SE8301786L - SET TO PREPARE 2-THIOPHENIC ACETIC ACID DERIVATIVES - Google Patents
SET TO PREPARE 2-THIOPHENIC ACETIC ACID DERIVATIVESInfo
- Publication number
- SE8301786L SE8301786L SE8301786A SE8301786A SE8301786L SE 8301786 L SE8301786 L SE 8301786L SE 8301786 A SE8301786 A SE 8301786A SE 8301786 A SE8301786 A SE 8301786A SE 8301786 L SE8301786 L SE 8301786L
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- acetic acid
- image
- thiophenic
- prepare
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/12—Radicals substituted by halogen atoms or nitro or nitroso radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A 2-thiophene acetic acid compound of formula (I): <IMAGE> in which: R represents an alkyl radical of 1 to 4 carbon atoms; and R1, R2 and R3 are the same or different and each represents a hydrogen atom, an alkyl radical of 1 to 4 carbon atoms or a halogen atom; is prepared by reacting a haloalkylthiophene of formula (III): <IMAGE> in which R, R1, R2 and R3 are as defined above and Hal represents a halogen atom, with a cyanide of formula A-CN in which A represents an alkali metal atom, an alkaline-earth metal equivalent or a hydrogen atom to produce a cyanoalkylthiophene of formula (IV): <IMAGE> in which R, R1, R2 and R3 are as defined above, and hydrolysing the cyanoalkylthiophene of formula (IV) to the 2-thiophene acetic acid compound of formula (I). The compound of formula (I) is an intermediate in the production of pharmaceuticals.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8220272A FR2537138A1 (en) | 1982-12-03 | 1982-12-03 | PROCESS FOR THE PREPARATION OF ACETIC 2-THIOPHENE ACID DERIVATIVES |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8301786D0 SE8301786D0 (en) | 1983-03-30 |
SE8301786L true SE8301786L (en) | 1984-06-04 |
SE453918B SE453918B (en) | 1988-03-14 |
Family
ID=9279758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8301786A SE453918B (en) | 1982-12-03 | 1983-03-30 | SET TO PREPARE 2-THIOPHENIC ACETIC ACID DERIVATIVES |
Country Status (22)
Country | Link |
---|---|
JP (1) | JPS59106483A (en) |
KR (1) | KR900003281B1 (en) |
AT (1) | AT392785B (en) |
AU (1) | AU557065B2 (en) |
BE (1) | BE896440A (en) |
CA (1) | CA1201442A (en) |
CH (1) | CH653681A5 (en) |
DE (1) | DE3314028C2 (en) |
DK (1) | DK157492C (en) |
ES (1) | ES521231A0 (en) |
FI (1) | FI80882C (en) |
FR (1) | FR2537138A1 (en) |
GB (1) | GB2132608B (en) |
HU (1) | HU191831B (en) |
IE (1) | IE55097B1 (en) |
IT (1) | IT1174758B (en) |
LU (1) | LU84749A1 (en) |
NL (1) | NL8301693A (en) |
NZ (1) | NZ204510A (en) |
PT (1) | PT76535B (en) |
SE (1) | SE453918B (en) |
ZA (1) | ZA832697B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1276738B1 (en) * | 1995-06-16 | 1997-11-03 | Erregierre Spa | PROCESS FOR THE PREPARATION OF DERIVATIVES OF -METHYL-2- THIOPHENEACETIC ACID |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE33054B1 (en) * | 1968-04-16 | 1974-03-06 | Ici Ltd | Heterocyclic compounds |
GB2003570B (en) * | 1977-06-08 | 1982-01-20 | Imi Opella Ltd | Stop valve |
-
1982
- 1982-12-03 FR FR8220272A patent/FR2537138A1/en active Granted
-
1983
- 1983-03-28 DK DK140083A patent/DK157492C/en not_active IP Right Cessation
- 1983-03-30 SE SE8301786A patent/SE453918B/en not_active IP Right Cessation
- 1983-03-31 FI FI831116A patent/FI80882C/en not_active IP Right Cessation
- 1983-04-05 ES ES521231A patent/ES521231A0/en active Granted
- 1983-04-11 PT PT76535A patent/PT76535B/en not_active IP Right Cessation
- 1983-04-12 CH CH1966/83A patent/CH653681A5/en not_active IP Right Cessation
- 1983-04-12 BE BE0/210537A patent/BE896440A/en unknown
- 1983-04-14 HU HU831307A patent/HU191831B/en unknown
- 1983-04-14 LU LU84749A patent/LU84749A1/en unknown
- 1983-04-15 AU AU13573/83A patent/AU557065B2/en not_active Ceased
- 1983-04-18 DE DE3314028A patent/DE3314028C2/en not_active Expired - Lifetime
- 1983-04-18 ZA ZA832697A patent/ZA832697B/en unknown
- 1983-04-23 KR KR1019830001730A patent/KR900003281B1/en not_active IP Right Cessation
- 1983-05-04 IT IT48216/83A patent/IT1174758B/en active Protection Beyond IP Right Term
- 1983-05-09 GB GB08312702A patent/GB2132608B/en not_active Expired
- 1983-05-10 IE IE1074/83A patent/IE55097B1/en not_active IP Right Cessation
- 1983-05-11 NL NL8301693A patent/NL8301693A/en active Search and Examination
- 1983-05-20 JP JP58087836A patent/JPS59106483A/en active Granted
- 1983-06-09 NZ NZ204510A patent/NZ204510A/en unknown
- 1983-07-28 CA CA000433422A patent/CA1201442A/en not_active Expired
- 1983-08-08 AT AT2867/83A patent/AT392785B/en not_active IP Right Cessation
Also Published As
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