MX371304B - Dihidropirrolopiridinas inhibidoras del receptor huérfano-gamma. - Google Patents

Dihidropirrolopiridinas inhibidoras del receptor huérfano-gamma.

Info

Publication number
MX371304B
MX371304B MX2017004906A MX2017004906A MX371304B MX 371304 B MX371304 B MX 371304B MX 2017004906 A MX2017004906 A MX 2017004906A MX 2017004906 A MX2017004906 A MX 2017004906A MX 371304 B MX371304 B MX 371304B
Authority
MX
Mexico
Prior art keywords
ror
gamma
dihydropyrrolopyridine
inhibitors
diseases
Prior art date
Application number
MX2017004906A
Other languages
English (en)
Other versions
MX2017004906A (es
Inventor
Jing Yuan
David A Claremon
Wei Zhao
Colin M Tice
Suresh B Singh
Linghang Zhuang
Lanqi Jia
Yajun Zheng
Lawrence Wayne Dillard
Chengguo Dong
Yi Fan
D Lotesta Stephen
Marcus Andrew
Original Assignee
Vitae Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitae Pharmaceuticals Llc filed Critical Vitae Pharmaceuticals Llc
Publication of MX2017004906A publication Critical patent/MX2017004906A/es
Publication of MX371304B publication Critical patent/MX371304B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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  • Hematology (AREA)
  • Obesity (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

Se proveen compuestos novedosos de Fórmula (I): sales farmacéuticamente aceptables de los mismos, y composiciones farmacéuticas de los mismos, que son útiles en el tratamiento de enfermedades y trastornos mediados por RORy. También se proveen composiciones farmacéuticas que comprenden los compuestos novedosos de Fórmula (I) y métodos para su uso en el tratamiento de una o más enfermedades inflamatorias, metabólicas, autoinmunes y otras enfermedades o trastornos.
MX2017004906A 2014-10-14 2015-10-14 Dihidropirrolopiridinas inhibidoras del receptor huérfano-gamma. MX371304B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US201462074406P 2014-11-03 2014-11-03
PCT/US2015/055420 WO2016061160A1 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (2)

Publication Number Publication Date
MX2017004906A MX2017004906A (es) 2017-12-07
MX371304B true MX371304B (es) 2020-01-24

Family

ID=54352515

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017004906A MX371304B (es) 2014-10-14 2015-10-14 Dihidropirrolopiridinas inhibidoras del receptor huérfano-gamma.

Country Status (28)

Country Link
US (3) US9796710B2 (es)
EP (1) EP3207043B3 (es)
JP (1) JP6564029B2 (es)
KR (1) KR20170066628A (es)
CN (1) CN107074852B (es)
AU (1) AU2015333610B2 (es)
BR (1) BR112017007460A2 (es)
CA (1) CA2963140A1 (es)
CL (1) CL2017000902A1 (es)
CO (1) CO2017004525A2 (es)
CY (1) CY1121413T1 (es)
DK (1) DK3207043T6 (es)
EA (1) EA031967B1 (es)
EC (1) ECSP17029371A (es)
ES (1) ES2715458T7 (es)
HU (1) HUE042335T2 (es)
IL (1) IL251584B (es)
MX (1) MX371304B (es)
MY (1) MY182454A (es)
PH (1) PH12017500583A1 (es)
PL (1) PL3207043T6 (es)
PT (1) PT3207043T (es)
SG (1) SG11201702362SA (es)
SI (1) SI3207043T1 (es)
TW (1) TWI675032B (es)
UA (1) UA118989C2 (es)
WO (1) WO2016061160A1 (es)
ZA (1) ZA201702237B (es)

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AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
SI3074400T1 (en) 2013-11-26 2018-03-30 F. Hoffmann-La Roche Ag Octahydro-cyclobut (1,2-c, 3,4-cy) dipyrrole derivatives as autoantaxine inhibitors
RS59007B1 (sr) 2014-02-03 2019-08-30 Vitae Pharmaceuticals Llc Dihidropirolopiridinski inhibitori ror-gama
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JP6845230B2 (ja) 2015-09-24 2021-03-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物
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