DK1384707T3 - 4-Nitroxybutylester af naproxen - Google Patents

4-Nitroxybutylester af naproxen

Info

Publication number
DK1384707T3
DK1384707T3 DK03102132T DK03102132T DK1384707T3 DK 1384707 T3 DK1384707 T3 DK 1384707T3 DK 03102132 T DK03102132 T DK 03102132T DK 03102132 T DK03102132 T DK 03102132T DK 1384707 T3 DK1384707 T3 DK 1384707T3
Authority
DK
Denmark
Prior art keywords
naproxen
nitroxybutyl ester
nitroxybutyl
ester
naphthyl
Prior art date
Application number
DK03102132T
Other languages
Danish (da)
English (en)
Inventor
Francesca Benedini
Erminio Oldani
Graziano Castaldi
Antonio Tarquini
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of DK1384707T3 publication Critical patent/DK1384707T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK03102132T 1999-08-04 2000-07-27 4-Nitroxybutylester af naproxen DK1384707T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene

Publications (1)

Publication Number Publication Date
DK1384707T3 true DK1384707T3 (da) 2005-08-15

Family

ID=11383500

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03102132T DK1384707T3 (da) 1999-08-04 2000-07-27 4-Nitroxybutylester af naproxen
DK00951456T DK1200386T3 (da) 1999-08-04 2000-07-27 Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK00951456T DK1200386T3 (da) 1999-08-04 2000-07-27 Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen

Country Status (23)

Country Link
US (2) US6700011B1 (it)
EP (2) EP1200386B1 (it)
JP (2) JP4667691B2 (it)
KR (1) KR100687820B1 (it)
CN (1) CN1198786C (it)
AT (2) ATE251109T1 (it)
AU (1) AU778694B2 (it)
BR (1) BRPI0012915B1 (it)
CA (1) CA2380116C (it)
DE (2) DE60020753T2 (it)
DK (2) DK1384707T3 (it)
ES (2) ES2243859T3 (it)
HU (1) HU227109B1 (it)
IL (1) IL147639A0 (it)
IT (1) IT1313596B1 (it)
MX (1) MXPA02001256A (it)
NO (1) NO327669B1 (it)
PL (1) PL200165B1 (it)
PT (2) PT1200386E (it)
RU (1) RU2248348C2 (it)
TR (1) TR200200290T2 (it)
WO (1) WO2001010814A1 (it)
ZA (2) ZA200200478B (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2348741C (en) 1998-10-30 2010-04-20 Nitromed Inc. Nitrosasted and nitrosylated nonsteroidal antiinflammatory compounds, comositions and methods of use
DE60122939T2 (de) 2000-12-21 2007-01-11 Nitromed, Inc., Bedford Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
JP4771659B2 (ja) * 2001-11-27 2011-09-14 ニコックス・ソシエテ・アノニム 新規な方法
AU2003248642A1 (en) 2002-06-11 2003-12-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
CA2491127A1 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
CA2493156A1 (en) 2002-07-29 2004-02-05 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) * 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
ES2520893T3 (es) * 2006-02-03 2014-11-12 Nicox Science Ireland Derivados de nitrooxi para usar en el tratamiento de distrofias musculares
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
EP2170803A1 (en) * 2007-06-28 2010-04-07 Nicox S.A. Process for preparing 1,4-butandiol mononitrate
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
WO2014111957A1 (en) 2013-01-21 2014-07-24 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents
US11660282B2 (en) 2020-02-10 2023-05-30 Nicox Sa Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
AU678063B2 (en) * 1993-10-06 1997-05-15 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
DK0759899T3 (da) 1994-05-10 1999-12-20 Nicox Sa Nitroforbindelser og sammensætninger deraf med antiinflammatoriske, analgetiske og antitrombotiske aktiviteter
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
WO1997013519A1 (en) * 1995-10-09 1997-04-17 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
JP2003506425A (ja) 2003-02-18
KR100687820B1 (ko) 2007-02-28
PL353092A1 (en) 2003-10-06
DE60005682D1 (de) 2003-11-06
JP4667691B2 (ja) 2011-04-13
BR0012915A (pt) 2002-06-04
US7238829B2 (en) 2007-07-03
DE60020753T2 (de) 2006-03-16
KR20020013974A (ko) 2002-02-21
ITMI991753A1 (it) 2001-02-04
DE60020753D1 (de) 2005-07-14
HUP0202435A2 (hu) 2002-11-28
CA2380116C (en) 2011-07-05
CN1198786C (zh) 2005-04-27
ZA200200478B (en) 2003-10-29
PT1200386E (pt) 2004-02-27
ATE297372T1 (de) 2005-06-15
ITMI991753A0 (it) 1999-08-04
HU227109B1 (en) 2010-07-28
NO20020515D0 (no) 2002-02-01
CN1367773A (zh) 2002-09-04
ATE251109T1 (de) 2003-10-15
NO327669B1 (no) 2009-09-07
MXPA02001256A (es) 2005-06-06
IT1313596B1 (it) 2002-09-09
EP1200386A1 (en) 2002-05-02
RU2248348C2 (ru) 2005-03-20
WO2001010814A1 (en) 2001-02-15
EP1384707B1 (en) 2005-06-08
BRPI0012915B1 (pt) 2015-09-01
ES2208390T3 (es) 2004-06-16
PL200165B1 (pl) 2008-12-31
IL147639A0 (en) 2002-08-14
AU6438500A (en) 2001-03-05
NO20020515L (no) 2002-02-01
DE60005682T2 (de) 2004-09-16
PT1384707E (pt) 2005-08-31
ES2243859T3 (es) 2005-12-01
HUP0202435A3 (en) 2004-03-01
TR200200290T2 (tr) 2002-05-21
JP2011042690A (ja) 2011-03-03
US6700011B1 (en) 2004-03-02
EP1200386B1 (en) 2003-10-01
AU778694B2 (en) 2004-12-16
DK1200386T3 (da) 2003-12-22
CA2380116A1 (en) 2001-02-15
EP1384707A1 (en) 2004-01-28
US20050119339A1 (en) 2005-06-02
ZA200304525B (en) 2004-04-28

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