EA039074B1 - Жирные кислоты и их конъюгаты с биомолекулами - Google Patents

Жирные кислоты и их конъюгаты с биомолекулами Download PDF

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Publication number
EA039074B1
EA039074B1 EA201692466A EA201692466A EA039074B1 EA 039074 B1 EA039074 B1 EA 039074B1 EA 201692466 A EA201692466 A EA 201692466A EA 201692466 A EA201692466 A EA 201692466A EA 039074 B1 EA039074 B1 EA 039074B1
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Eurasian Patent Office
Prior art keywords
conjugate
hgdf15
disease
fatty acid
linker
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EA201692466A
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English (en)
Russian (ru)
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EA201692466A1 (ru
Inventor
Дэвид Венингер Барнс
Кен Ямада
Чиквенду Ибебунджо
Алокеш Дуттарой
Луиз Клэр Кирман
Александра Маршалл Брюс
Эйми Ричардсон Юзера
Фредерик Зекри
Цзюнь Юань
Чанган Лоу
Аарон Кантер
Авируп Боуз
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Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201692466A1 publication Critical patent/EA201692466A1/ru
Publication of EA039074B1 publication Critical patent/EA039074B1/ru

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07C59/235—Saturated compounds containing more than one carboxyl group
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    • C12N2310/00—Structure or type of the nucleic acid
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Diabetes (AREA)
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  • Endocrinology (AREA)
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  • Biotechnology (AREA)
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  • Obesity (AREA)
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EA201692466A 2014-06-23 2015-06-18 Жирные кислоты и их конъюгаты с биомолекулами EA039074B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462015862P 2014-06-23 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US201562107016P 2015-01-23 2015-01-23
PCT/US2015/036328 WO2015200078A1 (en) 2014-06-23 2015-06-18 Fatty acids and their use in conjugation to biomolecules

Publications (2)

Publication Number Publication Date
EA201692466A1 EA201692466A1 (ru) 2017-04-28
EA039074B1 true EA039074B1 (ru) 2021-11-30

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EA201692466A EA039074B1 (ru) 2014-06-23 2015-06-18 Жирные кислоты и их конъюгаты с биомолекулами

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US (4) US10588980B2 (enExample)
EP (2) EP3157571B2 (enExample)
JP (5) JP6636959B2 (enExample)
KR (2) KR20230056796A (enExample)
CN (3) CN114133443A (enExample)
AP (1) AP2016009585A0 (enExample)
AU (1) AU2015280351C1 (enExample)
CA (1) CA2953480A1 (enExample)
CL (1) CL2016003281A1 (enExample)
CR (1) CR20160596A (enExample)
CU (1) CU24455B1 (enExample)
CY (1) CY1125006T1 (enExample)
DK (1) DK3157571T3 (enExample)
EA (1) EA039074B1 (enExample)
EC (1) ECSP17004665A (enExample)
ES (1) ES2905479T3 (enExample)
GT (1) GT201600263A (enExample)
HR (1) HRP20220152T1 (enExample)
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US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
JP5977814B2 (ja) 2011-04-08 2016-08-24 アムジエン・インコーポレーテツド 増殖分化因子１５（ｇｄｆ−１５）を使用して代謝障害を治療または改善する方法
LT3027642T (lt) 2013-07-31 2020-10-12 Amgen Inc. Augimo ir diferenciacijos faktoriaus 15(gdf-15) konstruktai
US10588980B2 (en) * 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
CA2969307A1 (en) 2014-12-04 2016-06-09 Novartis Ag Methods and compositions using klotho variant polypeptides
SG11201704758XA (en) * 2015-01-23 2017-08-30 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
EP3929293A3 (en) 2015-04-03 2022-03-16 University Of Massachusetts Fully stabilized asymmetric sirna
WO2017030973A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
US20190000923A1 (en) 2015-12-22 2019-01-03 Novartis Ag Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
WO2017132669A1 (en) 2016-01-31 2017-08-03 University Of Massachusetts Branched oligonucleotides
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