HK1008674A1 - Aza cyclohexapeptide compounds - Google Patents

Aza cyclohexapeptide compounds

Info

Publication number
HK1008674A1
HK1008674A1 HK98109267A HK98109267A HK1008674A1 HK 1008674 A1 HK1008674 A1 HK 1008674A1 HK 98109267 A HK98109267 A HK 98109267A HK 98109267 A HK98109267 A HK 98109267A HK 1008674 A1 HK1008674 A1 HK 1008674A1
Authority
HK
Hong Kong
Prior art keywords
aza cyclohexapeptide
cyclohexapeptide compounds
compounds
aza
ceretain
Prior art date
Application number
HK98109267A
Other languages
English (en)
Inventor
James M Balkovec
Frances Aileen Bouffard
Regina M Black
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1008674(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HK1008674A1 publication Critical patent/HK1008674A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein
HK98109267A 1993-03-16 1998-07-20 Aza cyclohexapeptide compounds HK1008674A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (1)

Publication Number Publication Date
HK1008674A1 true HK1008674A1 (en) 1999-05-14

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98109267A HK1008674A1 (en) 1993-03-16 1998-07-20 Aza cyclohexapeptide compounds

Country Status (33)

Country Link
US (3) US5378804A (zh)
EP (1) EP0620232B1 (zh)
JP (1) JP2568474B2 (zh)
KR (1) KR100329693B1 (zh)
CN (1) CN1098274C (zh)
AT (1) ATE186736T1 (zh)
AU (1) AU668804B2 (zh)
BG (1) BG63047B1 (zh)
BR (2) BR9406009A (zh)
CA (1) CA2118757C (zh)
CZ (1) CZ286235B6 (zh)
DE (2) DE69421639T2 (zh)
DK (1) DK0620232T3 (zh)
ES (1) ES2139043T3 (zh)
FI (1) FI109542B (zh)
GR (1) GR3031872T3 (zh)
HK (1) HK1008674A1 (zh)
HR (1) HRP940161B1 (zh)
HU (2) HU217614B (zh)
IL (1) IL108892A (zh)
LU (1) LU90875I2 (zh)
LV (1) LV12574B (zh)
NL (1) NL300076I2 (zh)
NO (2) NO318372B1 (zh)
NZ (1) NZ263360A (zh)
PL (1) PL179261B1 (zh)
RO (1) RO113246B1 (zh)
RU (1) RU2122548C1 (zh)
SI (1) SI9420013B (zh)
SK (1) SK282527B6 (zh)
UA (1) UA59329C2 (zh)
WO (1) WO1994021677A1 (zh)
ZA (1) ZA941807B (zh)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
EP0779895B1 (en) * 1994-08-23 1999-11-17 Merck & Co. Inc. An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
AU692308B2 (en) * 1994-09-16 1998-06-04 Merck Sharp & Dohme Corp. Aza cyclohexapeptide compounds
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
EP0805685B1 (en) * 1995-01-26 2001-09-26 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
WO1997017365A1 (en) * 1995-11-09 1997-05-15 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
AR006598A1 (es) * 1996-04-19 1999-09-08 Merck Sharp & Dohme "composiciones anti-fungosas, su uso en la manufactura de medicamentos y un procedimiento para su preparación"
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
EA002469B1 (ru) * 1996-09-12 2002-06-27 Мерк Энд Ко., Инк. Способ лечения грибковой инфекции
US6069126A (en) * 1996-09-12 2000-05-30 Merck & Co., Inc. Antifungal combination therapy
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
CA2380176A1 (en) * 1999-07-27 2001-02-01 Aventis Pharma Deutschland Gmbh Novel cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
EP1490090A4 (en) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc SYSTEMS FOR DELIVERING ACTIVE AGENTS AND METHODS FOR PROTECTING AND DELIVERING ACTIVE AGENTS
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
WO2005018743A1 (en) 2003-07-22 2005-03-03 Theravance, Inc. Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
EA012569B1 (ru) * 2004-02-24 2009-10-30 Коммонвелт Сайентифик Энд Индастриал Рисёч Организейшн Пептид насекомых, обладающий противогрибковой и/или антибактериальной активностью, и способы его применения
EP1785432A1 (en) * 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
KR101536781B1 (ko) * 2006-07-26 2015-07-14 산도즈 아게 카스포펀진 제형
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
EP2170362B1 (en) 2007-06-26 2015-11-04 Merck Sharp & Dohme Corp. Lyophilized anti-fungal composition
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
US20090291996A1 (en) * 2008-05-21 2009-11-26 Ferenc Korodi Caspofungin free of caspofungin Co
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
WO2009158034A1 (en) * 2008-06-25 2009-12-30 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin free of caspofungin impurity a
US20100256074A1 (en) * 2008-06-25 2010-10-07 Chaim Eidelman Processes for preparing high purity aza cyclohexapeptides
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
WO2011014990A1 (zh) * 2009-08-06 2011-02-10 上海天伟生物制药有限公司 一种氮杂环己肽或其药学上可接受的盐及其制备方法和用途
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
PL2618814T3 (pl) 2010-09-20 2017-01-31 Xellia Pharmaceuticals Aps Kompozycja kaspofunginy
RU2535489C1 (ru) * 2010-09-29 2014-12-10 Шанхай Техвелл Биофармасьютикал Ко., Лтд. Способ очистки циклолипопептидных соединений или их солей
AU2011307733B2 (en) * 2010-09-30 2015-03-26 Shanghai Techwell Biopharmaceutical Co., Ltd. Method for purifying cyclic lipopeptide or salt thereof
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
EP2661441A4 (en) * 2011-01-03 2015-04-08 Biocon Ltd PROCESS FOR THE PREPARATION OF ACETATE CASPOFUNGIN AND ITS INTERMEDIATES
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
JP5809296B2 (ja) 2011-03-03 2015-11-10 シーチェイド ファーマシューティカルズ，インコーポレーテッド 抗真菌薬及びそれらの使用
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
CN103003295B (zh) 2011-04-28 2014-09-17 上海源力生物技术有限公司 用于合成卡帕芬净的中间体及其制备方法
ES2957620T3 (es) 2012-03-19 2024-01-23 Cidara Therapeutics Inc Regímenes de dosificación para los compuestos de la clase de las equinocandinas
US9636407B2 (en) * 2012-11-20 2017-05-02 Fresenius Kabi Usa, Llc Caspofungin acetate formulations
CN112110991A (zh) * 2014-12-24 2020-12-22 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
WO2017034961A1 (en) 2015-08-21 2017-03-02 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
CN108883152A (zh) 2016-01-08 2018-11-23 奇达拉治疗公司 防止和治疗肺孢子虫感染的方法
MA43825A (fr) 2016-03-16 2021-04-07 Cidara Therapeutics Inc Schémas posologiques pour le traitement d'infections fongiques
WO2017185030A1 (en) * 2016-04-22 2017-10-26 Fresenius Kabi Usa, Llc Caspofungin formulation with low impurities
JP2020529973A (ja) 2017-07-12 2020-10-15 シダラ セラピューティクス インコーポレーテッド 真菌感染症の処置のための組成物及び方法
WO2019157453A1 (en) 2018-02-12 2019-08-15 Trilogy Therapeutics, Inc. Caspofungin compositions for inhalation
EP3620462A1 (en) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Process for the preparation of caspofungin

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4320053A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912D nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
EP0030844A1 (en) * 1979-12-13 1981-06-24 Eli Lilly And Company Recovery process for A-30912 antibiotics
DE3030554A1 (de) * 1980-08-13 1982-03-25 Chemische Werke Hüls AG, 4370 Marl Einbrennlacke
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
NZ234225A (en) * 1989-06-30 1993-09-27 Merck & Co Inc Antibiotic from zalerion arboricola and its use as an antifungal agent and antipneumocystis agent
US5194377A (en) * 1989-06-30 1993-03-16 Merck & Co., Inc. Antibiotic agent
US5202309A (en) * 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
IL105048A (en) * 1992-03-19 2001-06-14 Eli Lilly And Company U S Antifungal substances of the cyclic peptide type and a process for their preparation
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
EP0620232B1 (en) 1999-11-17
LU90875I2 (en) 2002-03-04
HRP940161A2 (en) 1996-08-31
FI109542B (fi) 2002-08-30
UA59329C2 (uk) 2003-09-15
NO953648D0 (no) 1995-09-15
CA2118757A1 (en) 1994-09-17
HUT73496A (en) 1996-08-28
NZ263360A (en) 1997-08-22
SK113695A3 (en) 1996-02-07
HU211890A9 (en) 1995-12-28
JP2568474B2 (ja) 1997-01-08
PL310634A1 (en) 1995-12-27
BG63047B1 (bg) 2001-02-28
BR9406009A (pt) 1995-12-26
NL300076I1 (nl) 2002-03-01
ZA941807B (en) 1994-10-13
HRP940161B1 (en) 2001-04-30
US5792746A (en) 1998-08-11
PL179261B1 (pl) 2000-08-31
DE10299013I2 (de) 2009-11-19
NO953648L (no) 1995-11-15
NO318372B1 (no) 2005-03-14
CN1098274C (zh) 2003-01-08
CA2118757C (en) 2002-05-14
RU2122548C1 (ru) 1998-11-27
FI954327A0 (fi) 1995-09-14
GR3031872T3 (en) 2000-02-29
NL300076I2 (nl) 2002-04-02
BG99999A (bg) 1996-04-30
CZ286235B6 (cs) 2000-02-16
DE10299013I1 (de) 2003-01-23
DE69421639D1 (de) 1999-12-23
US5514650A (en) 1996-05-07
IL108892A (en) 1998-07-15
NO2005020I1 (no) 2005-09-13
CN1119441A (zh) 1996-03-27
EP0620232A1 (en) 1994-10-19
KR960701092A (ko) 1996-02-24
RO113246B1 (ro) 1998-05-29
HU217614B (hu) 2000-03-28
AU5783294A (en) 1994-09-22
LV12574B (en) 2001-04-20
DK0620232T3 (da) 2000-03-13
WO1994021677A1 (en) 1994-09-29
SI9420013A (en) 1996-08-31
SK282527B6 (sk) 2002-10-08
JPH06321986A (ja) 1994-11-22
SI9420013B (sl) 2002-12-31
HU9502703D0 (en) 1995-11-28
LV12574A (en) 2000-11-20
DE69421639T2 (de) 2000-06-08
CZ235895A3 (en) 1996-02-14
BR1100273A (pt) 1999-10-13
ATE186736T1 (de) 1999-12-15
FI954327A (fi) 1995-09-14
IL108892A0 (en) 1994-06-24
KR100329693B1 (ko) 2002-08-14
US5378804A (en) 1995-01-03
AU668804B2 (en) 1996-05-16
NO2005020I2 (no) 2008-12-01
ES2139043T3 (es) 2000-02-01

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