MX2010004669A - Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios. - Google Patents

Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios.

Info

Publication number
MX2010004669A
MX2010004669A MX2010004669A MX2010004669A MX2010004669A MX 2010004669 A MX2010004669 A MX 2010004669A MX 2010004669 A MX2010004669 A MX 2010004669A MX 2010004669 A MX2010004669 A MX 2010004669A MX 2010004669 A MX2010004669 A MX 2010004669A
Authority
MX
Mexico
Prior art keywords
preparation
dihydropyrrol
intermediates
derivatives
formula
Prior art date
Application number
MX2010004669A
Other languages
English (en)
Inventor
Paul Spurr
Pius Waldmeier
Christophe Pfleger
Rene Trussardi
Shaoning Wang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2010004669A publication Critical patent/MX2010004669A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención se refiere a un nuevo proceso escalable para la preparación de compuestos de fórmula (I), que comprende un nuevo proceso para la preparación del intermediario clave, un derivado de dihidropirrol de fórmula (II) o una sal del mismo.
MX2010004669A 2007-11-29 2008-11-19 Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios. MX2010004669A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07121841 2007-11-29
PCT/EP2008/065820 WO2009068463A2 (en) 2007-11-29 2008-11-19 Process for the preparation of isoindole derivatives as well as a process for the preparation of their intermediates

Publications (1)

Publication Number Publication Date
MX2010004669A true MX2010004669A (es) 2010-05-27

Family

ID=40551563

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004669A MX2010004669A (es) 2007-11-29 2008-11-19 Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios.

Country Status (13)

Country Link
US (3) US20090143589A1 (es)
EP (1) EP2225202B1 (es)
JP (1) JP5255647B2 (es)
KR (1) KR101196543B1 (es)
CN (1) CN101874019B (es)
AT (1) ATE539054T1 (es)
AU (1) AU2008328951B2 (es)
BR (1) BRPI0821102A2 (es)
CA (1) CA2705950A1 (es)
ES (1) ES2378185T3 (es)
IL (1) IL204936A (es)
MX (1) MX2010004669A (es)
WO (1) WO2009068463A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201606080SA (en) 2014-02-03 2016-08-30 Vitae Pharmaceuticals Inc Dihydropyrrolopyridine inhibitors of ror-gamma
MY182454A (en) 2014-10-14 2021-01-25 Vitae Pharmaceuticals Llc Dihydropyrrolopyridine inhibitors of ror-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
ES2856931T3 (es) 2015-08-05 2021-09-28 Vitae Pharmaceuticals Llc Moduladores de ROR-gamma
US11008340B2 (en) 2015-11-20 2021-05-18 Vitae Pharmaceuticals, Llc Modulators of ROR-gamma
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019023207A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF RORƳ
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
CN111448195A (zh) * 2017-09-27 2020-07-24 费多拉制药公司 二氮杂二环辛烷衍生物的晶型及其生产方法
CN111808102B (zh) * 2020-08-03 2021-12-31 南通大学 一种3-甲氧基-6,7-二氢-5H-吡咯并[3,4-b]吡啶盐酸盐及其合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4958029A (en) * 1987-01-13 1990-09-18 Banyu Pharmaceutical Co., Ltd. Process for the production of isoindoline derivatives, novel intermediates and process for their production
JP2832584B2 (ja) * 1995-03-27 1998-12-09 日本農薬株式会社 カルボン酸エステル類の製造方法
PT820987E (pt) * 1996-07-23 2003-03-31 Lonza Ag Processo para a preparacao de esteres de acidos piridino-2,3-dicarboxilicos
ATE449761T1 (de) * 2005-02-07 2009-12-15 Hoffmann La Roche Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1

Also Published As

Publication number Publication date
CN101874019B (zh) 2013-06-12
KR20100075664A (ko) 2010-07-02
WO2009068463A3 (en) 2009-09-11
US20130060038A1 (en) 2013-03-07
IL204936A0 (en) 2010-11-30
AU2008328951A1 (en) 2009-06-04
EP2225202B1 (en) 2011-12-28
JP2011504896A (ja) 2011-02-17
CN101874019A (zh) 2010-10-27
BRPI0821102A2 (pt) 2015-06-16
US20090143589A1 (en) 2009-06-04
AU2008328951B2 (en) 2012-12-13
IL204936A (en) 2013-12-31
ATE539054T1 (de) 2012-01-15
US20120041205A1 (en) 2012-02-16
EP2225202A2 (en) 2010-09-08
ES2378185T3 (es) 2012-04-09
WO2009068463A9 (en) 2009-11-12
WO2009068463A2 (en) 2009-06-04
JP5255647B2 (ja) 2013-08-07
CA2705950A1 (en) 2009-06-04
KR101196543B1 (ko) 2012-11-01

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