GB1074197A - Preparation of phenoxyacetic acids - Google Patents
Preparation of phenoxyacetic acidsInfo
- Publication number
- GB1074197A GB1074197A GB4496164A GB4496164A GB1074197A GB 1074197 A GB1074197 A GB 1074197A GB 4496164 A GB4496164 A GB 4496164A GB 4496164 A GB4496164 A GB 4496164A GB 1074197 A GB1074197 A GB 1074197A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- formula
- phenoxyacetic acids
- hydrogen
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Phenoxyacetic acids of the Formula I, wherein R2 represents a hydrogen atom or an alkyl radical, R3 represents a hydrogen or halogen atom or a C1- 5 alkyl, C1- 5 alkox or trifluoromethyl radical or two R3 radicals on adjacent carbon atoms of the benzene ring form a 1,3-butadienylene linkage, and m represents an integer from 1 to 4, are prepared by reacting phenoxyacetic acids of the Formula II, where Y represents a -CO2R, -CON(R1)2 or -CN radical wherein R represents a univalent organic radical comprised solely of carbon and hydrogen, R1 represents a hydrogen atom or a C1- 5 alkyl radical or, taken together, both R1 radicals and the nitrogen atom to which they are attached represent a 1-pyrrolidinyl, piperidino or morpholino radical, with compounds of the formula R2-C(: CH2)M, where M represents a magnesium halide radical or a lithium atom, and hydrolysing the resulting intermediates. The free bases are converted into salts by reaction with bases forming non-toxic pharmacologically acceptable cations. <FORM:1074197/C2/1> [4 - Imino - 2 - methylenepropyl)phenoxy] acetic acid is formed as an intermediate in an example of the above process by the reaction of 2-propenyl-magnesium chloride on 4-cyanophenoxyacetic acid. Phenoxyacetic acids of the Formula II may be prepared by converting an hydroxy-benzoic acid to its amide, nitrile or ester and reacting the latter with a 2-haloacetic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32392163A | 1963-11-15 | 1963-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1074197A true GB1074197A (en) | 1967-06-28 |
Family
ID=23261290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4496164A Expired GB1074197A (en) | 1963-11-15 | 1964-11-04 | Preparation of phenoxyacetic acids |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | AT259546B (en) |
| BR (1) | BR6464320D0 (en) |
| CH (1) | CH453336A (en) |
| GB (1) | GB1074197A (en) |
| NL (1) | NL6413270A (en) |
| SE (1) | SE326705B (en) |
-
1964
- 1964-11-04 GB GB4496164A patent/GB1074197A/en not_active Expired
- 1964-11-11 AT AT951164A patent/AT259546B/en active
- 1964-11-12 CH CH1462264A patent/CH453336A/en unknown
- 1964-11-13 SE SE1370964A patent/SE326705B/xx unknown
- 1964-11-13 NL NL6413270A patent/NL6413270A/xx unknown
- 1964-11-13 BR BR16432064A patent/BR6464320D0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT259546B (en) | 1968-01-25 |
| CH453336A (en) | 1968-06-14 |
| NL6413270A (en) | 1965-05-17 |
| BR6464320D0 (en) | 1973-07-26 |
| SE326705B (en) | 1970-08-03 |
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