SE8005493L - 4- (HAFTALENYLOXI) PIPERIDINE DERIVATIVES - Google Patents

4- (HAFTALENYLOXI) PIPERIDINE DERIVATIVES

Info

Publication number
SE8005493L
SE8005493L SE8005493A SE8005493A SE8005493L SE 8005493 L SE8005493 L SE 8005493L SE 8005493 A SE8005493 A SE 8005493A SE 8005493 A SE8005493 A SE 8005493A SE 8005493 L SE8005493 L SE 8005493L
Authority
SE
Sweden
Prior art keywords
hydrogen
alkyl
haftalenyloxi
alkoxy
halogen
Prior art date
Application number
SE8005493A
Other languages
Swedish (sv)
Other versions
SE448728B (en
Inventor
A A Carr
R A Farr
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of SE8005493L publication Critical patent/SE8005493L/en
Publication of SE448728B publication Critical patent/SE448728B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compounds of the formula <IMAGE> wherein n is an integer of from 2 to 5, R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl, R1 is hydrogen, alkyl, alkoxy or halogen, and Z is carbonyl or hydroxymethylene and their pharmaceutically acceptable acid addition salts are useful as antipsychotic agents having a low potential for extrapyramidal side effects. The novel compounds are prepared from novel intermediates of formula <IMAGE> or their salts wherein R has the meanings defined above and R2 is hydrogen, lower alkyl or phenyl(lower alkyl).
SE8005493A 1979-08-06 1980-07-31 4- (Naphthalene Nylloxy) PIPERIDINE DERIVATIVES AND A PHARMACEUTICAL COMPOSITION WITH ANTIPSYCOTIC EFFECTS SE448728B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6430579A 1979-08-06 1979-08-06

Publications (2)

Publication Number Publication Date
SE8005493L true SE8005493L (en) 1981-02-07
SE448728B SE448728B (en) 1987-03-16

Family

ID=22055014

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8005493A SE448728B (en) 1979-08-06 1980-07-31 4- (Naphthalene Nylloxy) PIPERIDINE DERIVATIVES AND A PHARMACEUTICAL COMPOSITION WITH ANTIPSYCOTIC EFFECTS

Country Status (18)

Country Link
JP (1) JPS5626875A (en)
AU (1) AU534398B2 (en)
BE (1) BE884581A (en)
CA (1) CA1123440A (en)
CH (1) CH644364A5 (en)
DE (1) DE3028064A1 (en)
DK (1) DK150477C (en)
ES (1) ES8105981A1 (en)
FR (1) FR2463129A1 (en)
GB (1) GB2056447B (en)
IE (1) IE49998B1 (en)
IL (1) IL60593A (en)
IT (1) IT1146966B (en)
NL (1) NL8004147A (en)
NO (1) NO153726C (en)
NZ (1) NZ194248A (en)
SE (1) SE448728B (en)
ZA (1) ZA804112B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508445A1 (en) * 1981-06-29 1982-12-31 Sori Soc Rech Ind NOVEL BENZOYL-PHENYL-PIPERIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR USE, IN PARTICULAR THERAPEUTICS
ATE13425T1 (en) * 1981-10-15 1985-06-15 Synthelabo PIPERIDINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.
GB8321157D0 (en) * 1983-08-05 1983-09-07 Fordonal Sa Piperidine derivatives
JP2751346B2 (en) * 1989-03-15 1998-05-18 ミノルタ株式会社 Printer
WO2010055006A1 (en) * 2008-11-17 2010-05-20 F. Hoffmann-La Roche Ag Naphthylacetic acids used as crth2 antagonists or partial agonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB895309A (en) * 1959-11-18 1962-05-02 Res Lab Dr C Janssen Nv Pyrrolidine and piperidine derivatives
BE637978A (en) * 1963-02-15
US3743645A (en) * 1970-10-19 1973-07-03 Robins Co Inc A H 1-substituted-4-phenoxypiperidines
ZA717147B (en) * 1970-11-27 1972-07-26 Richardson Merrell Inc 4-(4-(alpha-hydroxybenzyl)piperidino)-4'-fluorobutyrophenone derivatives
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
SE7409245L (en) * 1973-07-19 1975-01-20 Robins Co Inc A H
DE2718405A1 (en) * 1977-04-26 1978-11-02 Boehringer Sohn Ingelheim NEW N-NECK CLAMP ON 1- (3-BENZOYLPROPYL) -4-PIPERIDYL NECK CLAMP ON -SULPHONIC ACID AMIDES AND METHOD FOR THE PRODUCTION THEREOF
US4134982A (en) * 1977-09-26 1979-01-16 Warner-Lambert Company Antipsychotic 1-[4,4-Bis(4-fluorophenyl) butyl]-4-phenoxy-1,2,3,6-tetrahydropyridines

Also Published As

Publication number Publication date
AU6039480A (en) 1981-02-12
NO153726C (en) 1986-05-14
ES493591A0 (en) 1981-07-01
FR2463129A1 (en) 1981-02-20
BE884581A (en) 1980-11-17
SE448728B (en) 1987-03-16
CA1123440A (en) 1982-05-11
GB2056447B (en) 1983-07-06
JPS5626875A (en) 1981-03-16
AU534398B2 (en) 1984-01-26
DK150477B (en) 1987-03-09
IT8049394A0 (en) 1980-07-31
IE801382L (en) 1981-02-06
ZA804112B (en) 1981-07-29
DE3028064A1 (en) 1981-02-26
JPS6341390B2 (en) 1988-08-17
NZ194248A (en) 1984-07-06
IL60593A0 (en) 1980-09-16
ES8105981A1 (en) 1981-07-01
NO153726B (en) 1986-02-03
IT1146966B (en) 1986-11-19
DK337280A (en) 1981-02-07
IE49998B1 (en) 1986-01-22
DE3028064C2 (en) 1989-11-09
NO802346L (en) 1981-02-09
NL8004147A (en) 1981-02-10
IL60593A (en) 1984-03-30
DK150477C (en) 1987-10-12
CH644364A5 (en) 1984-07-31
FR2463129B1 (en) 1983-04-22
GB2056447A (en) 1981-03-18

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