SE8703494L - INTERMEDIATES USEFUL IN THE PREPARATION OF 2-THIOFENEETIC ACETIC ACID DERIVATIVES - Google Patents

INTERMEDIATES USEFUL IN THE PREPARATION OF 2-THIOFENEETIC ACETIC ACID DERIVATIVES

Info

Publication number
SE8703494L
SE8703494L SE8703494A SE8703494A SE8703494L SE 8703494 L SE8703494 L SE 8703494L SE 8703494 A SE8703494 A SE 8703494A SE 8703494 A SE8703494 A SE 8703494A SE 8703494 L SE8703494 L SE 8703494L
Authority
SE
Sweden
Prior art keywords
acetic acid
thiofeneetic
preparation
acid derivatives
intermediates useful
Prior art date
Application number
SE8703494A
Other languages
Swedish (sv)
Other versions
SE457724B (en
SE8703494D0 (en
Inventor
R Nabet
S Andres
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of SE8703494D0 publication Critical patent/SE8703494D0/en
Publication of SE8703494L publication Critical patent/SE8703494L/en
Publication of SE457724B publication Critical patent/SE457724B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A 2-thiophene acetic acid compound of formula (I): <IMAGE> in which: R represents an alkyl radical of 1 to 4 carbon atoms; and R1, R2 and R3 are the same or different and each represents a hydrogen atom, an alkyl radical of 1 to 4 carbon atoms or a halogen atom; is prepared by decarbalkoxylating an alkylmalonate of formula (IV): <IMAGE> in which R, R1, R2 and R3 are as defined above and Alk1 and Alk2 are the same or different and each represents an alkyl radical of 1 to 4 carbon atoms. The 2-thiophene acetic acid compound is an intermediate in the production of pharmaceuticals. The alkylmalonate used is itself claimed per se.
SE8703494A 1982-12-03 1987-09-09 2-TIENYL MALONE DERIVATIVES FOR USE IN THE PREPARATION OF 2-THIOPHENETIC ACID DERIVATIVES SE457724B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8220271A FR2537137B1 (en) 1982-12-03 1982-12-03 PROCESS FOR THE PREPARATION OF ACETIC 2-THIOPHENE ACID DERIVATIVES AND INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION

Publications (3)

Publication Number Publication Date
SE8703494D0 SE8703494D0 (en) 1987-09-09
SE8703494L true SE8703494L (en) 1987-09-09
SE457724B SE457724B (en) 1989-01-23

Family

ID=9279757

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8301785A SE453992B (en) 1982-12-03 1983-03-30 SET TO PREPARE 2-THIOPHENIC ACETIC ACID DERIVATIVES
SE8703494A SE457724B (en) 1982-12-03 1987-09-09 2-TIENYL MALONE DERIVATIVES FOR USE IN THE PREPARATION OF 2-THIOPHENETIC ACID DERIVATIVES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE8301785A SE453992B (en) 1982-12-03 1983-03-30 SET TO PREPARE 2-THIOPHENIC ACETIC ACID DERIVATIVES

Country Status (22)

Country Link
JP (1) JPS59106482A (en)
KR (1) KR900005681B1 (en)
AT (1) AT392784B (en)
AU (1) AU556803B2 (en)
BE (1) BE896439A (en)
CA (1) CA1201441A (en)
CH (2) CH659817A5 (en)
DE (1) DE3314029A1 (en)
DK (2) DK160427C (en)
ES (1) ES8401957A1 (en)
FI (1) FI83646C (en)
FR (1) FR2537137B1 (en)
GB (1) GB2132607B (en)
HU (1) HU192136B (en)
IE (1) IE55075B1 (en)
IT (1) IT1174757B (en)
LU (1) LU84748A1 (en)
NL (1) NL8301692A (en)
NZ (1) NZ204509A (en)
PT (1) PT76534B (en)
SE (2) SE453992B (en)
ZA (1) ZA832698B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338494B1 (en) * 1988-04-22 1996-01-10 Byk Gulden Lomberg Chemische Fabrik GmbH 3-Anilino-2-hydroxycarbonyl-4-thiophen-acetic acids
IT1276738B1 (en) * 1995-06-16 1997-11-03 Erregierre Spa PROCESS FOR THE PREPARATION OF DERIVATIVES OF -METHYL-2- THIOPHENEACETIC ACID
DE102004008807A1 (en) 2004-02-20 2005-09-08 Bayer Cropscience Ag pyrazolopyrimidine
CN113896709B (en) * 2021-11-22 2023-02-28 南京一苇医药科技有限公司 Synthetic method of benzothiophene-3-acetic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1055804A (en) * 1949-10-01 1954-02-22 Warner Hudnut Improvements in processes for preparing anti-spasmodic compounds
IE33054B1 (en) * 1968-04-16 1974-03-06 Ici Ltd Heterocyclic compounds
FR2260575A1 (en) * 1974-02-11 1975-09-05 Innothera Lab Sa Cyclohexyl 3-thienyl acetic acid prodn - from methyl 3-thienylacetate through diethyl cyclohexyl 3-thienyl malonate as starting material for basic esters as drugs
GB2003570B (en) * 1977-06-08 1982-01-20 Imi Opella Ltd Stop valve
FR2421897A1 (en) * 1978-04-04 1979-11-02 Labaz Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents

Also Published As

Publication number Publication date
FI83646B (en) 1991-04-30
SE457724B (en) 1989-01-23
LU84748A1 (en) 1983-12-05
AT392784B (en) 1991-06-10
FI83646C (en) 1991-08-12
KR840006986A (en) 1984-12-04
IT1174757B (en) 1987-07-01
JPS59106482A (en) 1984-06-20
DK138490D0 (en) 1990-06-06
DK160427C (en) 1991-08-19
ES521230A0 (en) 1984-01-01
JPH0480910B2 (en) 1992-12-21
DK164550C (en) 1992-11-30
ES8401957A1 (en) 1984-01-01
SE453992B (en) 1988-03-21
GB2132607A (en) 1984-07-11
DE3314029A1 (en) 1984-06-07
DK139983A (en) 1984-06-04
BE896439A (en) 1983-10-12
SE8703494D0 (en) 1987-09-09
KR900005681B1 (en) 1990-08-06
CH659817A5 (en) 1987-02-27
DE3314029C2 (en) 1993-03-04
DK139983D0 (en) 1983-03-28
PT76534A (en) 1983-05-01
CH655722A5 (en) 1986-05-15
NL8301692A (en) 1984-07-02
FR2537137A1 (en) 1984-06-08
FI831115A0 (en) 1983-03-31
CA1201441A (en) 1986-03-04
ATA286683A (en) 1990-11-15
FR2537137B1 (en) 1985-07-19
PT76534B (en) 1986-03-12
ZA832698B (en) 1984-05-30
GB8312701D0 (en) 1983-06-15
IE831075L (en) 1984-06-03
DK160427B (en) 1991-03-11
IT8348215A0 (en) 1983-05-04
SE8301785L (en) 1984-06-04
AU556803B2 (en) 1986-11-20
DK138490A (en) 1990-06-06
IE55075B1 (en) 1990-05-23
NZ204509A (en) 1986-02-21
FI831115L (en) 1984-06-04
SE8301785D0 (en) 1983-03-30
HU192136B (en) 1987-05-28
AU1357483A (en) 1984-06-07
DK164550B (en) 1992-07-13
GB2132607B (en) 1986-05-08

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