PL3207043T3 - Inhibitory dihydropirolopirydynowe ror-gamma - Google Patents

Inhibitory dihydropirolopirydynowe ror-gamma

Info

Publication number
PL3207043T3
PL3207043T3 PL15785013T PL15785013T PL3207043T3 PL 3207043 T3 PL3207043 T3 PL 3207043T3 PL 15785013 T PL15785013 T PL 15785013T PL 15785013 T PL15785013 T PL 15785013T PL 3207043 T3 PL3207043 T3 PL 3207043T3
Authority
PL
Poland
Prior art keywords
ror
gamma
dihydropyrrolopyridine
inhibitors
dihydropyrrolopyridine inhibitors
Prior art date
Application number
PL15785013T
Other languages
English (en)
Other versions
PL3207043T6 (pl
Inventor
David A. Claremon
Lawrence Wayne Dillard
Chengguo DONG
Yi Fan
Lanqi Jia
Stephen D. Lotesta
Andrew Marcus
Suresh B. Singh
Colin M. Tice
Jing Yuan
Wei Zhao
Yajun Zheng
Linghang Zhuang
Original Assignee
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitae Pharmaceuticals Inc filed Critical Vitae Pharmaceuticals Inc
Publication of PL3207043T3 publication Critical patent/PL3207043T3/pl
Publication of PL3207043T6 publication Critical patent/PL3207043T6/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
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PL15785013T 2014-10-14 2015-10-14 Inhibitory dihydropirolopirydynowe ror-gamma PL3207043T6 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US201462074406P 2014-11-03 2014-11-03
PCT/US2015/055420 WO2016061160A1 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma
EP15785013.2A EP3207043B3 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (2)

Publication Number Publication Date
PL3207043T3 true PL3207043T3 (pl) 2019-05-31
PL3207043T6 PL3207043T6 (pl) 2020-11-02

Family

ID=54352515

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15785013T PL3207043T6 (pl) 2014-10-14 2015-10-14 Inhibitory dihydropirolopirydynowe ror-gamma

Country Status (28)

Country Link
US (3) US9796710B2 (pl)
EP (1) EP3207043B3 (pl)
JP (1) JP6564029B2 (pl)
KR (1) KR20170066628A (pl)
CN (1) CN107074852B (pl)
AU (1) AU2015333610B2 (pl)
BR (1) BR112017007460A2 (pl)
CA (1) CA2963140A1 (pl)
CL (1) CL2017000902A1 (pl)
CO (1) CO2017004525A2 (pl)
CY (1) CY1121413T1 (pl)
DK (1) DK3207043T6 (pl)
EA (1) EA031967B1 (pl)
EC (1) ECSP17029371A (pl)
ES (1) ES2715458T7 (pl)
HU (1) HUE042335T2 (pl)
IL (1) IL251584B (pl)
MX (1) MX371304B (pl)
MY (1) MY182454A (pl)
PH (1) PH12017500583A1 (pl)
PL (1) PL3207043T6 (pl)
PT (1) PT3207043T (pl)
SG (1) SG11201702362SA (pl)
SI (1) SI3207043T1 (pl)
TW (1) TWI675032B (pl)
UA (1) UA118989C2 (pl)
WO (1) WO2016061160A1 (pl)
ZA (1) ZA201702237B (pl)

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AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
SI3074400T1 (en) 2013-11-26 2018-03-30 F. Hoffmann-La Roche Ag Octahydro-cyclobut (1,2-c, 3,4-cy) dipyrrole derivatives as autoantaxine inhibitors
RS59007B1 (sr) 2014-02-03 2019-08-30 Vitae Pharmaceuticals Llc Dihidropirolopiridinski inhibitori ror-gama
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AU2015333610B2 (en) 2014-10-14 2019-11-07 Vitae Pharmaceuticals, Llc Dihydropyrrolopyridine inhibitors of ROR-gamma
US9663515B2 (en) * 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
MY189194A (en) 2015-05-15 2022-01-31 Aurigene Discovery Tech Ltd Substituted tetrahydroquinolinone compounds as ror gamma modulators
TWI726888B (zh) 2015-06-09 2021-05-11 美商艾伯維有限公司 核受體調節劑
WO2017024018A1 (en) 2015-08-05 2017-02-09 Vitae Pharmaceuticals, Inc. Modulators of ror-gamma
PE20180479A1 (es) 2015-09-04 2018-03-07 Hoffmann La Roche Nuevos derivados de fenoximetilo
RU2018114289A (ru) 2015-09-24 2019-10-24 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов аутотаксина (atx)
MA42919A (fr) 2015-09-24 2018-08-01 Hoffmann La Roche Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
PE20180552A1 (es) 2015-09-24 2018-04-02 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca
JP6845230B2 (ja) 2015-09-24 2021-03-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物
EP3377482B1 (en) 2015-11-20 2021-05-12 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
EP3390396B1 (en) 2015-12-15 2022-07-06 Astrazeneca AB Isoindole compounds
TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
WO2018167001A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag Heterocyclic compounds useful as dual atx/ca inhibitors
US11034654B2 (en) 2017-06-14 2021-06-15 Astrazeneca Ab 2,3-dihydroisoindole-1-carboxamides useful as ROR-gamma modulators
JP2020142989A (ja) * 2017-06-21 2020-09-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
BR112019026945A2 (pt) 2017-07-06 2020-06-30 Jiangsu Hengrui Medicine Co., Ltd. derivado de indol-formamida, método de preparação para ele e seu uso em medicina
JP2020528904A (ja) 2017-07-24 2020-10-01 ヴァイティー ファーマシューティカルズ，エルエルシー ＲＯＲγの阻害剤
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EP3927329A4 (en) * 2019-02-20 2022-11-23 The Regents of the University of California TREATMENT OF CANCERS DEPENDENT ON THE ORPHAN RECEPTOR BOUND ON THE RETINOIC ACID y (RORy) RECEPTOR
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