MX2019005065A - Metodos de tratamiento de pacientes con cancer con inhibidores de farnesiltransferasa. - Google Patents

Metodos de tratamiento de pacientes con cancer con inhibidores de farnesiltransferasa.

Info

Publication number
MX2019005065A
MX2019005065A MX2019005065A MX2019005065A MX2019005065A MX 2019005065 A MX2019005065 A MX 2019005065A MX 2019005065 A MX2019005065 A MX 2019005065A MX 2019005065 A MX2019005065 A MX 2019005065A MX 2019005065 A MX2019005065 A MX 2019005065A
Authority
MX
Mexico
Prior art keywords
methods
egfr
subject
treating cancer
refractory
Prior art date
Application number
MX2019005065A
Other languages
English (en)
Inventor
Rose Scholz Catherine
Gualberto Antonio
Original Assignee
Kura Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kura Oncology Inc filed Critical Kura Oncology Inc
Publication of MX2019005065A publication Critical patent/MX2019005065A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113—PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

La presente invención se refiere al campo de biología molecular y la biología del cáncer. De manera específica, la presente invención se refiere a métodos de tratamiento de un sujeto con un inhibidor de farnesiltransferasa (FTI) que incluye determinar si es probable que el sujeto responda al tratamiento con FTI con base en el estado de mutación de HRAS en el sujeto.
MX2019005065A 2016-11-03 2017-11-02 Metodos de tratamiento de pacientes con cancer con inhibidores de farnesiltransferasa. MX2019005065A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662417044P 2016-11-03 2016-11-03
PCT/US2017/059686 WO2018085518A2 (en) 2016-11-03 2017-11-02 Methods of treating cancer patients with farnesyltransferase inhibitors

Publications (1)

Publication Number Publication Date
MX2019005065A true MX2019005065A (es) 2019-08-21

Family

ID=61249690

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019005065A MX2019005065A (es) 2016-11-03 2017-11-02 Metodos de tratamiento de pacientes con cancer con inhibidores de farnesiltransferasa.

Country Status (26)

Country Link
US (2) US11124839B2 (es)
EP (2) EP3534885B1 (es)
JP (1) JP2019534290A (es)
KR (1) KR20190082247A (es)
CN (1) CN110325212B (es)
AR (1) AR110031A1 (es)
AU (1) AU2017353838A1 (es)
BR (1) BR112019009000A2 (es)
CA (1) CA3042747A1 (es)
DK (1) DK3534885T3 (es)
EA (1) EA201991091A1 (es)
ES (1) ES2863730T3 (es)
HR (1) HRP20210544T1 (es)
HU (1) HUE053927T2 (es)
IL (1) IL266182A (es)
LT (1) LT3534885T (es)
MX (1) MX2019005065A (es)
MY (1) MY190861A (es)
PH (1) PH12019500927A1 (es)
PL (1) PL3534885T3 (es)
PT (1) PT3534885T (es)
RS (1) RS61745B1 (es)
SG (1) SG11201903786UA (es)
SI (1) SI3534885T1 (es)
TW (1) TW201818965A (es)
WO (1) WO2018085518A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3277842T5 (da) * 2015-08-17 2020-08-31 Kura Oncology Inc Fremgangsmåder til at behandle kræftpatienter med farnesyl-transferase-inhibitorer
US11124839B2 (en) 2016-11-03 2021-09-21 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
TW202016316A (zh) * 2018-06-19 2020-05-01 日商武田藥品工業股份有限公司 癌症治療方法
EP3873469A2 (en) * 2018-11-01 2021-09-08 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
EP3897638A1 (en) * 2018-12-21 2021-10-27 Kura Oncology, Inc. Therapies for squamous cell carcinomas
JP2022527495A (ja) 2019-03-29 2022-06-02 クラ オンコロジー， インコーポレイテッド ファルネシルトランスフェラーゼ阻害剤による扁平上皮癌の治療方法
US20220401436A1 (en) * 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors

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