GB937183A - 3,8-diazabicyclo-[3,2,1]-octanes - Google Patents

3,8-diazabicyclo-[3,2,1]-octanes

Info

Publication number
GB937183A
GB937183A GB5642/60A GB564260A GB937183A GB 937183 A GB937183 A GB 937183A GB 5642/60 A GB5642/60 A GB 5642/60A GB 564260 A GB564260 A GB 564260A GB 937183 A GB937183 A GB 937183A
Authority
GB
United Kingdom
Prior art keywords
reducing
hydrogen
general formula
group
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5642/60A
Inventor
Giorgio Cignarella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Priority to GB5642/60A priority Critical patent/GB937183A/en
Priority to CH163161A priority patent/CH404678A/en
Priority to CH702061A priority patent/CH408036A/en
Priority to DEL46485A priority patent/DE1200316B/en
Priority to DE19611445094 priority patent/DE1445094A1/en
Priority to US104016A priority patent/US3221015A/en
Publication of GB937183A publication Critical patent/GB937183A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention comprises compounds of the general formula: <FORM:0937183/IV(a)/1> (wherein R represents a hydrogen atom, a C1-8 alkyl group or an aryl or aralkyl group optionally substituted by halogen and R1 represents a hydrogen atom or a methyl group); their acid addition salts and the preparation thereof by reducing a bicycle-dione of the general formula: <FORM:0937183/IV(a)/2> (wherein X is a hydrogen atom or a carbobenzyloxy group) with an excess of lithium aluminium hydride or when both R and R1 represent hydrogen by reducing a compound of the general formula: <FORM:0937183/IV(a)/3> (wherein one of groups Z represents a hydrogen atom and the other a group which can be removed by hydrogenolysis) with catalytically activiated hydrogen, then reducing the dione with lithium aluminium hydride or by reducing a compound of the general formula: <FORM:0937183/IV(a)/4> with catalytically activated hydrogen; or when R1 represents hydrogen by reducing a compound of the general formula: <FORM:0937183/IV(a)/5> (wherein Y is a carbobenzyoxy group) with catalytically activated hydrogen and reducing the resulting dione with lithium aluminium hydride. Specification 937,184 is referred to.
GB5642/60A 1960-02-17 1960-02-17 3,8-diazabicyclo-[3,2,1]-octanes Expired GB937183A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB5642/60A GB937183A (en) 1960-02-17 1960-02-17 3,8-diazabicyclo-[3,2,1]-octanes
CH163161A CH404678A (en) 1960-02-17 1961-02-10 Process for the preparation of new 3,8-diazabicyclo- (3,2,1) -octanes
CH702061A CH408036A (en) 1960-02-17 1961-02-10 Process for the preparation of 3,8-diazabicyclo- (3,2,1) -octane-2,4-dione
DEL46485A DE1200316B (en) 1960-02-17 1961-02-16 Process for the preparation of 2,4-dioxo-3, 8-diazabicyclo [3, 2, 1] octanes
DE19611445094 DE1445094A1 (en) 1960-02-17 1961-02-16 3,8-Diazabicyclo [3.2.1] octanes and processes for their preparation
US104016A US3221015A (en) 1960-02-17 1961-04-19 3,8-diazabicyclo-[3,2,1]-octanes and process for preparing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5642/60A GB937183A (en) 1960-02-17 1960-02-17 3,8-diazabicyclo-[3,2,1]-octanes

Publications (1)

Publication Number Publication Date
GB937183A true GB937183A (en) 1963-09-18

Family

ID=9799922

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5642/60A Expired GB937183A (en) 1960-02-17 1960-02-17 3,8-diazabicyclo-[3,2,1]-octanes

Country Status (1)

Country Link
GB (1) GB937183A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531709A1 (en) * 1982-08-13 1984-02-17 Sanofi Sa Diazabicyclooctanes, process for preparing them and pharmaceutical compositions containing them
WO1988002627A1 (en) * 1986-10-08 1988-04-21 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine- and quinoline-carboxylic acid antibacterial agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531709A1 (en) * 1982-08-13 1984-02-17 Sanofi Sa Diazabicyclooctanes, process for preparing them and pharmaceutical compositions containing them
WO1988002627A1 (en) * 1986-10-08 1988-04-21 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine- and quinoline-carboxylic acid antibacterial agents

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