KR840008351A - Method for preparing a derivative of α-hydroxy-2-thiophene acetic acid - Google Patents

Method for preparing a derivative of α-hydroxy-2-thiophene acetic acid Download PDF

Info

Publication number
KR840008351A
KR840008351A KR1019830003476A KR830003476A KR840008351A KR 840008351 A KR840008351 A KR 840008351A KR 1019830003476 A KR1019830003476 A KR 1019830003476A KR 830003476 A KR830003476 A KR 830003476A KR 840008351 A KR840008351 A KR 840008351A
Authority
KR
South Korea
Prior art keywords
product
methyl
formula
hydroxy
acetic acid
Prior art date
Application number
KR1019830003476A
Other languages
Korean (ko)
Other versions
KR900006558B1 (en
Inventor
프로스트-마르셀 쟈끄 (외 1)
Original Assignee
허우트 후리텔
로우셀-우크라프
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 허우트 후리텔, 로우셀-우크라프 filed Critical 허우트 후리텔
Publication of KR840008351A publication Critical patent/KR840008351A/en
Application granted granted Critical
Publication of KR900006558B1 publication Critical patent/KR900006558B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음.No content.

Description

α-히드록시-2-티오펜 아센트산의 유도체의 제조방법Method for preparing derivatives of α-hydroxy-2-thiophene ascent acid

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (12)

다음 일반식(II)의 생성물을 다음 일반식(III)의 생성물과 반응시켜 얻어진 것의 마그네슘 그룹의 가수분해 후 원하는 일반식(I)의 생성물을 얻음을 특징으로 하는 다음 일반식(I)의 α-히드록시-2-티오펜 아세트산의 유도체의 제조방법.Α of the following general formula (I) characterized by the reaction of the product of the following general formula (II) with the product of the following general formula (III) to give the desired product of the general formula (I) A process for the derivative of hydroxy-2-thiophene acetic acid. 상기 식에서, R은 1 내지 4 탄소원자의 알킬기를 나타내고, 각각의 R1, R2및 R3는 같거나 다르며 수소원자 또는 1 내지 4 탄소원자를 나타내고 X는 할로겐 원자를 나타내고 A는 수소원자 또는 알칼리금속원자 또는 마그네슘 또는 알칼리토 금소의 등가량을 나타낸다.Wherein R represents an alkyl group of 1 to 4 carbon atoms, each of R 1 , R 2 and R 3 is the same or different and represents a hydrogen atom or 1 to 4 carbon atoms, X represents a halogen atom and A represents a hydrogen atom or an alkali metal It represents an atom or an equivalent amount of magnesium or alkaline earth gold. 상기 1항에 있어, 상기 1항에 기재한 공정은 2-티에닐 마그네슘 할라이드를 출발로 하는 공정임을 특징으로 하여 다음 일반식(II')의 생성물을 제조하는 방법.The process according to claim 1, wherein the process described in claim 1 is a process starting with 2-thienyl magnesium halide. 상기 식에서 R은 상기 1항에서 기재한 바와 같다.Wherein R is as described in 1 above. 상기 1 또는 2항에 있어 R이 메틸 또는 에틸기를 나타내는 일반식(III)의 생성물을 상기 1항에 기재한 방법에 사용됨을 특징으로 하여 R이 메틸 또는 일반식(I')의 생성물의 제조방법.A process for producing a product of formula (I ') wherein R is methyl or (I'), wherein the product of formula (III) wherein R represents a methyl or ethyl group is used in the process . 상기 1 내지 3항의 어느 하나에 있어 R1, R2및 R3가 각각 수소원자를 나타내는 일반식(II)의 생성물과 R이 메틸기를 나타내는 일반식(III)의 생성물을 1항에 기재한 방법에 사용함을 특징으로 하는 α-메틸-α-히드록시-2-티오펜 아세트산의 제조방법.The method according to any one of items 1 to 3, wherein R 1 , R 2 and R 3 each represent a hydrogen atom, and R represents a methyl group. A method for producing α-methyl-α-hydroxy-2-thiophene acetic acid, characterized in that it is used for. 상기 1 내지 4항의 어느 하나에 있어 1항 기재의 반응이 X가 브롬원자를 나타내는 일반식(II)의 생성물과 A가 수소원자 또는 리튬원자를 나타내는 일반식(III)의 생성물로 부터 실시됨을 특징으로 하는 상기의 제조방법.The reaction according to any one of the above 1 to 4, wherein the reaction according to claim 1 is carried out from the product of formula (II) in which X represents a bromine atom and from the product of formula (III) in which A represents a hydrogen atom or a lithium atom. The above production method. 상기 1 내지 5항의 하나에 있어 마그네슘 그룹의 가수분해를 수성산 매질중에서 수행됨을 특징으로 하는 상기의 제조방법.The process according to one of the preceding claims, characterized in that the hydrolysis of the magnesium groups is carried out in an aqueous acid medium. 상기 1 내지 6항의 하나에 있어 2-티에닐마그네슘 브로마이드를 리튬 피루베이트와 반응시키고 얻어진 생성물을 염산의 수성 용액으로 가수분해 시킴을 특징으로 하는 α-메틸-α-히드록시-2-티오펜 아세트산의 제조방법.Α-methyl-α-hydroxy-2-thiophene acetic acid according to one of the preceding claims, characterized in that 2-thienyl magnesium bromide is reacted with lithium pyruvate and the resulting product is hydrolyzed with an aqueous solution of hydrochloric acid. Manufacturing method. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019830003476A 1983-04-28 1983-07-27 Process for preparing derivatives of alpha-hydroxy 2-thiophene acetic acid KR900006558B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8307021A FR2545085B1 (en) 1983-04-28 1983-04-28 NOVEL PROCESS FOR THE PREPARATION OF A-HYDROXY 2-THIOPHENE ACETIC ACID DERIVATIVES
FR8307021 1983-04-28
FR83-07021 1983-04-28

Publications (2)

Publication Number Publication Date
KR840008351A true KR840008351A (en) 1984-12-14
KR900006558B1 KR900006558B1 (en) 1990-09-13

Family

ID=9288331

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830003476A KR900006558B1 (en) 1983-04-28 1983-07-27 Process for preparing derivatives of alpha-hydroxy 2-thiophene acetic acid

Country Status (22)

Country Link
JP (1) JPS59204185A (en)
KR (1) KR900006558B1 (en)
AT (1) AT392786B (en)
AU (1) AU559749B2 (en)
BE (1) BE897362A (en)
CA (1) CA1201443A (en)
CH (1) CH655316A5 (en)
DE (1) DE3325456A1 (en)
DK (1) DK157493C (en)
ES (1) ES524648A0 (en)
FI (1) FI832473L (en)
FR (1) FR2545085B1 (en)
GB (1) GB2139215B (en)
HU (1) HU194206B (en)
IE (1) IE55905B1 (en)
IT (1) IT1171855B (en)
LU (1) LU84931A1 (en)
NL (1) NL8302564A (en)
NZ (1) NZ205514A (en)
PT (1) PT77010B (en)
SE (1) SE451018B (en)
ZA (1) ZA835613B (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1067828A (en) * 1951-01-19 1954-06-18 Sterling Drug Inc Improvements relating to a process for preparing organic chemicals
GB820083A (en) * 1955-07-05 1959-09-16 Metal & Thermit Corp Reactions of organomagnesium chloride reagents
GB806710A (en) * 1955-07-05 1958-12-31 Metal & Thermit Corp Reactions of organomagnesium chloride complexes
FR2068425B1 (en) * 1969-11-12 1973-01-12 Roussel Uclaf
FR2167334A1 (en) * 1972-01-13 1973-08-24 Roussel Uclaf 4-aroyl-5-alkylthiophene-2-acetic acids - with analgesic and antiinflammatory activity
GB1584120A (en) * 1977-07-21 1981-02-04 Sagami Chem Res Process for the preparation of thiophene derivatives and thiophene derivatives obtained therethrough
GB2030131B (en) * 1978-09-12 1982-12-22 Taiyo Pharma Ind Process for producing 2-(4-(2-thienyl-carbonyl) phenyl) propionic acid
JPS5835145A (en) * 1981-08-26 1983-03-01 Taisho Pharmaceut Co Ltd Preparation of alpha-arylalkanoic acid ester

Also Published As

Publication number Publication date
FR2545085B1 (en) 1985-10-25
IE55905B1 (en) 1991-02-14
IE832074L (en) 1984-10-28
DE3325456A1 (en) 1984-10-31
LU84931A1 (en) 1984-03-22
PT77010A (en) 1983-08-01
JPS59204185A (en) 1984-11-19
NL8302564A (en) 1984-11-16
DK157493B (en) 1990-01-15
DK307583D0 (en) 1983-07-04
DK157493C (en) 1990-06-11
DE3325456C2 (en) 1993-04-29
AT392786B (en) 1991-06-10
AU559749B2 (en) 1987-03-19
IT1171855B (en) 1987-06-10
ZA835613B (en) 1985-03-27
HU194206B (en) 1988-01-28
GB8323492D0 (en) 1983-10-05
IT8348823A0 (en) 1983-08-08
BE897362A (en) 1984-01-25
ES8404345A1 (en) 1984-05-01
CH655316A5 (en) 1986-04-15
GB2139215B (en) 1986-10-08
CA1201443A (en) 1986-03-04
JPH0439469B2 (en) 1992-06-29
SE451018B (en) 1987-08-24
FR2545085A1 (en) 1984-11-02
SE8303887L (en) 1984-10-29
ATA286883A (en) 1990-11-15
KR900006558B1 (en) 1990-09-13
ES524648A0 (en) 1984-05-01
GB2139215A (en) 1984-11-07
FI832473L (en) 1984-10-29
DK307583A (en) 1984-10-29
SE8303887D0 (en) 1983-07-07
NZ205514A (en) 1987-03-31
FI832473A0 (en) 1983-07-05
AU1730983A (en) 1984-11-01
PT77010B (en) 1986-04-11

Similar Documents

Publication Publication Date Title
KR880000433A (en) Method for preparing imidazopyridine and intermediate compound
KR940014440A (en) Starch ester having a medium degree of substitution in aqueous solution and method for producing the same
KR840000463A (en) Method for preparing-1-alkanone substituted with optically active 1-aromatic group
KR830006154A (en) Method for producing novel cyclopropanecarboxylate
KR860000312A (en) Sialic acid derivatives, galactose derivatives and production methods thereof
KR850005845A (en) Process for preparing 7-amino-3-substituted-methyl-3-cepem-4-carboxylic acid and lower alkylsilyl derivatives thereof
KR860002502A (en) Method for preparing 1,3-oxazolidin-2-one derivative
KR880005145A (en) N-glycolyl-neuramic acid-containing glycolipid and its preparation method
KR920006321A (en) Method for preparing 3-methylpyrazole
KR860001045A (en) Method for producing naphthyl homologue of mevalonolactone
KR840008351A (en) Method for preparing a derivative of α-hydroxy-2-thiophene acetic acid
KR840006986A (en) Method of manufacturing 2-thiophene acetate semiconductor
KR910002764A (en) Process for preparing haloalkyl alkanoate
KR860000255A (en) Method for preparing amine derivative
KR840006183A (en) Method for preparing N-phosphonomethylglycine
KR890002011A (en) 5-halogeno-6-amino-nicotinic acid halide. Method of manufacture and use thereof
KR870008828A (en) 4,4-bis (4-hydroxyphenyl) cyclohexanecarboxylic acid derivative and its manufacturing method
KR840006987A (en) Method for preparing 2-thiophene acetic acid derivative
KR890005027A (en) Phenoxyalkylcarboxylic acid derivatives and preparation methods thereof
KR870002110A (en) Method for preparing guanidinothiazole derivatives
KR830006150A (en) Process for preparing alkyl and alkoxyalkyl substituted benzene compounds
KR830005153A (en) Method for preparing 4-benzoyl-5-hydroxypyrazole compound
KR850001744A (en) Preparation of 4-R'-5-Q-1,6-naphthyridine-2 (1H)-warms
KR830010061A (en) Method for preparing phenoxybenzoic acid derivative
KR940014320A (en) Method for preparing 4-amino-5-hydroxy-1,7-naphthalenedisulfonic acid

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20020807

Year of fee payment: 13

EXPY Expiration of term