EE03484B1 - Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine - Google Patents

Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine

Info

Publication number
EE03484B1
EE03484B1 EE9800146A EE9800146A EE03484B1 EE 03484 B1 EE03484 B1 EE 03484B1 EE 9800146 A EE9800146 A EE 9800146A EE 9800146 A EE9800146 A EE 9800146A EE 03484 B1 EE03484 B1 EE 03484B1
Authority
EE
Estonia
Prior art keywords
imidazolyl
methyl
protein transferase
farnesyl protein
quinolinone derivatives
Prior art date
Application number
EE9800146A
Other languages
English (en)
Estonian (et)
Other versions
EE9800146A (et
Inventor
Gaston Venet Marc
Ren� Angibaud Patrick
Charles Sanz G�rard
Muller Philippe
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE9800146A publication Critical patent/EE9800146A/xx
Publication of EE03484B1 publication Critical patent/EE03484B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EE9800146A 1995-12-08 1996-10-16 Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine EE03484B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95203427 1995-12-08
PCT/EP1996/004515 WO1997021701A1 (fr) 1995-12-08 1996-10-16 Derives de la (imidazol-5-yl)methyl-2-quinoleinone comme inhibiteur de la proteine farnesyle-transferase

Publications (2)

Publication Number Publication Date
EE9800146A EE9800146A (et) 1998-10-15
EE03484B1 true EE03484B1 (et) 2001-08-15

Family

ID=8220926

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800146A EE03484B1 (et) 1995-12-08 1996-10-16 Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine

Country Status (36)

Country Link
US (3) US6037350A (fr)
EP (2) EP1162201B1 (fr)
JP (1) JP3257559B2 (fr)
KR (1) KR100272676B1 (fr)
CN (1) CN1101392C (fr)
AP (1) AP1108A (fr)
AR (1) AR004992A1 (fr)
AT (2) ATE215541T1 (fr)
AU (1) AU711142B2 (fr)
BG (1) BG62615B1 (fr)
BR (1) BR9610745A (fr)
CA (1) CA2231105C (fr)
CY (1) CY2289B1 (fr)
CZ (1) CZ293296B6 (fr)
DE (2) DE69620445T2 (fr)
DK (2) DK1162201T3 (fr)
EA (1) EA000710B1 (fr)
EE (1) EE03484B1 (fr)
ES (2) ES2175137T3 (fr)
HK (2) HK1012188A1 (fr)
HR (1) HRP960576B1 (fr)
HU (1) HU221227B1 (fr)
IL (1) IL123568A (fr)
MX (1) MX9802068A (fr)
MY (1) MY114444A (fr)
NO (1) NO314036B1 (fr)
NZ (1) NZ320244A (fr)
PL (1) PL184171B1 (fr)
PT (2) PT865440E (fr)
SI (2) SI0865440T1 (fr)
SK (1) SK283335B6 (fr)
TR (1) TR199800825T2 (fr)
TW (1) TW494101B (fr)
UA (1) UA57717C2 (fr)
WO (1) WO1997021701A1 (fr)
ZA (1) ZA9610254B (fr)

Families Citing this family (225)

* Cited by examiner, † Cited by third party
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TR199800825T2 (xx) * 1995-12-08 1998-08-21 Janssen Pharmaceutica N.V. Farnesil protein transferini inhibe eden (imidazol-5-il) metil-2-kinolinon t�revleri.
ATE222104T1 (de) 1997-06-02 2002-08-15 Janssen Pharmaceutica Nv (imidazol-5-yl)methyl-2-quinolinone derivativen als inhibitoren von proliferation der glatten muskelzellen
US20030114503A1 (en) * 1997-06-16 2003-06-19 Pfizer Inc. Farnesyl transferase inhibitors in combination with HMG CoA reductase inhibitors for the treatment of cancer
US6420555B1 (en) * 1998-06-16 2002-07-16 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Imidazolyl derivatives
DK1097150T3 (da) * 1998-06-16 2004-07-26 Sod Conseils Rech Applic Imidazolylderivater
ATE238811T1 (de) 1998-07-06 2003-05-15 Janssen Pharmaceutica Nv Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften
TR200003882T2 (tr) * 1998-07-06 2001-06-21 Janssen Pharmaceutica N.V. Artropatilerin tedavisi için farnesil protein transferaz inhibitörleri.
FR2780892B1 (fr) * 1998-07-08 2001-08-17 Sod Conseils Rech Applic Utilisation d'inhibiteurs de prenyltransferases pour preparer un medicament destine a traiter les pathologies qui resultent de la fixation membranaire de la proteine g heterotrimerique
CA2341690C (fr) * 1998-08-27 2007-04-17 Pfizer Products Inc. Derives de quinolin-2-one a substitution alcynyle, utiles en tant qu'agents anticancereux
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AU2478500A (en) 1998-12-08 2000-06-26 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US6284755B1 (en) 1998-12-08 2001-09-04 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
PT1140935E (pt) 1998-12-23 2003-10-31 Janssen Pharmaceutica Nv Derivados da quinolina 1,2-ciclizada
JP3270834B2 (ja) 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
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US6143766A (en) * 1999-04-16 2000-11-07 Warner-Lambert Company Benzopyranone and quinolone inhibitors of ras farnesyl transferase
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DE69635966D1 (de) 2006-05-18
AP9801257A0 (en) 1998-06-30
ES2175137T3 (es) 2002-11-16
BG62615B1 (en) 2000-03-31
EP1162201A3 (fr) 2003-11-26
CZ157398A3 (cs) 1998-10-14
HK1012188A1 (en) 1999-07-30
AU711142B2 (en) 1999-10-07
NO980927D0 (no) 1998-03-04
DE69620445D1 (de) 2002-05-08
PL325962A1 (en) 1998-08-17
EP1162201A9 (fr) 2002-04-03
EP1162201A2 (fr) 2001-12-12
TW494101B (en) 2002-07-11
DE69635966T2 (de) 2006-11-30
ZA9610254B (en) 1998-06-05
SK283335B6 (sk) 2003-06-03
ATE215541T1 (de) 2002-04-15
CY2289B1 (en) 2003-07-04
PT865440E (pt) 2002-09-30
US6420387B1 (en) 2002-07-16
IL123568A0 (en) 1998-10-30
WO1997021701A1 (fr) 1997-06-19
PT1162201E (pt) 2006-08-31
CN1203598A (zh) 1998-12-30
ATE321757T1 (de) 2006-04-15
SI0865440T1 (en) 2002-08-31
HK1042482B (zh) 2006-06-09
CN1101392C (zh) 2003-02-12
JPH10511405A (ja) 1998-11-04
KR100272676B1 (ko) 2000-11-15
PL184171B1 (pl) 2002-09-30
MX9802068A (es) 1998-08-30
AR004992A1 (es) 1999-04-07
BG102458A (en) 1999-06-30
HUP9900185A2 (hu) 1999-04-28
IL123568A (en) 2001-08-08
MY114444A (en) 2002-10-31
HU221227B1 (en) 2002-08-28
KR19990063891A (ko) 1999-07-26
HRP960576B1 (en) 2002-04-30
SK70498A3 (en) 1998-10-07
HRP960576A2 (en) 1998-02-28
JP3257559B2 (ja) 2002-02-18
NZ320244A (en) 1999-06-29
EE9800146A (et) 1998-10-15
NO980927L (no) 1998-06-08
CA2231105C (fr) 2005-09-13
TR199800825T2 (xx) 1998-08-21
AP1108A (en) 2002-10-02
US6169096B1 (en) 2001-01-02
HK1042482A1 (en) 2002-08-16
DK1162201T3 (da) 2006-07-17
CA2231105A1 (fr) 1997-06-19
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HUP9900185A3 (en) 1999-11-29
ES2260156T3 (es) 2006-11-01

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