FR2421897A1 - Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents - Google Patents
Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agentsInfo
- Publication number
- FR2421897A1 FR2421897A1 FR7809885A FR7809885A FR2421897A1 FR 2421897 A1 FR2421897 A1 FR 2421897A1 FR 7809885 A FR7809885 A FR 7809885A FR 7809885 A FR7809885 A FR 7809885A FR 2421897 A1 FR2421897 A1 FR 2421897A1
- Authority
- FR
- France
- Prior art keywords
- hypnotic
- anticonvulsant
- useful
- tranquillising
- substd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Thiophene derivs. of formula (I) in racemic or optically active form are new. In (I), A is -CHR1-, -C(C2H5)(-CH2-CH=CH2)-, -CR2R3-, or gp. of formulae (II) or (III); R1 is 2-5C opt. branched alkyl, benzyl, propargyl, or 5-7C cycloalkyl; R2 and R3 are ethyl, propyl, allyl or propargyl; R4 is H or CH3; R5 is CH2 or O. (I) are made from the corresp. acid by chlorination then reaction with NH3. (I) have neuropsychotropic, esp. hypnotic, anticonvulsant and antianxiety-type tranquillising activity so are useful in human or veterinary medicine for treating insomnia, epilepsy or anxiety.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7809885A FR2421897A1 (en) | 1978-04-04 | 1978-04-04 | Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7809885A FR2421897A1 (en) | 1978-04-04 | 1978-04-04 | Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2421897A1 true FR2421897A1 (en) | 1979-11-02 |
FR2421897B1 FR2421897B1 (en) | 1981-05-22 |
Family
ID=9206643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7809885A Granted FR2421897A1 (en) | 1978-04-04 | 1978-04-04 | Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2421897A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2537137A1 (en) * | 1982-12-03 | 1984-06-08 | Roussel Uclaf | PROCESS FOR THE PREPARATION OF ACETIC 2-THIOPHENE ACID DERIVATIVES AND INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION |
FR2578253A1 (en) * | 1985-03-01 | 1986-09-05 | Roussel Uclaf | New products derived from 2-thienylmalonic acid, process for their preparation and their application |
EP0521365A1 (en) * | 1991-07-03 | 1993-01-07 | Nihon Bayer Agrochem K.K. | Acetanilides |
WO1998003498A1 (en) * | 1996-07-24 | 1998-01-29 | Societe D'expansion Scientifique Expansia | Thienylcyclohexane derivatives for thienylcyclohexyl synthesis |
JP2013513554A (en) * | 2009-12-11 | 2013-04-22 | アイメック | Polythiophene-based active layer for solar cells |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL101148C (en) * | ||||
FR2007466A1 (en) * | 1968-04-16 | 1970-01-09 | Ici Ltd | Heterocyclic cpds prepn |
-
1978
- 1978-04-04 FR FR7809885A patent/FR2421897A1/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL101148C (en) * | ||||
FR2007466A1 (en) * | 1968-04-16 | 1970-01-09 | Ici Ltd | Heterocyclic cpds prepn |
Non-Patent Citations (1)
Title |
---|
NV608/61 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2537137A1 (en) * | 1982-12-03 | 1984-06-08 | Roussel Uclaf | PROCESS FOR THE PREPARATION OF ACETIC 2-THIOPHENE ACID DERIVATIVES AND INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION |
FR2578253A1 (en) * | 1985-03-01 | 1986-09-05 | Roussel Uclaf | New products derived from 2-thienylmalonic acid, process for their preparation and their application |
EP0521365A1 (en) * | 1991-07-03 | 1993-01-07 | Nihon Bayer Agrochem K.K. | Acetanilides |
US5296454A (en) * | 1991-07-03 | 1994-03-22 | Nihon Bayer Agrochem K.K. | Acetanilide herbicides |
WO1998003498A1 (en) * | 1996-07-24 | 1998-01-29 | Societe D'expansion Scientifique Expansia | Thienylcyclohexane derivatives for thienylcyclohexyl synthesis |
FR2751652A1 (en) * | 1996-07-24 | 1998-01-30 | Expansia Sa | THIENYLCYCLOHEXANE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS NEW INDUSTRIAL PRODUCTS FOR THE SYNTHESIS OF THIENYLCYCLOHEXYL DERIVATIVES |
US6107495A (en) * | 1996-07-24 | 2000-08-22 | Societe D'expansion Scientifique Expansia | Thienylcyclohexane derivatives for thienylcyclohexyl synthesis |
JP2013513554A (en) * | 2009-12-11 | 2013-04-22 | アイメック | Polythiophene-based active layer for solar cells |
Also Published As
Publication number | Publication date |
---|---|
FR2421897B1 (en) | 1981-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
CA | Change of address | ||
CD | Change of name or company name | ||
ST | Notification of lapse |