CA2397253A1 - Combinaisons d'inhibiteurs de farnesyl proteine transferase et de derives antitumoraux d'anthracycline - Google Patents
Combinaisons d'inhibiteurs de farnesyl proteine transferase et de derives antitumoraux d'anthracycline Download PDFInfo
- Publication number
- CA2397253A1 CA2397253A1 CA002397253A CA2397253A CA2397253A1 CA 2397253 A1 CA2397253 A1 CA 2397253A1 CA 002397253 A CA002397253 A CA 002397253A CA 2397253 A CA2397253 A CA 2397253A CA 2397253 A1 CA2397253 A1 CA 2397253A1
- Authority
- CA
- Canada
- Prior art keywords
- 6alkyl
- hydrogen
- 6alkyloxy
- formula
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne des combinaisons d'un inhibiteur de farnésyl-transférase et d'un dérivé d'anthracycline destinées à inhiber la croissance de cellules tumorales et utiles dans le traitement du cancer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00200696 | 2000-02-29 | ||
EP00200696.3 | 2000-02-29 | ||
PCT/EP2001/002166 WO2001064197A2 (fr) | 2000-02-29 | 2001-02-26 | Combinaisons d'inhibiteurs de farnesyl proteine transferase et de derives antitumoraux d'anthracycline |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2397253A1 true CA2397253A1 (fr) | 2001-09-07 |
Family
ID=8171115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002397253A Abandoned CA2397253A1 (fr) | 2000-02-29 | 2001-02-26 | Combinaisons d'inhibiteurs de farnesyl proteine transferase et de derives antitumoraux d'anthracycline |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1267872A2 (fr) |
JP (1) | JP2003525237A (fr) |
AU (1) | AU2001244167A1 (fr) |
CA (1) | CA2397253A1 (fr) |
WO (1) | WO2001064197A2 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060166907A1 (en) * | 2002-09-27 | 2006-07-27 | Gregoire Prevost | Composition for the treatment of nasopharyngeal carcinoma and method of use thereof |
KR20070001922A (ko) | 2003-12-12 | 2007-01-04 | 와이어쓰 | 심장혈관질환 치료에 유용한 퀴놀린 |
EP2545919A1 (fr) | 2005-12-23 | 2013-01-16 | Link Medicine Corporation | Traitement de formes de synucleinopathie |
WO2014062658A1 (fr) | 2012-10-16 | 2014-04-24 | Janssen Pharmaceutica Nv | Modulateurs de ror-gamma-t de type quinolinyle à liaison méthylène |
EP2909189B8 (fr) | 2012-10-16 | 2017-04-19 | Janssen Pharmaceutica NV | Modulateurs de ror-gamma-t de type quinolinyle à liaison hétéroaryle |
CN105073729A (zh) | 2012-10-16 | 2015-11-18 | 詹森药业有限公司 | RORγt的苯基连接的喹啉基调节剂 |
US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
US9346782B2 (en) | 2013-10-15 | 2016-05-24 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
WO2015057626A1 (fr) | 2013-10-15 | 2015-04-23 | Janssen Pharmaceutica Nv | Modulateurs quinolinyl de roryt |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW349948B (en) * | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
TR199800825T2 (xx) * | 1995-12-08 | 1998-08-21 | Janssen Pharmaceutica N.V. | Farnesil protein transferini inhibe eden (imidazol-5-il) metil-2-kinolinon t�revleri. |
TW591030B (en) * | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
RU2205831C2 (ru) * | 1997-04-25 | 2003-06-10 | Янссен Фармацевтика Н.В. | Хиназолиноны, ингибирующие фарнезилтрансферазу |
JP4502503B2 (ja) * | 1997-12-22 | 2010-07-14 | シェーリング コーポレイション | 増殖性の疾患を処置するためのベンゾシクロヘプタピリジン化合物および抗腫瘍剤の組合せ |
EP1087770A4 (fr) * | 1998-06-15 | 2001-11-14 | Merck & Co Inc | Inhibiteurs de prenyl-proteine transferase |
EP1091736A4 (fr) * | 1998-07-02 | 2001-10-24 | Merck & Co Inc | Inhibiteurs de prenyl-proteine transferase |
PT1140935E (pt) * | 1998-12-23 | 2003-10-31 | Janssen Pharmaceutica Nv | Derivados da quinolina 1,2-ciclizada |
-
2001
- 2001-02-26 CA CA002397253A patent/CA2397253A1/fr not_active Abandoned
- 2001-02-26 EP EP01917033A patent/EP1267872A2/fr not_active Withdrawn
- 2001-02-26 WO PCT/EP2001/002166 patent/WO2001064197A2/fr not_active Application Discontinuation
- 2001-02-26 AU AU2001244167A patent/AU2001244167A1/en not_active Abandoned
- 2001-02-26 JP JP2001563094A patent/JP2003525237A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2003525237A (ja) | 2003-08-26 |
WO2001064197A2 (fr) | 2001-09-07 |
EP1267872A2 (fr) | 2003-01-02 |
WO2001064197A3 (fr) | 2002-03-21 |
AU2001244167A1 (en) | 2001-09-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |