FR2421897A1 - Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents - Google Patents

Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents

Info

Publication number
FR2421897A1
FR2421897A1 FR7809885A FR7809885A FR2421897A1 FR 2421897 A1 FR2421897 A1 FR 2421897A1 FR 7809885 A FR7809885 A FR 7809885A FR 7809885 A FR7809885 A FR 7809885A FR 2421897 A1 FR2421897 A1 FR 2421897A1
Authority
FR
France
Prior art keywords
hypnotic
anticonvulsant
useful
tranquillising
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7809885A
Other languages
French (fr)
Other versions
FR2421897B1 (en
Inventor
Pierre-Jean Grossi
Paul De Cointet De Fillain
Charles Pigerol
Madeleine Broll
Pierre Eymard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Priority to FR7809885A priority Critical patent/FR2421897A1/en
Publication of FR2421897A1 publication Critical patent/FR2421897A1/en
Application granted granted Critical
Publication of FR2421897B1 publication Critical patent/FR2421897B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Thiophene derivs. of formula (I) in racemic or optically active form are new. In (I), A is -CHR1-, -C(C2H5)(-CH2-CH=CH2)-, -CR2R3-, or gp. of formulae (II) or (III); R1 is 2-5C opt. branched alkyl, benzyl, propargyl, or 5-7C cycloalkyl; R2 and R3 are ethyl, propyl, allyl or propargyl; R4 is H or CH3; R5 is CH2 or O. (I) are made from the corresp. acid by chlorination then reaction with NH3. (I) have neuropsychotropic, esp. hypnotic, anticonvulsant and antianxiety-type tranquillising activity so are useful in human or veterinary medicine for treating insomnia, epilepsy or anxiety.
FR7809885A 1978-04-04 1978-04-04 Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents Granted FR2421897A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7809885A FR2421897A1 (en) 1978-04-04 1978-04-04 Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7809885A FR2421897A1 (en) 1978-04-04 1978-04-04 Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents

Publications (2)

Publication Number Publication Date
FR2421897A1 true FR2421897A1 (en) 1979-11-02
FR2421897B1 FR2421897B1 (en) 1981-05-22

Family

ID=9206643

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7809885A Granted FR2421897A1 (en) 1978-04-04 1978-04-04 Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents

Country Status (1)

Country Link
FR (1) FR2421897A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2537137A1 (en) * 1982-12-03 1984-06-08 Roussel Uclaf PROCESS FOR THE PREPARATION OF ACETIC 2-THIOPHENE ACID DERIVATIVES AND INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION
FR2578253A1 (en) * 1985-03-01 1986-09-05 Roussel Uclaf New products derived from 2-thienylmalonic acid, process for their preparation and their application
EP0521365A1 (en) * 1991-07-03 1993-01-07 Nihon Bayer Agrochem K.K. Acetanilides
WO1998003498A1 (en) * 1996-07-24 1998-01-29 Societe D'expansion Scientifique Expansia Thienylcyclohexane derivatives for thienylcyclohexyl synthesis
JP2013513554A (en) * 2009-12-11 2013-04-22 アイメック Polythiophene-based active layer for solar cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL101148C (en) *
FR2007466A1 (en) * 1968-04-16 1970-01-09 Ici Ltd Heterocyclic cpds prepn

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL101148C (en) *
FR2007466A1 (en) * 1968-04-16 1970-01-09 Ici Ltd Heterocyclic cpds prepn

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NV608/61 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2537137A1 (en) * 1982-12-03 1984-06-08 Roussel Uclaf PROCESS FOR THE PREPARATION OF ACETIC 2-THIOPHENE ACID DERIVATIVES AND INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION
FR2578253A1 (en) * 1985-03-01 1986-09-05 Roussel Uclaf New products derived from 2-thienylmalonic acid, process for their preparation and their application
EP0521365A1 (en) * 1991-07-03 1993-01-07 Nihon Bayer Agrochem K.K. Acetanilides
US5296454A (en) * 1991-07-03 1994-03-22 Nihon Bayer Agrochem K.K. Acetanilide herbicides
WO1998003498A1 (en) * 1996-07-24 1998-01-29 Societe D'expansion Scientifique Expansia Thienylcyclohexane derivatives for thienylcyclohexyl synthesis
FR2751652A1 (en) * 1996-07-24 1998-01-30 Expansia Sa THIENYLCYCLOHEXANE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS NEW INDUSTRIAL PRODUCTS FOR THE SYNTHESIS OF THIENYLCYCLOHEXYL DERIVATIVES
US6107495A (en) * 1996-07-24 2000-08-22 Societe D'expansion Scientifique Expansia Thienylcyclohexane derivatives for thienylcyclohexyl synthesis
JP2013513554A (en) * 2009-12-11 2013-04-22 アイメック Polythiophene-based active layer for solar cells

Also Published As

Publication number Publication date
FR2421897B1 (en) 1981-05-22

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