GB1042191A - Process for the preparation of hydroxylamine derivatives - Google Patents
Process for the preparation of hydroxylamine derivativesInfo
- Publication number
- GB1042191A GB1042191A GB3577461A GB3577461A GB1042191A GB 1042191 A GB1042191 A GB 1042191A GB 3577461 A GB3577461 A GB 3577461A GB 3577461 A GB3577461 A GB 3577461A GB 1042191 A GB1042191 A GB 1042191A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen atom
- alkyl radical
- radical
- compounds
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compounds of the general formula <FORM:1042191/C2/1> (wherein R and R1 each represent a hydrogen atom or C1-8 alkyl radical, n is 0 or 1, R2 represents a hydrogen atom or C1- 8 alkyl radical, R3 represents a hydrogen atom or C1- 8 alkyl radical or, when R2 is a hydrogen atom, a C1- 8 alkanoyl or phenylcarbamyl radical, and the grouping between the phenyl radical and the oxygen atom contains not less than two carbon atoms) and acid addition salts of those compounds in which R3 is a hydrogen atom or alkyl radical are prepared by heating a compound of the formula <FORM:1042191/C2/2> with an alkali metal hydroxide in an inert solvent at a temperature of 60-140 DEG C., optionally followed by (a) conversion to an N,N-dialkyl derivative and/or salt formation, or (b) acylation. The starting materials may be prepared by reacting hydroxyurethane with the corresponding aralkyl chloride or bromide in the presence of a proton acceptor, optionally followed by N-alkylation. The compounds of the first general formula above have central nervous system activity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3577461A GB1042191A (en) | 1961-10-04 | 1961-10-04 | Process for the preparation of hydroxylamine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3577461A GB1042191A (en) | 1961-10-04 | 1961-10-04 | Process for the preparation of hydroxylamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1042191A true GB1042191A (en) | 1966-09-14 |
Family
ID=10381415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3577461A Expired GB1042191A (en) | 1961-10-04 | 1961-10-04 | Process for the preparation of hydroxylamine derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1042191A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0581613A1 (en) * | 1992-07-31 | 1994-02-02 | Mitsui Petrochemical Industries, Ltd. | Process for preparing N,O-dialkylhydroxycarbamic acid esters |
| US10047066B2 (en) | 2007-11-30 | 2018-08-14 | Newlink Genetics Corporation | IDO inhibitors |
-
1961
- 1961-10-04 GB GB3577461A patent/GB1042191A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510511A (en) * | 1992-01-14 | 1996-04-23 | Mitsui Petrochemical Industries, Ltd. | Process for preparing N,O-dialkylhydroxylamine, its salts or intermediates in their synthesis |
| EP0581613A1 (en) * | 1992-07-31 | 1994-02-02 | Mitsui Petrochemical Industries, Ltd. | Process for preparing N,O-dialkylhydroxycarbamic acid esters |
| US10047066B2 (en) | 2007-11-30 | 2018-08-14 | Newlink Genetics Corporation | IDO inhibitors |
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