ES477709A1 - Benzothiazepines - Google Patents

Benzothiazepines

Info

Publication number
ES477709A1
ES477709A1 ES477709A ES477709A ES477709A1 ES 477709 A1 ES477709 A1 ES 477709A1 ES 477709 A ES477709 A ES 477709A ES 477709 A ES477709 A ES 477709A ES 477709 A1 ES477709 A1 ES 477709A1
Authority
ES
Spain
Prior art keywords
group
formula
hydrogen atom
compounds
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES477709A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maruko Pharmaceutical Co Ltd
Original Assignee
Maruko Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1580078A external-priority patent/JPS5840954B2/en
Priority claimed from JP1741478A external-priority patent/JPS5840955B2/en
Priority claimed from JP9299878A external-priority patent/JPS5519249A/en
Application filed by Maruko Pharmaceutical Co Ltd filed Critical Maruko Pharmaceutical Co Ltd
Publication of ES477709A1 publication Critical patent/ES477709A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Abstract

The Specification discloses cis or trans-1,5-benzo-thiazepine compounds of the formula (I): < IMAGE > wherein R1 represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and R2 represents a hydrogen atom, an alkyl group or a hydroxyalkyl group and the pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof which exhibit anticholinergic activity and are useful as anti-ulcer, gastric secretion inhibiting and anti- spasmodic agents in mammals. The compounds (I) are prepared by a route involving a novel class of intermediates of the formula (I) except in that the substituent in the 3-position is a hydroxymethyl group.
ES477709A 1978-02-14 1979-02-14 Benzothiazepines Expired ES477709A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1580078A JPS5840954B2 (en) 1978-02-14 1978-02-14 1,5↓-benzothiazepine derivatives and their salts
JP1741478A JPS5840955B2 (en) 1978-02-17 1978-02-17 2,3↓-dihydro↓-1,5↓-benzothiazepine derivative
JP9299878A JPS5519249A (en) 1978-07-29 1978-07-29 Optically active 1,5-benzothiazepine derivative

Publications (1)

Publication Number Publication Date
ES477709A1 true ES477709A1 (en) 1979-10-16

Family

ID=27281143

Family Applications (1)

Application Number Title Priority Date Filing Date
ES477709A Expired ES477709A1 (en) 1978-02-14 1979-02-14 Benzothiazepines

Country Status (6)

Country Link
CA (1) CA1114818A (en)
CH (1) CH639660A5 (en)
DE (1) DE2905637C3 (en)
ES (1) ES477709A1 (en)
FR (1) FR2416890A1 (en)
GB (1) GB2017080B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4477464A (en) * 1983-02-10 1984-10-16 Ciba-Geigy Corporation Hetero-benzazepine derivatives and their pharmaceutical use
US4694002A (en) * 1986-08-21 1987-09-15 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
JP2871811B2 (en) * 1990-02-28 1999-03-17 サントリー株式会社 7-membered condensed ring compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089872A (en) * 1961-03-31 1963-05-14 Olin Mathieson Benzothiazine and benzothiazepine compounds

Also Published As

Publication number Publication date
DE2905637B2 (en) 1980-07-03
DE2905637A1 (en) 1979-08-16
GB2017080B (en) 1982-07-21
CA1114818A (en) 1981-12-22
CH639660A5 (en) 1983-11-30
FR2416890A1 (en) 1979-09-07
FR2416890B1 (en) 1981-11-13
GB2017080A (en) 1979-10-03
DE2905637C3 (en) 1981-05-21

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