ES8401957A1 - Preparation of thiophene compounds - Google Patents

Preparation of thiophene compounds

Info

Publication number
ES8401957A1
ES8401957A1 ES521230A ES521230A ES8401957A1 ES 8401957 A1 ES8401957 A1 ES 8401957A1 ES 521230 A ES521230 A ES 521230A ES 521230 A ES521230 A ES 521230A ES 8401957 A1 ES8401957 A1 ES 8401957A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl radical
preparation
thiophene compounds
alkylmalonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521230A
Other languages
Spanish (es)
Other versions
ES521230A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES8401957A1 publication Critical patent/ES8401957A1/en
Publication of ES521230A0 publication Critical patent/ES521230A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A 2-thiophene acetic acid compound of formula (I): < IMAGE > in which: R represents an alkyl radical of 1 to 4 carbon atoms and R1, R2 and R3 are the same or different and each represents a hydrogen atom, an alkyl radical of 1 to 4 carbon atoms or a halogen atom is prepared by decarbalkoxylating an alkylmalonate of formula (IV): < IMAGE > in which R, R1, R2 and R3 are as defined above and Alk1 and Alk2 are the same or different and each represents an alkyl radical of 1 to 4 carbon atoms. The 2-thiophene acetic acid compound is an intermediate in the production of pharmaceuticals. The alkylmalonate used is itself claimed per se.
ES521230A 1982-12-03 1983-04-05 PROCEDURE FOR THE PREPARATION OF ACID 2-THIOFEN-ACETIC DERIVATIVES. Granted ES521230A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8220271A FR2537137B1 (en) 1982-12-03 1982-12-03 PROCESS FOR THE PREPARATION OF ACETIC 2-THIOPHENE ACID DERIVATIVES AND INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION

Publications (2)

Publication Number Publication Date
ES8401957A1 true ES8401957A1 (en) 1984-01-01
ES521230A0 ES521230A0 (en) 1984-01-01

Family

ID=9279757

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521230A Granted ES521230A0 (en) 1982-12-03 1983-04-05 PROCEDURE FOR THE PREPARATION OF ACID 2-THIOFEN-ACETIC DERIVATIVES.

Country Status (22)

Country Link
JP (1) JPS59106482A (en)
KR (1) KR900005681B1 (en)
AT (1) AT392784B (en)
AU (1) AU556803B2 (en)
BE (1) BE896439A (en)
CA (1) CA1201441A (en)
CH (2) CH655722A5 (en)
DE (1) DE3314029A1 (en)
DK (2) DK160427C (en)
ES (1) ES521230A0 (en)
FI (1) FI83646C (en)
FR (1) FR2537137B1 (en)
GB (1) GB2132607B (en)
HU (1) HU192136B (en)
IE (1) IE55075B1 (en)
IT (1) IT1174757B (en)
LU (1) LU84748A1 (en)
NL (1) NL8301692A (en)
NZ (1) NZ204509A (en)
PT (1) PT76534B (en)
SE (2) SE453992B (en)
ZA (1) ZA832698B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE58909563D1 (en) * 1988-04-22 1996-02-22 Byk Gulden Lomberg Chem Fab 3-anilino-2-hydroxycarbonyl-4-thiophenacetic acids
IT1276738B1 (en) * 1995-06-16 1997-11-03 Erregierre Spa PROCESS FOR THE PREPARATION OF DERIVATIVES OF -METHYL-2- THIOPHENEACETIC ACID
DE102004008807A1 (en) 2004-02-20 2005-09-08 Bayer Cropscience Ag pyrazolopyrimidine
CN113896709B (en) * 2021-11-22 2023-02-28 南京一苇医药科技有限公司 Synthetic method of benzothiophene-3-acetic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1055804A (en) * 1949-10-01 1954-02-22 Warner Hudnut Improvements in processes for preparing anti-spasmodic compounds
IE33054B1 (en) * 1968-04-16 1974-03-06 Ici Ltd Heterocyclic compounds
FR2260575A1 (en) * 1974-02-11 1975-09-05 Innothera Lab Sa Cyclohexyl 3-thienyl acetic acid prodn - from methyl 3-thienylacetate through diethyl cyclohexyl 3-thienyl malonate as starting material for basic esters as drugs
GB2003570B (en) * 1977-06-08 1982-01-20 Imi Opella Ltd Stop valve
FR2421897A1 (en) * 1978-04-04 1979-11-02 Labaz Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents

Also Published As

Publication number Publication date
HU192136B (en) 1987-05-28
JPS59106482A (en) 1984-06-20
IT1174757B (en) 1987-07-01
CH655722A5 (en) 1986-05-15
IE831075L (en) 1984-06-03
DE3314029A1 (en) 1984-06-07
GB8312701D0 (en) 1983-06-15
CA1201441A (en) 1986-03-04
PT76534A (en) 1983-05-01
FI831115A0 (en) 1983-03-31
IE55075B1 (en) 1990-05-23
LU84748A1 (en) 1983-12-05
SE8703494L (en) 1987-09-09
FR2537137A1 (en) 1984-06-08
NZ204509A (en) 1986-02-21
DK138490D0 (en) 1990-06-06
CH659817A5 (en) 1987-02-27
JPH0480910B2 (en) 1992-12-21
DK139983D0 (en) 1983-03-28
FI83646C (en) 1991-08-12
DK164550B (en) 1992-07-13
KR840006986A (en) 1984-12-04
KR900005681B1 (en) 1990-08-06
PT76534B (en) 1986-03-12
SE8301785D0 (en) 1983-03-30
ZA832698B (en) 1984-05-30
FR2537137B1 (en) 1985-07-19
DK160427C (en) 1991-08-19
BE896439A (en) 1983-10-12
DK138490A (en) 1990-06-06
DK139983A (en) 1984-06-04
ATA286683A (en) 1990-11-15
AU556803B2 (en) 1986-11-20
FI83646B (en) 1991-04-30
DK164550C (en) 1992-11-30
FI831115L (en) 1984-06-04
SE457724B (en) 1989-01-23
NL8301692A (en) 1984-07-02
SE453992B (en) 1988-03-21
AU1357483A (en) 1984-06-07
GB2132607A (en) 1984-07-11
IT8348215A0 (en) 1983-05-04
SE8301785L (en) 1984-06-04
DE3314029C2 (en) 1993-03-04
DK160427B (en) 1991-03-11
GB2132607B (en) 1986-05-08
SE8703494D0 (en) 1987-09-09
AT392784B (en) 1991-06-10
ES521230A0 (en) 1984-01-01

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