GB966015A - New basic dibenzo-oxepin and dibenzo-thiepin derivatives - Google Patents
New basic dibenzo-oxepin and dibenzo-thiepin derivativesInfo
- Publication number
- GB966015A GB966015A GB14356/63A GB1435663A GB966015A GB 966015 A GB966015 A GB 966015A GB 14356/63 A GB14356/63 A GB 14356/63A GB 1435663 A GB1435663 A GB 1435663A GB 966015 A GB966015 A GB 966015A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dibenzo
- oxepin
- formula
- new basic
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000008510 dibenzothiepins Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/12—[b,e]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
The invention comprises compounds of the general formula: <FORM:0966015/C1/1> wherein X is an oxygen or sulphur atom, R is a hydrogen or halogen atom or an alkyl or alkoxy radical and R1 is an alkyl radical containing up to 4 carbon atoms, and the acid addition salts thereof. The compounds are prepared by heating a compound of the formula: <FORM:0966015/C1/2> in which X, R and R1 are as defined above, in an inert solvent with a haloformic ester of the general formula Hal-COOR1, in which Hal is a halogen atom and R1 is an alkyl radical containing up to 4 carbon atoms, to give a compound of the formula: <FORM:0966015/C1/3> in which X, R, R1 and R1 are as defined above, and removing the carbothoxy group by acid or alkaline hydrolysis to give the desired end product, which can if desired be converted to its salts by conventional procedures. Examples are given.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEB66824A DE1239318B (en) | 1962-04-14 | 1962-04-14 | Process for the preparation of basic substituted dibenzo-oxepines or dibenzo-thiepines and their hydrohalides |
Publications (1)
Publication Number | Publication Date |
---|---|
GB966015A true GB966015A (en) | 1964-08-06 |
Family
ID=6975284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB14356/63A Expired GB966015A (en) | 1962-04-14 | 1963-04-10 | New basic dibenzo-oxepin and dibenzo-thiepin derivatives |
Country Status (7)
Country | Link |
---|---|
AT (1) | AT244980B (en) |
CH (1) | CH454164A (en) |
DE (1) | DE1239318B (en) |
DK (1) | DK111525B (en) |
FR (1) | FR3631M (en) |
GB (1) | GB966015A (en) |
LU (1) | LU43529A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4855462A (en) * | 1988-06-17 | 1989-08-08 | Pennwalt Corporation | Antihistamines |
-
1962
- 1962-04-14 DE DEB66824A patent/DE1239318B/en active Pending
-
1963
- 1963-04-09 CH CH452763A patent/CH454164A/en unknown
- 1963-04-10 LU LU43529D patent/LU43529A1/xx unknown
- 1963-04-10 GB GB14356/63A patent/GB966015A/en not_active Expired
- 1963-04-10 DK DK172163AA patent/DK111525B/en unknown
- 1963-04-12 AT AT303963A patent/AT244980B/en active
- 1963-07-12 FR FR941291A patent/FR3631M/en active Active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4855462A (en) * | 1988-06-17 | 1989-08-08 | Pennwalt Corporation | Antihistamines |
Also Published As
Publication number | Publication date |
---|---|
DE1239318B (en) | 1967-04-27 |
AT244980B (en) | 1966-02-10 |
FR3631M (en) | 1965-10-25 |
LU43529A1 (en) | 1963-06-10 |
DK111525B (en) | 1968-09-09 |
CH454164A (en) | 1968-04-15 |
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