DK1200386T3 - Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen - Google Patents

Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen

Info

Publication number
DK1200386T3
DK1200386T3 DK00951456T DK00951456T DK1200386T3 DK 1200386 T3 DK1200386 T3 DK 1200386T3 DK 00951456 T DK00951456 T DK 00951456T DK 00951456 T DK00951456 T DK 00951456T DK 1200386 T3 DK1200386 T3 DK 1200386T3
Authority
DK
Denmark
Prior art keywords
naproxen
preparation
nitroxyalkyl
esters
nitroxyalkyl esters
Prior art date
Application number
DK00951456T
Other languages
Danish (da)
English (en)
Inventor
Francesca Benedini
Erminio Oldani
Graziano Castaldi
Antonio Tarquini
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of DK1200386T3 publication Critical patent/DK1200386T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK00951456T 1999-08-04 2000-07-27 Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen DK1200386T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene
PCT/EP2000/007222 WO2001010814A1 (en) 1999-08-04 2000-07-27 Process for the preparation of naproxene nitroxyalkylesters

Publications (1)

Publication Number Publication Date
DK1200386T3 true DK1200386T3 (da) 2003-12-22

Family

ID=11383500

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03102132T DK1384707T3 (da) 1999-08-04 2000-07-27 4-Nitroxybutylester af naproxen
DK00951456T DK1200386T3 (da) 1999-08-04 2000-07-27 Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK03102132T DK1384707T3 (da) 1999-08-04 2000-07-27 4-Nitroxybutylester af naproxen

Country Status (23)

Country Link
US (2) US6700011B1 (ko)
EP (2) EP1384707B1 (ko)
JP (2) JP4667691B2 (ko)
KR (1) KR100687820B1 (ko)
CN (1) CN1198786C (ko)
AT (2) ATE297372T1 (ko)
AU (1) AU778694B2 (ko)
BR (1) BRPI0012915B1 (ko)
CA (1) CA2380116C (ko)
DE (2) DE60020753T2 (ko)
DK (2) DK1384707T3 (ko)
ES (2) ES2243859T3 (ko)
HU (1) HU227109B1 (ko)
IL (1) IL147639A0 (ko)
IT (1) IT1313596B1 (ko)
MX (1) MXPA02001256A (ko)
NO (1) NO327669B1 (ko)
PL (1) PL200165B1 (ko)
PT (2) PT1200386E (ko)
RU (1) RU2248348C2 (ko)
TR (1) TR200200290T2 (ko)
WO (1) WO2001010814A1 (ko)
ZA (2) ZA200200478B (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1126838A4 (en) 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
JP4092203B2 (ja) 2000-12-21 2008-05-28 ニトロメッド，インク． 新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法
CA2465697C (en) * 2001-11-27 2010-05-11 Astrazeneca Ab Process for the preparation of (s)-naproxen 4-nitrooxybutyl ester
EP1539134A4 (en) 2002-06-11 2007-04-11 Nitromed Inc SELECTIVE INHIBITORS OF CYCLOOXIGENASE-2 NITROSIS AND / OR NITROSYLES, COMPOSITIONS AND METHODS OF USE
US7163958B2 (en) 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en) 2002-07-29 2007-07-17 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
KR20080097989A (ko) * 2006-02-03 2008-11-06 니콕스 에스. 에이. 근위축증 치료를 위한 의약의 니트록시 유도체의 용도
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
KR20100032856A (ko) * 2007-06-28 2010-03-26 니콕스 에스. 에이. 1,4-부탄디올 모노니트레이트의 제조방법
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
JP2023513534A (ja) 2020-02-10 2023-03-31 ニコックス エス．エー． 鎌状赤血球症に関連する血管閉塞性クリーゼを処置するための方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
HU218923B (hu) * 1993-10-06 2000-12-28 Nicox S.A. Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
RU2145595C1 (ru) * 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
WO1997013519A1 (en) * 1995-10-09 1997-04-17 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
KR20020013974A (ko) 2002-02-21
IL147639A0 (en) 2002-08-14
DE60005682D1 (de) 2003-11-06
US20050119339A1 (en) 2005-06-02
NO20020515D0 (no) 2002-02-01
DE60005682T2 (de) 2004-09-16
AU6438500A (en) 2001-03-05
AU778694B2 (en) 2004-12-16
DE60020753D1 (de) 2005-07-14
HUP0202435A2 (hu) 2002-11-28
BRPI0012915B1 (pt) 2015-09-01
KR100687820B1 (ko) 2007-02-28
PT1200386E (pt) 2004-02-27
EP1384707B1 (en) 2005-06-08
IT1313596B1 (it) 2002-09-09
NO20020515L (no) 2002-02-01
HU227109B1 (en) 2010-07-28
MXPA02001256A (es) 2005-06-06
EP1384707A1 (en) 2004-01-28
PL353092A1 (en) 2003-10-06
HUP0202435A3 (en) 2004-03-01
CA2380116C (en) 2011-07-05
WO2001010814A1 (en) 2001-02-15
CN1198786C (zh) 2005-04-27
US7238829B2 (en) 2007-07-03
CA2380116A1 (en) 2001-02-15
ATE297372T1 (de) 2005-06-15
PT1384707E (pt) 2005-08-31
TR200200290T2 (tr) 2002-05-21
EP1200386B1 (en) 2003-10-01
NO327669B1 (no) 2009-09-07
RU2248348C2 (ru) 2005-03-20
EP1200386A1 (en) 2002-05-02
ES2243859T3 (es) 2005-12-01
ZA200200478B (en) 2003-10-29
PL200165B1 (pl) 2008-12-31
JP4667691B2 (ja) 2011-04-13
CN1367773A (zh) 2002-09-04
US6700011B1 (en) 2004-03-02
ZA200304525B (en) 2004-04-28
JP2011042690A (ja) 2011-03-03
ATE251109T1 (de) 2003-10-15
ITMI991753A1 (it) 2001-02-04
DK1384707T3 (da) 2005-08-15
ITMI991753A0 (it) 1999-08-04
BR0012915A (pt) 2002-06-04
DE60020753T2 (de) 2006-03-16
JP2003506425A (ja) 2003-02-18
ES2208390T3 (es) 2004-06-16

Similar Documents

Publication Publication Date Title
DK1200386T3 (da) Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen
DK0980349T3 (da) Fremgangsmåde til fremstilling af syntetiske triglycerider på basis af konjugeret linolsyre
ATE249418T1 (de) Neuartige ester abgeleitet von substituierten phenyl-cyclohexyl-verbindungen
DE59704095D1 (de) Verfahren zur kontinuierlichen Herstellung von Alkylestern der (Meth)acrylsäure
NO975035L (no) Fettsyreestere som bioaktive forbindelser
DE59904311D1 (de) Verfahren zur Herstellung von Estern der (Meth)acrylsäure
DE59902730D1 (de) Verfahren zur Herstellung von alpha-Cyano Essigsäureestern
DE59602043D1 (de) Verfahren zur kontinuierlichen Herstellung von Alkylestern der (Meth)acrylsäure
DE10084723T1 (de) Verfahren zur Herstellung von a-Sulfonfettsäurealkylestersalzen
WO2001002367A3 (en) Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid
DE69920568D1 (de) Verfahren zur Herstellung von optisch aktivem 4-Halo-3-hydroxybuttersäureester
DK0889873T3 (da) Fremgangsmåde til fremstilling af alkoxylerede fedtsyrealkylestere
DK0607795T3 (da) Fremgangsmåde til fremstilling af 2-alkyl-4-fluormethylthiazolcarboxylsyrealkylestere
ES2128093T3 (es) Procedimiento enzimatico para la preparacion de esteres de acidos carboxilicos quirales alfa-terciarios.
NO993796D0 (no) Fremgangsmåte for omforestring av <alfa>-ketokarboksylsyreestre
DK0888280T3 (da) Fremgangsmåde til fremstilling af 2-(2-methylphenyl)-3-methoxyacrylsyremethylester
EP0997534A3 (de) Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern
FI942581A (fi) Menetelmä 5-bromi-6-metoksi-1-naftoehappometyyliesterin valmistamiseksi
DE69819335D1 (de) Verfahren zur herstellung von phosphorsäureester-verbindungen
DK0923527T3 (da) Fremgangsmåde til fremstillingen af 2-(3-benzoyl-phenyl)-propionsyre ud fra arylolefiner
DE69821755D1 (de) Verfahren zur Herstellung von alpha-Tocopherol-4-aminobenzoesäureester-Verbindungen
DK0989112T3 (da) Mellemprodukter til fremstilling af guanidinomethylcyclohexancarboxylsyreesterderivater
DK0889872T3 (da) Fremgangsmåde til fremstilling af alkoxylerede fedtsyrealkylestere
ES2159665T3 (es) Preparacion y utilizacion de enantiomeros puros de los acidos 8-halogeno-6-hidroxioctanoicos, sus esteres alquilicos y sus sales con los enantiomeros puros de alfa-metilbencilamina.
DK1196622T3 (da) Anvendelse af orthoestere til syntese af chirale syrer i biokatalyserede irreversible esterificeringsfremgangsmåder