EG24928A - Heterocyclic inhibitors of mek and methods of use thereof - Google Patents

Heterocyclic inhibitors of mek and methods of use thereof

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Publication number
EG24928A
EG24928A EGNA2006000472A EG24928A EG 24928 A EG24928 A EG 24928A EG NA2006000472 A EGNA2006000472 A EG NA2006000472A EG 24928 A EG24928 A EG 24928A
Authority
EG
Egypt
Prior art keywords
compounds
methods
mek
heterocyclic inhibitors
mammals
Prior art date
Application number
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English (en)
Inventor
Allison L Marlow
Eli Wallace
Jeongbeob Seo
Joseph P Lyssikatos
Hong Woon Yang
Jim Blake
Original Assignee
Array Biopharma Inc
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Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
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Publication of EG24928A publication Critical patent/EG24928A/xx

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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