768537B2 (ja) * 2011-06-29 2015-08-26 大日本印刷株式会社 塗工液の評価方法
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
WO2013086486A1 (fr) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Systèmes microphysiologiques d'organes-sur-puce humains intégrés
WO2013108168A2 (fr) * 2012-01-16 2013-07-25 Koninklijke Philips N.V. Détermination de la présence de molécules cibles dans un fluide corporel contenant des cellules
KR101211862B1 (ko) * 2012-04-30 2012-12-12 한국기계연구원 자기장을 이용하는 자가 세포 추출장치 및 이를 이용하는 방법
CN103421683B (zh) * 2012-05-25 2015-06-17 曾勇 精子竞争受精皿及其使用方法
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US20140155295A1 (en) 2012-08-14 2014-06-05 10X Technologies, Inc. Capsule array devices and methods of use
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US20150376609A1 (en) 2014-06-26 2015-12-31 10X Genomics, Inc. Methods of Analyzing Nucleic Acids from Individual Cells or Cell Populations
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP2931919B1 (fr) 2012-12-14 2019-02-20 10X Genomics, Inc. Procédés et systèmes pour le traitement de polynucléotides
US10040018B2 (en) 2013-01-09 2018-08-07 Imagine Tf, Llc Fluid filters and methods of use
CN108753766A (zh) 2013-02-08 2018-11-06 10X基因组学有限公司 多核苷酸条形码生成
JP2016522880A (ja) 2013-03-15 2016-08-04 リチャード・ハリー・ターナー 体液内の粒子及び可溶化学物質の体外での検出のためのシステムおよび方法
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
CN110560187B (zh) 2013-11-18 2022-01-11 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
EP3071704B2 (fr) 2013-11-20 2024-06-19 Brigham and Women's Hospital, Inc. Système et procédé de tri de spermatozoïdes
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
EP3090063B1 (fr) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Procédé de détection de rétrovirus latent
CN103937658B (zh) * 2014-03-28 2015-11-04 武汉介观生物科技有限责任公司 一种稀有细胞检测芯片及其应用
CA2943624A1 (fr) 2014-04-10 2015-10-15 10X Genomics, Inc. Dispositifs fluidiques, systemes et procedes permettant d'encapsuler et de separer des reactifs, et leurs applications
US9861920B1 (en) 2015-05-01 2018-01-09 Imagine Tf, Llc Three dimensional nanometer filters and methods of use
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
AU2015276638B2 (en) 2014-06-18 2019-05-16 Zoetis Denmark Aps A microfluidic detection system and a microfluidic cartridge
US10730047B2 (en) 2014-06-24 2020-08-04 Imagine Tf, Llc Micro-channel fluid filters and methods of use
EP4235677A3 (fr) 2014-06-26 2023-11-22 10X Genomics, Inc. Procédés et systèmes pour l'assemblage de séquences d'acide nucléique
US10124275B2 (en) 2014-09-05 2018-11-13 Imagine Tf, Llc Microstructure separation filters
JP6509330B2 (ja) * 2014-09-05 2019-05-08 イマジン ティーエフ,エルエルシー 微細構造分離フィルタ
MX2017003454A (es) 2014-09-23 2017-11-13 Tearlab Res Inc Sistemas y metodos para la integracion de la recoleccion de microfluido lagrimal y el analisis por flujo lateral de analitos de interes.
EP3201309A4 (fr) * 2014-09-30 2018-07-11 Dxnow Inc. Systèmes et procédés de détermination d'échantillons probants et d'isolement et de quantification de cellules
EP3552690B1 (fr) 2014-10-22 2024-09-25 IntegenX Inc. Systèmes et procédés de préparation, de traitement et d'analyse d'échantillons
EP3212807B1 (fr) 2014-10-29 2020-09-02 10X Genomics, Inc. Procédés et compositions de séquençage ciblé d'acides nucléiques
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
WO2016115273A1 (fr) 2015-01-13 2016-07-21 10X Genomics, Inc. Systèmes et procédés de visualisation d'informations de variation structurelle et de phasage
AU2016219480B2 (en) 2015-02-09 2021-11-11 10X Genomics, Inc. Systems and methods for determining structural variation and phasing using variant call data
JP6466193B2 (ja) * 2015-02-16 2019-02-06 国立研究開発法人産業技術総合研究所 赤血球凝集検出装置および検出方法
US10758849B2 (en) 2015-02-18 2020-09-01 Imagine Tf, Llc Three dimensional filter devices and apparatuses
EP3822361A1 (fr) 2015-02-20 2021-05-19 Takara Bio USA, Inc. Procédé permettant une distribution, une visualisation et une analyse précises et rapides de cellules individuelles
US10697000B2 (en) 2015-02-24 2020-06-30 10X Genomics, Inc. Partition processing methods and systems
AU2016222719B2 (en) 2015-02-24 2022-03-31 10X Genomics, Inc. Methods for targeted nucleic acid sequence coverage
WO2016209735A1 (fr) 2015-06-22 2016-12-29 Fluxergy, Llc Système d'imagerie à caméra pour dosage d'échantillon de fluide et procédé d'utilisation associé
EP4276445A3 (fr) * 2015-06-22 2024-05-15 FluxErgy, Inc. Carte d'essai pour analyse et son procédé de fabrication
US11371091B2 (en) 2015-06-22 2022-06-28 Fluxergy, Inc. Device for analyzing a fluid sample and use of test card with same
US10214772B2 (en) 2015-06-22 2019-02-26 Fluxergy, Llc Test card for assay and method of manufacturing same
US10118842B2 (en) 2015-07-09 2018-11-06 Imagine Tf, Llc Deionizing fluid filter devices and methods of use
EP3325966B1 (fr) 2015-07-20 2021-01-20 Sentilus Holdco, LLC Puces, détecteurs et leurs procédés de fabrication et d'utilisation
US10479046B2 (en) 2015-08-19 2019-11-19 Imagine Tf, Llc Absorbent microstructure arrays and methods of use
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN105203523A (zh) * 2015-09-25 2015-12-30 中国计量学院 一种基于sers技术检测血清中特异性抗原的微流装置
CN115369161A (zh) 2015-12-04 2022-11-22 10X 基因组学有限公司 用于核酸分析的方法和组合物
WO2017098321A1 (fr) 2015-12-11 2017-06-15 Spartan Bioscience Inc. Système et procédés de fermeture étanche de tubes pour l'amplification d'acide nucléique
US11618882B2 (en) * 2016-01-22 2023-04-04 The Board Of Trustees Of The Leland Stanford Junior University Micro-fluidic device for selective sorting of highly motile and morphologically normal sperm from unprocessed semen
WO2017138984A1 (fr) 2016-02-11 2017-08-17 10X Genomics, Inc. Systèmes, procédés, et milieux destinés à l'assemblage de novo de données de séquence du génome entier
JP6846434B2 (ja) * 2016-04-29 2021-03-24 クレオプティクス・アーゲーCreoptix Ag 分子を回収するための方法およびアセンブリ
WO2017197338A1 (fr) 2016-05-13 2017-11-16 10X Genomics, Inc. Systèmes microfluidiques et procédés d'utilisation
CA3029682A1 (fr) * 2016-06-30 2018-01-04 Click Diagnostics, Inc. Dispositifs et methodes d'extraction d'acides nucleiques
JP7075394B2 (ja) 2016-07-21 2022-05-25 タカラ バイオ ユーエスエー, インコーポレイテッド マルチウェルデバイスを用いたマルチz撮像及び分注
JP6584373B2 (ja) * 2016-08-01 2019-10-02 日本板硝子株式会社 反応処理装置および反応処理方法
CN109844091B (zh) * 2016-11-01 2022-12-30 日本板硝子株式会社 反应处理容器及反应处理装置
IT201700004589A1 (it) * 2016-12-01 2018-06-01 Cellply S R L Kit e metodo per l’immissione di uno o più fluidi in un dispositivo microfluidico
DE102016224446A1 (de) * 2016-12-08 2018-06-14 Siemens Aktiengesellschaft Gehäusestruktur mit einer Kavität und einer mit dieser verbundenen Probenkammer und Verfahren zu deren Herstellung
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2018140966A1 (fr) 2017-01-30 2018-08-02 10X Genomics, Inc. Procédés et systèmes de codage à barres de cellules individuelles sur la base de gouttelettes
CN110870018A (zh) 2017-05-19 2020-03-06 10X基因组学有限公司 用于分析数据集的系统和方法
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
EP4230746A3 (fr) 2017-05-26 2023-11-01 10X Genomics, Inc. Analyse de cellule unique de chromatine accessible par transposase
CN110785491A (zh) * 2017-06-23 2020-02-11 日本板硝子株式会社 反应处理装置
KR101899733B1 (ko) 2017-09-27 2018-09-17 재단법인 구미전자정보기술원 혈액 내의 타겟 물질 검출 방법 및 장치
CN107884573B (zh) * 2017-10-24 2020-03-24 天津大学 基于反向荧光增强的高灵敏可视化双模态急性心肌梗塞免疫层析试纸条制备和检测方法
CN111051523B (zh) 2017-11-15 2024-03-19 10X基因组学有限公司 功能化凝胶珠
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
JP6864609B2 (ja) * 2017-11-27 2021-04-28 株式会社日立製作所 光学分析装置、物質の製造システム、物質の製造方法、及びプログラム
US20190292511A1 (en) * 2018-03-20 2019-09-26 Owl biomedical, Inc. Microfabricated particle manipulation device
SG11202009889VA (en) 2018-04-06 2020-11-27 10X Genomics Inc Systems and methods for quality control in single cell processing
TWI672136B (zh) * 2019-02-01 2019-09-21 國立清華大學 精子分選器與精子分選方法
DE102019106194B4 (de) * 2019-03-12 2020-12-03 Surflay Nanotec Gmbh Vorrichtung zur spektroskopischen Bestimmung der Bindungskinetik eines Analyten
JP6652677B2 (ja) * 2019-09-03 2020-02-26 日本板硝子株式会社 反応処理装置および反応処理方法
JP6876162B2 (ja) * 2020-01-23 2021-05-26 日本板硝子株式会社 反応処理装置および反応処理方法
US20230131184A1 (en) * 2020-03-30 2023-04-27 Hewlett-Packard Development Company, L.P. Intermittent warming of a biologic sample including a nucleic acid
CN115097096B (zh) * 2022-08-22 2022-12-13 天津美腾科技股份有限公司 避障检测系统及方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350768A (en) * 1980-09-19 1982-09-21 Bristol Myers Company Method for preparing single cell suspension
GB2131972A (en) * 1982-12-14 1984-06-27 Bums Ben Zion Hai Channelled surface and cover for determining sperm quality
US4676274A (en) * 1985-02-28 1987-06-30 Brown James F Capillary flow control
US4756884A (en) * 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US4790640A (en) * 1985-10-11 1988-12-13 Nason Frederic L Laboratory slide
US4999283A (en) * 1986-01-10 1991-03-12 University Of Kentucky Research Foundation Method for x and y spermatozoa separation
US4911782A (en) * 1988-03-28 1990-03-27 Cyto-Fluidics, Inc. Method for forming a miniaturized biological assembly
GB2220003B (en) * 1988-10-20 1993-03-10 Wang Fu Nan A method and device for separating motile cells from less motile cells in a mixed cell sample.
GB8903046D0 (en) * 1989-02-10 1989-03-30 Vale David R Testing of liquids
CA2016981C (fr) * 1989-06-12 1994-09-27 Mark Joseph Devaney, Jr. Regulateur de temperature et cuve a reaction
GB8917963D0 (en) * 1989-08-05 1989-09-20 Scras Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples
DE4028771A1 (de) * 1989-09-14 1991-02-21 Bert Sobolewski Verfahren zur trennung von parasiten, organellen o. dgl. von den sie umgebenden biologischen membranen
AU642444B2 (en) * 1989-11-30 1993-10-21 Mochida Pharmaceutical Co., Ltd. Reaction vessel
IL92884A0 (en) * 1989-12-26 1990-09-17 United Med Syst Israel Ltd Method and apparatus for measuring the motility of sperm cells
GB9008044D0 (en) * 1990-04-09 1990-06-06 Hatfield Polytechnic Higher Ed Microfabricated device for biological cell sorting
SE470347B (sv) * 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
EP0486117B1 (fr) * 1990-06-28 1996-02-07 EDKO Trading and Representation Co., Ltd Formulation pharmaceutique multiphasique
WO1993022058A1 (fr) * 1992-05-01 1993-11-11 Trustees Of The University Of Pennsylvania Analyse par amplification de polynucleotide a l'aide d'un dispositif micro-fabrique

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DE69303898T3 (de) 2007-01-18
DE69303483T2 (de) 1997-02-06
DE69319427D1 (de) 1998-08-06
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EP0639223A1 (fr) 1995-02-22
CA2134476A1 (fr) 1993-11-11
DE69303898D1 (de) 1996-09-05
EP0637999A1 (fr) 1995-02-15
CA2134478A1 (fr) 1993-11-11
AU677780B2 (en) 1997-05-08
CA2134474C (fr) 1999-07-06
CA2134476C (fr) 1999-08-10
JP3207424B2 (ja) 2001-09-10
CA2134478C (fr) 2001-12-18
ATE140880T1 (de) 1996-08-15
EP0637997A1 (fr) 1995-02-15
WO1993022421A1 (fr) 1993-11-11
EP0637999B1 (fr) 1998-12-23
HK1001305A1 (en) 1998-06-12
ES2127276T3 (es) 1999-04-16
WO1993022055A3 (fr) 1994-03-03
AU677781B2 (en) 1997-05-08
JPH07506256A (ja) 1995-07-13
AU674685B2 (en) 1997-01-09
JP3558294B2 (ja) 2004-08-25
JPH07506431A (ja) 1995-07-13
EP0637998B2 (fr) 2006-04-12
JP3298882B2 (ja) 2002-07-08
EP0637998A1 (fr) 1995-02-15
DE69322774T2 (de) 1999-06-17
AU677197B2 (en) 1997-04-17
AU4222393A (en) 1993-11-29
DE69322774D1 (de) 1999-02-04
DE69312483T2 (de) 1998-02-12
JPH07506257A (ja) 1995-07-13
EP0639223B1 (fr) 1996-07-03
CA2134475A1 (fr) 1993-11-11
WO1993022054A1 (fr) 1993-11-11
ATE140025T1 (de) 1996-07-15
CA2134477C (fr) 1999-07-06
DE69312483D1 (de) 1997-09-04
EP0637996B1 (fr) 1997-07-23
DE69319427T2 (de) 1998-12-10
ATE155711T1 (de) 1997-08-15
EP0637998B1 (fr) 1996-07-31
WO1993022058A1 (fr) 1993-11-11
ES2106341T3 (es) 1997-11-01
EP0637996A1 (fr) 1995-02-15
AU4222793A (en) 1993-11-29
WO1993022055A2 (fr) 1993-11-11
ATE167816T1 (de) 1998-07-15
AU4222593A (en) 1993-11-29
DE69303483D1 (de) 1996-08-08
AU4222693A (en) 1993-11-29
CA2134475C (fr) 1999-07-06
AU680195B2 (en) 1997-07-24
ATE174813T1 (de) 1999-01-15
AU4223593A (en) 1993-11-29
CA2134474A1 (fr) 1993-11-11
JPH07506430A (ja) 1995-07-13

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