HK1143738A1 - Ido inhibitors ido - Google Patents

Ido inhibitors ido

Info

Publication number
HK1143738A1
HK1143738A1 HK10110228.1A HK10110228A HK1143738A1 HK 1143738 A1 HK1143738 A1 HK 1143738A1 HK 10110228 A HK10110228 A HK 10110228A HK 1143738 A1 HK1143738 A1 HK 1143738A1
Authority
HK
Hong Kong
Prior art keywords
indoleamine
dioxygenase
compound
administering
aspects described
Prior art date
Application number
HK10110228.1A
Other languages
English (en)
Inventor
Mario Mautino
Firoz Jaipuri
Agnieszka Marcinowicz-Flick
Tanay Kesharwani
Jesse Waldo
Steven James Collier
Original Assignee
Newlink Genetics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newlink Genetics filed Critical Newlink Genetics
Publication of HK1143738A1 publication Critical patent/HK1143738A1/xx

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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Families Citing this family (266)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
WO2010074588A2 (en) 2008-12-24 2010-07-01 BIAL - PORTELA & Cª, S.A. Pharmaceutical compounds
SG175707A1 (en) 2009-06-10 2011-12-29 Chugai Pharmaceutical Co Ltd Tetracyclic compound
CA2689707A1 (en) 2009-11-16 2011-05-16 Jean-Simon Diallo Identification of the novel small molecule viral sensitizer vse1 using high-throughput screening
EP2641906B1 (en) 2009-07-08 2015-04-22 Dermira (Canada), Inc. Tofa analogs useful in treating dermatological disorders or conditions
WO2011011186A2 (en) * 2009-07-22 2011-01-27 The Board Of Trustees Of The University Of Illinois Hdac inhibitors and therapeutic methods using the same
US8722720B2 (en) 2009-10-28 2014-05-13 Newlink Genetics Corporation Imidazole derivatives as IDO inhibitors
RU2012136451A (ru) 2010-01-28 2014-03-10 Президент Энд Феллоуз Оф Гарвард Колледж Композиции и способы улучшения активности протеасомы
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
WO2011124697A1 (en) * 2010-04-09 2011-10-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Antimicrobial compounds of 1,4- naphtoquinone structure
NZ608312A (en) * 2010-08-20 2015-02-27 Chugai Pharmaceutical Co Ltd Composition containing tetracyclic compound
JP5006987B2 (ja) * 2010-11-22 2012-08-22 中外製薬株式会社 ４環性化合物を含む医薬
AU2012212323A1 (en) 2011-02-01 2013-09-12 The Board Of Trustees Of The University Of Illinois HDAC inhibitors and therapeutic methods using the same
NO2694640T3 (xx) 2011-04-15 2018-03-17
DK2707101T3 (da) 2011-05-12 2019-05-13 Proteostasis Therapeutics Inc Proteostaseregulatorer
US9878998B2 (en) 2011-08-18 2018-01-30 Nuhope Llc Barbiturate and thiobarbiturate compounds for use in cancer therapy
DE102011114780A1 (de) * 2011-10-01 2013-04-04 Merck Patent Gmbh Verwendung von Propanol- und Propenolderivaten als Antioxidantien
JP6099149B2 (ja) * 2011-10-25 2017-03-22 塩野義製薬株式会社 Ｈｉｖ複製阻害剤
EP2771341A4 (en) * 2011-10-28 2015-09-23 Univ Texas NEW COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER
CA2857193A1 (en) * 2011-11-29 2013-06-06 Beta Pharma Canada Inc. Heterocyclic amides compounds which are hdac6 inhibitors and used as anti-tumoral agents
AU2013205306B2 (en) 2012-03-16 2015-09-17 Axikin Pharmaceuticals, Inc. 3,5-diaminopyrazole kinase inhibitors
EP2671575A1 (en) * 2012-06-04 2013-12-11 Universität Regensburg Ras inhibitors
EP2682119A1 (en) * 2012-07-03 2014-01-08 Université Libre de Bruxelles Aromatic N-heterocycle derivatives for use as medicine
KR102137180B1 (ko) 2012-09-21 2020-07-24 로드아일랜드하스피틀 암 치료를 위한 베타-하이드록실라제의 억제제
WO2014047232A2 (en) * 2012-09-21 2014-03-27 Cornell University C-rel inhibitors and uses thereof
WO2014050781A1 (ja) 2012-09-25 2014-04-03 中外製薬株式会社 Ｒｅｔ阻害剤
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CA2895392A1 (en) 2012-12-28 2014-07-03 The Board Of Trustees Of The University Of Arkansas Indole compounds for use in treating inflammation and cancer
US9849135B2 (en) 2013-01-25 2017-12-26 President And Fellows Of Harvard College USP14 inhibitors for treating or preventing viral infections
PE20151593A1 (es) 2013-03-14 2015-11-05 Newlink Genetics Corp Compuestos triciclicos como inhibidores de la inmunosupresion mediada por el metabolismo del triptofano
PT2968284T (pt) 2013-03-14 2021-06-28 Osteoqc Inc Derivados alquilamina de harmina para promoção de crescimento ósseo
SG11201507395PA (en) * 2013-03-14 2015-10-29 Curadev Pharma Private Ltd Inhibitors of the kynurenine pathway
AU2014254078A1 (en) 2013-04-19 2015-10-15 Bioventures, Llc Combretastatin analogs
KR101642587B1 (ko) 2013-08-23 2016-07-25 가톨릭대학교 산학협력단 바이구아나이드 유도체 화합물을 유효성분으로 포함하는 면역질환 또는 염증질환의 예방 또는 치료용 약제학적 조성물
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
DK3466949T3 (da) 2013-12-24 2021-03-15 Bristol Myers Squibb Co Tricyklisk forbindelse som anticancermidler
AU2015240880A1 (en) 2014-03-31 2016-09-15 Bioventures, Llc Disubstituted triazole analogs
EP3126362B1 (en) 2014-04-02 2022-01-12 Intermune, Inc. Anti-fibrotic pyridinones
KR20170002410A (ko) 2014-04-03 2017-01-06 오거스타 유니버시티 리서치 인스티튜트, 인크. 종양 유도 면역 반응의 효능을 향상시키는 방법
MX2016013735A (es) 2014-04-25 2017-03-09 Chugai Pharmaceutical Co Ltd Cristales novedosos de compuesto tetraciclico.
US10350214B2 (en) 2014-04-25 2019-07-16 Chugai Seiyaku Kabushiki Kaisha Preparation containing tetracyclic compound at high dose
WO2015167243A1 (ko) * 2014-04-29 2015-11-05 가톨릭대학교 산학협력단 면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도
JP6462002B2 (ja) * 2014-04-29 2019-01-30 ザ カトリック ユニバーシティ オブ コリア インダストリー−アカデミック コーオペレイション ファウンデーション 免疫疾患治療効果を有する新規化合物およびその使用
US20170298056A1 (en) * 2014-05-08 2017-10-19 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of hiv-1 entry and methods of use thereof
SG10201810507WA (en) 2014-06-06 2018-12-28 Bristol Myers Squibb Co Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
JP6616790B2 (ja) 2014-06-27 2019-12-04 ノグラ ファーマ リミテッド アリール受容体モジュレーターならびにその作製および使用方法
US10519160B2 (en) 2014-07-18 2019-12-31 The General Hospital Corporation Imaging agents for neural flux
TWI803187B (zh) 2014-08-08 2023-05-21 日商中外製藥股份有限公司 包含４環性化合物的非晶質體之固體分散體及製劑
KR20170034439A (ko) 2014-08-13 2017-03-28 오클랜드 유니서비시즈 리미티드 트립토판 디옥시게나제 (ido1 및 tdo)의 억제제 및 치료에서 이들의 용도
CA2959414C (en) 2014-09-05 2023-03-14 Symbiomix Therapeutics, Llc Secnidazole for use in the treatment of bacterial vaginosis
NZ731633A (en) 2014-11-21 2022-01-28 Bristol Myers Squibb Co Antibodies against cd73 and uses thereof
US10525035B2 (en) 2014-12-18 2020-01-07 Lankenau Institute For Medical Research Methods and compositions for the treatment of retinopathy and other ocular diseases
AR103232A1 (es) 2014-12-22 2017-04-26 Bristol Myers Squibb Co ANTAGONISTAS DE TGFbR
AU2015369690B2 (en) 2014-12-23 2019-01-17 SMA Therapeutics Inc. 3,5-diaminopyrazole kinase inhibitors
SG10202006538TA (en) 2014-12-23 2020-08-28 Bristol Myers Squibb Co Antibodies to tigit
BR112017013982A2 (pt) 2015-01-16 2018-01-02 Chugai Seiyaku Kabushiki Kaisha fármaco de combinação
US20180305345A1 (en) * 2015-01-26 2018-10-25 Ottawa Hospital Research Institute Compositions and methods for enhancing oncolytic virus efficacy
US10983128B2 (en) 2015-02-05 2021-04-20 Bristol-Myers Squibb Company CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy
KR20170122799A (ko) 2015-03-02 2017-11-06 리겔 파마슈티칼스, 인크. TGF-β 억제제
PE20180117A1 (es) 2015-04-03 2018-01-18 Bristol Myers Squibb Co Inhibidores de indolamina-2,3-dioxigenasa para el tratamiento de cancer
WO2016162505A1 (en) 2015-04-08 2016-10-13 F-Star Biotechnology Limited Her2 binding agent therapies
CN114681608A (zh) 2015-04-13 2022-07-01 戊瑞治疗有限公司 癌症组合疗法
CA3020090A1 (en) * 2015-04-24 2016-10-27 University Of Louisville Research Foundation, Inc. Selective pfkfb4 inhibitors for the treatment of cancer
US10683290B2 (en) 2015-05-11 2020-06-16 Bristol-Myers Squibb Company Tricyclic compounds as anticancer agents
US9725449B2 (en) 2015-05-12 2017-08-08 Bristol-Myers Squibb Company Tricyclic compounds as anticancer agents
EP3307740B1 (en) 2015-05-12 2019-12-18 Bristol-Myers Squibb Company 5h-pyrido[3,2-b]indole compounds as anticancer agents
CN106176709B (zh) * 2015-05-26 2020-02-07 顺天乡大学校产学协力团 治疗结核病用药物组合物及其制备方法
PE20180926A1 (es) 2015-05-29 2018-06-08 Bristol Myers Squibb Co Anticuerpos contra el miembro 4 de la superfamilia del receptor del factor de necrosis tumoral (ox40) y sus usos
CN107922383A (zh) * 2015-06-12 2018-04-17 新加坡国立大学 选择性抗癌化合物
JP2018526977A (ja) 2015-06-29 2018-09-20 ザ ロックフェラー ユニヴァーシティ アゴニスト活性が増強されたｃｄ４０に対する抗体
WO2017009842A2 (en) 2015-07-16 2017-01-19 Biokine Therapeutics Ltd. Compositions and methods for treating cancer
MA43294A1 (fr) 2015-07-24 2020-04-30 Newlink Genetics Corp Sels et promédicaments de 1-méthyl -d-tryptophane
KR20180034548A (ko) 2015-07-28 2018-04-04 브리스톨-마이어스 스큅 컴퍼니 Tgf 베타 수용체 길항제
CN108349976A (zh) 2015-08-25 2018-07-31 百时美施贵宝公司 TGFβ受体拮抗剂
AU2016312848A1 (en) 2015-08-27 2018-03-29 Auckland Uniservices Limited Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
WO2017062354A1 (en) * 2015-10-05 2017-04-13 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors and immuno-oncology agents
JP6936221B2 (ja) 2015-11-02 2021-09-15 ファイブ プライム セラピューティクス， インコーポレイテッド Ｃｄ８０細胞外ドメインポリペプチドと、がん治療でのそれらの使用
WO2017087678A2 (en) 2015-11-19 2017-05-26 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
RU2021107536A (ru) 2015-11-23 2021-07-02 Файв Прайм Терапьютикс, Инк. Ингибиторы fgfr2 отдельно или в комбинации с иммуностимулирующими агентами в лечении рака
CN105884767B (zh) * 2015-11-24 2018-01-19 西华大学 9‑位取代的吡啶并[3,4‑b]吲哚衍生物及其制备方法和作为SIRT蛋白抑制剂的用途
JP6856648B2 (ja) 2015-12-15 2021-04-07 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃｘｃｒ４受容体アンタゴニスト
WO2017107979A1 (en) 2015-12-24 2017-06-29 Genentech, Inc. Tdo2 inhibitors
CN105503692B (zh) * 2015-12-27 2017-12-26 新乡医学院 一种α‑拉帕醇类似物及其合成方法和作为抗肿瘤药物的应用
CN105616408B (zh) * 2016-01-11 2019-03-08 西华大学 吡啶并[3,4-b]吲哚衍生物作为IDO抑制剂的用途
CN107619392B (zh) * 2016-07-15 2021-01-01 西华大学 1h-吲唑-4-醚类化合物及其作为ido抑制剂的用途
US11752131B2 (en) 2016-02-19 2023-09-12 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of obesity
CN107118209B (zh) * 2016-02-25 2019-06-25 西华大学 吡啶骈[3,4-b]吲哚脲类化合物及其作为IDO抑制剂的用途
EP3398942B1 (en) 2016-02-25 2021-01-27 Shenzhen TargetRx, Inc. Substituted oxadiazole chemical compound and composition containing said chemical compound and use thereof
EA201891983A8 (ru) 2016-03-04 2020-05-28 Бристол-Майерс Сквибб Компани Комбинированная терапия антителами к cd73
CN109071457A (zh) * 2016-03-09 2018-12-21 荷兰转化研究中心有限责任公司 吲哚胺2,3-双加氧酶的抑制剂
CN105801553B (zh) * 2016-04-12 2018-06-19 爱斯特（成都）生物制药股份有限公司 一种苯并色烯衍生物的制备方法
EA201892362A1 (ru) 2016-04-18 2019-04-30 Селлдекс Терапьютикс, Инк. Агонистические антитела, которые связываются с cd40 человека, и варианты их применения
WO2017192815A1 (en) 2016-05-04 2017-11-09 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
EP3452029A4 (en) 2016-05-04 2019-10-30 Bristol-Myers Squibb Company INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS AND METHODS OF USE
CN109414421A (zh) 2016-05-04 2019-03-01 百时美施贵宝公司 吲哚胺2,3-双加氧酶的抑制剂及其使用方法
CN109348714A (zh) 2016-05-04 2019-02-15 百时美施贵宝公司 吲哚胺2,3-双加氧酶的抑制剂及其使用方法
WO2017192813A1 (en) 2016-05-04 2017-11-09 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
SG11201900026TA (en) 2016-07-14 2019-01-30 Bristol Myers Squibb Co Antibodies against tim3 and uses thereof
WO2018017633A1 (en) 2016-07-21 2018-01-25 Bristol-Myers Squibb Company TGF Beta RECEPTOR ANTAGONISTS
AU2017315572B2 (en) * 2016-08-23 2021-07-15 Beijing Innocare Pharma Tech Co., Ltd. Fused heterocyclic derivative, preparation method therefor and medical use thereof
US11351164B2 (en) 2016-08-26 2022-06-07 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
EP3515914A4 (en) 2016-09-24 2020-04-15 BeiGene, Ltd. NEW IMIDAZO [1,5-A] PYRIDINES SUBSTITUTED IN POSITION 5 OR 8 AS INDOLEAMINE AND / OR TRYPTOPHANE 2,3-DIOXYGENASES
JP6902748B2 (ja) * 2016-09-29 2021-07-14 雪印種苗株式会社 植物成長調整剤
MA46649A (fr) 2016-10-13 2019-08-21 Juno Therapeutics Inc Méthodes et compositions d'immunothérapie impliquant des modulateurs de la voie métabolique du tryptophane
WO2018083635A2 (en) 2016-11-04 2018-05-11 Auckland Uniservices Limited Tricyclic heterocyclic derivatives and uses thereof
EP3321264A1 (en) * 2016-11-14 2018-05-16 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Selective inhibitors of genotoxic stress-induced ikk/nf-kb pathways
CN108203438B (zh) 2016-12-20 2021-09-28 深圳微芯生物科技股份有限公司 具有吲哚胺2,3-双加氧酶抑制活性的稠合咪唑化合物
ES2970715T3 (es) 2016-12-22 2024-05-30 Prec Pharmaceuticals Inc Composiciones y métodos para inhibir la actividad de la arginasa
US10961239B2 (en) 2017-01-05 2021-03-30 Bristol-Myers Squibb Company TGF beta receptor antagonists
US11173145B2 (en) 2017-01-17 2021-11-16 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
EP3592747A1 (en) 2017-03-10 2020-01-15 Council of Scientific and Industrial Research Spirooxindole compounds as gsk3 inhibitors and process for preparation thereof
CA3057687A1 (en) 2017-03-31 2018-10-04 Five Prime Therapeutics, Inc. Combination therapy for cancer using anti-gitr antibodies
TWI788340B (zh) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 抗icos促效劑抗體及其用途
MX2019012431A (es) 2017-04-21 2020-08-03 Ikena Oncology Inc Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
EP3628070B1 (en) 2017-04-28 2021-09-08 Five Prime Therapeutics, Inc. Cd80 extracellular domain polypeptides for use in increasing central memory t cells
US11066392B2 (en) 2017-05-12 2021-07-20 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
WO2019006047A1 (en) 2017-06-28 2019-01-03 Genentech, Inc. INHIBITORS OF TDO2 AND IDO1
WO2019005559A1 (en) 2017-06-28 2019-01-03 Genentech, Inc. INHIBITORS OF TDO2 AND IDO1
IL271601B2 (en) 2017-06-30 2024-05-01 Bristol Myers Squibb Co Amorphous and crystalline forms of IDO inhibitors
KR20200032180A (ko) 2017-07-28 2020-03-25 브리스톨-마이어스 스큅 컴퍼니 항암제로서의 시클릭 디뉴클레오티드
WO2019025426A1 (en) 2017-07-31 2019-02-07 Horitzonts Tecnologics Hungary Korlátolt Felelosségu Társaság COMPOUNDS FOR TREATING INFECTIONS
KR20200051646A (ko) 2017-08-17 2020-05-13 이케나 온콜로지, 인코포레이티드 Ahr 억제제 및 이의 용도
US10953032B2 (en) 2017-08-31 2021-03-23 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
US11708330B2 (en) 2017-08-31 2023-07-25 University Of Louisville Research Foundation, Inc. Compounds, compositions, methods for treating diseases, and methods for preparing compounds
US10947263B2 (en) 2017-08-31 2021-03-16 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
JP7316263B2 (ja) 2017-08-31 2023-07-27 ブリストル－マイヤーズ スクイブ カンパニー 抗癌剤としての環状ジヌクレオチド
WO2019051198A1 (en) * 2017-09-08 2019-03-14 Lankenau Institute For Medical Research INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE-1 (JDO1) PRODRUGS
US11358948B2 (en) 2017-09-22 2022-06-14 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
MX2020003190A (es) 2017-09-22 2020-11-11 Kymera Therapeutics Inc Degradadores de proteinas y usos de los mismos.
WO2019074822A1 (en) 2017-10-09 2019-04-18 Bristol-Myers Squibb Company INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS AND METHODS OF USE
US11203592B2 (en) 2017-10-09 2021-12-21 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
CN111344297B (zh) 2017-10-10 2023-10-20 百时美施贵宝公司 作为抗癌剂的环二核苷酸
WO2019075090A1 (en) 2017-10-10 2019-04-18 Tilos Therapeutics, Inc. ANTI-LAP ANTIBODIES AND USES THEREOF
KR20200065065A (ko) 2017-10-16 2020-06-08 브리스톨-마이어스 스큅 컴퍼니 항암제로서의 시클릭 디뉴클레오티드
US10774046B2 (en) 2017-10-26 2020-09-15 University Of Louisville Research Foundation, Inc. Inhibitors for the treatment of cancer and related methods
KR20200074214A (ko) 2017-11-01 2020-06-24 브리스톨-마이어스 스큅 컴퍼니 암을 치료하는데 사용하기 위한 면역자극 효능작용 항체
JP7167146B2 (ja) 2017-11-06 2022-11-08 ブリストル－マイヤーズ スクイブ カンパニー Ｈｐｋ１阻害剤として有用なイソフラノン化合物
US11498904B2 (en) 2017-11-14 2022-11-15 Merck Sharp & Dohme Llc Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
JP2021508703A (ja) 2017-12-26 2021-03-11 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋ分解剤およびそれらの使用
EP3732198A1 (en) 2017-12-27 2020-11-04 Bristol-Myers Squibb Company Anti-cd40 antibodies and uses thereof
WO2019136112A1 (en) 2018-01-05 2019-07-11 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
CN111886255A (zh) 2018-01-12 2020-11-03 百时美施贵宝公司 抗tim3抗体及其用途
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US10988477B2 (en) 2018-01-29 2021-04-27 Merck Patent Gmbh GCN2 inhibitors and uses thereof
TW201940481A (zh) 2018-01-29 2019-10-16 美商維泰克斯製藥公司 Gcn2抑制劑及其用途
US10519187B2 (en) 2018-02-13 2019-12-31 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
JP7250808B2 (ja) 2018-03-08 2023-04-03 ブリストル－マイヤーズ スクイブ カンパニー 抗がん剤としての環状ジヌクレオチド
JP2021518367A (ja) 2018-03-20 2021-08-02 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． Ｉｄｏおよびｔｄｏ調節のための化合物および方法、ならびにそれらのための兆候
CN111971304A (zh) 2018-03-21 2020-11-20 戊瑞治疗有限公司 在酸性pH结合至VISTA的抗体
TW202003565A (zh) 2018-03-23 2020-01-16 美商必治妥美雅史谷比公司 抗mica及/或micb抗體及其用途
EP3773714A1 (en) 2018-04-12 2021-02-17 Bristol-Myers Squibb Company Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody
CN112292128A (zh) 2018-04-16 2021-01-29 阿瑞斯医疗有限公司 Ep4抑制剂和其用途
WO2019213340A1 (en) 2018-05-03 2019-11-07 Bristol-Myers Squibb Company Uracil derivatives as mer-axl inhibitors
EA202092723A1 (ru) * 2018-05-09 2021-04-09 Зе Юниверсити Оф Чикаго Композиции и способы, касающиеся иммунной толерантности
CN110526898A (zh) * 2018-05-25 2019-12-03 北京诺诚健华医药科技有限公司 3-吲唑啉酮类化合物、其制备方法及其在医药学上的应用
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
EP3814347B1 (en) 2018-06-27 2023-05-03 Bristol-Myers Squibb Company Naphthyridinone compounds useful as t cell activators
FI3814348T3 (fi) 2018-06-27 2023-09-22 Bristol Myers Squibb Co Substituoituja naftyridinoniyhdisteitä, jotka ovat käyttökelpoisia t-solun aktivoijina
WO2020010177A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
EP3820904A2 (en) 2018-07-09 2021-05-19 Five Prime Therapeutics, Inc. Antibodies binding to ilt4
JP2022513421A (ja) 2018-07-11 2022-02-08 ファイブ プライム セラピューティクス， インコーポレイテッド 酸性ｐＨでＶＩＳＴＡと結合する抗体
WO2020018670A1 (en) 2018-07-17 2020-01-23 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
US20210299126A1 (en) 2018-07-23 2021-09-30 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US20210355113A1 (en) 2018-07-23 2021-11-18 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
CA3109104A1 (en) 2018-08-14 2020-02-20 Osteoqc Inc. Fluoro .beta.-carboline compounds
WO2020037004A1 (en) 2018-08-14 2020-02-20 Osteoqc Inc. Pyrrolo - dipyridine compounds
US11253525B2 (en) 2018-08-29 2022-02-22 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US10959986B2 (en) 2018-08-29 2021-03-30 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
KR102635225B1 (ko) 2018-09-04 2024-02-07 추가이 세이야쿠 가부시키가이샤 4환성 화합물의 제조방법
CN113164419A (zh) 2018-09-07 2021-07-23 皮克医疗公司 Eif4e抑制剂和其用途
CN110950749B (zh) * 2018-09-26 2023-07-25 中国科学院广州生物医药与健康研究院 Ido抑制剂及其制备方法和应用
US20210379052A1 (en) 2018-09-27 2021-12-09 Shenzhen Chipscreen Biosciences Co., Ltd. Quinoline derivative having indoleamine-2,3-dioxygenase inhibitory activity
CN113164780A (zh) 2018-10-10 2021-07-23 泰洛斯治疗公司 抗lap抗体变体及其用途
US11274150B2 (en) 2018-11-16 2022-03-15 Bristol-Myers Squibb Company Anti-human natural killer cell inhibitory receptor group 2A protein (NKG2A) antibodies
CA3119773A1 (en) 2018-11-30 2020-06-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
EP3670659A1 (en) 2018-12-20 2020-06-24 Abivax Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
WO2020187998A1 (en) 2019-03-19 2020-09-24 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Combination therapy with omomyc and an antibody binding pd-1 or ctla-4 for the treatment of cancer
AU2020253990A1 (en) 2019-04-02 2021-10-28 Bicycletx Limited Bicycle toxin conjugates and uses thereof
TW202106676A (zh) 2019-04-05 2021-02-16 美商凱麥拉醫療公司 Stat降解劑及其用途
WO2020231766A1 (en) 2019-05-13 2020-11-19 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
US12012374B2 (en) 2019-05-13 2024-06-18 Bristol-Myers Squibb Company Agonists of ROR GAMMAt
TW202110801A (zh) * 2019-05-16 2021-03-16 大陸商和記黃埔醫藥（上海）有限公司 新型醯胺類化合物及其用途
CN114502540A (zh) 2019-05-31 2022-05-13 医肯纳肿瘤学公司 Tead抑制剂和其用途
CN110330450B (zh) * 2019-06-12 2021-01-15 温州医科大学 一种不对称硫脲类化合物的制备方法
US20220306630A1 (en) 2019-08-06 2022-09-29 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
AR119821A1 (es) 2019-08-28 2022-01-12 Bristol Myers Squibb Co Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t
WO2021050964A1 (en) 2019-09-13 2021-03-18 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
JP2022548292A (ja) 2019-09-19 2022-11-17 ブリストル－マイヤーズ スクイブ カンパニー 酸性ｐＨでＶＩＳＴＡと結合する抗体
JP2023503052A (ja) 2019-11-19 2023-01-26 ブリストル－マイヤーズ スクイブ カンパニー Ｈｅｌｉｏｓタンパク質の阻害剤として有用な化合物
IL293357A (en) 2019-11-26 2022-07-01 Bristol Myers Squibb Co Salts/crystals of (r)-n-(4-chlorophenyl)-2-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide
EP4065582A1 (en) 2019-11-26 2022-10-05 Ikena Oncology, Inc. Polymorphic carbazole derivatives and uses thereof
US11779578B2 (en) 2019-12-17 2023-10-10 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
WO2021127283A2 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
CA3162502A1 (en) 2019-12-23 2021-07-01 Yi Zhang Smarca degraders and uses thereof
AR120823A1 (es) 2019-12-23 2022-03-23 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos útiles como activadores de células t
KR20220120624A (ko) 2019-12-23 2022-08-30 브리스톨-마이어스 스큅 컴퍼니 T 세포 활성화제로서 유용한 치환된 피페라진 유도체
BR112022012179A2 (pt) 2019-12-23 2022-09-06 Bristol Myers Squibb Co Compostos de quinazolina substituída úteis como ativadores de célula t
CN114846015A (zh) 2019-12-23 2022-08-02 百时美施贵宝公司 用作t细胞激活剂的经取代的杂芳基化合物
IL294269A (en) 2019-12-23 2022-08-01 Bristol Myers Squibb Co Substitute quinolinyl piperazine compounds are useful as t-cell activators
EP4087874A1 (en) 2020-01-06 2022-11-16 HiFiBiO (HK) Limited Anti-tnfr2 antibody and uses thereof
MX2022008421A (es) 2020-01-07 2022-09-23 Hifibio Hk Ltd Anticuerpo anti-galectina-9 y usos del mismo.
AR121047A1 (es) 2020-01-15 2022-04-13 Blueprint Medicines Corp Inhibidores de map4k1
WO2021145785A1 (ru) * 2020-01-17 2021-07-22 Борис Славинович ФАРБЕР Производные бензимидазолов, их соли, проявляющие анигериатрическое действие
KR20220164706A (ko) 2020-03-03 2022-12-13 피아이씨 테라퓨틱스 인코포레이티드 Eif4e 억제제 및 이의 용도
EP4118118A1 (en) 2020-03-09 2023-01-18 Bristol-Myers Squibb Company Antibodies to cd40 with enhanced agonist activity
JP2023518423A (ja) 2020-03-19 2023-05-01 カイメラ セラピューティクス， インコーポレイテッド Ｍｄｍ２分解剤およびそれらの使用
TW202140441A (zh) 2020-03-23 2021-11-01 美商必治妥美雅史谷比公司 經取代之側氧基異吲哚啉化合物
EP4132971A1 (en) 2020-04-09 2023-02-15 Merck Sharp & Dohme LLC Affinity matured anti-lap antibodies and uses thereof
CN111333614B (zh) * 2020-04-14 2021-01-15 遵义医科大学珠海校区 喹啉酮类化合物及其用途
CN113548999B (zh) * 2020-04-24 2023-04-28 复旦大学 消旋和手性3-(2,3-丁二烯基)氧化吲哚酮类化合物及制备方法及应用
US20230192867A1 (en) 2020-05-15 2023-06-22 Bristol-Myers Squibb Company Antibodies to garp
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
EP4165044A1 (en) 2020-06-11 2023-04-19 CHDI Foundation, Inc. Heterocyclic compounds and imaging agents for imaging huntingtin protein
WO2021258010A1 (en) 2020-06-19 2021-12-23 Gossamer Bio Services, Inc. Oxime compounds useful as t cell activators
US11857535B2 (en) 2020-07-30 2024-01-02 Kymera Therapeutics, Inc. Methods of treating mutant lymphomas
WO2022033419A2 (en) 2020-08-10 2022-02-17 Shanghai Xbh Biotechnology Co., Ltd. Compositions and methods for treating autoimmune diseases and cancers by targeting igsf8
EP4196792A1 (en) 2020-08-17 2023-06-21 BicycleTX Limited Bicycle conjugates specific for nectin-4 and uses thereof
CA3198456A1 (en) 2020-10-14 2022-04-21 Five Prime Therapeutics, Inc. Anti-c-c chemokine receptor 8 (ccr8) antibodies and methods of use thereof
KR20230131189A (ko) 2020-12-02 2023-09-12 이케나 온콜로지, 인코포레이티드 Tead 억제제 및 이의 용도
WO2022120353A1 (en) 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead inhibitors and uses thereof
CN116964050A (zh) 2020-12-16 2023-10-27 戈萨默生物服务公司 可用作t细胞激活剂的化合物
EP4274597A1 (en) 2021-01-11 2023-11-15 BicycleTX Limited Methods for treating cancer
AU2022216810A1 (en) 2021-02-02 2023-08-24 Liminal Biosciences Limited Gpr84 antagonists and uses thereof
US20230091528A1 (en) 2021-02-02 2023-03-23 Liminal Biosciences Limited Gpr84 antagonists and uses thereof
WO2022169921A1 (en) 2021-02-04 2022-08-11 Bristol-Myers Squibb Company Benzofuran compounds as sting agonists
CR20230382A (es) 2021-02-12 2023-09-06 Hoffmann La Roche Derivados de tetrahidroazepina bicíclicos para el tratamiento del cáncer
AU2022220869A1 (en) 2021-02-15 2023-08-24 Kymera Therapeutics, Inc. Irak4 degraders and uses thereof
WO2022187856A1 (en) 2021-03-05 2022-09-09 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
WO2022192145A1 (en) 2021-03-08 2022-09-15 Blueprint Medicines Corporation Map4k1 inhibitors
US11918582B2 (en) 2021-03-15 2024-03-05 Rapt Therapeutics, Inc. Pyrazole pyrimidine compounds and uses thereof
WO2022194087A1 (en) * 2021-03-16 2022-09-22 Cullgen (Shanghai) , Inc. Modified proteins and protein binders
EP4314068A1 (en) 2021-04-02 2024-02-07 The Regents Of The University Of California Antibodies against cleaved cdcp1 and uses thereof
IL307338A (en) 2021-04-05 2023-11-01 Bristol Myers Squibb Co Pyridinyl substituted oxisoisoindoline compounds for cancer therapy
US11718601B2 (en) 2021-04-06 2023-08-08 Bristol-Myers Squibb Company Pyridinyl substituted oxoisoindoline compounds
JP2024514879A (ja) 2021-04-16 2024-04-03 イケナ オンコロジー， インコーポレイテッド Ｍｅｋ阻害剤及びその使用
CN113372347B (zh) * 2021-06-07 2023-12-15 南京医科大学 β-咔啉衍生物及其作为吲哚胺-2,3-双加氧酶1抑制剂的用途
AR126442A1 (es) 2021-07-14 2023-10-11 Blueprint Medicines Corp Inhibidores de map4k1
CN117940406A (zh) 2021-07-15 2024-04-26 缆图药品公司 Map4k1抑制剂
US20230134932A1 (en) 2021-08-25 2023-05-04 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
WO2023028235A1 (en) 2021-08-25 2023-03-02 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
MX2021010532A (es) * 2021-09-01 2023-03-02 Napp Tecnologias S A De C V Alcaloide indolico como agente antineoplasico.
CN113896709B (zh) * 2021-11-22 2023-02-28 南京一苇医药科技有限公司 一种苯并噻吩-3-乙酸的合成方法
KR20230084421A (ko) * 2021-12-03 2023-06-13 서울대학교산학협력단 자연물로부터 합성된 신규한 형광체 및 이의 제조방법
WO2023114984A1 (en) 2021-12-17 2023-06-22 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2023122772A1 (en) 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Oxime derivatives useful as t cell activators
WO2023122778A1 (en) 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Pyridazinone derivatives useful as t cell activators
WO2023122777A1 (en) 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Oxime derivatives useful as t cell activators
WO2023150186A1 (en) 2022-02-01 2023-08-10 Arvinas Operations, Inc. Dgk targeting compounds and uses thereof
WO2023173053A1 (en) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023173057A1 (en) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023211889A1 (en) 2022-04-25 2023-11-02 Ikena Oncology, Inc. Polymorphic compounds and uses thereof
TW202404581A (zh) 2022-05-25 2024-02-01 美商醫肯納腫瘤學公司 Ｍｅｋ抑制劑及其用途
WO2024028364A1 (en) 2022-08-02 2024-02-08 Liminal Biosciences Limited Aryl-triazolyl and related gpr84 antagonists and uses thereof
WO2024028365A1 (en) 2022-08-02 2024-02-08 Liminal Biosciences Limited Substituted pyridone gpr84 antagonists and uses thereof
WO2024028363A1 (en) 2022-08-02 2024-02-08 Liminal Biosciences Limited Heteroaryl carboxamide and related gpr84 antagonists and uses thereof
WO2024036100A1 (en) 2022-08-08 2024-02-15 Bristol-Myers Squibb Company Substituted tetrazolyl compounds useful as t cell activators
WO2024036101A1 (en) 2022-08-09 2024-02-15 Bristol-Myers Squibb Company Tertiary amine substituted bicyclic compounds useful as t cell activators
WO2024033388A1 (en) 2022-08-11 2024-02-15 F. Hoffmann-La Roche Ag Bicyclic tetrahydrothiazepine derivatives
WO2024033458A1 (en) 2022-08-11 2024-02-15 F. Hoffmann-La Roche Ag Bicyclic tetrahydroazepine derivatives
WO2024033457A1 (en) 2022-08-11 2024-02-15 F. Hoffmann-La Roche Ag Bicyclic tetrahydrothiazepine derivatives
WO2024033389A1 (en) 2022-08-11 2024-02-15 F. Hoffmann-La Roche Ag Bicyclic tetrahydrothiazepine derivatives
US20240208961A1 (en) 2022-11-22 2024-06-27 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB977071A (en) * 1960-11-03 1964-12-02 Smith & Nephew Hydroxylamine derivatives and process for making them
FR1366727A (fr) * 1961-02-27 1964-07-17 Roussel Uclaf Nouveau dérivé du yohimbane et procédé de préparation
GB1042191A (en) 1961-10-04 1966-09-14 Lepetit Spa Process for the preparation of hydroxylamine derivatives
GB964721A (en) 1961-10-13 1964-07-22 Lepetit Spa New anti-bacterial o-hydroxy-or-phenyl-alkyloximes
US3245878A (en) * 1962-01-09 1966-04-12 Frank M Berger Methods for lowering blood cholesterol
GB984305A (en) * 1962-04-10 1965-02-24 Smith & Nephew Hydroxylamine derivatives and process for making them
US3192110A (en) * 1962-04-24 1965-06-29 Colgate Palmolive Co Therapeutic aryl and thienyl hydroxylamines
GB989557A (en) * 1962-05-15 1965-04-22 Smith & Nephew Hydroxylamine derivative and processes for making it
US3215706A (en) * 1962-05-31 1965-11-02 Warner Lambert Pharmaceutical Substituted benzyloxyamines
US3240802A (en) * 1962-10-30 1966-03-15 Colgate Palmolive Co Phenylalkyl-aminooxy carboxylic acids
US3378592A (en) * 1963-06-04 1968-04-16 Warner Lambert Pharmaceutical Process for the production of 3, 4-dihydroxybenzyloxyaminehydrobromide
US3262978A (en) * 1963-06-19 1966-07-26 Colgate Palmolive Co O-arylamino-and-aralkyl-amino-alkylhydroxyl-amines
US3284299A (en) 1963-10-21 1966-11-08 Richardson Merrell Inc Muscle relaxant compositions and methods
US3245879A (en) * 1963-11-29 1966-04-12 Babcock & Wilcox Co Compact nuclear steam generator
US3342678A (en) * 1964-02-10 1967-09-19 Carter Wallace Lowering blood cholesterol levels in warm-blooded animals with phenoxyethoxy or phenoxy-propoxy amine derivatives
US3329677A (en) * 1964-03-03 1967-07-04 Upjohn Co N-benzhydryloxyphthalimides and pryidinealdehyde o-benzhydryloximes
US3313824A (en) * 1964-03-13 1967-04-11 Upjohn Co 1-substituted -2- (aminooxymethyl) benzimidazoles and the corresponding 2-alkylideneaminooxymethyl intermediates therefor
GB1264261A (xx) 1969-02-10 1972-02-16
CH574396A5 (xx) * 1969-12-29 1976-04-15 Richter Gedeon Vegyeszet
HU162469B (xx) * 1969-12-29 1973-02-28
CA962696A (en) * 1970-12-14 1975-02-11 Gyogyszerkutato Intezet Methoxy amine derivatives and process for preparing them
HU162578B (xx) 1971-02-15 1973-03-28
GB1496757A (en) 1973-12-21 1978-01-05 Glaxo Lab Ltd Cephalosporin derivatives
US4095021A (en) * 1973-12-21 1978-06-13 Glaxo Laboratories Limited 3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxymethoxyimino-2-(fur-2-yl or thien-2-yl)acetamido]ceph-3-em-4-carboxylic acids and derivatives thereof
US4009175A (en) * 1976-03-15 1977-02-22 The Upjohn Company 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines
HU178552B (en) * 1978-07-14 1982-05-28 Gyogyszerkutato Intezet Process for producing new blood pressure lowering composition of increased activity
US4390534A (en) * 1978-12-29 1983-06-28 Fujisawa Pharmaceutical Co., Ltd. Cephem and cepham compounds
AU536842B2 (en) * 1978-12-29 1984-05-24 Fujisawa Pharmaceutical Co., Ltd. Cephalosporin antibiotics
US4332798A (en) * 1978-12-29 1982-06-01 Fujisawa Pharmaceutical Co., Ltd. 7-Amino-thia-diazole oxyimino derivatives of cephem and cephem compounds
FR2520194A1 (fr) * 1982-01-28 1983-07-29 Roussel Uclaf Application, comme facteur de croissance des vegetaux de la 4-nitrophenyl hydroxylamine
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US5403835A (en) * 1986-03-20 1995-04-04 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives
DE3615473A1 (de) * 1986-05-07 1987-11-12 Basf Ag Verfahren zur herstellung von o-substituierten hydroxylaminen
US5155127A (en) * 1989-02-09 1992-10-13 Warner-Lambert Company N-(substituted aryl)-n'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents
US4923896A (en) * 1989-02-09 1990-05-08 Warner-Lambert Company N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents
TW209223B (xx) * 1989-09-26 1993-07-11 Yamanouchi Pharma Co Ltd
JPH03176473A (ja) * 1989-12-01 1991-07-31 Kaken Pharmaceut Co Ltd ピリジン―ｎ―オキシド誘導体及びその製法
EP0544958A1 (en) 1990-08-09 1993-06-09 Tanabe Seiyaku Co., Ltd. Cephalosporin compounds and processes for preparing the same
JP2801381B2 (ja) * 1990-09-18 1998-09-21 三井化学株式会社 高純度アニリンの製造法
JPH04334358A (ja) 1991-05-02 1992-11-20 Ono Pharmaceut Co Ltd 縮合ベンゼンオキシ酢酸誘導体
EP0544166A3 (en) * 1991-11-26 1993-11-03 Hoffmann La Roche Cephalosporinderivatives
ATE196472T1 (de) * 1991-12-12 2000-10-15 Hoechst Marion Roussel Inc Antibiotische cephalosporine einen substituierten benzyloxyimino-radikal in position 7 tragend
US5587372A (en) * 1991-12-12 1996-12-24 Roussel Uclaf Cephalosporins
TW214545B (xx) * 1992-02-17 1993-10-11 Ciba Geigy Ag
CA2090283A1 (en) * 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
JP2783130B2 (ja) * 1992-10-02 1998-08-06 三菱化学株式会社 メトキシイミノ酢酸誘導体およびこれを有効成分とする農園芸用殺菌剤
US5358955A (en) * 1992-10-30 1994-10-25 Abbott Laboratories Aryl and heteroarylmethoxyphenyl inhibitors of leukotriene biosynthesis
TW279845B (xx) * 1992-12-01 1996-07-01 Ciba Geigy Ag
AU673736B2 (en) * 1993-04-13 1996-11-21 Novartis Ag Ornithine decarboxylase inhibiting cyclic aminooxy compounds
DE69408950T2 (de) 1993-12-14 1998-10-15 Mitsubishi Chem Corp N-Pyrazolylcarbamatderivate und Fungizide für Landwirtschaft und Gartenbau, die diese als aktive Bestandteile erhalten, Produktion und Zwischenprodukte
US5512581A (en) * 1994-07-18 1996-04-30 Abbott Laboratories Iminoxycarboxylates and derivatives as inhibitors of leukotriene biosynthesis
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
JP3915063B2 (ja) 1995-05-31 2007-05-16 日本農薬株式会社 Ｎ−メチル−メトキシイミノ酢酸アミド誘導体の製造方法およびその中間体
CN1192737A (zh) * 1995-07-06 1998-09-09 巴斯福股份公司 苄基羟基胺及制备其的中间产物
US6221865B1 (en) * 1995-11-06 2001-04-24 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
WO1998023582A1 (fr) 1996-11-26 1998-06-04 Mitsubishi Chemical Corporation Derives de methoxyiminoacetamide optiquement actifs, procedes de preparation de ces derives, intermediaires associes et pesticides contenant ces derives en tant qu'ingredient actif
CA2270884A1 (en) * 1997-01-27 1998-07-30 Haile Tecle Single pot process for producing (z)-azabicyclo oxime ethers
WO1999029852A1 (en) * 1997-12-05 1999-06-17 Medical College Of Georgia Research Institute, Inc. High-affinity tryptophan transporter
US6107291A (en) * 1997-12-19 2000-08-22 Amgen Inc. Azepine or larger medium ring derivatives and methods of use
WO2000011218A1 (en) * 1998-08-21 2000-03-02 Affymetrix, Inc. Expression monitoring for human cytomegalovirus (hcmv) infection
DE69940320D1 (de) * 1998-11-18 2009-03-05 Dabur Pharma Ltd Betulinsäurederivate zur inhibierung des krebswach
US6635677B2 (en) * 1999-08-13 2003-10-21 Case Western Reserve University Methoxyamine combinations in the treatment of cancer
EP1252897A4 (en) * 2000-01-21 2003-07-30 Hisamitsu Pharmaceutical Co MEDICINES FOR GENE THERAPY
AU2001231245A1 (en) * 2000-01-31 2001-08-07 The Regents Of The University Of California Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen
US20020002152A1 (en) * 2000-04-14 2002-01-03 Craig Richard A. Hydrazide and alkoxyamide angiogenesis inhibitors
WO2001098266A2 (en) * 2000-06-20 2001-12-27 Wayne State University N-and o-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating cns disorders therewith
US6627767B2 (en) * 2000-08-29 2003-09-30 Abbott Laboratories Amino(oxo) acetic acid protein tyrosine phosphatase inhibitors
KR20030034184A (ko) * 2000-09-15 2003-05-01 아노르메드 인코포레이티드 케모킨 수용체 결합 헤테로사이클릭 화합물
DE60108105T2 (de) 2001-08-02 2005-12-08 Infosint Sa Verfahren zur Herstellung von 5-substituierten Isobenzofuranen
AU2002347182A1 (en) * 2001-12-18 2003-06-30 Mondobiotech Licensing Out Ag Pharmaceutical composition of interferon gamma or pirfenidone with molecular diagnostics for the improved treatment of interstitial lung diseases
US7763251B2 (en) * 2002-04-12 2010-07-27 Medical College Of Georgia Research Institute, Inc. Kits to assess the risk of tumor progression
CA2483451C (en) * 2002-04-12 2014-07-29 Medical College Of Georgia Research Institute, Inc. Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance
CA2388441A1 (en) * 2002-06-10 2003-12-10 Wei-Ping Min Immunomodulation using rna interference
DE60318716T2 (de) 2002-08-21 2009-01-08 Astrazeneca Ab Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
US7465448B2 (en) * 2002-09-11 2008-12-16 Medical College Of Georgia Research Institute, Inc. Chemokine receptor antagonists as therapeutic agents
DE10301519A1 (de) * 2003-01-17 2004-07-29 Bayer Cropscience Ag 9-Ketospinosyn-Derivate
EP1613308A4 (en) * 2003-03-27 2008-02-20 Lankenau Inst Medical Res CANCER TREATMENT METHODS
US7598287B2 (en) * 2003-04-01 2009-10-06 Medical College Of Georgia Research Institute, Inc. Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities
US20050186289A1 (en) * 2003-04-01 2005-08-25 Medical College Of Georgia Research Institute, Inc. Regulation of T cell-mediated immunity by D isomers of inhibitors of indoleamine-2,3-dioxygenase
US20050249666A1 (en) * 2003-07-10 2005-11-10 Central Institute For Experimental Animals Establishment of human cancer cell lines with metastatic potential using NOD/SCID
US20070092881A1 (en) * 2003-07-10 2007-04-26 Central Institute For Experimental Animals Gene markers of tumor metastasis
CA2545825A1 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
WO2005051321A2 (en) * 2003-11-25 2005-06-09 Washington University Treatment of inflammatory bowel disease through induction of indoleamine 2,3-dioxygenase
US20050238651A1 (en) * 2003-11-25 2005-10-27 Gurtner Gregory J Treatment of inflammatory bowel disease
JP4021416B2 (ja) * 2004-01-20 2007-12-12 株式会社住化分析センター シアノ基含有ベンジルヒドロキシアミン化合物、および該化合物を有効成分とするカルボニル化合物捕集材
EP1595865A1 (en) 2004-05-10 2005-11-16 Laboratorios Del Dr. Esteve, S.A. New spirolactams and their synthesis
WO2006005185A1 (en) 2004-07-13 2006-01-19 The University Of British Columbia Indoleamine 2,3-dioxygenase (ido) inhibitors
US7384558B2 (en) * 2004-07-26 2008-06-10 Baxter International Inc. Compositions capable of inhibiting reactive oxygen and carbonyl species
KR100924610B1 (ko) * 2004-12-07 2009-11-02 이난타 파마슈티칼스, 인코포레이티드 3,6-비시클롤리드
US20060160883A1 (en) * 2005-01-14 2006-07-20 Stoops Linda M Regulation of immune system action in mammals through use of a multi-tiered model of immune system function
DK2559690T3 (en) * 2005-05-10 2016-04-25 Incyte Holdings Corp Modulators of indoleamine 2,3-dioxygenase and methods of use thereof
US7589067B2 (en) * 2005-10-12 2009-09-15 Enanta Pharmaceuticals, Inc. 6, 11-bridged tricyclic macrolides
US7705022B2 (en) * 2005-10-27 2010-04-27 Lankenau Institute For Medical Research IDO inhibitors and methods of use thereof
EP1940787A4 (en) 2005-10-27 2009-07-01 Lankenau Inst Medical Res NOVEL IDO INHIBITORS AND METHODS OF USE
DE102005053947A1 (de) * 2005-11-11 2007-05-16 Univ Ernst Moritz Arndt Neue Arzneimittel
WO2007095050A2 (en) * 2006-02-09 2007-08-23 Incyte Corporation N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase
WO2008008398A2 (en) 2006-07-14 2008-01-17 Shionogi & Co., Ltd. Oxime compounds and the use thereof
ATE531720T1 (de) 2006-08-21 2011-11-15 Genentech Inc Aza-benzofuranylverbindungen und anwendungsverfahren dafür
US8536157B2 (en) * 2007-04-13 2013-09-17 The University Of Melbourne Non-steroidal compounds
EP2164326A4 (en) 2007-05-31 2012-05-09 Euro Celtique Sa AMIDE COMPOUNDS AND USE THEREOF

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US20110053941A1 (en) 2011-03-03
JP2011505379A (ja) 2011-02-24
EP2227233B1 (en) 2013-02-13
CA2707308C (en) 2016-08-02
WO2009073620A2 (en) 2009-06-11
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JP2014159492A (ja) 2014-09-04
US10047066B2 (en) 2018-08-14

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