SE8301786D0 - PROCEDED PREPARATION DE DERIVES DE L'ACIDE 2-THIOPHENE ACETIQUE - Google Patents

PROCEDED PREPARATION DE DERIVES DE L'ACIDE 2-THIOPHENE ACETIQUE

Info

Publication number
SE8301786D0
SE8301786D0 SE8301786A SE8301786A SE8301786D0 SE 8301786 D0 SE8301786 D0 SE 8301786D0 SE 8301786 A SE8301786 A SE 8301786A SE 8301786 A SE8301786 A SE 8301786A SE 8301786 D0 SE8301786 D0 SE 8301786D0
Authority
SE
Sweden
Prior art keywords
formula
thiophene
image
acetique
proceded
Prior art date
Application number
SE8301786A
Other languages
Swedish (sv)
Other versions
SE453918B (en
SE8301786L (en
Inventor
R Nabet
J-L Grardel
M Gallois
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of SE8301786D0 publication Critical patent/SE8301786D0/en
Publication of SE8301786L publication Critical patent/SE8301786L/en
Publication of SE453918B publication Critical patent/SE453918B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/12—Radicals substituted by halogen atoms or nitro or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

A 2-thiophene acetic acid compound of formula (I): <IMAGE> in which: R represents an alkyl radical of 1 to 4 carbon atoms; and R1, R2 and R3 are the same or different and each represents a hydrogen atom, an alkyl radical of 1 to 4 carbon atoms or a halogen atom; is prepared by reacting a haloalkylthiophene of formula (III): <IMAGE> in which R, R1, R2 and R3 are as defined above and Hal represents a halogen atom, with a cyanide of formula A-CN in which A represents an alkali metal atom, an alkaline-earth metal equivalent or a hydrogen atom to produce a cyanoalkylthiophene of formula (IV): <IMAGE> in which R, R1, R2 and R3 are as defined above, and hydrolysing the cyanoalkylthiophene of formula (IV) to the 2-thiophene acetic acid compound of formula (I). The compound of formula (I) is an intermediate in the production of pharmaceuticals.
SE8301786A 1982-12-03 1983-03-30 SET TO PREPARE 2-THIOPHENIC ACETIC ACID DERIVATIVES SE453918B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8220272A FR2537138A1 (en) 1982-12-03 1982-12-03 PROCESS FOR THE PREPARATION OF ACETIC 2-THIOPHENE ACID DERIVATIVES

Publications (3)

Publication Number Publication Date
SE8301786D0 true SE8301786D0 (en) 1983-03-30
SE8301786L SE8301786L (en) 1984-06-04
SE453918B SE453918B (en) 1988-03-14

Family

ID=9279758

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8301786A SE453918B (en) 1982-12-03 1983-03-30 SET TO PREPARE 2-THIOPHENIC ACETIC ACID DERIVATIVES

Country Status (22)

Country Link
JP (1) JPS59106483A (en)
KR (1) KR900003281B1 (en)
AT (1) AT392785B (en)
AU (1) AU557065B2 (en)
BE (1) BE896440A (en)
CA (1) CA1201442A (en)
CH (1) CH653681A5 (en)
DE (1) DE3314028C2 (en)
DK (1) DK157492C (en)
ES (1) ES521231A0 (en)
FI (1) FI80882C (en)
FR (1) FR2537138A1 (en)
GB (1) GB2132608B (en)
HU (1) HU191831B (en)
IE (1) IE55097B1 (en)
IT (1) IT1174758B (en)
LU (1) LU84749A1 (en)
NL (1) NL8301693A (en)
NZ (1) NZ204510A (en)
PT (1) PT76535B (en)
SE (1) SE453918B (en)
ZA (1) ZA832697B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276738B1 (en) * 1995-06-16 1997-11-03 Erregierre Spa PROCESS FOR THE PREPARATION OF DERIVATIVES OF -METHYL-2- THIOPHENEACETIC ACID

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE33054B1 (en) * 1968-04-16 1974-03-06 Ici Ltd Heterocyclic compounds
GB2003570B (en) * 1977-06-08 1982-01-20 Imi Opella Ltd Stop valve

Also Published As

Publication number Publication date
ES8401958A1 (en) 1984-01-01
DK140083D0 (en) 1983-03-28
FI80882B (en) 1990-04-30
PT76535A (en) 1983-05-01
KR840006987A (en) 1984-12-04
FR2537138B1 (en) 1985-05-24
ZA832697B (en) 1983-12-28
SE453918B (en) 1988-03-14
AU1357383A (en) 1984-06-07
DE3314028A1 (en) 1984-06-07
KR900003281B1 (en) 1990-05-12
SE8301786L (en) 1984-06-04
AT392785B (en) 1991-06-10
NL8301693A (en) 1984-07-02
PT76535B (en) 1986-03-12
ES521231A0 (en) 1984-01-01
NZ204510A (en) 1986-02-21
GB2132608A (en) 1984-07-11
CA1201442A (en) 1986-03-04
JPS59106483A (en) 1984-06-20
GB8312702D0 (en) 1983-06-15
IE831074L (en) 1984-06-03
FR2537138A1 (en) 1984-06-08
FI80882C (en) 1990-08-10
IT8348216A0 (en) 1983-05-04
DK157492C (en) 1990-06-11
IE55097B1 (en) 1990-05-23
HU191831B (en) 1987-04-28
LU84749A1 (en) 1983-12-05
FI831116L (en) 1984-06-04
DE3314028C2 (en) 1995-05-24
GB2132608B (en) 1986-06-04
DK157492B (en) 1990-01-15
JPH0439468B2 (en) 1992-06-29
CH653681A5 (en) 1986-01-15
DK140083A (en) 1984-06-04
AU557065B2 (en) 1986-12-04
BE896440A (en) 1983-10-12
FI831116A0 (en) 1983-03-31
ATA286783A (en) 1990-11-15
IT1174758B (en) 1987-07-01

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