SE8303887L - NEW PROCEDURE FOR THE PREPARATION OF ALFA-HYDROXI-2-THIOPHENE ETHIC ACID DERIVATIVES - Google Patents

NEW PROCEDURE FOR THE PREPARATION OF ALFA-HYDROXI-2-THIOPHENE ETHIC ACID DERIVATIVES

Info

Publication number
SE8303887L
SE8303887L SE8303887A SE8303887A SE8303887L SE 8303887 L SE8303887 L SE 8303887L SE 8303887 A SE8303887 A SE 8303887A SE 8303887 A SE8303887 A SE 8303887A SE 8303887 L SE8303887 L SE 8303887L
Authority
SE
Sweden
Prior art keywords
thiophene
hydroxi
alfa
preparation
hydroxy
Prior art date
Application number
SE8303887A
Other languages
Swedish (sv)
Other versions
SE451018B (en
SE8303887D0 (en
Inventor
J Prost-Marechal
G Tomasik
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of SE8303887D0 publication Critical patent/SE8303887D0/en
Publication of SE8303887L publication Critical patent/SE8303887L/en
Publication of SE451018B publication Critical patent/SE451018B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The alpha -hydroxy-2-thiophene acetic acid of formula (I): <IMAGE> in which R represents an alkyl radical of 1-4 carbon atoms and R1, R2 and R3 are the same or different and each represents a hydrogen atom or an alkyl radical of 1-4 carbon atoms, is prepared by reacting a magnesium halide of formula (II): <IMAGE> in which X represents a halogen atom, with a ketone of formula (III): <IMAGE> in which R is as defined above and A represents a hydrogen atom, an alkali metal atom or an equivalent of magnesium or of an alkaline earth metal, to produce a product which is then reacted to hydrolyse its magnesium group and produce the desired alpha -hydroxy-2-thiophene acetic acid. The alpha - hydroxy-2-thiophene acetic acid is useful as an intermediate for producing pharmaceuticals, such as anti-inflammatory products.
SE8303887A 1983-04-28 1983-07-07 PROCEDURE FOR THE PREPARATION OF ALFA-HYDROXY-2-THIOFENE Ethyl Acid Derivatives SE451018B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8307021A FR2545085B1 (en) 1983-04-28 1983-04-28 NOVEL PROCESS FOR THE PREPARATION OF A-HYDROXY 2-THIOPHENE ACETIC ACID DERIVATIVES

Publications (3)

Publication Number Publication Date
SE8303887D0 SE8303887D0 (en) 1983-07-07
SE8303887L true SE8303887L (en) 1984-10-29
SE451018B SE451018B (en) 1987-08-24

Family

ID=9288331

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8303887A SE451018B (en) 1983-04-28 1983-07-07 PROCEDURE FOR THE PREPARATION OF ALFA-HYDROXY-2-THIOFENE Ethyl Acid Derivatives

Country Status (22)

Country Link
JP (1) JPS59204185A (en)
KR (1) KR900006558B1 (en)
AT (1) AT392786B (en)
AU (1) AU559749B2 (en)
BE (1) BE897362A (en)
CA (1) CA1201443A (en)
CH (1) CH655316A5 (en)
DE (1) DE3325456A1 (en)
DK (1) DK157493C (en)
ES (1) ES524648A0 (en)
FI (1) FI832473L (en)
FR (1) FR2545085B1 (en)
GB (1) GB2139215B (en)
HU (1) HU194206B (en)
IE (1) IE55905B1 (en)
IT (1) IT1171855B (en)
LU (1) LU84931A1 (en)
NL (1) NL8302564A (en)
NZ (1) NZ205514A (en)
PT (1) PT77010B (en)
SE (1) SE451018B (en)
ZA (1) ZA835613B (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1067828A (en) * 1951-01-19 1954-06-18 Sterling Drug Inc Improvements relating to a process for preparing organic chemicals
GB820083A (en) * 1955-07-05 1959-09-16 Metal & Thermit Corp Reactions of organomagnesium chloride reagents
GB806710A (en) * 1955-07-05 1958-12-31 Metal & Thermit Corp Reactions of organomagnesium chloride complexes
FR2068425B1 (en) * 1969-11-12 1973-01-12 Roussel Uclaf
FR2167334A1 (en) * 1972-01-13 1973-08-24 Roussel Uclaf 4-aroyl-5-alkylthiophene-2-acetic acids - with analgesic and antiinflammatory activity
GB1584120A (en) * 1977-07-21 1981-02-04 Sagami Chem Res Process for the preparation of thiophene derivatives and thiophene derivatives obtained therethrough
GB2030131B (en) * 1978-09-12 1982-12-22 Taiyo Pharma Ind Process for producing 2-(4-(2-thienyl-carbonyl) phenyl) propionic acid
JPS5835145A (en) * 1981-08-26 1983-03-01 Taisho Pharmaceut Co Ltd Preparation of alpha-arylalkanoic acid ester

Also Published As

Publication number Publication date
DE3325456A1 (en) 1984-10-31
PT77010A (en) 1983-08-01
JPS59204185A (en) 1984-11-19
LU84931A1 (en) 1984-03-22
JPH0439469B2 (en) 1992-06-29
GB8323492D0 (en) 1983-10-05
IT8348823A0 (en) 1983-08-08
HU194206B (en) 1988-01-28
IE55905B1 (en) 1991-02-14
DK307583D0 (en) 1983-07-04
CH655316A5 (en) 1986-04-15
SE451018B (en) 1987-08-24
SE8303887D0 (en) 1983-07-07
AU559749B2 (en) 1987-03-19
DE3325456C2 (en) 1993-04-29
KR900006558B1 (en) 1990-09-13
DK307583A (en) 1984-10-29
DK157493C (en) 1990-06-11
AU1730983A (en) 1984-11-01
ES8404345A1 (en) 1984-05-01
NL8302564A (en) 1984-11-16
CA1201443A (en) 1986-03-04
FR2545085B1 (en) 1985-10-25
BE897362A (en) 1984-01-25
FR2545085A1 (en) 1984-11-02
ATA286883A (en) 1990-11-15
IT1171855B (en) 1987-06-10
GB2139215A (en) 1984-11-07
ZA835613B (en) 1985-03-27
GB2139215B (en) 1986-10-08
FI832473L (en) 1984-10-29
KR840008351A (en) 1984-12-14
AT392786B (en) 1991-06-10
NZ205514A (en) 1987-03-31
IE832074L (en) 1984-10-28
ES524648A0 (en) 1984-05-01
DK157493B (en) 1990-01-15
PT77010B (en) 1986-04-11
FI832473A0 (en) 1983-07-05

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