ES2696825T3 - Modificación del ADN inducida por el efector TAL - Google Patents

Modificación del ADN inducida por el efector TAL Download PDF

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Publication number
ES2696825T3
ES2696825T3 ES14183521T ES14183521T ES2696825T3 ES 2696825 T3 ES2696825 T3 ES 2696825T3 ES 14183521 T ES14183521 T ES 14183521T ES 14183521 T ES14183521 T ES 14183521T ES 2696825 T3 ES2696825 T3 ES 2696825T3
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Prior art keywords
sequence
dna
cell
nucleic acid
tal
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ES14183521T
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English (en)
Spanish (es)
Inventor
Daniel Voytas
Adam J Bogdanove
Feng Zhang
Michelle Christian
Tomas Cermak
Clarice Lauer Schmidt
Erin Doyle
Li Wang
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Iowa State University Research Foundation Inc ISURF
University of Minnesota Twin Cities
University of Minnesota System
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Iowa State University Research Foundation Inc ISURF
University of Minnesota Twin Cities
University of Minnesota System
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21004—Type II site-specific deoxyribonuclease (3.1.21.4)

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  • General Chemical & Material Sciences (AREA)
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  • Oncology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
ES14183521T 2009-12-10 2010-12-10 Modificación del ADN inducida por el efector TAL Active ES2696825T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28532409P 2009-12-10 2009-12-10
US35210810P 2010-06-07 2010-06-07
US36668510P 2010-07-22 2010-07-22

Publications (1)

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ES2696825T3 true ES2696825T3 (es) 2019-01-18

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ID=43825298

Family Applications (2)

Application Number Title Priority Date Filing Date
ES10799163.0T Active ES2527997T5 (es) 2009-12-10 2010-12-10 Modificación del ADN inducida por el efector TAL
ES14183521T Active ES2696825T3 (es) 2009-12-10 2010-12-10 Modificación del ADN inducida por el efector TAL

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Country Status (17)

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US (10) US8586363B2 (OSRAM)
EP (3) EP2510096B2 (OSRAM)
JP (3) JP2013513389A (OSRAM)
KR (2) KR102110608B1 (OSRAM)
CN (2) CN102770539B (OSRAM)
AU (2) AU2010327998B2 (OSRAM)
CA (1) CA2783351C (OSRAM)
DK (2) DK2510096T4 (OSRAM)
ES (2) ES2527997T5 (OSRAM)
HU (1) HUE041436T2 (OSRAM)
IL (2) IL220234B (OSRAM)
NO (1) NO2510096T3 (OSRAM)
PL (2) PL2816112T3 (OSRAM)
PT (2) PT2510096E (OSRAM)
SG (1) SG181601A1 (OSRAM)
TR (1) TR201815882T4 (OSRAM)
WO (1) WO2011072246A2 (OSRAM)

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