EA200801806A1 - Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения - Google Patents
Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их примененияInfo
- Publication number
- EA200801806A1 EA200801806A1 EA200801806A EA200801806A EA200801806A1 EA 200801806 A1 EA200801806 A1 EA 200801806A1 EA 200801806 A EA200801806 A EA 200801806A EA 200801806 A EA200801806 A EA 200801806A EA 200801806 A1 EA200801806 A1 EA 200801806A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- norepinefrin
- application
- selective inhibitors
- reboxetine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
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- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
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- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pregnancy & Childbirth (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Представлены способы для лечения людей, страдающих от физиологического или психиатрического заболевания, расстройства или состояния, или для их предотвращения, в которых полезно ингибирование обратного захвата норэпинефрина. Композиции включают соединение, имеющее фармакологическую селективность серотонин (K)/норэпинефрин (K), равную по меньшей мере около 5000. Примеры таких соединений включают ребоксетин и более предпочтительно рацемический ребоксетин. Способы обычно включают введение терапевтического количества рацемического ребоксетина.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14196899P | 1999-07-01 | 1999-07-01 | |
US14413199P | 1999-07-16 | 1999-07-16 | |
US15825699P | 1999-10-06 | 1999-10-06 | |
US17038199P | 1999-12-13 | 1999-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200801806A1 true EA200801806A1 (ru) | 2008-12-30 |
Family
ID=27495506
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400589A EA006652B1 (ru) | 1999-07-01 | 2000-06-22 | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
EA200700232A EA011094B1 (ru) | 1999-07-01 | 2000-06-22 | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
EA200501496A EA008381B1 (ru) | 1999-07-01 | 2000-06-22 | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
EA200200111A EA005029B1 (ru) | 1999-07-01 | 2000-06-22 | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
EA200801805A EA200801805A1 (ru) | 1999-07-01 | 2000-06-22 | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
EA200801806A EA200801806A1 (ru) | 1999-07-01 | 2000-06-22 | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
Family Applications Before (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400589A EA006652B1 (ru) | 1999-07-01 | 2000-06-22 | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
EA200700232A EA011094B1 (ru) | 1999-07-01 | 2000-06-22 | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
EA200501496A EA008381B1 (ru) | 1999-07-01 | 2000-06-22 | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
EA200200111A EA005029B1 (ru) | 1999-07-01 | 2000-06-22 | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
EA200801805A EA200801805A1 (ru) | 1999-07-01 | 2000-06-22 | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
Country Status (31)
Country | Link |
---|---|
US (18) | US6465458B1 (ru) |
EP (3) | EP1196172B1 (ru) |
JP (3) | JP2003503450A (ru) |
KR (5) | KR100704319B1 (ru) |
CN (5) | CN1660108A (ru) |
AR (1) | AR035158A1 (ru) |
AT (9) | ATE305307T1 (ru) |
AU (2) | AU771258B2 (ru) |
BR (1) | BR0012136A (ru) |
CA (2) | CA2643231A1 (ru) |
CL (3) | CL2008002868A1 (ru) |
CO (1) | CO5190662A1 (ru) |
CZ (1) | CZ299847B6 (ru) |
DE (9) | DE60026627T2 (ru) |
DK (4) | DK1196172T3 (ru) |
EA (6) | EA006652B1 (ru) |
ES (9) | ES2242175T3 (ru) |
GE (1) | GEP20094798B (ru) |
HK (2) | HK1049630A1 (ru) |
HU (1) | HUP0201623A3 (ru) |
IL (3) | IL147246A0 (ru) |
MX (1) | MXPA02000562A (ru) |
MY (1) | MY137348A (ru) |
NO (4) | NO20016406L (ru) |
NZ (2) | NZ515885A (ru) |
PE (1) | PE20010684A1 (ru) |
PL (1) | PL196996B1 (ru) |
PT (5) | PT1459748E (ru) |
SK (5) | SK286104B6 (ru) |
TW (9) | TWI293250B (ru) |
WO (1) | WO2001001973A2 (ru) |
Families Citing this family (97)
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ATE305307T1 (de) * | 1999-07-01 | 2005-10-15 | Pharmacia & Upjohn Co Llc | Reboxetin zur behandlung von migränekopfschmerzen |
TWI238062B (en) * | 1999-12-01 | 2005-08-21 | Ucb Sa | A pyrrolidineacetamide derivative alone or in combination for treatment of CNS disorders |
EP1280530A1 (en) * | 2000-04-21 | 2003-02-05 | PHARMACIA & UPJOHN COMPANY | Treatment of fibromyalgia and chronic fatigue syndrome |
CN1554341A (zh) * | 2000-04-21 | 2004-12-15 | �������Ŷ���Լ��������˾ | 用于治疗纤维肌痛和慢性疲劳综合症的化合物 |
WO2002036125A1 (en) * | 2000-10-31 | 2002-05-10 | Head Explorer A/S | The use of selective noradrenaline reuptake inhibitors for the treatment of tension-type headache |
EP1395253A2 (en) * | 2000-11-15 | 2004-03-10 | Eli Lilly And Company | Treatment of anxiety disorders |
WO2002083141A1 (en) * | 2001-04-17 | 2002-10-24 | Pharmacia & Upjohn Company | Treatment of fibromyalgia and chronic fatigue syndrome |
US20040048874A1 (en) * | 2001-05-22 | 2004-03-11 | Bardsley Hazel Judith | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine |
GB0216027D0 (en) * | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
PT1627639E (pt) * | 2001-06-19 | 2010-03-01 | Norbert Mueller | Utilização de inibidores da cox-2 para o tratamento de distúrbios afectivos |
US20060167074A1 (en) * | 2001-06-19 | 2006-07-27 | Norbert Muller | Methods and compositions for the treatment of psychiatric disorders |
US6602911B2 (en) | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
WO2003047560A1 (en) * | 2001-11-30 | 2003-06-12 | Eli Lilly And Company | Use of norepinephrine reuptake inhibitors for the treatment of tic disorders |
CZ2004709A3 (cs) * | 2001-12-11 | 2004-10-13 | Eliálillyáandácompany | Použití inbibitorů vychytávání norepinefrinu pro léčení poruch kognitivních funkcí |
US20040102440A1 (en) * | 2002-07-01 | 2004-05-27 | Wong Erik Ho Fong | Method of promoting smoking cessation |
EP1482921A1 (en) * | 2002-02-12 | 2004-12-08 | Cypress Bioscience, Inc. | Methods of treating attention deficit/hyperactivity disorder (adhd) |
EP1499309A4 (en) * | 2002-04-24 | 2008-05-28 | Cypress Bioscience Inc | PREVENTION AND TREATMENT OF FUNCTIONAL SOMATIC DISEASES, INCLUDING STRESS-BASED DISEASES |
KR101072885B1 (ko) * | 2002-05-17 | 2011-10-17 | 듀크 유니버시티 | 비만치료방법 |
CN1655787A (zh) * | 2002-05-30 | 2005-08-17 | 神经研究公司 | 治疗慢性疼痛的三单胺再摄取抑制剂 |
JP4563172B2 (ja) * | 2002-06-17 | 2010-10-13 | ファイザー イタリア ソシエタ ア レスポンサビリタ リミタータ | レボキセチンの医薬用塩 |
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US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
US20040092519A1 (en) * | 2002-08-14 | 2004-05-13 | Fred Hassan | New treatment for hot flashes |
GB0219687D0 (en) | 2002-08-23 | 2002-10-02 | Lilly Co Eli | Benzyl morpholine derivatives |
ATE413882T1 (de) | 2002-08-23 | 2008-11-15 | Lilly Co Eli | 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin- wiederaufnahme-inhibitoren |
AU2003261245A1 (en) * | 2002-08-23 | 2004-03-11 | Eli Lilly And Company | Benzyl morpholine derivatives |
EP1558231A4 (en) * | 2002-10-03 | 2010-09-08 | Cypress Bioscience Inc | DOSAGE CLIMBING AND FRICTIONAL DAILY DOSE OF ANTIDEPRESSANTS TO TREAT NEUROLOGICAL DISORDERS |
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US20040204411A1 (en) * | 2002-12-17 | 2004-10-14 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
WO2004062623A2 (en) * | 2003-01-13 | 2004-07-29 | Dynogen Pharmaceuticals, Inc. | Method of treating functional bowel disorders |
DE602004005814T2 (de) * | 2003-01-13 | 2008-01-10 | Dynogen Pharmaceuticals Inc., Waltham | Verfahren zur behandlung von übelkeit, erbrechen, würgereiz oder jede kombination daraus |
EP1539181B1 (en) * | 2003-04-04 | 2007-06-27 | Dynogen Pharmaceuticals Inc. | Method of treating lower urinary tract disorders |
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- 2002-01-23 US US10/055,663 patent/US6987107B2/en not_active Expired - Fee Related
- 2002-09-26 US US10/255,450 patent/US20030040464A1/en not_active Abandoned
-
2003
- 2003-03-14 HK HK03101844A patent/HK1049630A1/xx not_active IP Right Cessation
- 2003-09-24 US US10/669,611 patent/US20040058925A1/en not_active Abandoned
-
2004
- 2004-01-16 US US10/758,864 patent/US7317011B2/en not_active Expired - Fee Related
- 2004-05-18 AU AU2004202096A patent/AU2004202096B2/en not_active Ceased
-
2005
- 2005-09-30 HK HK05108676A patent/HK1076723A1/xx not_active IP Right Cessation
-
2006
- 2006-02-07 US US11/348,948 patent/US20060142289A1/en not_active Abandoned
- 2006-02-07 US US11/349,373 patent/US7276503B2/en not_active Expired - Fee Related
- 2006-02-07 US US11/349,331 patent/US7338953B2/en not_active Expired - Fee Related
- 2006-02-07 US US11/349,022 patent/US7241762B2/en not_active Expired - Fee Related
- 2006-02-22 JP JP2006045459A patent/JP2006143749A/ja active Pending
- 2006-07-28 US US11/460,775 patent/US20060264436A1/en not_active Abandoned
- 2006-08-02 JP JP2006210418A patent/JP2006321815A/ja active Pending
-
2007
- 2007-10-30 US US11/928,781 patent/US20080103145A1/en not_active Abandoned
- 2007-10-30 US US11/928,917 patent/US7723334B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/928,980 patent/US20080103147A1/en not_active Abandoned
- 2007-10-30 US US11/928,812 patent/US20080096890A1/en not_active Abandoned
- 2007-11-20 IL IL187513A patent/IL187513A0/en unknown
- 2007-11-20 IL IL187512A patent/IL187512A0/en unknown
-
2008
- 2008-09-26 CL CL2008002868A patent/CL2008002868A1/es unknown
- 2008-09-26 CL CL2008002866A patent/CL2008002866A1/es unknown
- 2008-09-26 CL CL2008002867A patent/CL2008002867A1/es unknown
-
2009
- 2009-03-18 NO NO20091159A patent/NO20091159L/no unknown
- 2009-03-18 NO NO20091168A patent/NO20091168L/no not_active Application Discontinuation
- 2009-03-18 NO NO20091158A patent/NO20091158L/no unknown
- 2009-04-27 US US12/430,244 patent/US20090247528A1/en not_active Abandoned
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